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Article ; Online: TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal α-synuclein secretion from microglia.

Dai, Mingming / Yan, Limin / Yu, Hang / Chen, Changneng / Xie, Yuxiang

2023 Volume 129, Page(s) 102249

Abstract: A-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson's disease (PD), a neurodegenerative disease with no effective treatment. Therefore, there has been a strong drive to clarify the pathology of PD associated with α-syn. Several ...

Abstract	A-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson's disease (PD), a neurodegenerative disease with no effective treatment. Therefore, there has been a strong drive to clarify the pathology of PD associated with α-syn. Several mechanisms have been proposed to unravel the pathological cascade of this disease, and most of them share a particular similarity: cell-to-cell communication through exosomes (EXO). Here, we show that tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) promotes the secretion of α-syn-containing EXO by microglia, resulting in motor dysfunction in PD. Upregulation of TNFRSF10B predicted severer condition in PD patients. In response to α-syn preformed fibrils (PFF), the expression of TNFRSF10B was increased in microglia. PFF-treated microglia exhibited a pro-inflammatory phenotype and caused neuronal damage by secreting α-syn-containing EXO. TNFRSF10B downregulation in microglia inhibited the secretion of α-syn-containing EXO and the release of pro-inflammatory factors, and ameliorated neuronal injury. PFF induced motor dysfunction in mice, which was ameliorated by inhibiting TNFRSF10B to suppress microglia-mediated α-syn communication or by directly depleting microglia. Taken together, these results indicate that TNFRSF10B promotes neuronal injury and motor dysfunction by delivery of α-syn-containing EXO and highlight the TNFRSF10B knockdown as a potential therapeutic target in PD.
MeSH term(s)	Animals ; Mice ; alpha-Synuclein/metabolism ; Exosomes/metabolism ; Microglia/metabolism ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Neurons/metabolism ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Humans
Chemical Substances	alpha-Synuclein ; Receptors, TNF-Related Apoptosis-Inducing Ligand
Language	English
Publishing date	2023-02-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639443-7
ISSN	1873-6300 ; 0891-0618
ISSN (online)	1873-6300
ISSN	0891-0618
DOI	10.1016/j.jchemneu.2023.102249
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Zs.A 2363: Show issues

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Article ; Online: SMAD3 interacts with vitamin D receptor and affects vitamin D-mediated oxidative stress to ameliorate cerebral ischaemia-reperfusion injury.

Yu, Hang / Xie, Yuxiang / Dai, Mingming / Pan, Yuxiang / Xie, Chengzhi

The European journal of neuroscience

2022 Volume 56, Issue 11, Page(s) 6055–6068

Abstract: Cerebral ischaemia/reperfusion (I/R) injury is caused by blood flow restoration after an ischaemic insult, and effective treatments targeting I/R injury are still insufficient. Oxidative stress plays a critical role in the pathogenesis of cerebral I/R ... ...

Abstract	Cerebral ischaemia/reperfusion (I/R) injury is caused by blood flow restoration after an ischaemic insult, and effective treatments targeting I/R injury are still insufficient. Oxidative stress plays a critical role in the pathogenesis of cerebral I/R injury. This study investigated whether vitamin D receptor (VDR) could inhibit oxidative stress caused by cerebral I/R injury and explored the detailed mechanism. VDR was highly expressed in brain tissues of mice with cerebral I/R injury. Pretreatment with the active vitamin D calcitriol and synthetic vitamin D analogue paricalcitol (PC) reduced autophagy and apoptosis, improved neurological deficits and decreased infarct size in mice after cerebral I/R. Calcitriol or PC upregulated VDR expression to prevent cerebral I/R injury by affecting oxidative stress. Silencing of VDR reversed the protective effects of calcitriol or PC on brain tissues in mice with cerebral I/R. The bioinformatics analysis revealed that VDR interacted with SMAD family member 3 (SMAD3). It was validated through the chromatin immunoprecipitation assay that SMAD3 can bind to the VDR promoter and VDR can bind to the SMAD3 promoter. Collectively, these findings provide evidence that reciprocal activation between SMAD3 and VDR transcription factors defines vitamin D-mediated oxidative stress to prevent cerebral I/R injury.
MeSH term(s)	Animals ; Mice ; Receptors, Calcitriol/genetics ; Receptors, Calcitriol/metabolism ; Calcitriol/pharmacology ; Calcitriol/therapeutic use ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Oxidative Stress ; Reperfusion Injury/drug therapy ; Brain Ischemia/drug therapy
Chemical Substances	Receptors, Calcitriol ; Calcitriol (FXC9231JVH) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-10-10
Publishing country	France
Document type	Journal Article
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15833
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Zs.A 2548: Show issues

