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  1. Article ; Online: Deciphering cutaneous melanoma prognosis through LDL metabolism: Single-cell transcriptomics analysis via 101 machine learning algorithms.

    Xie, Jiaheng / Wu, Dan / Zhang, Pengpeng / Zhao, Songyun / Qi, Min

    Experimental dermatology

    2024  Volume 33, Issue 4, Page(s) e15070

    Abstract: Cutaneous melanoma poses a formidable challenge within the field of oncology, marked by its aggressive nature and capacity for metastasis. Despite extensive research uncovering numerous genetic and molecular contributors to cutaneous melanoma development, ...

    Abstract Cutaneous melanoma poses a formidable challenge within the field of oncology, marked by its aggressive nature and capacity for metastasis. Despite extensive research uncovering numerous genetic and molecular contributors to cutaneous melanoma development, there remains a critical knowledge gap concerning the role of lipids, notably low-density lipoprotein (LDL), in this lethal skin cancer. This article endeavours to bridge this knowledge gap by delving into the intricate interplay between LDL metabolism and cutaneous melanoma, shedding light on how lipids influence tumour progression, immune responses and potential therapeutic avenues. Genes associated with LDL metabolism were extracted from the GSEA database. We acquired and analysed single-cell sequencing data (GSE215120) and bulk-RNA sequencing data, including the TCGA data set, GSE19234, GSE22153 and GSE65904. Our analysis unveiled the heterogeneity of LDL across various cell types at the single-cell sequencing level. Additionally, we constructed an LDL-related signature (LRS) using machine learning algorithms, incorporating differentially expressed genes and highly correlated genes. The LRS serves as a valuable tool for assessing the prognosis, immunity and mutation status of patients with cutaneous melanoma. Furthermore, we conducted experiments on A375 and WM-115 cells to validate the function of PPP2R1A, a pivotal gene within the LRS. Our comprehensive approach, combining advanced bioinformatics analyses with an extensive review of current literature, presents compelling evidence regarding the significance of LDL within the cutaneous melanoma microenvironment.
    MeSH term(s) Humans ; Melanoma/genetics ; Skin Neoplasms/genetics ; Prognosis ; Algorithms ; Machine Learning ; Gene Expression Profiling ; Lipids ; Tumor Microenvironment/genetics
    Chemical Substances Lipids
    Language English
    Publishing date 2024-04-03
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.15070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Transcriptome and single-cell sequencing analysis in tumor microenvironment.

    Liu, Jinhui / Xie, Jiaheng / Dong, Peixin

    The journal of gene medicine

    2023  Volume 25, Issue 10, Page(s) e3520

    MeSH term(s) Transcriptome ; Tumor Microenvironment/genetics ; Gene Expression Profiling
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Editorial
    ZDB-ID 1458024-x
    ISSN 1521-2254 ; 1099-498X
    ISSN (online) 1521-2254
    ISSN 1099-498X
    DOI 10.1002/jgm.3520
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    Zs.A 5423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Editorial: Transcriptome analysis in tumor microenvironment and tumor heterogeneity.

    Liu, Jinhui / Xie, Jiaheng / Dong, Peixin

    Oncology research

    2023  Volume 32, Issue 1, Page(s) 99–100

    MeSH term(s) Humans ; Tumor Microenvironment/genetics ; Gene Expression Profiling ; Neoplasms/genetics
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 1114699-0
    ISSN 1555-3906 ; 0965-0407
    ISSN (online) 1555-3906
    ISSN 0965-0407
    DOI 10.32604/or.2023.045719
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    Zs.A 3087: Show issues Location:
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  4. Article ; Online: Identification and extraction of cementation patterns in sand modified by MICP: New insights at the pore scale.

    Wang, Baoquan / Guo, Liang / Luo, Xuanli / Jiang, Yuhong / Li, Quanwei / Xie, Jiaheng

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0296437

    Abstract: Microbially induced calcium carbonate precipitation (MICP) is an environmentally friendly technology that improves soil permeability resistance through biocementation. In this study, 2D microscopic analysis and 3D volume reconstruction were performed on ... ...

