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Article ; Online: Long non-coding RNA HOTAIR knockdown alleviates gouty arthritis through miR-20b upregulation and NLRP3 downregulation.

Liu, Ya-Fei / Xing, Guo-Lan / Chen, Zhe / Tu, Sheng-Hao

2021 Volume 20, Issue 3, Page(s) 332–344

Abstract: This study aimed to determine the mechanism underlying the regulation of gout by the HOX transcript antisense RNA (HOTAIR) long non-coding RNA (lncRNA). The expression levels of HOTAIR, miR-20b, and Nlrp3 were estimated by qRT-PCR and western blotting. ... ...

Abstract	This study aimed to determine the mechanism underlying the regulation of gout by the HOX transcript antisense RNA (HOTAIR) long non-coding RNA (lncRNA). The expression levels of HOTAIR, miR-20b, and Nlrp3 were estimated by qRT-PCR and western blotting. The methylation level of HOTAIR was detected by methylation-specific PCR. The recruitment of DNA methyltransferase 1 (DNMT1) to the lncRNA HOTAIR promoter was confirmed by a ChIP assay. RNA immunoprecipitation and RNA pull-down assays were used to confirm the interaction between HOTAIR and miR-20b. LncRNA HOTAIR and Nlrp3 expression was upregulated, and that of miR-20b was downregulated in synovial fluid mononuclear cells (SFMCs) collected from patients with gouty arthritis and monosodium urate (MSU)-stimulated THP-1 cells. Interleukin (IL)-1β level increased substantially upon stimulation by MSU crystals. The methylation percentage of HOTAIR was reduced in SFMCs from patients with gouty arthritis and MSU-stimulated THP-1 cells. DNMT1 expression was downregulated in MSU-stimulated THP-1 cells, and DNMT1 knockdown increased lncRNA HOTAIR expression. In addition, the interaction of HOTAIR with miR-20b was confirmed. HOTAIR knockdown suppressed Nlrp3 expression and the secretion of inflammatory cytokines
MeSH term(s)	Aged ; Animals ; Arthritis, Gouty/genetics ; Arthritis, Gouty/metabolism ; Down-Regulation/physiology ; Female ; Gene Knockdown Techniques/methods ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/biosynthesis ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/biosynthesis ; RNA, Long Noncoding/genetics ; THP-1 Cells ; Up-Regulation/physiology
Chemical Substances	HOTAIR long untranslated RNA, human ; MIRN20b microRNA, human ; MicroRNAs ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; RNA, Long Noncoding
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2021.1874696
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Zs.A 5881: Show issues

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Article ; Online: Characteristics of Complement Protein Deposition in Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition.

Liu, Meng-Yao / Yu, Xiao-Juan / Wang, Su-Xia / Li, Yuan / Xing, Guo-Lan / Chen, Ming / Zhou, Fu-de / Zhao, Ming-Hui

Clinical journal of the American Society of Nephrology : CJASN

2023 Volume 18, Issue 12, Page(s) 1573–1582

Abstract: Background: Hypocomplementemia and complement co-deposition with monoclonal immunoglobulins in glomeruli are not rare in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Deposition of monoclonal immunoglobulins in ... ...