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Article ; Online: Relationships between SLC26A7 expressions and extra-thyroid metastasis of papillary thyroid carcinoma.

Huang, Fengyan / Xiao, Juan / Wang, Lihua / Xie, Yuxiang / Jia, Hongying

Chinese medical journal

2021 Volume 135, Issue 2, Page(s) 225–227

MeSH term(s)	Antiporters/genetics ; Carcinoma, Papillary/pathology ; Humans ; Neoplasm Metastasis/genetics ; Sulfate Transporters/genetics ; Thyroid Cancer, Papillary/pathology ; Thyroid Neoplasms/pathology
Chemical Substances	Antiporters ; SLC26A7 protein, human ; Sulfate Transporters
Language	English
Publishing date	2021-09-28
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001662
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Article ; Online: Lightweight ZnO/Carbonated Cotton Fiber Nanocomposites for Electromagnetic Interference Applications: Preparation and Properties.

Waseem, Muhammad / Xie, Yuxiang / Yu, Kesong / Zhou, Xiling / Cai, Yingchun / Zhang, Xiaoli / Liu, Baochen / Chen, Jingbo

Polymers

2023 Volume 16, Issue 1

Abstract: Electromagnetic wave pollution has become a significant harm posed to human health and precision instruments. To shelter such instruments from electromagnetic radiation, high-frequency electromagnetic interference (EMI) shielding materials are extremely ... ...

Abstract	Electromagnetic wave pollution has become a significant harm posed to human health and precision instruments. To shelter such instruments from electromagnetic radiation, high-frequency electromagnetic interference (EMI) shielding materials are extremely desirable. The focus of this research is lightweight, high-absorption EMI shielding composites. Simple aqueous dispersion and drying procedures were used to prepare cotton fiber (CF)-based sheets combined with various zinc oxide (ZnO) contents. These composites were carbonated in a high-temperature furnace at 800 °C for two hours. The obtained CF/ZnO samples have densities of 1.02-1.08 g/cm
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym16010116
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Article ; Online: Dynamic profiles of lncRNAs reveal a functional natural antisense RNA that regulates the development of Schistosoma japonicum.

Cheng, Shaoyun / You, Yanmin / Wang, Xiaoling / Yi, Cun / Zhang, Wei / Xie, Yuxiang / Xiu, Lei / Luo, Fang / Lu, Yan / Wang, Jipeng / Hu, Wei

PLoS pathogens

2024 Volume 20, Issue 1, Page(s) e1011949

Abstract: Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite's developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non- ... ...

Abstract	Schistosomes are flatworm parasites that undergo a complex life cycle involving two hosts. The regulation of the parasite's developmental processes relies on both coding RNAs and non-coding RNAs. However, the roles of non-coding RNAs, including long non-coding RNAs (lncRNAs) in schistosomes remain largely unexplored. Here we conduct advanced RNA sequencing on male and female S. japonicum during their pairing and reproductive development, resulting in the identification of nearly 8,000 lncRNAs. This extensive dataset enables us to construct a comprehensive co-expression network of lncRNAs and mRNAs, shedding light on their interactions during the crucial reproductive stages within the mammalian host. Importantly, we have also revealed a specific lncRNA, LNC3385, which appears to play a critical role in the survival and reproduction of the parasite. These findings not only enhance our understanding of the dynamic nature of lncRNAs during the reproductive phase of schistosomes but also highlight LNC3385 as a potential therapeutic target for combating schistosomiasis.
MeSH term(s)	Animals ; Male ; Female ; Schistosoma japonicum/genetics ; RNA, Long Noncoding/genetics ; RNA, Antisense/genetics ; Schistosomiasis/parasitology ; Parasites/genetics ; Mammals
Chemical Substances	RNA, Long Noncoding ; RNA, Antisense
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1011949
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Article ; Online: Robust Cylindrical Panorama Stitching for Low-Texture Scenes Based on Image Alignment Using Deep Learning and Iterative Optimization.