    Abstract Microbially induced calcium carbonate precipitation (MICP) is an environmentally friendly technology that improves soil permeability resistance through biocementation. In this study, 2D microscopic analysis and 3D volume reconstruction were performed on river sand after 24 cycles of bio-treatment based on stacked images and computed tomography (CT) scanning data, respectively, to extract biocementation patterns between particles. Based on the mutual validation findings of the two techniques, three patterns in the biocemented sand were identified as G-C-G, G-C, and G-G. Specifically, 2D microscopic analysis showed that G-C-G featured multi-particle encapsulation and bridging, with a pore filling ratio of 81.2%; G-C was characterized by locally coated particle layers, with a pore filling ratio of 19.7%; and the G-G was marked by sporadic filling of interparticle pores, with a pore filling ratio of 11.7%. G-C-G had the best cementation effect and permeability resistance (effective sealing rate of 68.5%), whereas G-C (effective sealing rate of 2.4%) had a relatively minor contribution to pore-filling and flow sealing. 3D volume reconstruction showed that G-C-G had the highest pore filling rate, followed by G-G and G-C. The average filling ratios of area and volume for G-C-G were 83.979% and 77.257%, respectively; for G-G 20.360% and 23.600%; and for G-C 11.545% and 11.250%. The analysis of the representative element volume (REV) was conducted, and the feasibility and reliability of the micro-scale pattern extraction results were confirmed to guide the analysis of macro-scale characteristics. The exploration of the effectiveness of cementation patterns in fluid sealing provides valuable insights into effective biocementation at the pore scale of porous media, which may inspire future research.
    MeSH term(s) Sand ; Calcium Carbonate ; Cementation ; Reproducibility of Results ; Tomography, X-Ray Computed ; Chemical Precipitation
    Chemical Substances Sand ; Calcium Carbonate (H0G9379FGK)
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296437
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  5. Article ; Online: PANoptosis-related signature in melanoma: Transcriptomic mapping and clinical prognostication.

    Xie, Jiaheng / Zhang, Pengpeng / Xu, Xiaolong / Zhou, Xinxin / Zhao, Songyun / Zhang, Min / Qi, Min

    Environmental toxicology

    2024  Volume 39, Issue 5, Page(s) 2545–2559

    Abstract: Programmed cell death plays a pivotal role in maintaining tissue homeostasis, and recent advancements in cell biology have uncovered PANoptosis-a novel paradigm integrating pyroptosis, apoptosis, and necroptosis. This study investigates the implications ... ...

    Abstract Programmed cell death plays a pivotal role in maintaining tissue homeostasis, and recent advancements in cell biology have uncovered PANoptosis-a novel paradigm integrating pyroptosis, apoptosis, and necroptosis. This study investigates the implications of PANoptosis in melanoma, a formidable skin cancer known for its metastatic potential and resistance to conventional therapies. Leveraging bulk and single-cell transcriptome analyses, machine learning modeling, and immune correlation assessments, we unveil the molecular intricacies of PANoptosis in melanoma. Single-cell sequencing identifies diverse cell types involved in PANoptosis, while bulk transcriptome analysis reveals key gene sets correlated with PANoptosis. Machine learning algorithms construct a robust prognostic model, demonstrating consistent predictive power across diverse cohorts. Patients with different cohorts can be divided into high-risk and low-risk groups according to this PANoptosis score, with the high-risk group having a significantly worse prognosis. Immune correlation analyses unveil a link between PANoptosis and immunotherapy response, with potential therapeutic implications. Mutation analysis and enrichment studies provide insights into the mutational landscape associated with PANoptosis. Finally, we used cell experiments to verify the expression and function of key gene PARVA, showing that PARVA was highly expressed in melanoma cell lines, and after PARVA is knocked down, cell invasion, migration, and colony formation ability were significantly decreased. This study advances our understanding of PANoptosis in melanoma, offering a comprehensive framework for targeted therapeutic interventions and personalized medicine strategies in combating this aggressive malignancy.
    MeSH term(s) Humans ; Melanoma/genetics ; Gene Expression Profiling ; Transcriptome ; Skin Neoplasms/genetics ; Apoptosis
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24126
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Neural Endophenotype Assessment in Zebrafish Larvae Using Optomotor and ZebraBox Locomotion Assessment.

    Xie, Jiaheng / Goodbourn, Patrick / Sztal, Tamar / Jusuf, Patricia R

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2746, Page(s) 213–224

    Abstract: Due to the highly conserved genetics across the central nervous system, the easily probed visual system can act as an endophenotype for assessing neurological function. Here, we describe a psychophysics approach to assess visually driven swimming ... ...

