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Article ; Online: Effect and Mechanism of lncRNA-PCMF1/hsa-miR-137/Twist1 Axis Involved in the EMT Regulation of Prostate Cancer Cells.

Cui, Haoyu / Hou, Chuansheng / Ma, Qiang / Chen, Zhuo / Xie, Xuefeng

2023 Volume 65, Issue 12, Page(s) 1991–2003

Abstract: The metastasis is a major reason for the poor prognosis of the patients with prostate cancer (PC). Currently, androgen deprivation therapy (ADT) is the basic method for the treatment of PC regardless of surgery or drug treatments. However, ADT therapy is ...

Abstract	The metastasis is a major reason for the poor prognosis of the patients with prostate cancer (PC). Currently, androgen deprivation therapy (ADT) is the basic method for the treatment of PC regardless of surgery or drug treatments. However, ADT therapy is generally not recommended for patients with advanced/metastatic PC. Herein, we report for the first time a long non-coding RNA (lncRNA)-PCMF1 which promotes the progression of Epithelial-Mesenchymal Transition (EMT) in PC cells. Our data demonstrated that PCMF1 in metastatic PC tissues increased significantly compared to non-metastatic specimens. Mechanism research showed that PCMF1 could competitively bind to hsa-miR-137 instead of the 3' -Untranslated Region (UTR) of Twist Family BHLH Transcription Factor 1 (Twist1) by acting as an endogenous miRNA sponge. Furthermore, we found that silence of PCMF1 effectively blocked the EMT in PC cells by indirectly suppressing Twist1 protein mediated by hsa-miR-137 at post-transcriptional level. In summary, our research shows that PCMF1 promotes the EMT of PC cells by causing the functional inactivation of hsa-miR-137 on Twist1 protein, which is an independent risk factor of PC. PCMF1 knockdown combined with hsa-miR-137 expression is a promising PC-targeted therapy. Furthermore, PCMF1 is also expected to act as a useful marker for predicting malignant changes and assessing the prognosis of PC patients.
MeSH term(s)	Male ; Humans ; RNA, Long Noncoding/genetics ; Twist-Related Protein 1/genetics ; Twist-Related Protein 1/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Androgen Antagonists ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics
Chemical Substances	MIRN137 microRNA, human ; RNA, Long Noncoding ; Twist-Related Protein 1 ; Androgen Antagonists ; MicroRNAs
Language	English
Publishing date	2023-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1193057-3
ISSN	1559-0305 ; 1073-6085
ISSN (online)	1559-0305
ISSN	1073-6085
DOI	10.1007/s12033-023-00709-y
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Article: [Prediction of Spatial Distribution of Heavy Metals in Cultivated Soil Based on Multi-source Auxiliary Variables and Random Forest Model].

Xie, Xue-Feng / Guo, Wei-Wei / Pu, Li-Jie / Miu, Yuan-Qing / Jiang, Guo-Jun / Zhang, Jian-Zhen / Xu, Fei / Wu, Tao

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 1, Page(s) 386–395

Abstract: Spatial prediction of the concentrations of soil heavy metals (HMs) in cultivated land is critical for monitoring cultivated land contamination and ensuring sustainable eco-agriculture. In this study, 32 environmental variables from terrain, climate, ... ...

Abstract	Spatial prediction of the concentrations of soil heavy metals (HMs) in cultivated land is critical for monitoring cultivated land contamination and ensuring sustainable eco-agriculture. In this study, 32 environmental variables from terrain, climate, soil attributes, remote-sensing information, vegetation indices, and anthropogenic activities were used as auxiliary variables, and random forest (RF), regression Kriging (RK), ordinary Kriging (OK), and multiple linear regression (MLR) models were proposed to predict the concentrations of As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn in cultivated soils. In comparison to those of RK, OK, and MLR, the RF model had the best prediction performance for As, Cd, Cr, Hg, Pb, and Zn, whereas the OK and RK models had highest prediction performance for Cu and Ni, respectively, showing that
Language	Chinese
Publishing date	2024-01-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202303035
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Article: Cost-Effectiveness Analysis of Gefitinib Alone and Combined with Chemotherapy as First-Line Treatment for Patients with Advanced Non-Small-Cell Lung Cancer.

Wang, Yao / Huang, Kaiyu / Sun, Sijia / Deng, Yahong / Xie, Xuefeng

Risk management and healthcare policy

2022 Volume 15, Page(s) 351–359

Abstract: Background: The rational choice of drugs for treating patients with advanced non-small-cell lung cancer (NSCLC) is significantly impacted by changes in modern drug policy, health insurance negotiation, and budget impact analyses. Here, we provide a ... ...

