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Article: Modulating the catalytic activity of gold nanoparticles using amine-terminated ligands.

Zhang, Jiangjiang / Huang, Zhentao / Xie, Yangzhouyun / Jiang, Xingyu

2021 Volume 13, Issue 4, Page(s) 1080–1087

Abstract: Nanozymes have broad applications in theranostics and point-of-care tests. To enhance the catalytic activity of nanozymes, the conventional strategy is doping metals to form highly active nanoalloys. However, high-quality and stable nanoalloys are hard ... ...

Abstract	Nanozymes have broad applications in theranostics and point-of-care tests. To enhance the catalytic activity of nanozymes, the conventional strategy is doping metals to form highly active nanoalloys. However, high-quality and stable nanoalloys are hard to synthesize. Ligand modification is a powerful strategy to achieve chemoselectivity or bioactivity by changing the surface chemistry. Here, we explore different ligands to enhance the catalytic activity of nanozymes,
Language	English
Publishing date	2021-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d1sc05933e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections.

Xie, Yangzhouyun / Zhang, Qiang / Zheng, Wenfu / Jiang, Xingyu

ACS applied materials & interfaces

2021 Volume 13, Issue 30, Page(s) 35306–35314

Abstract: With the long-term and extensive abuse of antibiotics, bacteria can mutate into multidrug-resistant (MDR) strains, resist the existing antibiotics, and escape the danger of being killed. MDR bacteria-caused skin infections are intractable and chronic, ... ...

Abstract	With the long-term and extensive abuse of antibiotics, bacteria can mutate into multidrug-resistant (MDR) strains, resist the existing antibiotics, and escape the danger of being killed. MDR bacteria-caused skin infections are intractable and chronic, becoming one of the most significant and global public-health issues. Thus, the development of novel antimicrobial materials is urgently needed. Non-antibiotic small molecule-modified gold nanoclusters (AuNCs) have great potential as a substitute for commercial antibiotics. Still, their narrow antibacterial spectrum hinders their wide clinical applications. Herein, we report that 4,6-diamino-2-pyrimidinethiol (DAPT)-modified AuNCs (DAPT-AuNCs) can fight against Gram-negative and Gram-positive bacterial strains as well as their MDR counterparts. By modifying DAPT-AuNCs on nanofibrous films, we develop an antibiotic film as innovative dressings for curing incised wounds, which exhibits excellent therapeutic effects on wounds infected by MDR bacteria. Compared to the narrow-spectral one, the broad-spectral antibacterial activity of the DAPT-AuNCs-modified film is more suitable for preventing and treating skin infections caused by various kinds of unknown bacteria. Moreover, the antibacterial films display excellent biocompatibility, implying the great potential for clinical applications.
MeSH term(s)	Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/toxicity ; Bandages ; Drug Resistance, Multiple, Bacterial/drug effects ; Escherichia coli/drug effects ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/pathology ; Female ; Gold/chemistry ; Gold/toxicity ; Human Umbilical Vein Endothelial Cells ; Humans ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Metal Nanoparticles/toxicity ; Pyrimidines/chemistry ; Pyrimidines/toxicity ; Rats, Sprague-Dawley ; Skin/drug effects ; Skin/microbiology ; Skin/pathology ; Staphylococcal Skin Infections/drug therapy ; Staphylococcal Skin Infections/pathology ; Staphylococcus aureus/drug effects ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/toxicity ; Wound Healing/drug effects ; Rats
Chemical Substances	4,6-diaminopyrimidine-2-thiol ; Anti-Bacterial Agents ; Pyrimidines ; Sulfhydryl Compounds ; Gold (7440-57-5)
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c04944
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification.

Xie, Yangzhouyun / Lin, Tonghui / Jin, Ying / Berezowitz, Alexa G / Wang, Xue-Lin / Lu, Jinny / Cai, Yujun / Guzman, Raul J

Cardiovascular research

2024

Abstract: Aims: Vascular calcification is highly prevalent in atherosclerosis, diabetes, and chronic kidney disease. It is associated with increased morbidity and mortality in patients with cardiovascular disease. Matrix metalloproteinase 3 (MMP-3), also known as ...