    Abstract Due to the highly conserved genetics across the central nervous system, the easily probed visual system can act as an endophenotype for assessing neurological function. Here, we describe a psychophysics approach to assess visually driven swimming behavior in the high-throughput zebrafish genetic model system. We use the optomotor response test together with general locomotion behavior to assess neural processing while excluding motor defects related to muscle function.
    MeSH term(s) Animals ; Zebrafish/genetics ; Endophenotypes ; Larva/genetics ; Locomotion ; Swimming/physiology
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3585-8_17
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  7. Article: Advances and future directions in keloid research: Pathogenesis, diagnosis and personalized treatment strategies.

    Zhao, Song-Yun / Wu, Dan / Cheng, Chao / Xie, Jia-Heng

    World journal of clinical cases

    2023  Volume 11, Issue 34, Page(s) 8094–8098

    Abstract: Keloids, which are abnormal manifestations of wound healing, can result in significant functional impairment and aesthetic deformities. The pathogenesis of keloids is multifaceted and complex and influenced by various factors, such as genetics, the ... ...

    Abstract Keloids, which are abnormal manifestations of wound healing, can result in significant functional impairment and aesthetic deformities. The pathogenesis of keloids is multifaceted and complex and influenced by various factors, such as genetics, the environment, and immune responses. The evolution of keloid treatment has progressed from traditional surgical excision to a contemporary combination of therapies including injection and radiation treatments, among others. This article provides a comprehensive review of keloid pathogenesis and treatment, emphasizing the latest advances in the field. Ultimately, this review underscores the necessity for continued research to enhance our understanding of keloid pathogenesis and to devise more effective treatments for this challenging condition.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Editorial
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i34.8094
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  8. Article: Advances in Prepectoral Breast Reconstruction.

    Xie, Jiaheng / Yan, Wei / Zhu, Zhechen / Wang, Ming / Shi, Jingping

    Therapeutics and clinical risk management

    2023  Volume 19, Page(s) 361–368

    Abstract: Breast reconstruction can be divided into prepectoral breast reconstruction (PPBR) and subpectoral breast reconstruction (SPBR) according to the implant plane. The original prepectoral breast reconstruction was abandoned for a long time due to the ... ...

    Abstract Breast reconstruction can be divided into prepectoral breast reconstruction (PPBR) and subpectoral breast reconstruction (SPBR) according to the implant plane. The original prepectoral breast reconstruction was abandoned for a long time due to the frequent and severe complications. Now, advances in materials technology and improved methods of mastectomy have made safe prepectoral breast reconstruction possible. Moreover, a number of studies have gradually demonstrated the advantages of prepectoral breast reconstruction. As prepectoral breast reconstruction becomes more and more attractive, it is time to review the current advances in prepectoral breast reconstruction.
    Language English
    Publishing date 2023-04-18
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S404799
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    Zs.A 6067: Show issues Location:
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  9. Article: Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker.

    Zhang, Yaoting / Kadasah, Sultan / Xie, Jiaheng / Gu, Dongsheng

    Applied bionics and biomechanics

    2022  Volume 2022, Page(s) 3051907

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. The hypoxia-adenosine pathway, in which CD73 encoded by the NT5E gene is a key enzyme for adenosine production, has been identified as an immune checkpoint of great potential. Therefore, NT5E may play an important role in HNSCC. We performed a detailed bioinformatics analysis of NT5E in HNSCC, and the results showed that the overexpression of NT5E in HNSCC was associated with poor prognosis. Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies.
    Language English
    Publishing date 2022-04-25
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2179924-6
    ISSN 1754-2103 ; 1176-2322
    ISSN (online) 1754-2103
    ISSN 1176-2322
    DOI 10.1155/2022/3051907
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  10. Article ; Online: Response: Commentary: Single-Cell Sequencing Analysis and Weighted CoExpression Network Analysis Based on Public Databases Identified That TNC Is a Novel Biomarker for Keloid.

    Xie, Jiaheng / Cao, Yuan / Chen, Liang / Wang, Ming

    Frontiers in immunology

    2022  Volume 13, Page(s) 923283

    MeSH term(s) Biomarkers ; Gene Expression Profiling ; Gene Regulatory Networks ; Humans ; Keloid/diagnosis ; Keloid/genetics ; Single-Cell Analysis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.923283
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