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  1. Article: [Evidence mapping of Chinese patent medicines in treatment of premature ventricular contractions].

    Zhang, Wen-Jie / Tang, Jia-Wei / Li, Jun / Wu, Ji / Zhang, Yin-Ming / Xie, Zi-Cong / Zhang, Le-Song / Meng, Chao / Huang, Xuan-Chun

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2024  Volume 49, Issue 5, Page(s) 1397–1405

    Abstract: This study employed evidence mapping to systematically sort out the clinical studies about the treatment of premature ventricular contractions with Chinese patent medicines and to reveal the distribution of evidence in this field. The articles about the ... ...

    Abstract This study employed evidence mapping to systematically sort out the clinical studies about the treatment of premature ventricular contractions with Chinese patent medicines and to reveal the distribution of evidence in this field. The articles about the treatment of premature ventricular contractions with Chinese patent medicines were searched against PubMed, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP with the time interval from January 2016 to December 2022. Evidence was analyzed and presented by charts and graphs combined with text. According to the inclusion and exclusion criteria, 164 papers were included, including 147 interventional studies, 4 observational studies, and 13 systematic reviews. A total of 27 Chinese patent medicines were involved, in which Shensong Yangxin Capsules and Wenxin Granules had high frequency. There were off-label uses in clinical practice. In recent years, the number of articles published in this field showed a decreasing trend. Eight types of outcome indicators were used in interventional studies. Ambulatory electrocardiography, clinical response rate, safety, and echocardiography had high frequency, while the rate of β-blocker decompensation, major cardiovascular events, and pharmaceutical economic indicators were rarely reported. The evaluation was one-sided. The low quality of the included articles reduced the reliability of the findings. In the future, the clinical use of medicines should be standardized, and the quality of clinical studies should be improved. Comprehensive clinical evaluation should be carried out to provide a sound scientific basis for the treatment of premature ventricular contractions with Chinese patent medicines.
    MeSH term(s) Humans ; Ventricular Premature Complexes/drug therapy ; Nonprescription Drugs/therapeutic use ; Reproducibility of Results ; Drugs, Chinese Herbal/therapeutic use ; Medicine, East Asian Traditional ; Capsules
    Chemical Substances Nonprescription Drugs ; Drugs, Chinese Herbal ; Capsules
    Language Chinese
    Publishing date 2024-03-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20231125.501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and safety of Chinese herbal medicine Wen Xin granules for the treatment of unstable angina pectoris with Yang deficiency and blood stasis syndrome: study protocol for a randomized controlled trial.

    Tian, Pan-Pan / Wu, Qing-Juan / Li, Jun / Chen, Heng-Wen / Wu, Ji / Deng, Ya-Wen / Xie, Zi-Cong / Zhao, Wei / Tan, Yu-Qing

    Trials

    2021  Volume 22, Issue 1, Page(s) 798

    Abstract: Introduction: Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after ... ...

    Abstract Introduction: Unstable angina pectoris (UAP) is the common type of coronary heart disease with the risk of developing into acute myocardial infarction (AMI). Currently, there are still numerous patients suffering from recurrent angina after revascularization or conventional medication due to the microvascular lesions, endothelial dysfunction, chronic inflammation, in-stent restenosis, and other factors. As an important part of China's medical and health care system, traditional Chinese medicine (TCM) has rich clinical experience in the treatment of UAP. According to the theory of TCM, Yang deficiency and blood stasis syndrome is a common type of UAP. Wen Xin decoction, as a type of Chinese herbal medicine, has been used in the clinic for years and shown great efficacy in the treatment of UAP with Yang deficiency and blood stasis syndrome. This study aims to evaluate the efficacy and safety of Wen Xin granular in patients with UAP.
    Methods and analysis: This is a double-blinded, randomized, placebo-controlled clinical trial. A total of 502 participants will be randomly allocated to the intervention group and the placebo group. Based on conventional medication, the intervention group will be treated with Wen Xin granular and the placebo group will be treated with Wen Xin granular placebo. The primary outcomes are major adverse cardiovascular events (MACE). Assessments will be performed 1 year after the treatment. The secondary outcomes include TCM symptom scale score, Seattle angina questionnaire, and thromboelastography. Assessments will be performed at baseline (before randomization) and 4 and 8 weeks after randomization.
    Discussion: This trial will provide high-quality data on the benefits and risks of Wen Xin granular in patients with UAP.
    Trial registration: ClinicalTrials.gov NCT04661709 . Registered on 30 November 2020.
    MeSH term(s) Angina, Unstable/diagnosis ; Angina, Unstable/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/adverse effects ; Humans ; Medicine, Chinese Traditional ; Myocardial Infarction ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Yang Deficiency
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-11-13
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-021-05771-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Panax Notoginseng Saponins Inhibits Ventricular Remodeling after Myocardial Infarction in Rats Through Regulating ATF3/MAP2K3/p38 MAPK and NF κ B Pathway.

    Ma, Ru-Feng / Chen, Guang / Li, Hong-Zheng / Zhang, Yun / Liu, Yong-Mei / He, Hao-Qiang / Liu, Chen-Yue / Xie, Zi-Cong / Zhang, Zhen-Peng / Wang, Jie

    Chinese journal of integrative medicine

    2020  Volume 26, Issue 12, Page(s) 897–904

    Abstract: Objective: To explore whether Panax notoginseng saponins (PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.: Methods: MI rats induced by ligating the left anterior ... ...