Abstract	Background: Hypocomplementemia and complement co-deposition with monoclonal immunoglobulins in glomeruli are not rare in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Deposition of monoclonal immunoglobulins in glomeruli has been suggested to activate complement and cause kidney injury. However, the profiles of complement activation in PGNMID and their clinical and pathologic significance need to be clarified. Methods: Forty-six patients with PGNMID were enrolled. Proteomic analysis of glomeruli using laser microdissection and mass spectrometry was performed for ten patients with PGNMID to determine the composition of glomerular deposits. Kidney deposition of complement components was detected by immunohistochemistry and immunofluorescence. Urinary and plasma levels of complement components were measured by an enzyme-linked immunosorbent assay. Group differences were assessed using t tests or Mann-Whitney U tests depending on the distribution. Correlation analysis was performed using Spearman rank correlation or Pearson correlation. Results: Laser microdissection and mass spectrometry-based proteomic analysis showed that complement components were the most enriched proteins deposited in the glomeruli of patients with PGNMID. Glomerular deposition of C3c, C4d, and C5b-9 was detected in most patients. Levels of urinary and plasma C3a, C5a, soluble C5b-9, C4d, Bb, and C1q as well as urinary mannose-binding lectin were significantly higher in patients with PGNMID compared with healthy controls. The intensity of C3c and C4d deposition in glomeruli correlated with serum creatinine and the percentage of crescents, respectively. Furthermore, levels of urinary complement components correlated positively with serum creatinine, urinary protein excretion, percentage of crescents, and global glomerulosclerosis in kidney biopsies, whereas plasma levels of most complement components did not show a significant correlation with clinicopathologic parameters. In multivariable analysis, a higher level of urinary C4d was identified as an independent risk factor of kidney failure. Conclusions: The complement system was found to be overactivated in PGNMID, and levels of urinary complements correlated with disease severity. A higher level of urinary C4d was identified as an independent risk factor of kidney failure.
MeSH term(s)	Humans ; Complement Membrane Attack Complex ; Creatinine ; Proteomics ; Complement System Proteins ; Glomerulonephritis/pathology ; Complement Activation ; Antibodies, Monoclonal ; Renal Insufficiency
Chemical Substances	Complement Membrane Attack Complex ; Creatinine (AYI8EX34EU) ; Complement System Proteins (9007-36-7) ; Antibodies, Monoclonal
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000295
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Article: The Derivative of

Liu, Ya-Fei / Zhang, Zhe / Zhang, Jun-Jun / Chen, Zhe / Tu, Sheng-Hao / Xing, Guo-Lan

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 4178140

Abstract: The study aimed to explore the efficacy and safety of Kunxian Capsule (KXC) in the treatment of rheumatoid arthritis (RA). The randomized controlled trials (RCTs) comparing the effects of KXC in patients with RA were included in this study. Weighted mean ...

Abstract	The study aimed to explore the efficacy and safety of Kunxian Capsule (KXC) in the treatment of rheumatoid arthritis (RA). The randomized controlled trials (RCTs) comparing the effects of KXC in patients with RA were included in this study. Weighted mean differences (MDs) were calculated for net changes by employing Review Manager meta-analysis software. Nine RCTs were included in the systematic review with a total of 747 patients. The overall effects showed that KXC alone or combined with disease-modifying antirheumatic and drugs decreased tender joint counts (
Language	English
Publishing date	2020-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/4178140
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Article ; Online: Biotic Supplements in Patients With Chronic Kidney Disease: Meta-Analysis of Randomized Controlled Trials.

Liu, Jing / Zhong, JianYong / Yang, HaiChun / Wang, DongQin / Zhang, Ying / Yang, YuMeng / Xing, GuoLan / Kon, Valentina

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

2021 Volume 32, Issue 1, Page(s) 10–21

Abstract: Objective: Gut flora imbalance characterizes patients with chronic kidney disease (CKD). Although biotic supplementation has been proposed to lessen inflammation and oxidative stress and, thus, reduce the risk of progressive kidney damage and ... ...

Abstract	Objective: Gut flora imbalance characterizes patients with chronic kidney disease (CKD). Although biotic supplementation has been proposed to lessen inflammation and oxidative stress and, thus, reduce the risk of progressive kidney damage and cardiovascular disease, the effects remain controversial. We conducted a meta-analysis to assess the therapeutic benefits of biotics in CKD. Methods: PubMed, Embase, and Cochrane databases were systematically searched for randomized controlled trials that evaluated any biotic (prebiotic, probiotic, synbiotics) supplements in patients with CKD (CKD, stage 3-4 to end-stage renal disease). Primary endpoints included changes in renal function, markers of inflammation, and oxidative stress. Secondary endpoints included changes in levels of uremic toxins and variations in lipid metabolism. Results: Twenty-three eligible studies included 842 participants. In a pooled-analysis, biotics did not change estimated glomerular filtration rate (mean difference [MD] = 0.08, P = .92) or serum albumin (MD = -0.01, P = .86), although prebiotics reduced serum creatinine (standardized mean difference [SMD] = -0.23, P = .009) and blood urea nitrogen (MD = -6.05, P < .00001). Biotics improved total antioxidative capacity (SMD = 0.37, P = .007) and malondialdehyde (SMD = -0.96, P = .006) and reduced the inflammatory marker interleukin-6 (SMD = -0.30, P = .01) although not C-reactive protein (SMD = -0.22, P = .20). Biotic intervention reduced some uremic toxins, including p-cresol sulfate (SMD = -2.18, P < .0001) and indoxyl sulfate (MD = -5.14, P = .0009), which decreased in dialysis-dependent patients. Another toxin, indole-3-acetic acid (MD = -0.22, P = .63), did not change. Lipids were unaffected by biotic intervention (total cholesterol: SMD = -0.01, P = .89; high-density lipoprotein: SMD = -0.08, P = .76; low-density lipoprotein: MD = 3.54, P = .28; triglyceride: MD = -2.26, P = .58). Conclusion: The results highlight the favorable influence of biotics on circulating markers of creatinine, oxidant stress (malondialdehyde, total antioxidative capacity), inflammation (interleukin-6), and uremic toxins (p-cresol sulfate) in patients with CKD. Biotics did not affect estimated glomerular filtration rate, albumin, indole-3-acetic acid, or lipids in either predialysis or dialysis patients.
MeSH term(s)	Humans ; Prebiotics ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Synbiotics ; Uremic Toxins
Chemical Substances	Prebiotics ; Uremic Toxins
Language	English
Publishing date	2021-10-16
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1080003-7
ISSN	1532-8503 ; 1051-2276
ISSN (online)	1532-8503
ISSN	1051-2276
DOI	10.1053/j.jrn.2021.08.005
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Zs.A 3273: Show issues

