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Article: Immune dysregulation in sepsis: experiences, lessons and perspectives.

Cao, Min / Wang, Guozheng / Xie, Jianfeng

Cell death discovery

2023 Volume 9, Issue 1, Page(s) 465

Abstract: Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system. The ... ...

Abstract	Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host responses to infection. Not only does sepsis pose a serious hazard to human health, but it also imposes a substantial economic burden on the healthcare system. The cornerstones of current treatment for sepsis remain source control, fluid resuscitation, and rapid administration of antibiotics, etc. To date, no drugs have been approved for treating sepsis, and most clinical trials of potential therapies have failed to reduce mortality. The immune response caused by the pathogen is complex, resulting in a dysregulated innate and adaptive immune response that, if not promptly controlled, can lead to excessive inflammation, immunosuppression, and failure to re-establish immune homeostasis. The impaired immune response in patients with sepsis and the potential immunotherapy to modulate the immune response causing excessive inflammation or enhancing immunity suggest the importance of demonstrating individualized therapy. Here, we review the immune dysfunction caused by sepsis, where immune cell production, effector cell function, and survival are directly affected during sepsis. In addition, we discuss potential immunotherapy in septic patients and highlight the need for precise treatment according to clinical and immune stratification.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01766-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Xuebijing Injection for Sepsis Treatment: When Will It Be Approved Outside of China?-Reply.

Liu, Songqiao / Xie, Jianfeng / Qiu, Haibo

JAMA internal medicine

2023 Volume 183, Issue 11, Page(s) 1281

MeSH term(s)	Humans ; Sepsis/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; China
Chemical Substances	Xuebijing ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2699338-7
ISSN	2168-6114 ; 2168-6106
ISSN (online)	2168-6114
ISSN	2168-6106
DOI	10.1001/jamainternmed.2023.4395
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Article ; Online: THE EFFICACY AND SAFETY OF VASOPRESSORS FOR SEPTIC SHOCK PATIENTS: A SYSTEMIC REVIEW AND NETWORK META-ANALYSIS.

Jia, Lu / Wang, Pufeng / Li, Cong / Xie, Jianfeng

Shock (Augusta, Ga.)

2023 Volume 60, Issue 6, Page(s) 746–752

Abstract: Abstract: Background: Septic shock is a distributive shock with decreased systemic vascular resistance and MAP. Septic shock contributes to the most common causes of death in the intensive care unit (ICU). Current guidelines recommend the use of ... ...