    Abstract Objective: To explore whether Panax notoginseng saponins (PNS) exhibits heart protective effect in myocardial infarction (MI) rats and to identify the potential signaling pathways involved.
    Methods: MI rats induced by ligating the left anterior descending (LAD) coronary artery were assigned to sham coronary artery ligation or coronary artery ligation. Totally 36 Sprague-Dawley rats were randomly divided into sham group (distilled water, n=9), MI group (distilled water, n=9), PNS group (PNS, 40 mg/kg daily, n=9) and fosinopril group (FIP, 1.2 mg/kg daily, n=9) according to a random number table. The left ventricular morphology and function were conducted by echocardiography. Histological alterations were evaluated by the stainings of HE and Masson. The serum levels of C reactive protein (CRP), tumor necrosis factor α (TNF-α), growth differentiation factor-15 (GDF-15) and the ratio of metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-9 (TIMP-1) were determined by ELISA. The levels of activating transcription factor 3 (ATF3), mitogen-activated protein kinase kinase 3 (MAP2K3), p38 mitogen-activated protein kinase (p38 MAPK), phosphorylation of p38 MAPK (p-p38 MAPK), transforming growth factor-β (TGF-β1), collagen I, nuclear factor kappa B p65 (NFκB p65), phosphorylation of NFκB p65 (p-NFκB p65), and phosphorylation of inhibitory kappa Bα (p-Iκ Bα) in hearts were measured by Western blot and immunohistochemical staining, respectively.
    Results: PNS improved cardiac function and fibrosis in MI rats (P<0.05). The serum levels of CRP, TNF-α, GDF-15 and the ratio of MMP9/TIMP1 were reversed by PNS in MI rats. The expressions of TGF-β1, collagen I, MAP2K3, p38 MAPK, p-p38 MAPK, NFκB p65, p-NFκB p65, and p-IκBα were down-regulated, while ATF3 increased with the treatment of PNS (P<0.05).
    Conclusions: PNS may improve cardiac function and fibrosis in MI rats via regulating ATF3/MAP2K3/p38 MAPK and NFκB signaling pathways. These results suggest the potential of PNS in preventing the development of ventricular remodeling in MI rats.
    MeSH term(s) Activating Transcription Factor 3/metabolism ; Animals ; Biomarkers/metabolism ; Disease Models, Animal ; MAP Kinase Kinase 3/metabolism ; Male ; Myocardial Infarction ; NF-kappa B/metabolism ; Panax notoginseng ; Rats ; Rats, Sprague-Dawley ; Saponins/pharmacology ; Ventricular Remodeling/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances Activating Transcription Factor 3 ; Biomarkers ; NF-kappa B ; Saponins ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase 3 (EC 2.7.12.2) ; Map2k3 protein, rat (EC 2.7.12.2)
    Language English
    Publishing date 2020-12-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-020-2856-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early lethality of shRNA-transgenic pigs due to saturation of microRNA pathways.

    Dai, Zhen / Wu, Rong / Zhao, Yi-cheng / Wang, Kan-kan / Huang, Yong-ye / Yang, Xin / Xie, Zi-cong / Tu, Chang-chun / Ouyang, Hong-sheng / Wang, Tie-dong / Pang, Da-xin

    Journal of Zhejiang University. Science. B

    2014  Volume 15, Issue 5, Page(s) 466–473

    Abstract: RNA interference (RNAi) is considered as a potential modality for clinical treatment and anti-virus animal breeding. Here, we investigate the feasibility of inhibiting classical swine fever virus (CSFV) replication by short hairpin RNA (shRNA) in vitro ... ...

    Abstract RNA interference (RNAi) is considered as a potential modality for clinical treatment and anti-virus animal breeding. Here, we investigate the feasibility of inhibiting classical swine fever virus (CSFV) replication by short hairpin RNA (shRNA) in vitro and in vivo. We generate four different shRNA-positive clonal cells and two types of shRNA-transgenic pigs. CSFV could be effectively inhibited in shRNA-positive clonal cells and tail tip fibroblasts of shRNA-transgenic pigs. Unexpectedly, an early lethality due to shRNA is observed in these shRNA-transgenic pigs. With further research on shRNA-positive clonal cells and transgenic pigs, we report a great induction of interferon (IFN)-responsive genes in shRNA-positive clonal cells, altered levels of endogenous microRNAs (miRNA), and their processing enzymes in shRNA-positive cells. What is more, abnormal expressions of miRNAs and their processing enzymes are also observed in the livers of shRNA-transgenic pigs, indicating saturation of miRNA/shRNA pathways induced by shRNA. In addition, we investigate the effects of shRNAs on the development of somatic cell nuclear transfer (SCNT) embryos. These results show that shRNA causes adverse effects in vitro and in vivo and shRNA-induced disruption of the endogenous miRNA pathway may lead to the early lethality of shRNA-transgenic pigs. We firstly report abnormalities of the miRNA pathway in shRNA-transgenic animals, which may explain the early lethality of shRNA-transgenic pigs and has important implications for shRNA-transgenic animal preparation.
    MeSH term(s) Animals ; Animals, Genetically Modified/genetics ; Classical Swine Fever Virus/genetics ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Signal Transduction/genetics ; Survival Rate ; Swine/genetics
    Chemical Substances RNA, Messenger ; RNA, Small Interfering
    Language English
    Publishing date 2014-05-03
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2247290-3
    ISSN 1862-1783 ; 1673-1581
    ISSN (online) 1862-1783
    ISSN 1673-1581
    DOI 10.1631/jzus.B1400001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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