Kang, Lai / Wei, Yingmei / Jiang, Jie / Xie, Yuxiang

Sensors (Basel, Switzerland)

2019 Volume 19, Issue 23

Abstract: Cylindrical panorama stitching is able to generate high resolution images of a scene with a wide field-of-view (FOV), making it a useful scene representation for applications like environmental sensing and robot localization. Traditional image stitching ... ...

Abstract	Cylindrical panorama stitching is able to generate high resolution images of a scene with a wide field-of-view (FOV), making it a useful scene representation for applications like environmental sensing and robot localization. Traditional image stitching methods based on hand-crafted features are effective for constructing a cylindrical panorama from a sequence of images in the case when there are sufficient reliable features in the scene. However, these methods are unable to handle low-texture environments where no reliable feature correspondence can be established. This paper proposes a novel two-step image alignment method based on deep learning and iterative optimization to address the above issue. In particular, a light-weight end-to-end trainable convolutional neural network (CNN) architecture called ShiftNet is proposed to estimate the initial shifts between images, which is further optimized in a sub-pixel refinement procedure based on a specified camera motion model. Extensive experiments on a synthetic dataset, rendered photo-realistic images, and real images were carried out to evaluate the performance of our proposed method. Both qualitative and quantitative experimental results demonstrate that cylindrical panorama stitching based on our proposed image alignment method leads to significant improvements over traditional feature based methods and recent deep learning based methods for challenging low-texture environments.
Language	English
Publishing date	2019-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s19235310
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Article ; Online: WTAP-induced N

Liu, Qi-Zhi / Zhang, Nan / Chen, Jun-Yi / Zhou, Min-Jun / Zhou, De-Hua / Chen, Zhuo / Huang, Zhen-Xing / Xie, Yu-Xiang / Qiao, Guang-Lei / Tu, Xiao-Huang

Cancer science

2024

Abstract: ... ...

Abstract	N
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.16136
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Article ; Online: Constructing the Polymer Molecules to Regulate the Electrode/Electrolyte Interface to Enhance Lithium-Metal Battery Performance.

Chen, Hui / Xie, Yu-Xiang / Dong, Long-Ji / Peng, Hao / Lin, Meng-Wei / Sun, Miao-Lan / Liu, Shi-Shi / Ma, Jun-Bo / Huang, Ling / Sun, Shi-Gang

ChemSusChem

2024 , Page(s) e202301710

Abstract: Lithium-ion batteries, with high energy density and long cycle life, have become the battery of choice for most vehicles and portable electronic devices; however, energy density, safety and cycle life require further improvements. Single-functional group ...

Abstract	Lithium-ion batteries, with high energy density and long cycle life, have become the battery of choice for most vehicles and portable electronic devices; however, energy density, safety and cycle life require further improvements. Single-functional group electrolyte additives are very limited in practical applications, a ternary polymer bifunctional electrolyte additive copolymer (acrylonitrile-butyl hexafluoro methacrylate- poly (ethylene glycol) methacrylate- methyl ether) (PMANHF) was synthesized by free radical polymerization of acrylonitrile, 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate and poly (ethylene glycol) methyl ether methacrylate. A series of characterizations show that in Li metal anodes, the preferential reduction of PMANHF is conducive to the formation of a uniform and stable solid electrolyte interphase layer, and Li deposition is uniform and dense. At the NCM811 cathode, a film composed of LiF- and Li
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202301710
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Article ; Online: BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.

Liu, Jianing / Shangguan, Yumeng / Sun, Jingfu / Cong, Wei / Xie, Yuxiang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 129, Page(s) 110414

Abstract: Introduction: Gastric cancer is third leading cause of cancer-related deaths worldwide and remarkably threatens human health and life. BAIAP2L2 is an epithelial-specific BAR domain protein that considered to be closely related to cell migration. In this ...