Abstract	Aims: Vascular calcification is highly prevalent in atherosclerosis, diabetes, and chronic kidney disease. It is associated with increased morbidity and mortality in patients with cardiovascular disease. Matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, is part of the large matrix metalloproteinase family. It can degrade extracellular matrix components of the arterial wall including elastin, which plays a central role in medial calcification. In this study, we sought to determine the role of MMP-3 in medial calcification. Methods and results: We found that MMP-3 was increased in rodent models of medial calcification as well as in vascular smooth muscle cells (SMCs) cultured in a phosphate calcification medium. It was also highly expressed in calcified tibial arteries from patients with peripheral arterial disease (PAD). Knockdown and inhibition of MMP-3 suppressed phosphate-induced SMC osteogenic transformation and calcification, whereas the addition of a recombinant MMP-3 protein facilitated SMC calcification. In an ex vivo organ culture model and a rodent model of medial calcification induced by vitamin D3, we found that MMP-3 deficiency significantly suppressed medial calcification in the aorta. We further found that medial calcification and osteogenic transformation were significantly reduced in SMC-specific MMP-3-deficient mice, suggesting that MMP-3 in SMCs is an important factor in this process. Conclusion: These findings suggest that MMP-3 expression in vascular SMCs is an important regulator of medial calcification and that targeting MMP-3 could provide a therapeutic strategy to reduce it and address its consequences in patients with PAD.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvae035
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Small Molecule-Capped Gold Nanoclusters for Curing Skin Infections

Xie, Yangzhouyun / Zhang, Qiang / Zheng, Wenfu / Jiang, Xingyu

ACS applied materials & interfaces. 2021 July 21, v. 13, no. 30

2021

Abstract	With the long-term and extensive abuse of antibiotics, bacteria can mutate into multidrug-resistant (MDR) strains, resist the existing antibiotics, and escape the danger of being killed. MDR bacteria-caused skin infections are intractable and chronic, becoming one of the most significant and global public-health issues. Thus, the development of novel antimicrobial materials is urgently needed. Non-antibiotic small molecule-modified gold nanoclusters (AuNCs) have great potential as a substitute for commercial antibiotics. Still, their narrow antibacterial spectrum hinders their wide clinical applications. Herein, we report that 4,6-diamino-2-pyrimidinethiol (DAPT)-modified AuNCs (DAPT-AuNCs) can fight against Gram-negative and Gram-positive bacterial strains as well as their MDR counterparts. By modifying DAPT-AuNCs on nanofibrous films, we develop an antibiotic film as innovative dressings for curing incised wounds, which exhibits excellent therapeutic effects on wounds infected by MDR bacteria. Compared to the narrow-spectral one, the broad-spectral antibacterial activity of the DAPT-AuNCs-modified film is more suitable for preventing and treating skin infections caused by various kinds of unknown bacteria. Moreover, the antibacterial films display excellent biocompatibility, implying the great potential for clinical applications.
Keywords	Gram-positive bacteria ; antibacterial properties ; antibiotics ; biocompatibility ; multiple drug resistance ; nanofibers ; nanogold ; public health ; therapeutics
Language	English
Dates of publication	2021-0721
Size	p. 35306-35314.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c04944
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms.

Xie, Yangzhouyun / Zheng, Wenfu / Jiang, Xingyu

ACS applied materials & interfaces

2020 Volume 12, Issue 8, Page(s) 9041–9049

Abstract: A bacterial biofilm is strongly associated with chronic infections and is difficult to be eradicated, posing serious threats to public health. Development of effective therapeutic strategies to prevent and control hospital-acquired infections via ... ...

Abstract	A bacterial biofilm is strongly associated with chronic infections and is difficult to be eradicated, posing serious threats to public health. Development of effective therapeutic strategies to prevent and control hospital-acquired infections via eradication of bacteria shielded by biofilms is challenging. Herein, we developed deoxyribonuclease (DNase)-functionalized gold nanoclusters (AuNCs) (DNase-AuNCs), which are capable of killing Gram-positive and Gram-negative bacteria, especially dispersing the surrounding biofilms. The DNase can break down the extracellular polymeric substance matrix to expose the defenseless bacteria to photothermal therapy (PTT) and photodynamic therapy (PDT) by DNase-AuNCs under 808 nm laser irradiation. The combination of enzymolysis, PDT, and PTT can effectively remove biofilms with a dispersion rate of up to 80% and kill ∼90% of the shielded bacteria. DNase-AuNCs exhibit an outstanding therapeutic effect in treating bacterial biofilm-coated orthodontic devices (Invisalign aligners), suggesting their potential applications in medical devices.
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Biofilms/radiation effects ; Deoxyribonucleases/chemistry ; Deoxyribonucleases/pharmacology ; Gold/chemistry ; Gold/pharmacology ; Gram-Negative Bacteria/physiology ; Gram-Positive Bacteria/physiology ; Humans ; Infrared Rays ; Metal Nanoparticles/chemistry ; Photochemotherapy
Chemical Substances	Anti-Bacterial Agents ; Gold (7440-57-5) ; Deoxyribonucleases (EC 3.1.-)
Language	English
Publishing date	2020-02-17
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.9b21777
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Near-Infrared Light-Activated Phototherapy by Gold Nanoclusters for Dispersing Biofilms

