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Article ; Online: Erratum. A High-Fat Diet AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo. Diabetes 2021;70:577-588.

Yan, Chenghui / Tian, Xiaoxiang / Li, Jiayin / Liu, Dan / Ye, Ding / Xie, Zhonglin / Han, Yaling / Zou, Ming-Hui

2023 Volume 72, Issue 7, Page(s) 1035

Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Published Erratum
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db23-er07
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Article ; Online: Pycard

Li, Jian / Yao, Hongmin / Zhao, Fujie / An, Junqing / Wang, Qilong / Mu, Jing / Liu, Zhixue / Zou, Ming-Hui / Xie, Zhonglin

Autophagy

2023 Volume 20, Issue 3, Page(s) 629–644

Abstract: PYCARD (PYD and CARD domain containing), a pivotal adaptor protein in inflammasome assembly and activation, contributes to innate immunity, and plays an essential role in the pathogenesis of atherosclerosis and restenosis. However, its roles in microRNA ... ...

Abstract	PYCARD (PYD and CARD domain containing), a pivotal adaptor protein in inflammasome assembly and activation, contributes to innate immunity, and plays an essential role in the pathogenesis of atherosclerosis and restenosis. However, its roles in microRNA biogenesis remain unknown. Therefore, this study aimed to investigate the roles of PYCARD in miRNA biogenesis and neointima formation using
MeSH term(s)	Animals ; Mice ; MicroRNAs/genetics ; Chaperone-Mediated Autophagy ; Inflammasomes/metabolism ; Autophagy/physiology ; Neointima ; Vascular System Injuries ; RNA-Binding Proteins ; Heat-Shock Proteins/metabolism ; CARD Signaling Adaptor Proteins/metabolism ; Guanine Nucleotide Exchange Factors/metabolism ; GTPase-Activating Proteins/metabolism ; Protein-Arginine N-Methyltransferases/metabolism
Chemical Substances	MicroRNAs ; Inflammasomes ; RNA-Binding Proteins ; Heat-Shock Proteins ; Pycard protein, mouse ; CARD Signaling Adaptor Proteins ; DOCK2 protein, mouse ; Guanine Nucleotide Exchange Factors ; GTPase-Activating Proteins ; PRMT8 protein, mouse (EC 2.1.1.319) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319)
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2023.2277610
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Article ; Online: Ablation of endothelial

Yao, Hongmin / Li, Jian / Liu, Zhixue / Ouyang, Changhan / Qiu, Yu / Zheng, Xiaoxu / Mu, Jing / Xie, Zhonglin

Autophagy

2022 Volume 19, Issue 5, Page(s) 1491–1511

Abstract: Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/autophagy and ... ...

Abstract	Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/autophagy and cell cycle regulation. However, whether and how ATG7 influences endothelial cell (EC) function and regulates post-ischemic angiogenesis remain unknown. Here, we showed that in mice subjected to femoral artery ligation, EC-specific deletion of
MeSH term(s)	Mice ; Humans ; Animals ; Autophagy/genetics ; HEK293 Cells ; STAT1 Transcription Factor ; Fibroblasts ; Human Umbilical Vein Endothelial Cells ; Ischemia ; Hypoxia-Inducible Factor 1 ; Karyopherins ; DNA-Binding Proteins ; Transcription Factors ; Hypoxia-Inducible Factor 1, alpha Subunit
Chemical Substances	STAT1 Transcription Factor ; Hypoxia-Inducible Factor 1 ; Karyopherins ; ZNF148 protein, human ; DNA-Binding Proteins ; Transcription Factors ; STAT1 protein, human ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; ATG7 protein, human (EC 6.2.1.45) ; Zfp148 protein, mouse ; Stat1 protein, mouse ; Atg7 protein, mouse
Language	English
Publishing date	2022-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2022.2139920
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Article ; Online: Tip-enhanced four-wave mixing internally illuminated by an ultrafast vector light field.

Meng, Chao / Xie, Zhonglin / Li, Weijian / Xu, Lei / Gao, Feng / Zhang, Wending / Mei, Ting / Zhao, Jianlin

Optics letters

2022 Volume 47, Issue 5, Page(s) 1037–1040

Abstract: A tip nanofocusing light field, with high electric-field intensity and nanoscale mode volume, can significantly improve nonlinear light scattering efficiency, thereby greatly promoting the development of strong-field nano-optics. Here, tip-enhanced four- ... ...

