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Book ; Online: Identifying patients from a large number of people by a small number of tests

Xie, Y.H.

2020

Abstract: An approach is proposed for screening patients from more people with less tests. It can be used for various diseases, and one of the direct application is the suppression of pandemic (e.g., coronavirus pneumonia). In this approach, people are divided ... ...

Abstract	An approach is proposed for screening patients from more people with less tests. It can be used for various diseases, and one of the direct application is the suppression of pandemic (e.g., coronavirus pneumonia). In this approach, people are divided into several groups, and each group has multiple people. For each group, the samples (e.g., respiratory secretions) of all the people are mixed to generate a merged sample. All the people can be excluded if the merged sample indicates no illness. If the merged sample indicates illness, the group will be divided into smaller groups, and then handled recursively in the same way. By doing so, negative groups are excluded gradually, and the group size becomes smaller and smaller. Finally, each group has only one person. This approach is especially suitable for the case when only small percentage of people are ill (e.g., infected). Presently, a pandemic is threatening public health. Limited by the time, we did not investigate literatures extensively. Instead, we focused on the application and effectiveness of this approach. (By the way, sometimes there is no need to identify every patient, but only need to identify relatively small ranges instead. In that case, the proposed approach can be stopped before the whole procedure finishes.)
Keywords	covid19
Subject code	310
Publishing date	2020-02-17
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Identifying patients from a large number of people by a small number of tests

Xie, Y.H.

2020

Abstract: For many diseases, patients need to be screened to determine whether they are ill or not. An approach, termed "Merged Testing for Recursive Groups (MTRG)", is proposed for screening patients from more people with less tests. It can be used for various ... ...

Abstract	For many diseases, patients need to be screened to determine whether they are ill or not. An approach, termed "Merged Testing for Recursive Groups (MTRG)", is proposed for screening patients from more people with less tests. It can be used for various diseases, and one of the direct application is the suppression of pandemic (e.g., coronavirus pneumonia). In this approach, people are divided into several groups, and each group has multiple people. For each group, the samples (e.g., respiratory secretions) of all the people are mixed to generate a merged sample. All the people can be excluded if the merged sample indicates no illness. If the merged sample indicates illness, the group will be divided into smaller groups, and then handled recursively in the same way. By doing so, negative groups are excluded gradually, and the group size becomes smaller and smaller. Finally, each group has only one person. This approach is especially suitable for the case when only small percentage of people are ill (e.g., infected). It can be treated as the extension and generalization of conventional procedure of pool testing. Furtherly, we propose to apply pool tests to mask bins, i.e., the trash bins for collecting masks only. This strategy has several advantages: making masks more useful, further saving resources for pool tests, efficient monitoring and control of pandemic, avoiding pollution caused by used masks. Presently, a pandemic is threatening public health. Limited by the time, we did not investigate literatures extensively. Instead, we focused on the application and effectiveness of this approach. Wish it helps somehow. 2020.05.13 update: we further propose to apply pool tests to mask bins, i.e., the trash bins for collecting masks only. 2020.05.26 update: further discuss the advantages of the above strategy: making masks more useful, further saving resources for pool tests, efficient monitoring and control of pandemic, avoiding pollution caused by used masks. (Using this strategy, testing/screening is performed without explicit sampling from people's body) Another URL of this work: https://github.com/EdwardYSheffield/MTRG
Keywords	covid19
Publishing date	2020-02-17
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Identifying patients from a large number of people by a small number of tests

Xie, Y.H.

2020

Abstract: For many diseases, patients need to be screened to determine whether they are ill or not. An approach, termed “Merged Testing for Recursive Groups (MTRG)”, is proposed for screening patients from more people with less tests. It can be used for various ... ...