Abstract	Background: The rational choice of drugs for treating patients with advanced non-small-cell lung cancer (NSCLC) is significantly impacted by changes in modern drug policy, health insurance negotiation, and budget impact analyses. Here, we provide a basis for rational drug use decisions in clinical practice and promote the widespread use of pharmacoeconomic methods in clinical decision-making based on current drug policies in China and real-world data. Methods: A Markov model was developed to evaluate the health and economic outcomes in patients with advanced NSCLC treated with first-line chemotherapy with gefitinib and gefitinib plus chemotherapy. Clinical data, cost, and utility data were extracted from published literature or real-world data; sensitivity analysis was performed to assess the uncertainty in the results. The results were summarized as QALYs and the ICER. Results: The average cost and QALYs associated with gefitinib and gefitinib plus chemotherapy strategies were $62,882.83 and 1.70 and $84,509.30 and 1.93, respectively. The ICER for gefitinib plus chemotherapy versus gefitinib alone was $95,135.50. The one-way sensitivity analysis showed that the utility value of progressive disease (PD) had the greatest impact on the treatment outcome. Probabilistic sensitivity analysis showed that if China's willingness to pay threshold was $33,300/QALY, the probability of superiority of the gefitinib plus chemotherapy regimen was 0. Conclusion: The study suggests that, from the perspective of the Chinese health system, gefitinib plus chemotherapy is not a cost-effective option for NSCLC patients with EGFR mutations. These findings may help clinicians make the best treatment decisions for patients with NSCLC.
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S352827
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Article: [Changes in Soil Nitrogen Components and Their Relationship with Environmental Factors with Different Tea Plantation Ages].

Shao, Qi / Wu, Tao / Xie, Xue-Feng / Xu, Zi-Qing / Li, Wen-Qi / Jiang, Guo-Jun / Zhang, Jian-Zhen / Xu, Fei

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 3, Page(s) 1665–1673

Abstract: Changes in soil nitrogen components in tea gardens affect the soil nitrogen supply capacity and nitrogen cycle. In this study, soil samples were collected from forest land, cultivated land, and tea gardens with different plantation ages (30, 50, and 70 ... ...

Abstract	Changes in soil nitrogen components in tea gardens affect the soil nitrogen supply capacity and nitrogen cycle. In this study, soil samples were collected from forest land, cultivated land, and tea gardens with different plantation ages (30, 50, and 70 years) to explore the changes in soil nitrogen components and their relationship with physicochemical properties and enzyme activities. The results showed that:① with the increase in tea plantation age, the silt, total phosphorus, and urease and catalase activities gradually increased, whereas the sand, clay, pH, electrical conductivity, soil organic carbon, and the activities of invertase gradually decreased. The alkaline phosphatase activity increased first and then decreased with the increase in tea plantation age, and no significant differences were observed in soil water content and acid phosphatase activity. ② With the increase in tea plantation age, the contents of acid ammonia nitrogen, amino acid nitrogen, and nitrate nitrogen (NO
MeSH term(s)	Soil/chemistry ; Alkaline Phosphatase ; Sand ; Nitrogen/analysis ; Carbon ; Urease ; Ammonia ; Phosphorus/analysis ; Tea ; Soil Microbiology ; China
Chemical Substances	Soil ; Alkaline Phosphatase (EC 3.1.3.1) ; Sand ; Nitrogen (N762921K75) ; Carbon (7440-44-0) ; Urease (EC 3.5.1.5) ; Ammonia (7664-41-7) ; Phosphorus (27YLU75U4W) ; Tea
Language	Chinese
Publishing date	2024-03-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202304162
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Article ; Online: Cross-sectional study on the drug utilization and evaluation indicator of antibiotics used in pediatric population.

Hu, Xu / Zhang, Xueting / Wang, Yao / Xie, Xuefeng

BMC health services research

2021 Volume 21, Issue 1, Page(s) 1091

Abstract: Background: The lack of medication standards is a serious problem in paediatrics mainly because of age-related differences in organ development and physiological functions in children. Consequently, dosage measurement becomes inaccurate. For this reason, ...

