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Article ; Online: Bearing Behavior of Cold-Formed Thick-Walled Steel Plates with a Single Bolt

Lingling Wang / Xin Zhu

Applied Sciences, Vol 13, Iss 6897, p

2023 Volume 6897

Abstract: This paper presents the results of an experimental and analytical study on the behavior of cold-formed thick-walled steel plates connected by a single bolt under double shear. Experimental studies were conducted on a total of 54 bolted connections ... ...

Abstract	This paper presents the results of an experimental and analytical study on the behavior of cold-formed thick-walled steel plates connected by a single bolt under double shear. Experimental studies were conducted on a total of 54 bolted connections fabricated from two thicknesses of cold-formed thick-walled steel plates, with nominal thicknesses of 6 mm and 10 mm. The effects of the end distance, edge distance, and steel plate thickness on the bolt bearing behavior were investigated. The codes of (modified) ANSI/AISC 360-22 and EN1993-1-8 were applied to predict the failure modes and bearing resistance of the connections, and the predictions were compared with those of the measurements. The studies show that fractures occurred on the shear planes of the specimens that failed because of the shear-out that occurred due to reduced ductility, which was caused by the cold forming process. The modified ANSI/AISC gives the most accurate predictions of the failure modes and bearing resistance. However, the bearing resistance will be overestimated if the reduction in the area of the shear planes caused by the occurrence of fractures is ignored in specimens with an end distance higher than 2.0 d 0 , and a reduction factor is needed to calculate the bearing resistance of the connections.
Keywords	thick-walled steel ; shear connection ; bearing resistance ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: 胎龄<34周早产儿一氧化氮吸入的研究进展.

Liang, Guo-Bao / Lin, Xin-Zhu

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2023 Volume 25, Issue 9, Page(s) 982–988

Abstract: Nitric oxide is a messenger molecule for vasodilation of vascular smooth muscle cells, and inhaled nitric oxide (iNO) can dilate pulmonary blood vessels and reduce pulmonary vascular resistance, thereby reducing pulmonary artery pressure, but with no ... ...

Title translation	Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks.
Abstract	Nitric oxide is a messenger molecule for vasodilation of vascular smooth muscle cells, and inhaled nitric oxide (iNO) can dilate pulmonary blood vessels and reduce pulmonary vascular resistance, thereby reducing pulmonary artery pressure, but with no influence on systemic circulation pressure. Guidelines in China and overseas recommend the use of iNO in full-term infants and late preterm infants, and it has been proved that it has a marked effect on persistent pulmonary hypertension and hypoxic respiratory failure in such infants. However, recent studies have shown that there is an increase in the off-label use of iNO in preterm infants with a gestational age of <34 weeks. This article reviews the research progress on the efficacy, safety, timing, dose, and withdrawal mode of iNO and its combination with vasoactive drugs in the treatment of preterm infants with a gestational age of <34 weeks in China and overseas, so as to provide a reference for clinical application.
Language	Chinese
Publishing date	2023-09-16
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2303146
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Atomically precise Au nanoclusters for electrochemical hydrogen evolution catalysis

Xin Zhu / Leyi Chen / Yonggang Liu / Zhenghua Tang

Polyoxometalates, Vol 2, Iss 4, p

Progress and perspectives

2023 Volume 9140031

Abstract: Hydrogen evolution reaction (HER) is a vital step in water electrolysis toward H2 production. However, conventional nanocatalysts lack uniform size, composition, structure, and a homogeneous chemical coordination environment, causing the retrieval of an ... ...

Abstract	Hydrogen evolution reaction (HER) is a vital step in water electrolysis toward H2 production. However, conventional nanocatalysts lack uniform size, composition, structure, and a homogeneous chemical coordination environment, causing the retrieval of an unambiguous structure–performance relationship to be extremely challenging. Owing to its ultra-small size, definitive composition, well-defined structure, and uniform chemical environment at the atomic level, atomically precise Au nanoclusters can serve as a model catalyst to improve understanding of the relationship between the structure and its catalytic properties. First, this review describes the fundamental mechanism and significance of HER and highlights the unique advantages of employing Au nanoclusters as a model catalyst. Then, the recent progress involving the promotion and catalysis of HER by Au and Au-alloy nanoclusters is discussed, with a focus on elaborating the structure–performance relationship. The key factors affecting the catalytic performance, including but not limited to the electronic interaction, interfacial effect, size effect, charge state, ligand effect, metal core composition, single-atom doping, and geometric configuration effect, are analyzed with explicit examples. Finally, the current critical challenges involved in this process and future perspectives are discussed. We hope that this review can shed light on the design of efficient and stable coinage metal-nanocluster-based catalysts toward electrochemical H2 production and beyond.
Keywords	hydrogen evolution reaction ; atomically precise au nanoclusters ; model catalysts ; structure–performance relationship ; progress and perspectives ; Inorganic chemistry ; QD146-197
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Tsinghua University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: 咖啡因治疗早产儿呼吸暂停相关基因多态性的研究进展.