Abstract	For many diseases, patients need to be screened to determine whether they are ill or not. An approach, termed “Merged Testing for Recursive Groups (MTRG)”, is proposed for screening patients from more people with less tests. It can be used for various diseases, and one of the direct application is the suppression of pandemic (e.g., coronavirus pneumonia). In this approach, people are divided into several groups, and each group has multiple people. For each group, the samples (e.g., respiratory secretions) of all the people are mixed to generate a merged sample. All the people can be excluded if the merged sample indicates no illness. If the merged sample indicates illness, the group will be divided into smaller groups, and then handled recursively in the same way. By doing so, negative groups are excluded gradually, and the group size becomes smaller and smaller. Finally, each group has only one person. This approach is especially suitable for the case when only small percentage of people are ill (e.g., infected). Presently, a pandemic is threatening public health. Limited by the time, we did not investigate literatures extensively. Instead, we focused on the application and effectiveness of this approach. Wish it helps somehow.
Keywords	covid19
Publishing date	2020-02-17
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Identifying patients from a large number of people by a small number of tests

Xie, Y.H.

2020

Abstract	For many diseases, patients need to be screened to determine whether they are ill or not. An approach, termed “Merged Testing for Recursive Groups (MTRG)”, is proposed for screening patients from more people with less tests. It can be used for various diseases, and one of the direct application is the suppression of pandemic (e.g., coronavirus pneumonia). In this approach, people are divided into several groups, and each group has multiple people. For each group, the samples (e.g., respiratory secretions) of all the people are mixed to generate a merged sample. All the people can be excluded if the merged sample indicates no illness. If the merged sample indicates illness, the group will be divided into smaller groups, and then handled recursively in the same way. By doing so, negative groups are excluded gradually, and the group size becomes smaller and smaller. Finally, each group has only one person. This approach is especially suitable for the case when only small percentage of people are ill (e.g., infected). Presently, a pandemic is threatening public health. Limited by the time, we did not investigate literatures extensively. Instead, we focused on the application and effectiveness of this approach. Wish it helps somehow. (2020.05.13 update: we further propose to apply pool tests to mask bins, i.e., the trash bins for collecting masks only.)
Keywords	covid19
Publishing date	2020-02-17
Publishing country	eu
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of shroud on the energy extraction performance of oscillating foil

Jiang, W. / Mei, Z.Y. / Wu, F. / Han, A. / Xie, Y.H. / Xie, D.M.

Energy. 2022 Jan. 15, v. 239

2022

Abstract: A shrouded oscillating-foil turbine is proposed to augment the energy extraction performance. The oscillating foil undergoes combined plunging and pitching motion to convert the flow energy. A diffuser is introduced into the oscillating-foil-based ... ...

Abstract	A shrouded oscillating-foil turbine is proposed to augment the energy extraction performance. The oscillating foil undergoes combined plunging and pitching motion to convert the flow energy. A diffuser is introduced into the oscillating-foil-based turbine as the shroud. The speed-up and energy extraction performance of the turbine were assessed numerically. The effects of three cost-independent geometrical factors, namely shroud entrance width, shroud angle and streamwise distance between shroud and foil, and shroud sectional shape on energy extraction performance were investigated in detail. The optimal motion parameters for the shrouded oscillating-foil turbine were re-explored due to the altered flow field in the shroud. The results demonstrated that the maximum energy extraction efficiency of bare oscillating foil (0.336) can be augmented by 35.8% to 0.456 by appropriate arrangement of the shroud with a relative chord length of 0.8. The optimal motion parameters for the shrouded foil are slightly different from those of bare foil. The re-tuned motion parameters can further improve the efficiency to 0.47. Considering both the manufacturing cost of the shaped sections and their performance, it is more advantageous and attractive to use a flat plate as the shroud in engineering practices.
Keywords	diffusers ; energy efficiency ; engineers ; fields ; foil ; manufacturing ; turbines
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2021.122387
Database	NAL-Catalogue (AGRICOLA)

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Article: Shear stress-induced MMP1 and PDE2A expressions in coronary atherosclerosis.

Ma, Y S / Xie, Y H / Ma, D / Zhang, J J / Liu, H J

Bratislavske lekarske listy

2021 Volume 122, Issue 4, Page(s) 287–292

Abstract: Aim: Biomechanical stress plays an essential role in coronary atherosclerosis (CAS), however, inter-relations between mechanical conditions and gene expressions remain unclear.: Methods: We constructed finite element model of CAS to map human wall ... ...

Abstract	Aim: Biomechanical stress plays an essential role in coronary atherosclerosis (CAS), however, inter-relations between mechanical conditions and gene expressions remain unclear. Methods: We constructed finite element model of CAS to map human wall shear stress (WSS). Biopsy aortic tissue samples were obtained from 3 CAS patients. Gene expression pattern in CAS was analyzed by GEO datasets. Immunofluorescence staining and western blot confirmed protein expression and localization. Results: Peak WSS was signiﬁcantly increased in the vessel stenosis of CAS at 0.25 s (mean 55.1 Pa). Analyses results of GSE76275 showed matrix metalloproteinases1 (MMP1) and phosphodiesterase-2A (PDE2A) up-regulation in endothelial shear responsiveness, which was further validated and localized in vascular endothelial cells, smooth muscle cells and other cells by double immunofluorescence staining. Western blotting assay demonstrated up-regulation of MMP1 and PDE2A expression dependent on the WSS. Conclusions: MMP1 and PDE2A up-regulations rely on increased WSS in development and risk of CAS, suggesting that their elevation may be potential target for diagnosis and treatment (Fig. 3, Ref. 28).
MeSH term(s)	Coronary Artery Disease/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 2 ; Endothelial Cells ; Gene Expression ; Humans ; Matrix Metalloproteinase 1/genetics ; Stress, Mechanical
Chemical Substances	Cyclic Nucleotide Phosphodiesterases, Type 2 (EC 3.1.4.17) ; PDE2A protein, human (EC 3.1.4.17) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2021-01-14
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	127421-1
ISSN	0006-9248
ISSN	0006-9248
DOI	10.4149/BLL_2021_048
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Article: [Clinical characteristics and prognosis of patients with aggressive NK cell leukemia].

Qian, W S / Shen, L / Wulipan, Fulati / Wu, M / Ma, J X / Chen, P P / Xu, Y / Xie, Y H

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2022 Volume 43, Issue 5, Page(s) 424–426

MeSH term(s)	Humans ; Leukemia ; Leukemia, Large Granular Lymphocytic ; Lymphoma, Extranodal NK-T-Cell ; Prognosis
Language	Chinese
Publishing date	2022-06-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2022.05.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Numerical investigation into the energy extraction characteristics of 3D self-induced oscillating foil

Jiang, W / Wang, Y.L / Xie, Y.H / Zhang, D

Renewable energy. 2020 Apr., v. 148

2020

Abstract: The energy extraction performance of the flow energy convertor based on fully passive oscillating foil is investigated numerically. The foil undergoes combined pitching and swing motions. The pitching motion is driven by periodically varying moment ... ...

Abstract	The energy extraction performance of the flow energy convertor based on fully passive oscillating foil is investigated numerically. The foil undergoes combined pitching and swing motions. The pitching motion is driven by periodically varying moment generated by vortex shedding, then the resulting varying angle-of-attack and lift force drives the swing motion and the connected generator. The study focuses on the three-dimensional flow characteristics and their effects on the energy extraction performance. Numerical results demonstrate that the convertor with theoretically infinite foil can reach maximum power coefficient of 1.34 and efficiency of 0.4, but the performance of the convertor with limited-length foil is reduced significantly. The relationship between power coefficient and foil length is described with a linear equation. Longer foil can release the loss caused by 3D effect; the drop in the efficiency of the 3D foil could be limited to around 15% as the foil length increases to 8 times mid-arc length. The examination of the flow filed shows that the loss caused by 3D effect is mainly attributed to the tip leakage flow and no obvious non-conformal or disorder vortex shedding is observed. The oscillation of the foil can synchronize the vortex shedding and suppress 3D instability.
Keywords	energy ; equations ; foil ; renewable energy sources
Language	English
Dates of publication	2020-04
Size	p. 60-71.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	0960-1481
ISSN	0960-1481
DOI	10.1016/j.renene.2019.11.137
Database	NAL-Catalogue (AGRICOLA)