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Article ; Online: The chronic kidney disease and acute kidney injury involvement in COVID-19 pandemic: A systematic review and meta-analysis.

Liu, Ya-Fei / Zhang, Zhe / Pan, Xiao-Li / Xing, Guo-Lan / Zhang, Ying / Liu, Zhang-Suo / Tu, Sheng-Hao

PloS one

2021 Volume 16, Issue 1, Page(s) e0244779

Abstract: Background: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether preexisting chronic kidney disease (CKD) and acute kidney injury complication (AKI) are involved in the COVID-19 ... ...

Abstract	Background: Currently, the SARS-CoV-2 promptly spread across China and around the world. However, there are controversies about whether preexisting chronic kidney disease (CKD) and acute kidney injury complication (AKI) are involved in the COVID-19 pandemic. Measurements: Studies reported the kidney outcomes in different severity of COVID-19 were included in this study. Standardized mean differences or odds ratios were calculated by employing Review Manager meta-analysis software. Results: Thirty-six trials were included in this systematic review with a total of 6395 COVID-19 patients. The overall effects indicated that preexisting CKD (OR = 3.28), complication of AKI (OR = 11.02), serum creatinine (SMD = 0.68), abnormal serum creatinine (OR = 4.86), blood urea nitrogen (SMD = 1.95), abnormal blood urea nitrogen (OR = 6.53), received continuous renal replacement therapy (CRRT) (OR = 23.63) were significantly increased in severe group than that in nonsevere group. Additionally, the complication of AKI (OR = 13.92) and blood urea nitrogen (SMD = 1.18) were remarkably elevated in the critical group than that in the severe group. Conclusions: CKD and AKI are susceptible to occur in patients with severe COVID-19. CRRT is applied frequently in severe COVID-19 patients than that in nonsevere COVID-19 patients. The risk of AKI is higher in the critical group than that in the severe group.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/epidemiology ; Blood Urea Nitrogen ; COVID-19/blood ; COVID-19/epidemiology ; China/epidemiology ; Creatinine/blood ; Humans ; Odds Ratio ; Pandemics ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/epidemiology ; SARS-CoV-2/isolation & purification ; Treatment Outcome
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0244779
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Article: Development and External Validation of a Nomogram and a Risk Table for Prediction of Type 2 Diabetic Kidney Disease Progression Based on a Retrospective Cohort Study in China.

Gao, Yue-Ming / Feng, Song-Tao / Yang, Yang / Li, Zuo-Lin / Wen, Yi / Wang, Bin / Lv, Lin-Li / Xing, Guo-Lan / Liu, Bi-Cheng

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 799–811

Abstract: Purpose: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Risk assessment provides information about patient prognosis, contributing to the risk stratification of patients and the rational allocation of medical ... ...

