LIVIVO - Search results -

Search results

Result 1 - 10 of total 45

Search options

Article ; Online: Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation.

Pfaffenbach, Magnus / Bolduc, Philippe N / Xin, Zhili / Gao, Fang / Evans, Ryan / Fang, Terry / Chodaparambil, Jayanth V / Henry, Kate L / Li, Pei / Mathieu, Steven / Metrick, Claire / Vera Rebollar, Jorge A / Gu, Rong-Fang / Mccarl, Christie-Ann / Silbereis, John / Peterson, Emily A

Journal of medicinal chemistry

2024

Abstract: Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases and cancer. We previously ... ...

Abstract	Interleukin receptor associated kinase 4 (IRAK4) plays an important role in innate immune signaling through Toll-like and interleukin-1 receptors and represents an attractive target for the treatment of inflammatory diseases and cancer. We previously reported the development of a potent, selective, and brain-penetrant imidazopyrimidine series of IRAK4 inhibitors. However, lead molecule BIO-7488 (
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00560
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Blood and Salivary MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

Liu, Dingshan / Xin, Zhili / Guo, Songsong / Li, Sheng / Cheng, Jie / Jiang, Hongbing

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2020 Volume 79, Issue 5, Page(s) 1082.e1–1082.e13

Abstract: Purpose: This meta-analysis aimed to compare and evaluate the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma (OSCC).: Methods: The PubMed, Embase, Web of Science, and Cochrane Library were ... ...

Abstract	Purpose: This meta-analysis aimed to compare and evaluate the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma (OSCC). Methods: The PubMed, Embase, Web of Science, and Cochrane Library were searched (updated to February 2020) to identify all articles describing the diagnostic value of blood and salivary miRNAs for OSCC. The pooled parameters were calculated using Revman (v.5.3) and STATA (v.14.0). Results: Twenty articles involving 1,106 patients and 732 controls were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNAs were 0.70 (95% CI: 0.63-0.77) and 0.82 (95% CI: 0.72-0.90). For blood miRNAs, they were 0.79 (95% CI: 0.73-0.84) and 0.82 (95% CI: 0.77-0.86). The areas under receiver operating characteristic curve in saliva, blood, and body fluid miRNAs were 0.80 (95% CI: 0.77-0.84), 0.88 (95% CI: 0.84-0.90), and 0.87 (95% CI: 0.84-0.90), respectively. Conclusions: The results of this meta-analysis indicate a moderate diagnostic accuracy of blood and salivary miRNAs presented for OSCC. These findings may provide less invasive and relatively reliable diagnostic tools for OSCC detection.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/genetics ; Head and Neck Neoplasms ; Humans ; MicroRNAs ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/genetics ; Squamous Cell Carcinoma of Head and Neck
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2020-12-30
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2020.12.043
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.113: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation resolution of diabetic periodontitis.

Li, Bang / Xin, Zhili / Gao, Shiyu / Li, Yangjie / Guo, Songsong / Fu, Yu / Xu, Rongyao / Wang, Dongmiao / Cheng, Jie / Liu, Laikui / Zhang, Ping / Jiang, Hongbing

Theranostics

2023 Volume 13, Issue 1, Page(s) 231–249

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Animals ; Humans ; Mice ; Antagomirs/metabolism ; Diabetes Mellitus/metabolism ; Inflammation/metabolism ; Macrophages/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Periodontitis/genetics ; Periodontitis/metabolism ; RNA-Binding Proteins/metabolism ; Sirtuins/genetics ; Sirtuins/metabolism ; Phagocytosis
Chemical Substances	Antagomirs ; MicroRNAs ; MIRN216 microRNA, human ; RNA-Binding Proteins ; SIRT6 protein, human (EC 3.5.1.-) ; Sirt6 protein, mouse (EC 2.4.2.31) ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2023-01-01
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.78878
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.

Fu, Yu / Xin, Zhili / Ling, Ziji / Xie, Hanyu / Xiao, Tao / Shen, Xin / Lin, Jialin / Xu, Ling / Jiang, Hongbing

Molecular medicine (Cambridge, Mass.)

