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Article ; Online: Cardioprotective effects of fucoidan against hypoxia-induced apoptosis in H9c2 cardiomyoblast cells.

Zhang, S M / Xie, Z P / Xu, M L / Shi, L F

2015 Volume 53, Issue 9, Page(s) 1352–1357

Abstract: Context: Cardiomyocyte apoptosis plays a critical role in the progress of heart diseases. Fucoidan, a complex-sulfated polysaccharide, has been reported to possess potential cardioprotective efficacy in vivo.: Objective: The present study determines ... ...

Abstract	Context: Cardiomyocyte apoptosis plays a critical role in the progress of heart diseases. Fucoidan, a complex-sulfated polysaccharide, has been reported to possess potential cardioprotective efficacy in vivo. Objective: The present study determines whether fucoidan could provide cardioprotection on hypoxia-induced cardiomyocyte apoptosis. Materials and methods: H9c2 cardiomyoblast cells were incubated with various concentrations (15, 30, and 60 μg/ml) of fucoidan in a humidified incubator at 37 °C with 95% O2 and 5% CO2. After 6 h, hypoxia was processed and the cardioprotective effects of fucoidan were evaluated by applying MTT, ELISA, Hoechst 33258 nucleus staining, and western blot. Results: Following a 6 h exposure of H9c2 to hypoxic condition, significant reduction was found in cell survival (0.57-fold) and superoxide dismutase (SOD) activity (0.56-fold), which were associated with the increase of malondialdehyde (MDA) level (2.58-fold), creatine phosphokinase (CK, 3.57-fold), and lactate dehydrogenase (LDH) activities (2.39-fold). Moreover, hypoxia-induced apoptosis was confirmed by Hoechst 33258 nuclear staining, and these changes were accompanied by the increase of Bcl-2 (1.27-fold) and Bax expression (2.6-fold). However, preincubation of the cells with fucoidan prior to hypoxia exposure elevated the cell viability (30 μg/ml, 1.18-fold; 60 μg/ml, 1.32-fold) and SOD activity (30 μg/ml, 1.12-fold; 60 μg/ml, 1.25-fold), but decreased the MDA level (30 μg/ml, 0.70-fold; 60 μg/ml, 0.80-fold), CK (30 μg/ml, 0.69-fold; 60 μg/ml, 0.76-fold), and LDH (30 μg/ml, 0.67-fold; 60 μg/ml, 0.86-fold) leakages. Hoechst 33258 nuclear staining observations demonstrated the same protective effect of fucoidan on hypoxia-induced myocardial injury. Also, cardioprotective effects of fucoidan were reflected by increasing Bcl-2 (60 μg/ml, 1.84-fold), as well as decreasing Bax (60 μg/ml, 0.6-fold). Conclusion: Fucoidan had protective effect against hypoxia-induced cardiomyocytes apoptosis, and the mechanism might involve protections of the cell from oxidative injury.
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Biomarkers/metabolism ; Cell Hypoxia ; Cell Line ; Cell Survival/drug effects ; Creatine Kinase/metabolism ; Cytoprotection ; Dose-Response Relationship, Drug ; L-Lactate Dehydrogenase/metabolism ; Malondialdehyde/metabolism ; Myoblasts, Cardiac/drug effects ; Myoblasts, Cardiac/metabolism ; Myoblasts, Cardiac/pathology ; Polysaccharides/pharmacology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Superoxide Dismutase/metabolism ; Time Factors ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Antioxidants ; Bax protein, rat ; Biomarkers ; Polysaccharides ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein ; Malondialdehyde (4Y8F71G49Q) ; fucoidan (9072-19-9) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Superoxide Dismutase (EC 1.15.1.1) ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2015
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.3109/13880209.2014.982298
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Article ; Online: Comparative genome-wide gene expression analysis of rheumatoid arthritis and osteoarthritis.

Yi, C Q / Ma, C H / Xie, Z P / Cao, Y / Zhang, G Q / Zhou, X K / Liu, Z Q

Genetics and molecular research : GMR

2013 Volume 12, Issue 3, Page(s) 3136–3145

Abstract: Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives ... ...