Abstract	Purpose: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. Risk assessment provides information about patient prognosis, contributing to the risk stratification of patients and the rational allocation of medical resources. We aimed to develop a model for individualized prediction of renal function decline in patients with type 2 DKD (T2DKD). Patients and methods: In a retrospective observational study, we followed 307 T2DKD patients and evaluated the determinants of 1) risk of doubling in serum creatinine (Scr), 2) risk of eGFR<15 mL/min/1.73m Results: Four predictors were selected to establish the final model: Scr, urinary albumin/creatinine ratio, plasma albumin, and insulin treatment. The nomogram achieved satisfactory prediction performance, with a C-index of 0.791 [95% confidence interval (CI) 0.762-0.820] in the derivation cohort and 0.793 (95% CI 0.746-0.840) in the external validation cohort. Then, all predictors were scored according to their weightings. A risk table with the highest score of 11.5 was developed. The C-index of the risk table was 0.764 (95% CI: 0.731-0.797), which was similar to the external validation cohort (0.763; 95% CI: 0.714-0.812). Additionally, the patients were divided into two groups based on the risk table, and significant differences in the probability of outcome events were observed between the high-risk (score >2) and low-risk (score ≤2) groups in the derivation and external validation cohorts ( Conclusion: The nomogram and the risk table using readily available clinical parameters could be new tools for bedside prediction of renal function decline in T2DKD patients.
Language	English
Publishing date	2022-03-14
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S352154
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Article: [Clinical and Pathological Characteristics of Related-Renal Damage in Patients with POEMS Syndrome].

Wang, Wei-Min / Wan, Ding-Ming / Liu, Lin-Xiang / Guo, Rong / Sun, Ling / Xing, Guo-Lan / Cao, Wei-Jie

Zhongguo shi yan xue ye xue za zhi

2020 Volume 28, Issue 3, Page(s) 977–982

Abstract: Objective: To investigated the clinical and pathological characteristics of related-renal damage in patients with POEMS syndrome.: Methods: Five patients diagnosed as POEMS syndrome in our hospital were selected. Their clinical manifestation, ... ...

Abstract	Objective: To investigated the clinical and pathological characteristics of related-renal damage in patients with POEMS syndrome. Methods: Five patients diagnosed as POEMS syndrome in our hospital were selected. Their clinical manifestation, pathological characteristics of kidney and laboratory examination were analyzed retrospectively. Among the 5 patients, three males and two females with a median age of 50 years old. The mean interval before diagnosis was 13.0±7.2 months. Results: All the patients showed neuropathy, endocrinopathy, monoclonal plasma cell-proliferative disorder, skin changes and extravascular volume overload, in which 4 patients showed organomegaly. Proteinuria was found in 5 patients, and microhematuria was found in 4 patients. Moreover, 4 patients showed an elevated blood urea, while 2 patients showed creatinine elevation. 1 patient at chronic kidney disease (CKD)-G1 stage, 2 patients at CKD-G2 stage, and 1 patient at CKD-G3b stage, moreover, 1 patient at CKD-G5 stage. Endothelial injury and mesangial lesion were the main characteristics of renal pathology. 3 patients were pathologically diagnosed as thrombotic microangiopathy kidney damage, while 2 patients as light chain amyloidosis. Conclusion: POEMS syndrome is a multi-systemic disease with complex clinical manifestations. 5 patients had different degrees of renal insufficiency. Endothelial injury and mesangial lesion are the main features of renal pathology.
MeSH term(s)	Female ; Humans ; Kidney ; Male ; Middle Aged ; POEMS Syndrome ; Paraproteinemias ; Renal Insufficiency ; Retrospective Studies
Language	Chinese
Publishing date	2020-07-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2020.03.043
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Zs.A 6603: Show issues

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Article: Urinary sediment CCL5 messenger RNA as a potential prognostic biomarker of diabetic nephropathy.

Feng, Song-Tao / Yang, Yang / Yang, Jin-Fei / Gao, Yue-Ming / Cao, Jing-Yuan / Li, Zuo-Lin / Tang, Tao-Tao / Lv, Lin-Li / Wang, Bin / Wen, Yi / Sun, Lin / Xing, Guo-Lan / Liu, Bi-Cheng

Clinical kidney journal

2021 Volume 15, Issue 3, Page(s) 534–544

Abstract: Background: Urinary sediment messenger RNAs (mRNAs) have been shown as novel biomarkers of kidney disease. We aimed to identify targeted urinary mRNAs in diabetic nephropathy (DN) based on bioinformatics analysis and clinical validation.: Methods: ... ...

