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  1. Article ; Online: H

    Guo, Jin-Ming / Xing, Hou-Juan / Cai, Jing-Zeng / Zhang, Hong-Fu / Xu, Shi-Wen

    Ecotoxicology and environmental safety

    2020  Volume 209, Page(s) 111801

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Animals ; Antioxidants/metabolism ; Autophagy/drug effects ; Catalase/metabolism ; Chickens/metabolism ; Glutathione Peroxidase/metabolism ; Hepatocytes/metabolism ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/toxicity ; Lipopolysaccharides/metabolism ; Liver Diseases ; Oxidative Stress/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Superoxide Dismutase/metabolism
    Chemical Substances Antioxidants ; Lipopolysaccharides ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2020-12-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2020.111801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Effects of Atrazine and Chlorpyrifos on Autophagy-Related Genes in the Brain of Common Carp: Health-Risk Assessments.

    Xing, Hou-Juan / Wang, Liang-Liang / Yao, Hai-Dong / Wang, Xiao-Long / Xu, Shi-Wen

    Archives of environmental contamination and toxicology

    2016  Volume 70, Issue 2, Page(s) 301–310

    Abstract: This study assessed the impacts of atrazine (ATR), chlorpyrifos (CPF), and a combined ATR/CPF exposure on the brain of common carp (Cyprinus carpio L.). The carp were sampled after a 40-days exposure to CPF and ATR, individually or in combination, ... ...

    Abstract This study assessed the impacts of atrazine (ATR), chlorpyrifos (CPF), and a combined ATR/CPF exposure on the brain of common carp (Cyprinus carpio L.). The carp were sampled after a 40-days exposure to CPF and ATR, individually or in combination, followed by a 40-days recovery period to measure autophagy and antioxidant activity. The results indicate that the anti-superoxide anion and anti-hydroxy radical activities decreased upon exposure to ATR, CPF, and the ATR/CPF combination but increased after a subsequent 40-days recovery period. Quantitative real-time PCR and Western blot analyses revealed that the mRNA and protein levels of LC3B and dynein in common carp decreased significantly after exposure to ATR and CPF alone or in combination. Moreover, the mRNA and protein levels of beclin1 gene decreased significantly only in the 116 and 11.3 μg/L treatment groups. However, the mRNA and protein levels of all tested genes increased significantly after a 40-days recovery. Transmission electron microscope demonstrated the occurrence of autolysosomes in the recovery groups but not in the exposure groups. These results suggest that exposure to ATR, CPF, or their combination promotes oxidative stress and autophagic responses in the brain of common carp.
    MeSH term(s) Animals ; Atrazine/toxicity ; Autophagy/genetics ; Brain/drug effects ; Brain/metabolism ; Carps/physiology ; Chlorpyrifos/toxicity ; Environmental Monitoring ; Herbicides/toxicity ; Insecticides/toxicity ; Oxidative Stress ; RNA, Messenger/metabolism ; Risk Assessment ; Water Pollutants, Chemical/toxicity
    Chemical Substances Herbicides ; Insecticides ; RNA, Messenger ; Water Pollutants, Chemical ; Chlorpyrifos (JCS58I644W) ; Atrazine (QJA9M5H4IM)
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 185986-9
    ISSN 1432-0703 ; 0090-4341
    ISSN (online) 1432-0703
    ISSN 0090-4341
    DOI 10.1007/s00244-015-0246-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1182: Show issues Location:
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  3. Article ; Online: Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills.

    Fu, Yao / Li, Ming / Liu, Ci / Qu, Jian-Ping / Zhu, Wen-Jun / Xing, Hou-Juan / Xu, Shi-Wen / Li, Shu

    Ecotoxicology and environmental safety

    2013  Volume 94, Page(s) 28–36

    Abstract: Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d ... ...

    Abstract Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d exposure and 40-d recovery experiments. Cytochrome P450 content, activities of aminopyrine N-demethylase (APND) and erythromycin N-demethylase (ERND) and the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) were determined. In total, 220 common carps were divided into eleven groups, and each group was treated with a specific concentration of ATR (4.28, 42.8 and 428 μg/L), CPF (1.16, 11.6 and 116 μg/L) or ATR-CPF mixture (1.13, 11.3 and 113 μg/L). The results showed that P450 content and activities of APND and ERND in fish exposed to ATR and mixture were significantly higher than those in the control group. After the 40-d recovery treatment (i.e., depuration), the P450 content and the activities of APND and ERND in fish decreased to the background levels. A similar tendency was also found in the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) in common carp gills. The CPF-treated fish showed no significant difference from the control groups, except for a significant CYP1C induction. These results indicated that CYP enzyme levels are induced by ATR but were only slightly affected by CPF in common carp gills. In addition, the ATR and CPF exposure showed an antagonistic effect on P450 enzymes in common carp gills.
    MeSH term(s) Aminopyrine N-Demethylase/genetics ; Aminopyrine N-Demethylase/metabolism ; Animals ; Atrazine/toxicity ; Carps/physiology ; Chlorpyrifos/toxicity ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Gills/drug effects ; Gills/enzymology ; Gills/metabolism ; Herbicides/toxicity ; Insecticides/toxicity ; RNA, Messenger/metabolism ; Water Pollutants, Chemical/toxicity
    Chemical Substances Herbicides ; Insecticides ; RNA, Messenger ; Water Pollutants, Chemical ; Cytochrome P-450 Enzyme System (9035-51-2) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Aminopyrine N-Demethylase (EC 1.5.3.-) ; Chlorpyrifos (JCS58I644W) ; Atrazine (QJA9M5H4IM)
    Language English
    Publishing date 2013-05-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2013.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effects of atrazine and chlorpyrifos on the production of nitric oxide and expression of inducible nitric oxide synthase in the brain of common carp (Cyprinus carpio L.).