Abstract	Background: The lack of medication standards is a serious problem in paediatrics mainly because of age-related differences in organ development and physiological functions in children. Consequently, dosage measurement becomes inaccurate. For this reason, methods for evaluating and monitoring rational paediatric medications should be developed. Drug use indicators, such as those similar to the drug utilisation index (DUI) based on the Anatomical Therapeutic Chemical/Defined Daily Dose (DDD) and widely used for the assessment of appropriate dosage in adults, should be explored in terms of their applicability to children. Methods: A total of 5,538 prescriptions of antibiotics selected from a general teaching hospital were included. Drug, dose, frequency and treatment duration were obtained from each prescription. The prescription daily dose (PDD) of each antibiotic drug was calculated as the average of the daily doses. Underdose and overdose were determined in terms of the PDD/DDD ratio for each prescription. Children's DUI (cDUI) was explored in terms of the appropriate dosage for children as follows: the meaning of children's DDD (cDDD) and the evaluation of paediatric drug dosage. Results: The top five antibiotics and their utilisation rates were as follows: cefmetazole sodium injection (18.47 %), erythromycin lactobionate injection (15.07 %), amoxicillin/clavulanate potassium injection (10.72 %), ceftriaxone sodium injection (9.50 %) and azithromycin dry suspension (8.02 %). The ratio of cDUI and PDD/cDDD was mostly not close to 1. Conclusions: The establishment of a cDUI system is an effective means of paediatric dosage evaluation. In addition to DDDs, cDUI and PDD/cDDD should be used to analyse the utilisation of antibiotics in children.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Child ; Cross-Sectional Studies ; Drug Prescriptions ; Drug Utilization ; Hospitals, Teaching ; Humans ; Pediatrics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-10-13
Publishing country	England
Document type	Journal Article
ISSN	1472-6963
ISSN (online)	1472-6963
DOI	10.1186/s12913-021-06727-3
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Article ; Online: Polygenic adaptation of a cosmopolitan pest to a novel thermal environment.

Lei, Gaoke / Huang, Jieling / Zhou, Huiling / Chen, Yanting / Song, Jun / Xie, Xuefeng / Vasseur, Liette / You, Minsheng / You, Shijun

Insect molecular biology

2024

Abstract: The fluctuation in temperature poses a significant challenge for poikilothermic organisms, notably insects, particularly in the context of changing climatic conditions. In insects, temperature adaptation has been driven by polygenes. In addition to genes ...

Abstract	The fluctuation in temperature poses a significant challenge for poikilothermic organisms, notably insects, particularly in the context of changing climatic conditions. In insects, temperature adaptation has been driven by polygenes. In addition to genes that directly affect traits (core genes), other genes (peripheral genes) may also play a role in insect temperature adaptation. This study focuses on two peripheral genes, the GRIP and coiled-coil domain containing 2 (GCC2) and karyopherin subunit beta 1 (KPNB1). These genes are differentially expressed at different temperatures in the cosmopolitan pest, Plutella xylostella. GCC2 and KPNB1 in P. xylostella were cloned, and their relative expression patterns were identified. Reduced capacity for thermal adaptation (development, reproduction and response to temperature extremes) in the GCC2-deficient and KPNB1-deficient P. xylostella strains, which were constructed by CRISPR/Cas9 technique. Deletion of the PxGCC2 or PxKPNB1 genes in P. xylostella also had a differential effect on gene expression for many traits including stress resistance, resistance to pesticides, involved in immunity, trehalose metabolism, fatty acid metabolism and so forth. The ability of the moth to adapt to temperature via different pathways is likely to be key to its ability to remain an important pest species under predicted climate change conditions.
Language	English
Publishing date	2024-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	33602-6
ISSN	1365-2583 ; 0962-1075
ISSN (online)	1365-2583
ISSN	0962-1075
DOI	10.1111/imb.12908
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Article ; Online: Substantial Increase in Accessibility to Essential Anticancer Medicines in Anhui, China: A Longitudinal Study.

Xu, Rixiang / Li, Shuting / Mu, Tingyu / Xie, Xuefeng / Xu, Caiming / Lv, Xiongwen

Inquiry : a journal of medical care organization, provision and financing

2023 Volume 60, Page(s) 469580231151783

Abstract: The study aimed to evaluate the change in accessibility of essential anticancer medicines, from 2015 to 2018 in a pilot province for health care reform in China. Data on access to 23 essential anticancer medicines was obtained from 6 provincial tertiary ... ...

Abstract	The study aimed to evaluate the change in accessibility of essential anticancer medicines, from 2015 to 2018 in a pilot province for health care reform in China. Data on access to 23 essential anticancer medicines was obtained from 6 provincial tertiary hospitals. A comprehensive analysis was applied to explore these trends. The total utilization of anticancer medicines had increased by an average of 2.57 times (
MeSH term(s)	Humans ; Longitudinal Studies ; China ; Drugs, Essential ; Health Care Reform ; Tertiary Care Centers
Chemical Substances	Drugs, Essential
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	42153-4
ISSN	1945-7243 ; 0046-9580
ISSN (online)	1945-7243
ISSN	0046-9580
DOI	10.1177/00469580231151783
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Article: [Effect of

Li, Wen-Qi / Xiang, Qi / Xie, Xue-Feng / Wu, Tao / Jiang, Guo-Jun / Zhang, Jian-Zhen / Pu, Li-Jie / Xu, Fei

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 5, Page(s) 2735–2745

Abstract: The invasion ... ...