Abstract	Background: Urinary sediment messenger RNAs (mRNAs) have been shown as novel biomarkers of kidney disease. We aimed to identify targeted urinary mRNAs in diabetic nephropathy (DN) based on bioinformatics analysis and clinical validation. Methods: Microarray studies of DN were searched in the GEO database and Nephroseq platform. Gene modules negatively correlated with estimated glomerular filtration rate (eGFR) were identified by informatics methods. Hub genes were screened within the selected modules. In validation cohorts, a quantitative polymerase chain reaction assay was used to compare the expression levels of candidate mRNAs. Patients with renal biopsy-confirmed DN were then followed up for a median time of 21 months. End-stage renal disease (ESRD) was defined as the primary endpoint. Multivariate Cox proportional hazards regression was developed to evaluate the prognostic values of candidate mRNAs. Results: Bioinformatics analysis revealed four chemokines (CCL5, CXCL1, CXLC6 and CXCL12) as candidate mRNAs negatively correlated with eGFR, of which CCL5 and CXCL1 mRNA levels were upregulated in the urinary sediment of patients with DN. In addition, urinary sediment mRNA of CXCL1 was negatively correlated with eGFR ( Conclusions: Urinary sediment CCL5 and CXCL1 mRNAs were upregulated in DN patients and associated with a decline in renal function and degree of renal interstitial fibrosis. Urinary sediment CCL5 mRNA could be used as a potential prognostic biomarker of DN.
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfab186
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Article: The Effects of Modified Simiao Decoction in the Treatment of Gouty Arthritis: A Systematic Review and Meta-Analysis.

Liu, Ya-Fei / Huang, Ying / Wen, Cai-Yu-Zhu / Zhang, Jun-Jun / Xing, Guo-Lan / Tu, Sheng-Hao / Chen, Zhe

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 6037037

Abstract: The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials ( ... ...

Abstract	The modified Simiao decoctions (MSD) have been wildly applied in the treatment of gouty arthritis in China. However, the evidence needs to be evaluated by a systematic review and meta-analysis. After filtering, twenty-four randomised, controlled trials (RCTs) comparing the effects of MSD and anti-inflammation medications and/or urate-lowering therapies in patients with gouty arthritis were included. In comparison with anti-inflammation medications, urate-lowering therapies, or coadministration of anti-inflammation medications and urate-lowering therapies, MSD monotherapy significantly lowered serum uric acid (
Language	English
Publishing date	2017-03-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/6037037
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Article ; Online: Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.

Guo, Jun-Hui / Xing, Guo-Lan / Fang, Xin-Hui / Wu, Hui-Fang / Zhang, Bo / Yu, Jin-Zhong / Fan, Zong-Min / Wang, Li-Dong

World journal of gastroenterology

2017 Volume 23, Issue 8, Page(s) 1434–1442

Abstract: Aim: To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis.: Methods: Two-dimensional electrophoresis combined with mass spectrometry were adopted ... ...

Abstract	Aim: To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. Methods: Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor-adjacent normal esophageal epithelium collected from fetuses of different gestational age, or esophageal cancer patients from a high-risk area of esophageal cancer in China. Immunohistochemistry (avidin-biotin-horseradish peroxidase complex method) was used to detect the expression of peroxiredoxin (PRX)6 in 91 cases of esophageal cancer, tumor-adjacent normal esophageal tissue, basal cell hyperplasia, dysplasia, and carcinoma Results: After peptide mass fingerprint analysis and search of protein databases, 21 differential proteins were identified; some of which represent a protein isoform. Varying degrees of expression of PRX6 protein, which was localized mainly in the cytoplasm, were detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend ( Conclusion: Development and progression of esophageal cancer result from interactions of genetic changes (accumulation or superposition). PRX6 protein is associated with fetal esophageal development and cancer differentiation.
MeSH term(s)	Adult ; Aged ; Carcinoma, Squamous Cell/metabolism ; Electrophoresis, Gel, Two-Dimensional ; Epithelium/embryology ; Epithelium/metabolism ; Esophageal Neoplasms/metabolism ; Esophagus/embryology ; Esophagus/metabolism ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Infant ; Male ; Middle Aged ; Peptides/chemistry ; Peroxiredoxin VI/metabolism ; Proteomics
Chemical Substances	Peptides ; PRDX6 protein, human (EC 1.11.1.15) ; Peroxiredoxin VI (EC 1.11.1.15)
Language	English
Publishing date	2017-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v23.i8.1434
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