    Wang, Liang-Liang / Liu, Tao / Wang, Chao / Zhao, Fu-Qing / Zhang, Zi-Wei / Yao, Hai-Dong / Xing, Hou-Juan / Xu, Shi-Wen

    Ecotoxicology and environmental safety

    2013  Volume 93, Page(s) 7–12

    Abstract: The study aimed to investigate the effects of atrazine (ATR), chlorpyrifos (CPF), and the mixture of them on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in the brain of common carp. The triazine herbicide ATR and the organophosphorus ... ...

    Abstract The study aimed to investigate the effects of atrazine (ATR), chlorpyrifos (CPF), and the mixture of them on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in the brain of common carp. The triazine herbicide ATR and the organophosphorus insecticide CPF are frequently and extensively applied in agriculture all over the world. 220 Carps were averagely divided into eleven groups according to the different treatments and concentration, including the exposure and recovery experiments. In the present study, we investigated production of NO, iNOS activity and iNOS mRNA and protein expression in the brain of the common carp after a 40d exposure to ATR, CPF, alone or in combination, and a 40d recovery treatment. The results showed that the activity of iNOS and production of NO were significantly higher in all groups of fish exposed to high doses ATR, CPF and their mixture compared to control fish. After a 40d recovery treatment, iNOS activity and production of NO were lower than in the corresponding exposure groups in all the recovery groups. The mRNA and protein levels of iNOS were significantly higher in the high-dose group of ATR and CPF compared to control group, but were significantly lower in the group of the mixture of ATR and CPF compared to control group. Results indicated that NO and iNOS were involved in oxidative stress and brain tissue damage induced by ATR, CPF, and their mixture. Thus, the information presented in this study is helpful to understand the mechanism of ATR-, CPF- and ATR/CPF-mixture-induced neurotoxicity in fish.
    MeSH term(s) Animals ; Atrazine/metabolism ; Atrazine/toxicity ; Brain/drug effects ; Brain/metabolism ; Carps/metabolism ; Chlorpyrifos/metabolism ; Chlorpyrifos/toxicity ; Herbicides/metabolism ; Herbicides/toxicity ; Insecticides/metabolism ; Insecticides/toxicity ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Oxidative Stress ; RNA, Messenger/metabolism ; Water Pollutants, Chemical/toxicity
    Chemical Substances Herbicides ; Insecticides ; RNA, Messenger ; Water Pollutants, Chemical ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Chlorpyrifos (JCS58I644W) ; Atrazine (QJA9M5H4IM)
    Language English
    Publishing date 2013-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2013.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills

    Fu, Yao / Li, Ming / Liu, Ci / Qu, Jian-Ping / Zhu, Wen-Jun / Xing, Hou-Juan / Xu, Shi-Wen / Li, Shu

    Ecotoxicology and environmental safety. 2013 Aug. 1, v. 94

    2013  

    Abstract: Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d ... ...

    Abstract Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d exposure and 40-d recovery experiments. Cytochrome P450 content, activities of aminopyrine N-demethylase (APND) and erythromycin N-demethylase (ERND) and the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) were determined. In total, 220 common carps were divided into eleven groups, and each group was treated with a specific concentration of ATR (4.28, 42.8 and 428μg/L), CPF (1.16, 11.6 and 116μg/L) or ATR–CPF mixture (1.13, 11.3 and 113μg/L). The results showed that P450 content and activities of APND and ERND in fish exposed to ATR and mixture were significantly higher than those in the control group. After the 40-d recovery treatment (i.e., depuration), the P450 content and the activities of APND and ERND in fish decreased to the background levels. A similar tendency was also found in the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) in common carp gills. The CPF-treated fish showed no significant difference from the control groups, except for a significant CYP1C induction. These results indicated that CYP enzyme levels are induced by ATR but were only slightly affected by CPF in common carp gills. In addition, the ATR and CPF exposure showed an antagonistic effect on P450 enzymes in common carp gills.
    Keywords Cyprinus carpio ; atrazine ; carp ; chlorpyrifos ; cytochrome P-450 ; enzyme activity ; enzymes ; erythromycin ; gills ; messenger RNA
    Language English
    Dates of publication 2013-0801
    Size p. 28-36.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 436536-7
    ISSN 0147-6513
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2013.04.018
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3684: Show issues

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  6. Article: Effects of atrazine and chlorpyrifos on the production of nitric oxide and expression of inducible nitric oxide synthase in the brain of common carp (Cyprinus carpio L.)