Abstract	Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We found 32 highly significant pathways, including 18 downregulated and 14 upregulated pathways associated with RA. We also identified 18 highly significant pathways, including 7 downregulated and 11 up-regulated pathways associated with OA. Several such pathways were found in both RA and OA, including an upregulated PPAR signaling pathway and downregulated leukocyte transendothelial migration. Regulatory mechanisms in RA seem to be more complex than in OA. This information could be useful for diagnosis and treatment of these two diseases.
MeSH term(s)	Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/pathology ; Down-Regulation ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Gene Expression Regulation/genetics ; Genome, Human ; Humans ; Metabolic Networks and Pathways/genetics ; Oligonucleotide Array Sequence Analysis ; Osteoarthritis/genetics ; Osteoarthritis/pathology ; Peroxisome Proliferator-Activated Receptors/genetics ; Signal Transduction/genetics ; Up-Regulation
Chemical Substances	Peroxisome Proliferator-Activated Receptors
Language	English
Publishing date	2013-03-11
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2013.March.11.3
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Article: [Food poisoning caused by Heiberg's group II Vibrio].

Xie, Z P

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

1984 Volume 18, Issue 1, Page(s) 35–36

MeSH term(s)	Adult ; Animals ; Foodborne Diseases/etiology ; Humans ; Male ; Mice ; Vibrio/drug effects ; Vibrio/isolation & purification ; Vibrio/pathogenicity
Language	Chinese
Publishing date	1984-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
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Zs.B 2487: Show issues

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Article: Retraction of articles by T. Liu et al.

Liu, T / Wang, Y-X / Wang, Z-W / Xie, Z-P / Zhu, J Y

Acta crystallographica. Section E, Structure reports online

2009 Volume 66, Issue Pt 1, Page(s) e13–4

Abstract: A series of 29 papers by Liu et al. are retracted. ...

Abstract	A series of 29 papers by Liu et al. are retracted.
Language	English
Publishing date	2009-12-19
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2041947-8
ISSN	1600-5368
ISSN	1600-5368
DOI	10.1107/S1600536809049976
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Article: Comparison of driving forces in sustainable food production and the future of plant biotechnology in Switzerland and China

Xie, Z.P / Auberson-Huang, L / Malnoe, P / Yao, H.O / Kaeppeli, O

Trends in plant science. Sept 2002. v. 7 (9)

2002

Keywords	plant breeding ; biotechnology ; transgenic plants ; crop production ; Switzerland ; China
Language	English
Dates of publication	2002-09
Size	p. 416-418.
Document type	Article
ZDB-ID	1305448-x
ISSN	1878-4372 ; 1360-1385
ISSN (online)	1878-4372
ISSN	1360-1385
Database	NAL-Catalogue (AGRICOLA)

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Article: Initial events in the formation of neuromuscular synapse: rapid induction of acetylcholine release from embryonic neuron.

Xie, Z P / Poo, M M

Proceedings of the National Academy of Sciences of the United States of America

1986 Volume 83, Issue 18, Page(s) 7069–7073

Abstract: We have studied the electrical events during the initial phase of nerve-muscle contact in embryonic Xenopus culture. Using a G omega-seal, whole-cell recording method, we monitored the membrane current of a muscle cell continuously while it was ... ...

Abstract	We have studied the electrical events during the initial phase of nerve-muscle contact in embryonic Xenopus culture. Using a G omega-seal, whole-cell recording method, we monitored the membrane current of a muscle cell continuously while it was manipulated into close proximity of the growth cone of a cocultured spinal neuron. We found a rapid appearance of pulsatile inward currents at the muscle cell after the neurite-muscle contact. These currents were abolished by d-tubocurarine and alpha-bungarotoxin but were unaffected by tetrodotoxin. Both the drug sensitivity and the time course of these currents are similar to that of the spontaneous miniature end-plate currents (MEPCs) resulting from spontaneous release of pulses of acetylcholine (AcCho) from the nerve terminal. Unlike the MEPCs at the mature neuromuscular synapse, these early MEPCs varied greatly in their amplitudes, and there was a gradual increase in the frequency of the MEPCs of larger amplitudes during the first 20 min after the contact. Independent measurement of AcCho concentration near the growth cone by an excised patch of AcCho-sensitive muscle membrane showed that very little AcCho is released from the isolated growth cone, and marked release can be triggered by the contact with a muscle cell or with the excised membrane itself. The induction of release is relatively specific: contact with a neuron or the tip of a clean glass pipette was capable of inducing only a transient release, while persistent release was induced by contacts made with muscle membrane. This contact-dependent AcCho release may be responsible for an early induction of muscle activity and serve as a signal for the establishment of synaptic contact.
MeSH term(s)	Acetylcholine/metabolism ; Animals ; Bungarotoxins/pharmacology ; Cell Communication ; Embryo, Nonmammalian ; Membrane Potentials ; Neuromuscular Junction/physiology ; Organ Culture Techniques ; Synapses/physiology ; Xenopus
Chemical Substances	Bungarotoxins ; Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	1986-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.83.18.7069
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Zs.A 1148: Show issues