Xie, Jiang-Biao / Lin, Xin-Zhu

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2022 Volume 24, Issue 7, Page(s) 832–837

Abstract: Apnea of prematurity (AOP) is one of the common diseases in preterm infants. The main cause of AOP is immature development of the respiratory control center. If AOP is not treated timely and effectively, it will lead to respiratory failure, hypoxic brain ...

Title translation	Recent research on gene polymorphisms related to caffeine therapy in preterm infants with apnea of prematurity.
Abstract	Apnea of prematurity (AOP) is one of the common diseases in preterm infants. The main cause of AOP is immature development of the respiratory control center. If AOP is not treated timely and effectively, it will lead to respiratory failure, hypoxic brain injury, and even death in severe cases. Caffeine is the first choice for the treatment of AOP, but its effectiveness varies in preterm infants. With the deepening of AOP research, more and more genetic factors have been confirmed to play important roles in the pathogenesis and treatment of AOP; in particular, the influence of single nucleotide polymorphism on the efficacy of caffeine has become a research hotspot in recent years. This article reviews the gene polymorphisms that affect the efficacy of caffeine, in order to provide a reference for individualized caffeine therapy. Citation.
MeSH term(s)	Apnea/drug therapy ; Apnea/genetics ; Caffeine/therapeutic use ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Infant, Premature, Diseases ; Polymorphism, Single Nucleotide
Chemical Substances	Caffeine (3G6A5W338E)
Language	Chinese
Publishing date	2022-07-26
Publishing country	China
Document type	Journal Article ; Review
ISSN	1008-8830
ISSN	1008-8830
DOI	10.7499/j.issn.1008-8830.2203134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of molecular characteristics of FUT8 and alteration of core fucosylation in kidney renal clear cell cancer.

Xin, Zhu / Wen, Xinyu / Zhou, Mengying / Lin, Hongli / Liu, Jia

Aging

2024 Volume 16, Issue 3, Page(s) 2299–2319

Abstract: Background: Kidney renal clear cell cancer (KIRC) is a type of urological cancer that occurs worldwide. Core fucosylation (CF), as the most common post-translational modification, is involved in the tumorigenesis.: Methods: The alterations of CF- ... ...

Abstract	Background: Kidney renal clear cell cancer (KIRC) is a type of urological cancer that occurs worldwide. Core fucosylation (CF), as the most common post-translational modification, is involved in the tumorigenesis. Methods: The alterations of CF-related genes were summarized in pan-cancer. The "ConsensusClusterPlus" package was utilized to identify two CF-related KIRC subtypes. The "ssgsea" function was chosen to estimate the CF score, signaling pathways and cell deaths. Multiple algorithms were applied to assess immune responses. The "oncoPredict" was utilized to estimate the drug sensitivity. The IHC and subgroup analysis was performed to reveal the molecular features of FUT8. Single-cell RNA sequencing (scRNA-seq) data were scrutinized to evaluate the CF state. Results: In pan-cancer, there was a noticeable alteration in the expression of CF-related genes. In KIRC, two CF-related subtypes (i.e., C1, C2) were obtained. In comparison to C2, C1 exhibited a higher CF score and correlated with poorer overall survival. Additionally, the TME of C2 demonstrated increased activity in neutrophils, macrophages, myeloid dendritic cells, and B cells, alongside a higher presence of silent mast cells, NK cells, and endothelial cells. Compared to normal samples, higher expression of FUT8 is observed in KIRC. The mutation of SETD2 was more frequent in low-FUT8 samples while the mutation of DNAH9 was more frequent in high-FUT8 samples. scRNA-seq analyses revealed that the CF score was predominantly higher in endothelial cells and fibroblast cells. Conclusions: Two CF-related subtypes with distinct prognosis and TME were identified in KIRC. FUT8 exhibited elevated expression in KIRC samples.
MeSH term(s)	Humans ; Endothelial Cells/metabolism ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Glycosylation ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney/metabolism ; Axonemal Dyneins/metabolism
Chemical Substances	DNAH9 protein, human (EC 3.6.4.2) ; Axonemal Dyneins (EC 3.6.4.2)
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205482
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interaction between dietary digestible tryptophan and soy oligosaccharides in broiler chickens

Jing Chen / Hansong Jing / Haiying Liu / Xin Zhu / Guiqin Yang

Animal Bioscience, Vol 36, Iss 3, Pp 471-

effects on caecal skatole level and microflora

2023 Volume 483

Abstract: Objective This study was conducted to evaluate the interactive effects of dietary digestible tryptophan (dTry) and soy oligosaccharides (SO) on growth performance, caecal skatole level, and microflora of broiler chickens aged from 14 to 42 days. Methods ... ...