Abstract	A tip nanofocusing light field, with high electric-field intensity and nanoscale mode volume, can significantly improve nonlinear light scattering efficiency, thereby greatly promoting the development of strong-field nano-optics. Here, tip-enhanced four-wave mixing (FWM) is theoretically analyzed through two ultrafast radial vector beams internally illuminating an Ag-coated silica tip (ACST). Two femtosecond pulses, with radial electric vectors and pulse width of 100 fs, are adopted as excitation sources to illuminate the ACST. Degenerate tip-enhanced FWM (ω
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.452493
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Article ; Online: Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis.

Zhang, Donghong / Ning, Jinfeng / Ramprasath, Tharmarajan / Yu, Changjiang / Zheng, Xiaoxu / Song, Ping / Xie, Zhonglin / Zou, Ming-Hui

Nature communications

2022 Volume 13, Issue 1, Page(s) 6371

Abstract: Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ... ...

Abstract	Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and heart regeneration. However, the IDO1-catalyzed tryptophan metabolism during heart regeneration is largely unexplored. Here, we find that apical neonatal mouse heart resection surgery led to rapid and consistent increases in cardiac IDO1 expression and kynurenine accumulation. Cardiac deletion of Ido1 gene or chemical inhibition of IDO1 impairs heart regeneration. Mechanistically, elevated kynurenine triggers cardiomyocyte proliferation by activating the cytoplasmic aryl hydrocarbon receptor-SRC-YAP/ERK pathway. In addition, cardiomyocyte-derived kynurenine transports to endothelial cells and stimulates cardiac angiogenesis by promoting aryl hydrocarbon receptor nuclear translocation and enhancing vascular endothelial growth factor A expression. Notably, Ahr deletion prevents indoleamine 2,3 dioxygenase -kynurenine-associated heart regeneration. In summary, increasing indoleamine 2,3 dioxygenase-derived kynurenine level promotes cardiac regeneration by functioning as an endogenous regulator of cardiomyocyte proliferation and cardiac angiogenesis.
MeSH term(s)	Mice ; Animals ; Kynurenine/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Tryptophan/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Endothelial Cells/metabolism ; Myocytes, Cardiac/metabolism ; Signal Transduction/physiology ; Cell Proliferation
Chemical Substances	Kynurenine (343-65-7) ; Receptors, Aryl Hydrocarbon ; Vascular Endothelial Growth Factor A ; Tryptophan (8DUH1N11BX) ; Indoleamine-Pyrrole 2,3,-Dioxygenase
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-33734-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo.

Mu, Jing / Zhang, Donghong / Tian, Yunli / Xie, Zhonglin / Zou, Ming-Hui

Journal of molecular and cellular cardiology

2020 Volume 149, Page(s) 1–14

Abstract: BRD4 is a member of the BET family of epigenetic regulators. Inhibition of BRD4 by the selective bromodomain inhibitor JQ1, alleviates thoracic aortic constriction-induced cardiac hypertrophy and heart failure. However, whether BRD4 inhibition by JQ1 has ...

Abstract	BRD4 is a member of the BET family of epigenetic regulators. Inhibition of BRD4 by the selective bromodomain inhibitor JQ1, alleviates thoracic aortic constriction-induced cardiac hypertrophy and heart failure. However, whether BRD4 inhibition by JQ1 has therapeutic effect on diabetic cardiomyopathy, a major cause of heart failure in patients with Type 2 diabetes, remains unknown. Here, we discover a novel link between BRD4 and PINK1/Parkin-mediated mitophagy during diabetic cardiomyopathy. Upregulation of BRD4 in diabetic mouse hearts inhibits PINK1/Parkin-mediated mitophagy, resulting in accumulation of damaged mitochondria and subsequent impairment of cardiac structure and function. BRD4 inhibition by JQ1 improves mitochondrial function, and repairs the cardiac structure and function of the diabetic heart. These effects depended on rewiring of the BRD4-driven transcription and repression of PINK1. Deletion of Pink1 suppresses mitophagy, exacerbates cardiomyopathy, and abrogates the therapeutic effect of JQ1 on diabetic cardiomyopathy. Our results illustrate a valid therapeutic strategy for treating diabetic cardiomyopathy by inhibition of BRD4.
MeSH term(s)	Animals ; Animals, Newborn ; Azepines/pharmacology ; Diabetes Mellitus, Type 2/complications ; Diabetic Cardiomyopathies/pathology ; Diet, High-Fat ; Gene Deletion ; Mice, Inbred C57BL ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Mitochondria, Heart/pathology ; Mitophagy/drug effects ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Promoter Regions, Genetic/genetics ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Triazoles/pharmacology ; Ubiquitin-Protein Ligases/metabolism ; Up-Regulation/drug effects
Chemical Substances	(+)-JQ1 compound ; Azepines ; Brd4 protein, mouse ; Nuclear Proteins ; Transcription Factors ; Triazoles ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; PTEN-induced putative kinase (EC 2.7.11.1)
Language	English
Publishing date	2020-09-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2020.09.003
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Article ; Online: Withdrawal: Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells.