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Article ; Online: Newly identified respiratory viruses associated with acute lower respiratory tract infections in children in Lanzou, China, from 2006 to 2009.

Jin, Y / Zhang, R-F / Xie, Z-P / Yan, K-L / Gao, H-C / Song, J-R / Yuan, X-H / Cheng, W-X / Hou, Y-D / Duan, Z-J

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2011 Volume 18, Issue 1, Page(s) 74–80

Abstract: Nasopharyngeal aspirates were collected from 813 children ≤ 14 years old with acute lower respiratory tract infections in Lanzhou, China, from December 2006 to November 2009. PCR or RT-PCR was used to screen for the presence of 10 respiratory viruses. ... ...

Abstract	Nasopharyngeal aspirates were collected from 813 children ≤ 14 years old with acute lower respiratory tract infections in Lanzhou, China, from December 2006 to November 2009. PCR or RT-PCR was used to screen for the presence of 10 respiratory viruses. Viral agents were identified in 73.92% (601/813) of specimens, including RSV in 40.71%, hMPV in 6.15%, IFVA in 7.13%, IFVB in 0.98%, PIV1-3 in 7.87%, HCoV-HKU1 in 2.21%, HCoV-NL63 in 3.81%, HRV in 19.93%, AdV in 7.50% and HBoV in 11.56%. Two or more viruses were detected in 34.44% (280/813) of cases. The newly identified respiratory viruses, HBoV, hMPV, HCoV-HKU1 and HCoV-NL63, accounted for 22.01% of the detected viral pathogens. RSV and HRV were frequently detected in patients with bronchiolitis, and hMPV was frequently associated with pneumonia. HCoV-NL63 was found to be one of the causative agents of acute respiratory wheezing in young children. No seasonal variation was found in the incidence of detection of HCoV-HKU1, HCoV-NL63 or HBoV. This 3-year study demonstrated that viral pathogens play an important role in children with ALRTIs, and more attention should be paid to these newly identified viral agents.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; China ; DNA, Viral/analysis ; DNA, Viral/genetics ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; RNA, Viral/analysis ; RNA, Viral/genetics ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Virus Diseases/virology ; Viruses/isolation & purification ; Viruses/pathogenicity
Chemical Substances	DNA, Viral ; RNA, Viral
Keywords	covid19
Language	English
Publishing date	2011-07-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1111/j.1469-0691.2011.03541.x
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [Whole-cell recordings of the supraoptic nucleus neurons from rat hypothalamic slices in vitro].

Liu, Q S / Jia, Y S / Xie, Z P / Ju, G

Sheng li xue bao : [Acta physiologica Sinica

1997 Volume 49, Issue 4, Page(s) 467–470

Abstract: Fifty-two supraoptic nucleus neurons in rat slice preparations were studied using whole cell patch-clamp technique. The mean passive and active membrane properties were measured as follows: resting membrane potential, 59 +/- 8 mV; input resistance, 535 +/ ...

Abstract	Fifty-two supraoptic nucleus neurons in rat slice preparations were studied using whole cell patch-clamp technique. The mean passive and active membrane properties were measured as follows: resting membrane potential, 59 +/- 8 mV; input resistance, 535 +/- 129 M omega; time constant, 32 +/- 9 ms; amplitude of the action potentials, 99 +/- 11 mV; overshoot, 37 +/- 13 mV (n = 39). Most of these neurons showed a prominent slow after-hyperpolarization potential or current in response to depolarizing pulse. In votage-clamp condition, it was found that virtually all supraoptic neurons (n = 13) were invaded by spontaneous synaptic inputs. Pharmacological experiments showed that the excitatory postsynaptic currents (EPSCs) were mediated by non-NMDA glutamate receptors, whereas inhibitory postsynaptic currents (IPSCs) by GABAA receptors.
MeSH term(s)	Animals ; Animals, Newborn ; Excitatory Postsynaptic Potentials ; Hypothalamus/physiology ; Membrane Potentials ; Neurons/physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley ; Supraoptic Nucleus/physiology ; Synaptic Transmission
Language	Chinese
Publishing date	1997-08
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
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Zs.A 386: Show issues

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Article: Nod factors and chitooligomers elicit an increase in cytosolic calcium in aequorin-expressing soybean cells

Muller, J / Staehelin, C / Xie, Z.P / Neuhaus-Url, G / Boller, T

Plant physiology (Lancaster, Pa.) Plant physiology. Oct 2000. v. 124 (2)

2000

Abstract: Rhizobial Nod factors (NFs) function as nodulation signals that trigger symbiotic responses of leguminous host plants. NFs consist of a chitin oligomer backbone carrying a fatty acid at the non-reducing end. Depending on the rhizobial strain, NFs carry ... ...

Abstract	Rhizobial Nod factors (NFs) function as nodulation signals that trigger symbiotic responses of leguminous host plants. NFs consist of a chitin oligomer backbone carrying a fatty acid at the non-reducing end. Depending on the rhizobial strain, NFs carry additional substituents, which may determine host specificity. Transgenic suspension-cultured soybean (Glycine max [L.] Merr.) cells expressing aequorin have been used to record cytosolic [Ca2+] changes upon treatment with purified NFs and chitin fragments. Both compounds elicited an increase of cytosolic [Ca2+] at nanomolar concentrations. The shape and amplitude of cytosolic [Ca2+] changes was similar to the response elicited by un-derivatized chitin oligomers. Cells challenged first with NFs did not respond to a subsequent treatment with chitin oligomers and vice versa. Dose-response experiments showed that un-derivatized chitin oligomers were more active compared with NFs. The capacity of NFs to elicit the calcium response depended on their structure. The presence of reducing end substituents in methylfucosylated NFs from Rhizobium sp. NGR234 and the O-acetyl group at the non-reducing end in NFs from Sinorhizobium meliloti attenuated the activity to cause the calcium changes. The sulfate group in NFs from Rhizobium tropici did not affect the elicitor activity. Pentameric S. meliloti NFs were more active than tetrameric molecules, whereas trimeric or dimeric degradation products were inactive. Substituents in NFs may have the function to avoid stimulation of defense reactions mediated by the perception system for chitin oligomers.
Keywords	Glycine max ; cultured cells ; Rhizobium ; symbiosis ; nodulation ; chitin ; oligosaccharides ; cytosol ; calcium ; quantitative analysis ; luminescence ; chemical constituents of plants ; stress response
Language	English
Dates of publication	2000-10
Size	p. 733-739.
Document type	Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
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Z 1193: Show issues
IZMB/IMBIO: Kirschallee: Show issues

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Article: [Two types of nondepolarizing-activated calcium channels on the spinal cholinergic neurons from embryonic Xenopus laevis].

Wang, J H / Yang, S R / Xie, Z P

Sheng li xue bao : [Acta physiologica Sinica

1991 Volume 43, Issue 5, Page(s) 436–442

Abstract: Single calcium channel current was studied on the identified spinal cholinergic neurons from embryonic Xenopus laevis with patch clamp method. The results indicate that some calcium channels show opening activity at resting membrane potential. According ... ...

Abstract	Single calcium channel current was studied on the identified spinal cholinergic neurons from embryonic Xenopus laevis with patch clamp method. The results indicate that some calcium channels show opening activity at resting membrane potential. According to the characteristics of conductance and kinetics of such channels, they could be divided into two types: a stretch sensitive Type-NS with a slope conductance of 7.5 pS (mean open time 0.58 ms at resting membrane potential) and a Type-NL with a slope conductance of 16.7 pS (and two opening times of 2 ms and 19.3 ms). Both types of channel are predominantly active at resting potential and negative membrane phases. It is suggested that they may be involved in the calcium-dependent neuronal events at resting state.
MeSH term(s)	Animals ; Calcium Channels/physiology ; Cholinergic Fibers/physiology ; Embryo, Nonmammalian ; Membrane Potentials ; Neurons/physiology ; Spinal Cord/physiology ; Xenopus laevis
Chemical Substances	Calcium Channels
Language	Chinese
Publishing date	1991-10
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
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Zs.A 386: Show issues

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