Abstract	Objective This study was conducted to evaluate the interactive effects of dietary digestible tryptophan (dTry) and soy oligosaccharides (SO) on growth performance, caecal skatole level, and microflora of broiler chickens aged from 14 to 42 days. Methods Three hundred and sixty broiler chicks were allocated equally to 36 cages at 14-day-of-age according to body weight and gender. Using a 3×2 factorial arrangement, 3 dietary dTry levels (0.18%, 0.23%, and 0.28%) supplemented with 0 or 3.5 g/kg of SO were used to create 6 diets (treatments). Each diet was fed to six replicates of 10 birds (60 birds/treatment), growth performance was measured. Caecal content samples were collected at 42 days of age. Results Results showed that significantly different dTry level×SO interactions were found for average daily gain (ADG), caecal levels of indole, propionic acid, and butyric acid, and microbial Shannon index (p<0.05). Birds fed diet containing 0.23% dTry level with SO supplementation had higher ADG and lower feed/gain ratio than those fed the other diets (p<0.05). Broilers fed diets containing 0.28% dTry increased their caecal levels of indole and skatole compared with those containing 0.18% or 0.23% dTry (p<0.01), regardless of SO addition. SO supplementation to diets decreased the caecal skatole level by 16.17% (p<0.05), and increased the relative frequency of Clostridium IV (p<0.05), regardless of dietary dTry level. Conclusion These results indicated that diets containing 0.23% dTry with SO supplementation positively promoted ADG, and decreased caecal skatole levels of broiler chickens. The dietary dTry level, SO affected the caecal skatole level, however, there was no interaction between them.
Keywords	aromatic amino acid ; growth performance ; non-digestible carbohydrates ; odour-causing compounds ; volatile fatty acids ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Asian-Australasian Association of Animal Production Societies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of enzymolytic soybean meal supplementation on performance, nitrogen excretion, serum biochemical parameters and intestinal morphology in broilers fed low-protein diets

Xin Zhu / Kai Gao / Ziyi Zhang / Haiying Liu / Guiqin Yang

Animal Bioscience, Vol 36, Iss 11, Pp 1718-

2023 Volume 1726

Abstract: Objective The objective of this study was to investigate the effect of supplementation with enzymolytic soybean meal (ESBM) on broilers fed low crude protein (CP) diets. Methods A total of 360 one-day-old broilers were randomly assigned to six treatments ...

Abstract	Objective The objective of this study was to investigate the effect of supplementation with enzymolytic soybean meal (ESBM) on broilers fed low crude protein (CP) diets. Methods A total of 360 one-day-old broilers were randomly assigned to six treatments with 6 replicates per treatment and 10 chicks per replicate for a period of 42 days. Chicks were fed a basal standard high-CP diet as a positive control (PC), a low-CP diet (reducing 10 g/kg CP from the PC) as a negative control (NC), or an NC + 0.5%, 1.0%, 1.5%, or 2.0% ESBM diet. Results Compared to chicks fed the PC, chicks fed the NC had a decreased body weight gain (BWG, p<0.05) from 1 to 42 days, but supplementation with 2.0% ESBM restored BWG (p<0.05) and even linearly improved the feed conversion rate (FCR, p<0.05). Digestibility of CP and ether extract was increased (p<0.05) in chicks fed a 1.0% ESBM diet compared to the PC. With increasing levels of ESBM, nitrogen (N) excretion decreased (p<0.05). The addition of ESBM to the diet did not affect (p>0.05) serum concentrations of total protein, albumin and total cholesterol but led to a descending trend in triglycerides and an ascending trend in calcium and urea N at 42 days (p<0.10). There were no differences (p>0.05) in villus height (VH), crypt depth (CD), and VH/CD (V/C) of the duodenum and jejunum between the PC and NC at both 21 days and 42 days, while increasing dietary ESBM levels linearly (p<0.05) decreased CD and increased V/C of the duodenum and jejunum at both 21 days and 42 days. Conclusion The findings indicated that ESBM could be used in broiler low-CP diets to improve production performance, decrease N excretion, and enhance intestinal health.
Keywords	chicken ; enzymolytic soybean meal ; growth performance ; intestinal health ; low crude protein diet ; nitrogen excretion ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Asian-Australasian Association of Animal Production Societies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Understanding the Effect of Speed on Human Emotion Perception in Mediated Social Touch Using Voice Coil Actuators

Xin Zhu / Tiantian Feng / Heather Culbertson

Frontiers in Computer Science, Vol

2022 Volume 4

Abstract: Touch as a modality in social communication has been getting more attention with recent developments in wearable technology and an increase in awareness of how limited physical contact can lead to touch starvation and feelings of depression. Although ... ...