2021 Volume 27, Issue 1, Page(s) 81

Abstract: Background: Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by increased proliferative activity ... ...

Abstract	Background: Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by increased proliferative activity and disrupted osteogenesis of BMSCs. However, the molecular mechanisms regulating the pathophysiologic features of BMSCs in FD remain unknown. This study aimed to identify and verify the roles of the CREB1-miR-181a-5p regulatory loop in FD pathophysiology. Methods: MicroRNA (miRNA) sequencing analysis was used to identify the possible miRNAs implicated in FD. The proliferation, apoptosis, and osteogenic differentiation of BMSCs, as well as the osteoclast-induced phenotype, were measured and compared after exogenous miR-181a-5p transfection into FD BMSCs or miR-181a-5p inhibitor transfection into normal BMSCs. Chromatin immunoprecipitation and luciferase reporter assays were performed to verify the interactions between CREB1 and miR-181a-5p and their effects on the FD pathological phenotype. Results: Compared to normal BMSCs, FD BMSCs showed decreased miR-181a-5p levels and exhibited increased proliferative activity, decreased apoptotic capacity, and impaired osteogenesis. FD BMSCs also showed a stronger osteoclast activation effect. miR-181a-5p overexpression reversed the pathophysiologic features of FD BMSCs, whereas miR-181a-5p suppression induced an FD-like phenotype in normal BMSCs. Mechanistically, miR-181a-5p was the downstream target of CREB1, and CREB1 was posttranscriptionally regulated by miR-181a-5p. Conclusions: Our study identifies that the interaction loop between CREB1 and miR-181a-5p plays a crucial role in regulating the pathophysiologic features of FD BMSCs. MiR-181a-5p may be a potential therapeutic target for the treatment of FD.
MeSH term(s)	Apoptosis ; Biomarkers ; Cell Differentiation/genetics ; Cell Proliferation ; Cells, Cultured ; Cyclic AMP Response Element-Binding Protein/metabolism ; Disease Susceptibility ; Fibrous Dysplasia of Bone/etiology ; Fibrous Dysplasia of Bone/metabolism ; Fibrous Dysplasia of Bone/pathology ; Gene Expression Regulation ; Humans ; Mesenchymal Stem Cells/metabolism ; MicroRNAs/genetics ; Models, Biological ; Osteoclasts/cytology ; Osteoclasts/metabolism ; Osteogenesis/genetics
Chemical Substances	Biomarkers ; CREB1 protein, human ; Cyclic AMP Response Element-Binding Protein ; MIRN-181 microRNA, human ; MicroRNAs
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-021-00341-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4456: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.

Ma, Bin / Zhang, Lei / Sun, Lihong / Xin, Zhili / Kumaravel, Gnanasambandam / Marcotte, Douglas / Chodaparambil, Jayanth V / Wang, Qin / Wehr, Angela / Jing, Jing / Hong, Victor Sukbong / Wang, Ti / Huang, Carol / Shao, Zhaohui / Mi, Sha

ACS medicinal chemistry letters

2021 Volume 12, Issue 7, Page(s) 1124–1129

Abstract: Autotaxin (ATX) is a lysophospholipase D that is the main enzyme responsible for generating LPA in body fluids. Although ATX was isolated from a conditioned medium of melanoma cells, later it was discovered to play a critical role in vascular and ... ...

Abstract	Autotaxin (ATX) is a lysophospholipase D that is the main enzyme responsible for generating LPA in body fluids. Although ATX was isolated from a conditioned medium of melanoma cells, later it was discovered to play a critical role in vascular and neuronal development. ATX has also been implicated in primary brain tumor, fibrosis, and rheumatoid arthritis, as well as neurological diseases such as multiple sclerosis, Alzheimer's disease, and neuropathic pain. As ATX and LPA levels are increased upon neuronal injury, a selective ATX inhibitor could provide a new approach to treat neuropathic pain. Herein we describe the discovery of a novel series of nonzinc binding reversible ATX inhibitors, particularly a potent, selective, orally bioavailable, brain-penetrable tool compound BIO-32546, as well as its synthesis, X-ray cocrystal structure, pharmacokinetics, and in vivo efficacy.
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.1c00211
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: LncRNA NEAT1 controls the lineage fates of BMSCs during skeletal aging by impairing mitochondrial function and pluripotency maintenance.