Zhang, Junhua / Xie, Zhonglin / Dong, Yunzhou / Wang, Shuangxi / Liu, Chao / Zou, Ming-Hui

The Journal of biological chemistry

2020 Volume 295, Issue 2, Page(s) 670

Language	English
Publishing date	2020-01-03
Publishing country	United States
Document type	Journal Article ; Retraction of Publication
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.W119.012218
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Article ; Online: Metallic nanosphere-assisted coupling ultrafast surface plasmon polaritons background-free tip nanofocusing.

Meng, Chao / Li, Weijian / Xie, Zhonglin / Zhang, Lu / Xu, Lei / Gao, Feng / Zhang, Wending / Mei, Ting / Zhao, Jianlin

Optics letters

2021 Volume 46, Issue 22, Page(s) 5554–5557

Abstract: Plasmonic tip nanofocusing has gained much attention owing to its wide application in the field of nanospectroscopy. Here, we present the Au nanosphere (AuNS)-assisted coupling ultrafast surface plasmon polaritons (SPP) background-free tip nanofocusing. ... ...

Abstract	Plasmonic tip nanofocusing has gained much attention owing to its wide application in the field of nanospectroscopy. Here, we present the Au nanosphere (AuNS)-assisted coupling ultrafast surface plasmon polaritons (SPP) background-free tip nanofocusing. The plasmonic tip was prepared by attaching an AuNS on the shaft of an Au conical tip fabricated by electrochemical etching. The AuNS was adopted as an antenna to couple the far-field excitation light to the propagating SPP along the shaft to the tip apex for achieving power compression. Importantly, we experimentally and theoretically demonstrate that such a plasmonic tip can realize background-free ultrafast SPP tip nanofocusing with radially polarized features in a wide spectral range based on the localized SPP resonance effect supported by AuNS. Furthermore, the intensity of the tip nanofocusing light field has strong polarization dependence under linearly polarized light excitation, providing a powerful platform for spatiotemporal light control on the nanoscale. Our technique realizes remote excitation of background-free tip nanofocusing with a structured light feature, and it holds promising potential for tip-enhanced nanospectroscopies, nonlinear nanophotonics, etc.
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.443079
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Article ; Online: Erratum. A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo. Diabetes 2021;70:577-588.

Yan, Chenghui / Tian, Xiaoxiang / Li, Jiayin / Liu, Dan / Ye, Ding / Xie, Zhonglin / Han, Yaling / Zou, Ming-Hui

Diabetes

2021 Volume 70, Issue 9, Page(s) 2160

Language	English
Publishing date	2021-07-22
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db21-er09b
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Article ; Online: Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK.

Zou, Ming-Hui / Xie, Zhonglin

Autophagy

2013 Volume 9, Issue 4, Page(s) 624–625

Abstract: Diabetes induces cardiomyocyte apoptosis and suppresses cardiac autophagy, indicating that the interplay between autophagy and apoptotic cell death pathways is important in the pathogenesis of diabetic cardiomyopathy. The potential mechanism, however, ... ...

Abstract	Diabetes induces cardiomyocyte apoptosis and suppresses cardiac autophagy, indicating that the interplay between autophagy and apoptotic cell death pathways is important in the pathogenesis of diabetic cardiomyopathy. The potential mechanism, however, remains unknown. We recently reported that diabetes depresses AMP-activated protein kinase (AMPK) activity, inhibits MAPK8/JNK1-BCL2 signaling, and promotes the interaction between BECN1 and BCL2. Concomitantly, diabetes induces cardiomyocyte apoptosis and suppresses cardiac autophagy. Activation of AMPK directly phosphorylates MAPK8, which mediates BCL2 phosphorylation and subsequent BECN1-BCL2 dissociation, leading to restoration of cardiac autophagy, protection against cardiac apoptosis, and ultimately improvement in cardiac structure and function. We conclude that dissociation of BCL2 from BECN1 through activation of MAPK8-BCL2 signaling may be an important mechanism by which AMPK activation restores autophagy, protects against cardiac apoptosis, and prevents diabetic cardiomyopathy.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Apoptosis ; Autophagy ; Diabetic Cardiomyopathies/enzymology ; Diabetic Cardiomyopathies/pathology ; Homeostasis ; Humans ; Mice ; Myocardium/enzymology ; Myocardium/pathology ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/pathology ; Signal Transduction
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2013-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.4161/auto.23577
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