Abstract	Touch as a modality in social communication has been getting more attention with recent developments in wearable technology and an increase in awareness of how limited physical contact can lead to touch starvation and feelings of depression. Although several mediated touch methods have been developed for conveying emotional support, the transfer of emotion through mediated touch has not been widely studied. This work addresses this need by exploring emotional communication through a novel wearable haptic system. The system records physical touch patterns through an array of force sensors, processes the recordings using novel gesture-based algorithms to create actuator control signals, and generates mediated social touch through an array of voice coil actuators. We conducted a human subject study (N = 20) to understand the perception and emotional components of this mediated social touch for common social touch gestures, including poking, patting, massaging, squeezing, and stroking. Our results show that the speed of the virtual gesture significantly alters the participants' ratings of valence, arousal, realism, and comfort of these gestures with increased speed producing negative emotions and decreased realism. The findings from the study will allow us to better recognize generic patterns from human mediated touch perception and determine how mediated social touch can be used to convey emotion. Our system design, signal processing methods, and results can provide guidance in future mediated social touch design.
Keywords	mediated social touch ; emotion ; tactile rendering ; wearable haptics ; data-driven modeling ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	629
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: fermentation profiles of different soybean oligosaccharides and their effects on skatole production and cecal microbiota of broilers

Xin Zhu / Miao Xu / Haiying Liu / Guiqin Yang

Animal Bioscience, Vol 35, Iss 8, Pp 1195-

2022 Volume 1204

Abstract: Objective The objective of this study was to investigate the in vitro fermentation profiles of different soybean oligosaccharides (SBOs) and their effects on skatole production and cecal microbiota of broilers. Methods Five SBOs with varying main ... ...

Abstract	Objective The objective of this study was to investigate the in vitro fermentation profiles of different soybean oligosaccharides (SBOs) and their effects on skatole production and cecal microbiota of broilers. Methods Five SBOs with varying main component contents were fermented using an in vitro batch incubation inoculated with broiler cecal microbiota. Gas production was recorded automatically, skatole, indole and short-chain fatty acids (SCFAs) were determined using high-performance liquid chromatography, and microbial changes were analyzed using 16S DNA gene sequencing. Results The addition of SBOs increased (p<0.05) gas production, suggesting bacterial growth-stimulating activities. In addition, the concentrations of indole were significantly (p<0.05) decreased after SBO supplementation, and SBO III, with higher sucrose and stachyose contents, decreased (p<0.05) the skatole level. Our results also revealed that the fermentation of SBOs by cecal microbiota produced (p<0.05) SCFAs, which were dominated by propionic acid, butyrate acid and lactic acid compared to the control. In addition, SBO III increased (p<0.05) the abundance of Firmicutes and Subdoligranulum and decreased that of Bacteroides. Conclusion These results suggest that SBOs with higher sucrose and stachyose contents are promising prebiotics in modulating gut microbiota and reducing odor emission in broilers.
Keywords	broilers ; gut microbiota ; odors ; oligosaccharides ; short chain fatty acids ; Zoology ; QL1-991
Subject code	660
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Asian-Australasian Association of Animal Production Societies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Research advances in the effect of long-chain polyunsaturated fatty acids on neonates].

Yang, Qing / Lin, Xin-Zhu

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

2021 Volume 23, Issue 7, Page(s) 755–760

Abstract: Adequate supply of long-chain polyunsaturated fatty acids (LCPUFAs) is of great importance for neonates, especially preterm infants. In particular, ...

Abstract	Adequate supply of long-chain polyunsaturated fatty acids (LCPUFAs) is of great importance for neonates, especially preterm infants. In particular,
MeSH term(s)	Fatty Acids ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated ; Humans ; Infant ; Infant, Newborn ; Infant, Premature
Chemical Substances	Fatty Acids ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated
Language	Chinese
Publishing date	2021-07-15
Publishing country	China
Document type	Journal Article ; Review
ISSN	1008-8830
ISSN	1008-8830
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