Zhang, Hengguo / Xu, Rongyao / Li, Bang / Xin, Zhili / Ling, Ziji / Zhu, Weiwen / Li, Xiang / Zhang, Ping / Fu, Yu / Chen, Jiyu / Liu, Laikui / Cheng, Jie / Jiang, Hongbing

Cell death and differentiation

2021 Volume 29, Issue 2, Page(s) 351–365

Abstract: Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In addition to known master regulators of lineage commitment, it is crucial to ... ...

Abstract	Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In addition to known master regulators of lineage commitment, it is crucial to identify pivotal switches governing the specific differentiation fate of aged BMSCs. Here, we profiled differences in epigenetic regulation between adipogenesis and osteogenesis and identified super-enhancer associated lncRNA nuclear-enriched abundant transcript 1 (NEAT1) as a key bone-fat switch in aged BMSCs. We validated that NEAT1 with high enhancer activity was transcriptionally activated by ATF2 and directed aged BMSCs to a greater propensity to differentiate toward adipocytes than osteoblasts by mediating mitochondrial function. Furthermore, we confirmed NEAT1 as a protein-binding scaffold in which phosphorylation modification of SOX2 Ser249/250 by CDK2 impaired SOX2/OCT4 complex stability and dysregulated downstream transcription networks of pluripotency maintenance. In addition, by sponging miR-27b-3p, NEAT1 upregulated BNIP3L, BMP2K, and PPARG expression to shape mitochondrial function and osteogenic/adipogenic differentiation commitment, respectively. In extracellular communication, NEAT1 promoted CSF1 secretion from aged BMSCs and then strengthened osteoclastic differentiation by extracellular vesicle delivery. Notably, Neat1 small interfering RNA delivery induced increased bone mass in aged mice and decreased fat accumulation in the bone marrow. These findings suggest that NEAT1 regulates the lineage fates of BMSCs by orchestrating mitochondrial function and pluripotency maintenance, and might be a potential therapeutic target for skeletal aging.
MeSH term(s)	Adipogenesis/genetics ; Aging/genetics ; Aging/metabolism ; Animals ; Cell Differentiation/genetics ; Epigenesis, Genetic ; Mesenchymal Stem Cells/metabolism ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Osteogenesis/genetics ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	MicroRNAs ; RNA, Long Noncoding
Language	English
Publishing date	2021-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/s41418-021-00858-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 80: Show issues

Order via subito

Details ▾

Article: Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.

Xin, Zhili / Himmelbauer, Martin K / Jones, J Howard / Enyedy, Istvan / Gilfillan, Rab / Hesson, Thomas / King, Kristopher / Marcotte, Douglas J / Murugan, Paramasivam / Santoro, Joseph C / Gonzalez-Lopez de Turiso, Felix

ACS medicinal chemistry letters

2020 Volume 11, Issue 4, Page(s) 485–490

Abstract: Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurological disease, we have completed medicinal chemistry ... ...

Abstract	Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurological disease, we have completed medicinal chemistry studies to identify novel CNS-penetrant ASK1 inhibitors starting from peripherally restricted compounds reported in the literature. This effort led to the discovery of
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.9b00611
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Catalytic asymmetric Petasis reactions of vinylboronates.

Shi, Xianglin / Kiesman, William F / Levina, Anna / Xin, Zhili

The Journal of organic chemistry

2013 Volume 78, Issue 18, Page(s) 9415–9423

Abstract: Binaphthol-catalyzed asymmetric Petasis reactions of salicylaldehydes with dibutyl vinylboronates and secondary amines in the presence of 4 Å molecular sieves (MS) afforded products with up to 99% ee in isolated yields of 39-94%. The 99% ee of the ... ...