Abstract	The invasion of
MeSH term(s)	Wetlands ; Ecosystem ; Soil/chemistry ; Bays ; Clay ; Carbon/analysis ; Introduced Species ; Poaceae ; Nitrogen/analysis ; Phosphorus/analysis ; China
Chemical Substances	Soil ; Clay (T1FAD4SS2M) ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W)
Language	Chinese
Publishing date	2023-05-08
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202206204
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Article: Assembly and analytical validation of a metagenomic reference catalog of human gut microbiota based on co-barcoding sequencing.

Huang, Yufen / Jiang, Puzi / Liang, Zhengjiao / Chen, Rouxi / Yue, Zhen / Xie, Xuefeng / Guan, Changge / Fang, Xiaodong

Frontiers in microbiology

2023 Volume 14, Page(s) 1145315

Abstract: Human gut microbiota is associated with human health and disease, and is known to have the second-largest genome in the human body. The microbiota genome is important for their functions and metabolites; however, accurate genomic access to the microbiota ...

Abstract	Human gut microbiota is associated with human health and disease, and is known to have the second-largest genome in the human body. The microbiota genome is important for their functions and metabolites; however, accurate genomic access to the microbiota of the human gut is hindered due to the difficulty of cultivating and the shortcomings of sequencing technology. Therefore, we applied the stLFR library construction method to assemble the microbiota genomes and demonstrated that assembly property outperformed standard metagenome sequencing. Using the assembled genomes as references, SNP, INDEL, and HGT gene analyses were performed. The results demonstrated significant differences in the number of SNPs and INDELs among different individuals. The individual displayed a unique species variation spectrum, and the similarity of strains within individuals decreased over time. In addition, the coverage depth analysis of the stLFR method shows that a sequencing depth of 60X is sufficient for SNP calling. HGT analysis revealed that the genes involved in replication, recombination and repair, mobilome prophages, and transposons were the most transferred genes among different bacterial species in individuals. A preliminary framework for human gut microbiome studies was established using the stLFR library construction method.
Language	English
Publishing date	2023-05-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1145315
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Article: [Effects of Supplementation of Different Amendments on Soil Heavy Metals and Enzyme Activities in Coastal Saline Land].

Xie, Xue-Feng / Xu, Zi-Qing / Tian, Zai-Yang / Bu, Xin-Guo / Xu, Fei / Liang, Jing / Pu, Li-Jie

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 10, Page(s) 5649–5656

Abstract: The supplementation of soil amendments may not only improve the soil physical and chemical properties but also lead to the accumulation of heavy metals in soil. This experiment included six treatments:control (CK), organic manure (OM), polyacrylamide+ ... ...

Abstract	The supplementation of soil amendments may not only improve the soil physical and chemical properties but also lead to the accumulation of heavy metals in soil. This experiment included six treatments:control (CK), organic manure (OM), polyacrylamide+organic manure (PAM+OM), straw mulching+organic manure (SM+OM), buried straw+organic manure (BS+OM), and bio-organic manure+organic manure (BM+OM) to explore the effects of different soil amendments on heavy metals and soil enzyme activities in coastal saline land and the relationship between them. The results revealed that compared with that in the CK treatment, the contents of soil Cr, Cu, Ni, and Pb exhibited an upward trend after the supplementation of soil amendments, among which the SM+OM and PAM+OM treatments had the most significant effects on the contents of soil Cr and Cu, respectively, whereas the BM+OM treatment had the most significant effects on the contents of soil Ni and Pb. Compared with those in the CK treatment, the activities of soil invertase and urease increased significantly following supplementation of soil amendments, and the BM+OM treatment had the best effect. The alkaline phosphatase activity exhibited a slightly upward trend after the supplementation of soil amendments, whereas the catalase activity did not change significantly. The redundancy analysis revealed that the first two axes cumulatively accounted for 70.3% of the variability in enzyme activities, and the importance of single soil heavy metals on soil enzyme activity was as follows:Ni>Cu>Cr>Pb.
MeSH term(s)	Soil/chemistry ; Manure/analysis ; Lead/analysis ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; Dietary Supplements/analysis
Chemical Substances	Soil ; Manure ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy
Language	Chinese
Publishing date	2023-10-12
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202211164
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