Xie, Yangzhouyun / Zheng, Wenfu / Jiang, Xingyu

ACS applied materials & interfaces. 2020 Feb. 03, v. 12, no. 8

2020

Abstract	A bacterial biofilm is strongly associated with chronic infections and is difficult to be eradicated, posing serious threats to public health. Development of effective therapeutic strategies to prevent and control hospital-acquired infections via eradication of bacteria shielded by biofilms is challenging. Herein, we developed deoxyribonuclease (DNase)-functionalized gold nanoclusters (AuNCs) (DNase-AuNCs), which are capable of killing Gram-positive and Gram-negative bacteria, especially dispersing the surrounding biofilms. The DNase can break down the extracellular polymeric substance matrix to expose the defenseless bacteria to photothermal therapy (PTT) and photodynamic therapy (PDT) by DNase-AuNCs under 808 nm laser irradiation. The combination of enzymolysis, PDT, and PTT can effectively remove biofilms with a dispersion rate of up to 80% and kill ∼90% of the shielded bacteria. DNase-AuNCs exhibit an outstanding therapeutic effect in treating bacterial biofilm-coated orthodontic devices (Invisalign aligners), suggesting their potential applications in medical devices.
Keywords	Gram-negative bacteria ; biofilm ; chronic diseases ; deoxyribonucleases ; irradiation ; medical equipment ; nanogold ; photochemotherapy ; photothermotherapy ; polymers
Language	English
Dates of publication	2020-0203
Size	p. 9041-9049.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.9b21777
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA-Induced Keratitis.

Pang, Zeyang / Ren, Ning / Wu, Yujie / Qi, Jie / Hu, Fupin / Guo, Yuan / Xie, Yangzhouyun / Zhou, Dejian / Jiang, Xingyu

Advanced materials (Deerfield Beach, Fla.)

2023 Volume 35, Issue 40, Page(s) e2303562

Abstract: Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. ... ...

Abstract	Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin-resistant S. aureus (MRSA) affects ≈120 000-190 000 people annually and is a significant cause of infectious blindness. Atomically precise gold nanoclusters (GNCs) recently emerged as promising antibacterial agents; although how the GNC structure and capping ligands control the antibacterial properties remains largely unexplored. In this study, by adjusting the ratio of a "bulky" thiol fragrance to a linear zwitterionic ligand, the GNC conformation is transformed from Au
Language	English
Publishing date	2023-08-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202303562
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes.

Xie, Yangzhouyun / Yang, Junchuan / Zhang, Jiangjiang / Zheng, Wenfu / Jiang, Xingyu

Angewandte Chemie (International ed. in English)

2020 Volume 59, Issue 52, Page(s) 23471–23475

Abstract: Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy ... ...

Abstract	Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)-modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (lDGNPs) and medium-sized (3-4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G-) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nanomaterials and their applications.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria/drug effects ; Gold/chemistry ; Humans ; Metal Nanoparticles/chemistry
Chemical Substances	Anti-Bacterial Agents ; Gold (7440-57-5)
Language	English
Publishing date	2020-09-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202008584
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Screening on-chip fabricated nanoparticles for penetrating the blood-brain barrier.

Hou, Qinghong / Zhu, Lina / Wang, Le / Liu, Xiaoyan / Xiao, Feng / Xie, Yangzhouyun / Zheng, Wenfu / Jiang, Xingyu

Nanoscale

2022 Volume 14, Issue 8, Page(s) 3234–3241

Abstract: The inability of drugs to cross the blood-brain barrier (BBB) makes it difficult to treat diseases in the central nervous system. It is known that peptides with or without specific receptors on the BBB showed different or even controversial neuron ... ...

Abstract	The inability of drugs to cross the blood-brain barrier (BBB) makes it difficult to treat diseases in the central nervous system. It is known that peptides with or without specific receptors on the BBB showed different or even controversial neuron targeting capability in different reports. So, it is necessary to clarify how these peptides work as targeting molecules in the central nervous system. Herein, we evaluate and compare the performance of 6 kinds of peptides with (T7, D-T7, and GSH) or without (TGN, CGN, and TAT) BBB-specific receptors by conjugating these peptides on lipids to serve as a shell to encapsulate a core of PLGA and lamotrigine to form nanoparticles for targeted epilepsy therapy.
MeSH term(s)	Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain Neoplasms/drug therapy ; Drug Delivery Systems ; Mice ; Nanoparticles/chemistry
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr05825h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Screening on-chip fabricated nanoparticles for penetrating the blood-brain barrier.

Hou, Qinghong / Zhu, Lina / Wang, Le / Liu, Xiaoyan / Xiao, Feng / Xie, Yangzhouyun / Zheng, Wenfu / Jiang, Xingyu

Nanoscale

2022 Volume 14, Issue 10, Page(s) 3971

Abstract: Correction for 'Screening on-chip fabricated nanoparticles for penetrating the blood-brain barrier' by Qinghong ... ...

Abstract	Correction for 'Screening on-chip fabricated nanoparticles for penetrating the blood-brain barrier' by Qinghong Hou
Language	English
Publishing date	2022-03-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d2nr90040h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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