Abstract	Abstract: Background: Septic shock is a distributive shock with decreased systemic vascular resistance and MAP. Septic shock contributes to the most common causes of death in the intensive care unit (ICU). Current guidelines recommend the use of norepinephrine as the first-line vasopressor, whereas adrenergic agonists and vasopressin analogs are also commonly used by physicians. To date, very few studies have synthetically compared the effects of multiple types of vasoactive medications. The aim of this study was to systemically evaluate the efficacy of vasoactive agents both individually and in combination to treat septic shock. Methods: The PubMed, MEDLINE, Embase, Web of Science, and Cochrane Central Register for Controlled Trials (CENTRAL) were searched up to May 12, 2022, to identify relevant randomized controlled trials. A network meta-analysis was performed to evaluate the effect of different types of vasopressors. The primary outcome was 28-day all-cause mortality. The secondary outcome was the ICU length of stay. Adverse events are defined as any undesirable outcomes, including myocardial infarction, cardiac arrhythmia, peripheral ischemia, or stroke and cerebrovascular events. Findings: Thirty-three randomized controlled trials comprising 4,966 patients and assessing 8 types of vasoactive treatments were included in the network meta-analysis. The surface under the cumulative ranking curve provided a ranking of vasoactive medications in terms of 28-day all-cause mortality from most effective to least effective: norepinephrine plus dobutamine, epinephrine, vasopressin, terlipressin, norepinephrine, norepinephrine plus vasopressin, dopamine, and dobutamine. Dopamine was associated with a significantly shorter ICU stay than norepinephrine, terlipressin, and vasopressin, whereas other vasoactive medications showed no definite difference in ICU length of stay. Regarding adverse events, norepinephrine was associated with the highest incidences of myocardial infarction and peripheral ischemia. Dopamine was associated with the highest incidence of cardiac arrhythmia. Epinephrine and terlipressin were associated with the highest incidences of myocardial infarction and peripheral ischemia. Interpretation: The results of this network meta-analysis suggest that norepinephrine plus dobutamine is associated with a lower risk of 28-day mortality in septic shock patients than other vasoactive medications, and the use of dopamine is associated with a higher risk of 28-day mortality due to septic shock than norepinephrine, terlipressin, and vasopressin.
MeSH term(s)	Humans ; Shock, Septic ; Dopamine/therapeutic use ; Terlipressin/therapeutic use ; Dobutamine/therapeutic use ; Network Meta-Analysis ; Vasoconstrictor Agents/adverse effects ; Epinephrine/therapeutic use ; Norepinephrine/therapeutic use ; Vasopressins/therapeutic use ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/drug therapy ; Ischemia/drug therapy ; Myocardial Infarction/drug therapy
Chemical Substances	Dopamine (VTD58H1Z2X) ; Terlipressin (7Z5X49W53P) ; Dobutamine (3S12J47372) ; Vasoconstrictor Agents ; Epinephrine (YKH834O4BH) ; Norepinephrine (X4W3ENH1CV) ; Vasopressins (11000-17-2)
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000002193
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Article ; Online: Mucosal membrane pressure injury in intensive care units: A scoping review.

Chen, Guanjie / Li, Xiaoqing / Li, Xuezhu / Liu, Songqiao / Xie, Jianfeng

Intensive & critical care nursing

2023 Volume 80, Page(s) 103560

Abstract: Aim: To describe published work on the current situation of mucosal membrane pressure injury of patients in the intensive care unit.: Background: Device-related pressure injuries in critically ill patients are mostly focused on skin surface injuries, ...

Abstract	Aim: To describe published work on the current situation of mucosal membrane pressure injury of patients in the intensive care unit. Background: Device-related pressure injuries in critically ill patients are mostly focused on skin surface injuries, and less attention is paid to mucosal membrane pressure injury. Methods: We searched PubMed, Embase, Web of Science, CINAHL, and Cochrane Library from database construction until March 1, 2023. Two researchers independently screened and extracted data. Results: Eighteen articles met our criteria and were published in 2014-2023. The included studies showed that the incidence of mucosal membrane pressure injury in critically ill patients ranged from 0.83% to 88.2%, and the prevalence ranged from 0.16% to 55.6%. The most frequently reported site of mucosal injury is the oral mucosa, followed by the nasal mucosa. Ten studies used Braden to assess the risk of mucosal membrane pressure injury, and only six studies reported specific stages of mucosal membrane pressure injury. Thirteen studies described 30 risk factors for mucosal membrane pressure injury, with albumin being the most frequently reported risk factor, followed by the vasoconstrictive drugs use. Thirty risk factors were summarized in six aspects: medical device-related factors, disease-related factors, treatment- related factors, physiological and biochemical parameters, demographic-related factors, and microbial colonisation. Conclusions: The incidence or prevalence of mucosal membrane pressure injury varies widely, and specific risk assessment tools and standardized staging criteria need to be further determined. The risk factors of mucosal membrane pressure injury involve multiple aspects, and some risk factors have only been explored in few studies and need to be further verified, in order to detect the risk group of mucosal membrane pressure injury early and take targeted preventive measures. Implications for clinical practice: We synthesized the current research status of mucosal membrane pressure injury in critically ill patients, which can provide a valuable reference for the clinical staff to develop preventive and management measures for such patients.
MeSH term(s)	Humans ; Pressure Ulcer/epidemiology ; Pressure Ulcer/etiology ; Critical Illness ; Intensive Care Units ; Risk Factors
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2023.103560
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Article ; Online: Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome.