Abstract	Introduction: Gastric cancer is third leading cause of cancer-related deaths worldwide and remarkably threatens human health and life. BAIAP2L2 is an epithelial-specific BAR domain protein that considered to be closely related to cell migration. In this study, we explored the specific role of BAIAP2L2 in human gastric cancer. Methods: BAIAP2L2 expression was analyzed via online database and immunohistochemistry. The proliferation was detected using CCK8 and colony formation assay. The migration and invasion was confirmed by transwell assay, and the apoptosis of gastric cancer cells was detected by flow cytometry. Results: BAIAP2L2 was highly expressed in tumour tissues and its expression significantly correlated with tumor diameter, T stage, pTNM stage and lymph node metastasis, respectively. Compared with GES-1 cells, SGC7901, MKN28, MKN45, AGS and BGC-823 tumor cells were all presented a high-expression of BAIAP2L2. The in vitro results showed that knockdown of BAIAP2L2 inhibited the proliferation, migration and invasion, and induced the apoptosis of gastric cancer cell. Further, knockdown of BAIAP2L2 inhibited the expression of the related proteins of AKT/mTOR and Wnt3a/β-catenin signaling pathways. Conclusion: BAIAP2L2 is upregulated in gastric cancer, and knockdown of BAIAP2L2 inhibited the proliferation and metastasis through the inactivation of AKT/mTOR and Wnt3a/β-catenin signaling pathways.
MeSH term(s)	Aged ; Apoptosis ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Proto-Oncogene Proteins c-akt/metabolism ; Stomach Neoplasms/enzymology ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; TOR Serine-Threonine Kinases/metabolism ; Wnt Signaling Pathway ; Wnt3A Protein/genetics ; Wnt3A Protein/metabolism
Chemical Substances	WNT3A protein, human ; Wnt3A Protein ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-06-20
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110414
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Ud II Zs.198: Show issues

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Article ; Online: Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia.

Huang, Ning / Li, Sunan / Xie, Yuxiang / Han, Qi / Xu, Xiao-Ming / Sheng, Zu-Hang

Current biology : CB

2021 Volume 31, Issue 14, Page(s) 3098–3114.e7

Abstract: Mitochondria supply adenosine triphosphate (ATP) essential for neuronal survival and regeneration. Brain injury and ischemia trigger acute mitochondrial damage and a local energy crisis, leading to degeneration. Boosting local ATP supply in injured axons ...

Abstract	Mitochondria supply adenosine triphosphate (ATP) essential for neuronal survival and regeneration. Brain injury and ischemia trigger acute mitochondrial damage and a local energy crisis, leading to degeneration. Boosting local ATP supply in injured axons is thus critical to meet increased energy demand during nerve repair and regeneration in adult brains, where mitochondria remain largely stationary. Here, we elucidate an intrinsic energetic repair signaling axis that boosts axonal energy supply by reprogramming mitochondrial trafficking and anchoring in response to acute injury-ischemic stress in mature neurons and adult brains. P21-activated kinase 5 (PAK5) is a brain mitochondrial kinase with declined expression in mature neurons. PAK5 synthesis and signaling is spatiotemporally activated within axons in response to ischemic stress and axonal injury. PAK5 signaling remobilizes and replaces damaged mitochondria via the phosphorylation switch that turns off the axonal mitochondrial anchor syntaphilin. Injury-ischemic insults trigger AKT growth signaling that activates PAK5 and boosts local energy supply, thus protecting axon survival and facilitating regeneration in in vitro and in vivo models. Our study reveals an axonal mitochondrial signaling axis that responds to injury and ischemia by remobilizing damaged mitochondria for replacement, thereby maintaining local energy supply to support central nervous system (CNS) survival and regeneration.
MeSH term(s)	Adenosine Triphosphate ; Animals ; Axons ; Cellular Reprogramming ; HEK293 Cells ; Humans ; Ischemia ; Mice, Knockout ; Mitochondria ; Neurons ; Proto-Oncogene Proteins c-akt/metabolism ; Regeneration ; Signal Transduction ; p21-Activated Kinases/metabolism ; Mice
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Pak7 protein, mouse (EC 2.7.1.11) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; p21-Activated Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-06-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2021.04.079
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