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Article: Numerical investigation into power extraction by a fully passive oscillating foil with double generators

Jiang, W / Wang, Y.L / Zhang, D / Xie, Y.H

Renewable energy. 2019 Apr., v. 133

2019

Abstract: A new concept of energy conversion system based on fully passive oscillating foil with double generators to extract energy from pitching and swing motions respectively is proposed and numerically tested. The shedding vortices in the wake drive a C-shape ... ...

Abstract	A new concept of energy conversion system based on fully passive oscillating foil with double generators to extract energy from pitching and swing motions respectively is proposed and numerically tested. The shedding vortices in the wake drive a C-shape foil to pitch around a pivoting axis, and the resulting periodic lift force drives the foil to swing around an arm. Two-dimensional incompressible Navier-Stokes simulations under Re from 1100 to 11000 are carried out to study the fluid-foil interaction. The effects of pitching damping factor, swing damping factor and incoming flow speed are systematically studied. Numerical results demonstrate that the use of pitching generator not only provides extra pitching power, but also improves the swing power. It is also found that the maximum power coefficient and efficiency increase with flow speed slightly in the laminar flow region, but the influence of Re is very limited. The analysis of the correlation between pitching and swing motions shows that the energy conversion system possesses the possibility of connecting pitching motion with swing motion and further simplifying the system.
Keywords	energy conversion ; foil ; laminar flow ; renewable energy sources
Language	English
Dates of publication	2019-04
Size	p. 32-43.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	0960-1481
ISSN	0960-1481
DOI	10.1016/j.renene.2018.09.094
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of washed platelets vs platelet-rich plasma on the proliferation and mineralization of rat dental pulp cells.

Zhang, L / Xie, Y H / Lin, B R

Genetics and molecular research : GMR

2015 Volume 14, Issue 3, Page(s) 9486–9496

Abstract: We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L ...

Abstract	We examined the effects of washed platelets (WPLTs) and platelet-rich plasma (PRP) on the proliferation and mineralization of rat dental pulp cells. Rat dental pulp cells were separated, cultured, and identified. Medium containing 1, 10, 100, or 500 mL/L PRP or WPLTs was added to 4th generation cells. The MTS method was used to determine cell proliferation. Alizarin red staining was used to observe the formation of mineralized nodules after cell mineralization and induction for 10 and 20 days under different culture conditions, and the areas of the mineralized nodules formed 20 days after induction were computed. The addition of 1, 10, and 100 mL/L WPLTs or PRP significantly promoted rat dental pulp cell proliferation (P < 0.05) whereas 500 mL/L WPLTs or PRP had no significant effect (P > 0.05). Under the same concentrations, no significant differences on cell proliferation were observed between WPLT and PRP treatments (P > 0.05 in all groups). After 10 days mineralization and culture, the 100 and 500 mL/L WPLT and PRP group positive nodule rates were significantly higher than those of the low concentration and the control groups (P < 0.05). After 20 days, the areas of the mineralized nodules formed in the 100 and 500 mL/L WPLT and PRP groups were significantly larger than those in the control group (P < 0.05). These results demonstrate that both WPLTs and PRP are equally able to significantly promote the proliferation and calcification of rat dental pulp cells under a certain range of concentrations.
MeSH term(s)	Animals ; Blood Platelets/metabolism ; Calcification, Physiologic/drug effects ; Cell Proliferation ; Cells, Cultured ; Dental Pulp/cytology ; Phenotype ; Platelet Count ; Platelet-Rich Plasma/metabolism ; Rats ; Stem Cells/cytology ; Stem Cells/metabolism
Language	English
Publishing date	2015-08-14
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2015.August.14.12
Database	MEDical Literature Analysis and Retrieval System OnLINE

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