Jiang, Lianlian / Chen, Hui / Xie, Jianfeng / Liu, Ling / Yang, Yi

Journal of intensive medicine

2023 Volume 4, Issue 2, Page(s) 187–193

Abstract: Background: The dead space fraction (V: Methods: This retrospective observational study was conducted using data from the Chinese database in intensive care (CDIC). Eligible participants were adult ARDS patients receiving invasive mechanical ... ...

Abstract	Background: The dead space fraction (V Methods: This retrospective observational study was conducted using data from the Chinese database in intensive care (CDIC). Eligible participants were adult ARDS patients receiving invasive mechanical ventilation while in the intensive care unit between 1st January 2014 and 31st March 2021. We collected data during the first 7 days of ventilation to calculate various dead space estimates, including ventilatory ratio (VR), corrected minute ventilation ( Results: A total of 392 patients (median age 66 [interquartile range: 55-77] years, median SOFA score 9 [interquartile range: 7-12]) were finally included in our analysis, among whom 132 (33.7%) patients died within 28 days of admission. VR (hazard ratio [HR]=1.04 per 0.1 increase, 95% confidence interval [CI]: 1.01 to 1.06; Conclusions: In cases where V
Language	English
Publishing date	2023-10-09
Publishing country	China
Document type	Journal Article
ISSN	2667-100X
ISSN (online)	2667-100X
DOI	10.1016/j.jointm.2023.08.002
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Article: High Dose Vitamin D3 Supplementation Is Not Associated With Lower Mortality in Critically Ill Patients: A Meta-Analysis of Randomized Control Trials.

Gao, Zhiwei / Xie, Jianfeng / Li, Cong / Liu, Ling / Yang, Yi

Frontiers in nutrition

2022 Volume 9, Page(s) 762316

Abstract: Background: Vitamin D deficiency is a common condition in critically ill patients. A high dose of vitamin D3 can rapidly restore vitamin D levels. The aim of this meta-analysis was to synthesize the results from up-to-date randomized control trials (RCT) ...

Abstract	Background: Vitamin D deficiency is a common condition in critically ill patients. A high dose of vitamin D3 can rapidly restore vitamin D levels. The aim of this meta-analysis was to synthesize the results from up-to-date randomized control trials (RCT) and validate the effect of vitamin D3 in critically ill patients. Study methods: Several databases, including PubMed, Web of Science, EMBASE, and the Cochrane Central database, were searched up to December 4th, 2020. All RCTs that investigated the use of a high dose of vitamin D3 in critically ill patients and reported mortality data were included in the meta-analysis. The primary outcome was the mortality truncated to day 28 and day 90. Results: A total of 10 RCTs enrolling 2058 patients were finally included. The use of a high dose of vitamin D3 in critically ill patients could not decrease the mortality truncated to day 28 (RR 0.93, 95% CI 0.78-1.11, Conclusion: The use of high dose vitamin D3 was not associated with decreased mortality in critically ill patients, but could significantly reduce the ventilator days. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier: CRD42020179195.
Language	English
Publishing date	2022-05-04
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.762316
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Article ; Online: An expanded definition of acute respiratory distress syndrome: Challenging the

Yuan, Xueyan / Pan, Chun / Xie, Jianfeng / Qiu, Haibo / Liu, Ling

Journal of intensive medicine

2022 Volume 3, Issue 1, Page(s) 62–64

Abstract: Although the Berlin definition of acute respiratory distress syndrome (ARDS), 2012 has been widely used in clinical practice, issues have occasionally been raised regarding various criteria since it was proposed. High-flow nasal oxygen (HFNO) is widely ... ...

Abstract	Although the Berlin definition of acute respiratory distress syndrome (ARDS), 2012 has been widely used in clinical practice, issues have occasionally been raised regarding various criteria since it was proposed. High-flow nasal oxygen (HFNO) is widely used for effective respiratory support in acute respiratory failure. As patients who do not require ventilation but meet the Berlin criteria have similar characteristics to those with ARDS, the definition of ARDS may be broadened to include patients receiving HFNO. As the PaO
Language	English
Publishing date	2022-07-25
Publishing country	China
Document type	Journal Article ; Review
ISSN	2667-100X
ISSN (online)	2667-100X
DOI	10.1016/j.jointm.2022.06.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical characteristics of patients with COVID-19 in Huangshi, China.

Zhang, Xiwen / Xie, Jianfeng / Lu, Xiang / Ha, Weichao / Huang, Yingzi

Journal of intensive medicine

2022 Volume 2, Issue 3, Page(s) 195–196

Language	English
Publishing date	2022-06-13
Publishing country	China
Document type	Journal Article
ISSN	2667-100X
ISSN (online)	2667-100X
DOI	10.1016/j.jointm.2022.05.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Polarization-controllable perfect vortex beam by a dielectric metasurface.

Xie, Jianfeng / Guo, Hanming / Zhuang, Songlin / Hu, Jinbing

Optics express

2021 Volume 29, Issue 3, Page(s) 3081–3089

Abstract: A perfect vortex beam has been attracting tremendous attention due to the fact that its ring radius is independent of the topological charge. Taking advantage of the superposition principle of phase in Fourier space, we proposed to generate perfect ... ...

Abstract	A perfect vortex beam has been attracting tremendous attention due to the fact that its ring radius is independent of the topological charge. Taking advantage of the superposition principle of phase in Fourier space, we proposed to generate perfect vortex beam using propagation-phase-based dielectric metasurface, which exhibits production efficiency larger than 83.5%. Due to the sensitivity of propagation phase to the polarization of incident beam, two sets of phase profiles can be imposed on a single dielectric metasurface, enabling the simultaneous generation of dual perfect vortex beams. Based on this property, convenient control to the radius and/or topological charge of perfect vortex beam is achieved by switching the incident polarization between two orthogonal polarizations, without redesigning metasurface or changing optical path. What's more important, the crosstalk of these two channels is low, less than 4%. Thus, the propagation-phase method of producing perfect vortex beam will find significant applications in optical communication, particle trapping, particle manipulation and holographic display.
Language	English
Publishing date	2021-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.413573
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Article ; Online: A low-jitter timing generator based on completely on-chip self-measurement and calibration in a field programmable gate array.

Qiu, Wenjie / Xie, Jianfeng / Liu, Qinying / Han, Xiaotao

The Review of scientific instruments

2021 Volume 92, Issue 11, Page(s) 114703

Abstract: This paper presents a high-stability and low-jitter Arbitrary Timing Generator (ATG) design based on the Xilinx Field Programmable Gate Array (FPGA) and its special integrated delay line. In recent years, FPGA-based or application specific integrated ... ...

Abstract	This paper presents a high-stability and low-jitter Arbitrary Timing Generator (ATG) design based on the Xilinx Field Programmable Gate Array (FPGA) and its special integrated delay line. In recent years, FPGA-based or application specific integrated circuit-based delay lines have been used to achieve picosecond-level timing resolution. Devices with pure digital delay methods can only acquire triggers at the clock rising edges when triggered externally. Therefore, there is a large time irregularity caused by the uncertainty of the entry time of the trigger, which is difficult to compensate and leads to a large time jitter of outputs. We describe the design of an ATG that includes jitter self-measurement and calibration methods, which is available for both internal and external trigger modes. This structure is completely based on the FPGA's own resources and has the advantages of being simple and flexible. Experimental results show a sub-nanosecond timing resolution of 78 ± 20 ps with a minimum of 120 ps and a time jitter of 160 ± 20 ps in the external trigger mode after compensation.
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0059264
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