Abstract	Binaphthol-catalyzed asymmetric Petasis reactions of salicylaldehydes with dibutyl vinylboronates and secondary amines in the presence of 4 Å molecular sieves (MS) afforded products with up to 99% ee in isolated yields of 39-94%. The 99% ee of the product indicated that the reaction by the binaphthol-catalyzed pathway was roughly 500 times faster than the uncatalyzed pathway. NMR experiments ((1)H and (11)B) showed that the amine component played a role in triggering the reaction between the binaphthol catalyst and the vinylboronate in the catalytic reaction sequence. The 4 Å MS enhanced both the rate and enantioselectivity by effective removal of water from the reaction system. A novel rearrangement reaction of the unconjugated allylic amine Petasis reaction product to a conjugated allylic amine was also observed.
MeSH term(s)	Aldehydes/chemistry ; Amines/chemistry ; Boronic Acids/chemistry ; Catalysis ; Molecular Structure ; Naphthols/chemistry ; Vinyl Compounds/chemistry
Chemical Substances	Aldehydes ; Amines ; Boronic Acids ; Naphthols ; Vinyl Compounds ; salicylaldehyde (17K64GZH20)
Language	English
Publishing date	2013-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo4016425
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4473: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Catalytic Asymmetric Petasis Reactions of Vinylboronates

Shi, Xianglin / Kiesman William F / Levina Anna / Xin Zhili

Journal of organic chemistry. 2013 Sept. 20, v. 78, no. 18

2013

Abstract: Binaphthol-catalyzed asymmetric Petasis reactions of salicylaldehydes with dibutyl vinylboronates and secondary amines in the presence of 4 Ã molecular sieves (MS) afforded products with up to 99% ee in isolated yields of 39â94%. The 99% ee of the ... ...

Abstract	Binaphthol-catalyzed asymmetric Petasis reactions of salicylaldehydes with dibutyl vinylboronates and secondary amines in the presence of 4 Ã molecular sieves (MS) afforded products with up to 99% ee in isolated yields of 39â94%. The 99% ee of the product indicated that the reaction by the binaphthol-catalyzed pathway was roughly 500 times faster than the uncatalyzed pathway. NMR experiments (Â¹H and Â¹Â¹B) showed that the amine component played a role in triggering the reaction between the binaphthol catalyst and the vinylboronate in the catalytic reaction sequence. The 4 Ã MS enhanced both the rate and enantioselectivity by effective removal of water from the reaction system. A novel rearrangement reaction of the unconjugated allylic amine Petasis reaction product to a conjugated allylic amine was also observed.
Keywords	catalysts ; catalytic activity ; chemical reactions ; chemical structure ; enantioselectivity ; nuclear magnetic resonance spectroscopy ; organic chemistry ; secondary amines ; sieves
Language	English
Dates of publication	2013-0920
Size	p. 9415-9423.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021%2Fjo4016425
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 49/42: Show issues
Z 7.1: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation

Journal of medicinal chemistry

2021 Volume 64, Issue 20, Page(s) 15402–15419

Abstract: Apoptosis signal-regulating kinase 1 (ASK1) is one of the key mediators of the cellular stress response that regulates inflammation and apoptosis. To probe the therapeutic value of modulating this pathway in preclinical models of neurological disease, we ...

Abstract	Apoptosis signal-regulating kinase 1 (ASK1) is one of the key mediators of the cellular stress response that regulates inflammation and apoptosis. To probe the therapeutic value of modulating this pathway in preclinical models of neurological disease, we further optimized the profile of our previously reported inhibitor
MeSH term(s)	Animals ; Brain/drug effects ; Brain/metabolism ; Dose-Response Relationship, Drug ; Drug Discovery ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; MAP Kinase Kinase Kinase 5/antagonists & inhibitors ; MAP Kinase Kinase Kinase 5/metabolism ; Mice ; Mice, Transgenic ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Rats ; Structure-Activity Relationship
Chemical Substances	Protein Kinase Inhibitors ; Pyrazoles ; pyrazole (3QD5KJZ7ZJ) ; MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; MAP3K5 protein, human (EC 2.7.11.25)
Language	English
Publishing date	2021-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.1c01458
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito