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Article: Editorial: Microenvironmental stimuli-responsive nanomedicine for biomedical application.

Xia, Donglin / Xie, Jingwei / Hu, Yong

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1206895

Language	English
Publishing date	2023-05-04
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1206895
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Article ; Online: Advances in Nerve Injury Models on a Chip.

Lee, Donghee / Yang, Kai / Xie, Jingwei

Advanced biology

2023 Volume 7, Issue 8, Page(s) e2200227

Abstract: Regeneration and functional recovery of the damaged nerve are challenging due to the need for effective therapeutic drugs, biomaterials, and approaches. The poor outcome of the treatment of nerve injury stems from the incomplete understanding of axonal ... ...

Abstract	Regeneration and functional recovery of the damaged nerve are challenging due to the need for effective therapeutic drugs, biomaterials, and approaches. The poor outcome of the treatment of nerve injury stems from the incomplete understanding of axonal biology and interactions between neurons and the surrounding environment, such as glial cells and extracellular matrix. Microfluidic devices, in combination with various injury techniques, have been applied to test biological hypotheses in nerve injury and nerve regeneration. The microfluidic devices provide multiple advantages over the in vitro cell culture on a petri dish and in vivo animal models because a specific part of the neuronal environment can be manipulated using physical and chemical interventions. In addition, single-cell behavior and interactions between neurons and glial cells can be visualized and quantified on microfluidic platforms. In this article, current in vitro nerve injury models on a chip that mimics in vivo axonal injuries and the regeneration process of axons are summarized. The microfluidic-based nerve injury models could enhance the understanding of the physiological and pathophysiological mechanisms of nerve tissues and simultaneously serve as powerful drug and biomaterial screening platforms.
MeSH term(s)	Animals ; Axons/physiology ; Neurons/physiology ; Microfluidics ; Cell Culture Techniques/methods ; Trauma, Nervous System ; Lab-On-A-Chip Devices
Language	English
Publishing date	2023-01-29
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2701-0198
ISSN (online)	2701-0198
DOI	10.1002/adbi.202200227
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Article ; Online: Numerical modeling of ultrasound-triggered microneedle-mediated delivery of drug particles into bacterial biofilms.

Tian, Yiran / Chen, Jiaji / Yan, Zheng / Xie, Jingwei / Jiang, Xiaoning / Li, Guangfu / Huang, Guoliang

Ultrasonics

2024 Volume 141, Page(s) 107344

Abstract: Ultrasonic microneedle patches, a class of ultrasound-driven transdermal drug delivery systems, are promising in addressing bacterial biofilms. This device has been proven to be more effective in treating Staphylococcus aureus biofilms than drug in free ... ...

Abstract	Ultrasonic microneedle patches, a class of ultrasound-driven transdermal drug delivery systems, are promising in addressing bacterial biofilms. This device has been proven to be more effective in treating Staphylococcus aureus biofilms than drug in free solution. However, there exists a notable gap in understanding how various excitation conditions and material parameters affect drug delivery efficiency. This study aims to fill this void by conducting an comprehensive multi-physics numerical analysis of ultrasonic microneedle patches, with the ultimate goal of enhancing drug delivery. First, we investigate the impact of various ultrasound frequencies on drug penetration depths. The findings reveal that local resonance can accelerate drug release within a shorter time window (first 1.5 h), whereas non-resonant frequencies enable more profound and prolonged diffusion. This information is crucial for medical professionals in selecting the most effective frequency for optimal drug administration. Furthermore, our investigation extends to the effects of applied voltage on temperature distribution, a critical aspect for ensuring medical safety during the application of these patches. Additionally, we examine how particles of different sizes respond to acoustic pressure and streaming fields, providing valuable insights for tailoring drug delivery strategies to specific therapeutic needs. Overall, our findings offer comprehensive guidelines for the effective use of ultrasonic microneedle patches, potentially shifting the paradigm in patient care and enhancing the overall quality of life.
Language	English
Publishing date	2024-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	200839-7
ISSN	1874-9968 ; 0041-624X
ISSN (online)	1874-9968
ISSN	0041-624X
DOI	10.1016/j.ultras.2024.107344
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Article ; Online: Enhanced Antimicrobial Screening Sensitivity Enabled the Identification of an Ultrashort Peptide KR-8 for Engineering of LL-37mini to Combat Drug-Resistant Pathogens.

Mechesso, Abraham Fikru / Su, Yajuan / Xie, Jingwei / Wang, Guangshun

ACS infectious diseases

2023 Volume 9, Issue 11, Page(s) 2215–2225

Abstract: Identification of novel antibiotics is of top importance because of the threat of antibiotic-resistant pathogens. Antimicrobial screening in Mueller-Hinton broth is frequently the first step in antimicrobial discovery. Although widely utilized, this ... ...

Abstract	Identification of novel antibiotics is of top importance because of the threat of antibiotic-resistant pathogens. Antimicrobial screening in Mueller-Hinton broth is frequently the first step in antimicrobial discovery. Although widely utilized, this medium is not ideal as it could mask activity of candidates such as human cathelicidin LL-37 against methicillin-resistant
MeSH term(s)	Animals ; Humans ; Mice ; Antimicrobial Cationic Peptides/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Mammals
Chemical Substances	Antimicrobial Cationic Peptides ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.3c00293
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Article: Recent Advances in Functional Wound Dressings.

Tran, Huy Quang / Shahriar, S M Shatil / Yan, Zheng / Xie, Jingwei

Advances in wound care

2022 Volume 12, Issue 7, Page(s) 399–427

Abstract: Significance: ...

Abstract	Significance:
MeSH term(s)	Humans ; Bandages, Hydrocolloid ; Diabetic Foot ; Wound Healing ; Hydrogels ; Nanofibers
Chemical Substances	Hydrogels
Language	English
Publishing date	2022-12-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2650541-1
ISSN	2162-1934 ; 2162-1918
ISSN (online)	2162-1934
ISSN	2162-1918
DOI	10.1089/wound.2022.0059
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Article ; Online: Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms.

Su, Yajuan / Andrabi, Syed Muntazir / Shahriar, S M Shatil / Wong, Shannon L / Wang, Guangshun / Xie, Jingwei

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 356, Page(s) 131–141

Abstract: Biofilms pose a great challenge for wound management. Herein, this study describes a near-infrared (NIR) light-responsive microneedle patch for on-demand release of antimicrobial peptide for treatment of wound biofilms. IR780 iodide as a photothermal ... ...

Abstract	Biofilms pose a great challenge for wound management. Herein, this study describes a near-infrared (NIR) light-responsive microneedle patch for on-demand release of antimicrobial peptide for treatment of wound biofilms. IR780 iodide as a photothermal conversion agent and molecularly engineered peptide W379 as an antimicrobial agent are loaded in dissolvable poly(vinylpyrrolidone) (PVP) microneedle patches followed by coating with a phase change material 1-tetradecanol (TD). After placing in an aqueous solution or biofilm containing wounds ex vivo and in vivo, upon exposure to NIR light, the incorporated IR780 induces light-to-heat conversion, causing the melting of TD. This leads to the dissolution of PVP microneedles, enabling the release of loaded W379 peptide from the microneedles into surrounding regions (e.g., solution, biofilm, wound bed). Compared with traditional microneedle patches, NIR light responsive microneedle patches can program the release of antimicrobial peptide and show high antibacterial efficacy in vitro. Meanwhile, this work indicates that NIR light responsive TD-coated, W379-loaded PVP microneedle patches show excellent antibiofilm activities ex vivo and in vivo. Additionally, this microneedle system could be a promising platform for delivering other antimicrobial agents.
MeSH term(s)	Antimicrobial Peptides ; Drug Delivery Systems ; Anti-Infective Agents ; Administration, Cutaneous ; Biofilms
Chemical Substances	Antimicrobial Peptides ; Anti-Infective Agents
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.02.030
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Article ; Online: Effect of sampling duration on the estimate of pollutant concentration behind a heavy-duty vehicle: A large-eddy simulation.

Xie, Jingwei / Liu, Chun-Ho / Huang, Yuhan / Mok, Wai-Chuen

Environmental pollution (Barking, Essex : 1987)

2022 Volume 305, Page(s) 119132

Abstract: Plume chasing is cost-effective, measuring individual, on-road vehicular emissions. Whereas, wake-flow-generated turbulence results in intermittent, rapid pollutant dilution and substantial fluctuating concentrations right behind the vehicle being chased. ...

Abstract	Plume chasing is cost-effective, measuring individual, on-road vehicular emissions. Whereas, wake-flow-generated turbulence results in intermittent, rapid pollutant dilution and substantial fluctuating concentrations right behind the vehicle being chased. The sampling duration is therefore one of the important factors for acquiring representative (average) concentrations, which, however, has been seldom addressed. This paper, which is based on the detailed spatio-temporal dispersion data after a heavy-duty truck calculated by large-eddy simulation (LES), examines how sampling duration affects the uncertainty of the measured concentrations in plume chasing. The tailpipe dispersion is largely driven by the jet-like flows through the vehicle underbody with approximate Gaussian concentration distribution for x ≤ 0.6h, where x is the distance after the vehicle and h the characteristic vehicle size. Thereafter for x ≥ 0.6h, the major recirculation plays an important role in near-wake pollutant transport whose concentrations are highly fluctuating and positively shewed. Plume chasing for a longer sampling duration is more favourable but is logistically impractical in busy traffic. Sampling duration, also known as averaging time in the statistical analysis, thus has a crucial role in sampling accuracy. With a longer sampling (averaging) duration, the sample mean concentration converges to the population mean, improving the sample reliability. However, this effect is less pronounced in long sampling duration. The sampling accuracy is also influenced by the locations of sampling points. For the region x > 0.6h, the sampling accuracy is degraded to a large extent. As a result, acceptable sample mean is hardly achievable. Finally, frequency analysis unveils the mechanism leading to the variance in concentration measurements which is attributed to sampling duration. Those data with frequency higher than the sampling frequency are filtered out by moving average in the statistical analyses.
MeSH term(s)	Air Pollutants/analysis ; Environmental Monitoring/methods ; Environmental Pollutants/analysis ; Reproducibility of Results ; Vehicle Emissions/analysis
Chemical Substances	Air Pollutants ; Environmental Pollutants ; Vehicle Emissions
Language	English
Publishing date	2022-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119132
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Article ; Online: Injectable and rapidly expandable thrombin-decorated cryogels achieve rapid hemostasis and high survival rates in a swine model of lethal junctional hemorrhage.

Andrabi, Syed Muntazir / Shahriar, S M Shatil / Al-Gahmi, Al-Murtadha / Wilczewski, Benjamin L / Carlson, Mark A / Xie, Jingwei

Bioactive materials

2024 Volume 38, Page(s) 154–168

Abstract: Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough to get them to the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide and ... ...

Abstract	Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough to get them to the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide and thrombin (AT cryogels) created by cryo-polymerization for the efficient management of lethal junctional hemorrhage in swine. The produced cryogels have small pore sizes and highly interconnected porous architecture with robust mechanical strength. The cryogels exhibit rapid shape memory properties and prove to be resilient against fatigue. These cryogels also show high water/blood absorption capacity, fast blood clotting effect, and enhanced adhesion of red blood cells and platelets
Language	English
Publishing date	2024-04-30
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2024.04.024
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Article ; Online: Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms

Su, Yajuan / Andrabi, Syed Muntazir / Shahriar, S.M. Shatil / Wong, Shannon L. / Wang, Guangshun / Xie, Jingwei

Journal of Controlled Release. 2023 Apr., v. 356 p.131-141

2023

Abstract	Biofilms pose a great challenge for wound management. Herein, this study describes a near-infrared (NIR) light-responsive microneedle patch for on-demand release of antimicrobial peptide for treatment of wound biofilms. IR780 iodide as a photothermal conversion agent and molecularly engineered peptide W379 as an antimicrobial agent are loaded in dissolvable poly(vinylpyrrolidone) (PVP) microneedle patches followed by coating with a phase change material 1-tetradecanol (TD). After placing in an aqueous solution or biofilm containing wounds ex vivo and in vivo, upon exposure to NIR light, the incorporated IR780 induces light-to-heat conversion, causing the melting of TD. This leads to the dissolution of PVP microneedles, enabling the release of loaded W379 peptide from the microneedles into surrounding regions (e.g., solution, biofilm, wound bed). Compared with traditional microneedle patches, NIR light responsive microneedle patches can program the release of antimicrobial peptide and show high antibacterial efficacy in vitro. Meanwhile, this work indicates that NIR light responsive TD-coated, W379-loaded PVP microneedle patches show excellent antibiofilm activities ex vivo and in vivo. Additionally, this microneedle system could be a promising platform for delivering other antimicrobial agents.
Keywords	anti-infective agents ; antibacterial properties ; antimicrobial peptides ; aqueous solutions ; biofilm ; iodides ; phase transition ; wound treatment ; NIR triggered release ; Antimicrobial peptide ; Phase changing material coating ; Microneedle patch ; Wound biofilm
Language	English
Dates of publication	2023-04
Size	p. 131-141.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.02.030
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Article: Effect of sampling duration on the estimate of pollutant concentration behind a heavy-duty vehicle: A large-eddy simulation

Xie, Jingwei / Liu, Chun-Ho / Huang, Yuhan / Mok, Wai-Chuen

Environmental pollution. 2022 July 15, v. 305

2022

Abstract	Plume chasing is cost-effective, measuring individual, on-road vehicular emissions. Whereas, wake-flow-generated turbulence results in intermittent, rapid pollutant dilution and substantial fluctuating concentrations right behind the vehicle being chased. The sampling duration is therefore one of the important factors for acquiring representative (average) concentrations, which, however, has been seldom addressed. This paper, which is based on the detailed spatio-temporal dispersion data after a heavy-duty truck calculated by large-eddy simulation (LES), examines how sampling duration affects the uncertainty of the measured concentrations in plume chasing. The tailpipe dispersion is largely driven by the jet-like flows through the vehicle underbody with approximate Gaussian concentration distribution for x ≤ 0.6h, where x is the distance after the vehicle and h the characteristic vehicle size. Thereafter for x ≥ 0.6h, the major recirculation plays an important role in near-wake pollutant transport whose concentrations are highly fluctuating and positively shewed. Plume chasing for a longer sampling duration is more favourable but is logistically impractical in busy traffic. Sampling duration, also known as averaging time in the statistical analysis, thus has a crucial role in sampling accuracy. With a longer sampling (averaging) duration, the sample mean concentration converges to the population mean, improving the sample reliability. However, this effect is less pronounced in long sampling duration. The sampling accuracy is also influenced by the locations of sampling points. For the region x > 0.6h, the sampling accuracy is degraded to a large extent. As a result, acceptable sample mean is hardly achievable. Finally, frequency analysis unveils the mechanism leading to the variance in concentration measurements which is attributed to sampling duration. Those data with frequency higher than the sampling frequency are filtered out by moving average in the statistical analyses.
Keywords	cost effectiveness ; pollutants ; pollution ; statistical analysis ; traffic ; turbulent flow ; uncertainty ; variance
Language	English
Dates of publication	2022-0715
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119132
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