    Wang, Liang-Liang / Liu, Tao / Wang, Chao / Zhao, Fu-Qing / Zhang, Zi-Wei / Yao, Hai-Dong / Xing, Hou-Juan / Xu, Shi-Wen

    Ecotoxicology and environmental safety. 2013 July 1, v. 93

    2013  

    Abstract: The study aimed to investigate the effects of atrazine (ATR), chlorpyrifos (CPF), and the mixture of them on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in the brain of common carp. The triazine herbicide ATR and the organophosphorus ... ...

    Abstract The study aimed to investigate the effects of atrazine (ATR), chlorpyrifos (CPF), and the mixture of them on nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in the brain of common carp. The triazine herbicide ATR and the organophosphorus insecticide CPF are frequently and extensively applied in agriculture all over the world. 220 Carps were averagely divided into eleven groups according to the different treatments and concentration, including the exposure and recovery experiments. In the present study, we investigated production of NO, iNOS activity and iNOS mRNA and protein expression in the brain of the common carp after a 40d exposure to ATR, CPF, alone or in combination, and a 40d recovery treatment. The results showed that the activity of iNOS and production of NO were significantly higher in all groups of fish exposed to high doses ATR, CPF and their mixture compared to control fish. After a 40d recovery treatment, iNOS activity and production of NO were lower than in the corresponding exposure groups in all the recovery groups. The mRNA and protein levels of iNOS were significantly higher in the high-dose group of ATR and CPF compared to control group, but were significantly lower in the group of the mixture of ATR and CPF compared to control group. Results indicated that NO and iNOS were involved in oxidative stress and brain tissue damage induced by ATR, CPF, and their mixture. Thus, the information presented in this study is helpful to understand the mechanism of ATR-, CPF- and ATR/CPF-mixture-induced neurotoxicity in fish.
    Keywords Cyprinus carpio ; atrazine ; brain ; carp ; chlorpyrifos ; inducible nitric oxide synthase ; messenger RNA ; neuronal nitric oxide synthase ; neurotoxicity ; nitric oxide ; oxidative stress ; protein synthesis
    Language English
    Dates of publication 2013-0701
    Size p. 7-12.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 436536-7
    ISSN 0147-6513
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2013.03.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  7. Article: Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills

    Fu, Yao / Li, Ming / Liu, Ci / Qu, Jian-Ping / Zhu, Wen-Jun / Xing, Hou-Juan / Xu, Shi-Wen / Li, Shu

    Ecotoxicology and environmental safety

    2013  Volume 94, Issue 1, Page(s) 28

    Language English
    Document type Article
    ZDB-ID 436536-7
    ISSN 0147-6513
    Database Current Contents Nutrition, Environment, Agriculture

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  8. Article: Effects of atrazine and chlorpyrifos on the production of nitric oxide and expression of inducible nitric oxide synthase in the brain of common carp (Cyprinus carpio L.)

    Wang, Liang-Liang / Liu, Tao / Wang, Chao / Zhao, Fu-Qing / Zhang, Zi-Wei / Yao, Hai-Dong / Xing, Hou-Juan / Xu, Shi-Wen

    Ecotoxicology and environmental safety

    2013  Volume 93, Issue 1, Page(s) 7

    Language English
    Document type Article
    ZDB-ID 436536-7
    ISSN 0147-6513
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

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  9. Article: Effects of Atrazine and Chlorpyrifos on Autophagy-Related Genes in the Brain of Common Carp: Health-Risk Assessments

    Xing, Hou-Juan / Wang, Liang-Liang / Yao, Hai-Dong / Wang, Xiao-long / Xu, Shi-Wen

    Archives of environmental contamination and toxicology

    Volume v. 70,, Issue no. 2

    Abstract: This study assessed the impacts of atrazine (ATR), chlorpyrifos (CPF), and a combined ATR/CPF exposure on the brain of common carp (Cyprinus carpio L.). The carp were sampled after a 40-days exposure to CPF and ATR, individually or in combination, ... ...

    Abstract This study assessed the impacts of atrazine (ATR), chlorpyrifos (CPF), and a combined ATR/CPF exposure on the brain of common carp (Cyprinus carpio L.). The carp were sampled after a 40-days exposure to CPF and ATR, individually or in combination, followed by a 40-days recovery period to measure autophagy and antioxidant activity. The results indicate that the anti-superoxide anion and anti-hydroxy radical activities decreased upon exposure to ATR, CPF, and the ATR/CPF combination but increased after a subsequent 40-days recovery period. Quantitative real-time PCR and Western blot analyses revealed that the mRNA and protein levels of LC3B and dynein in common carp decreased significantly after exposure to ATR and CPF alone or in combination. Moreover, the mRNA and protein levels of beclin1 gene decreased significantly only in the 116 and 11.3 μg/L treatment groups. However, the mRNA and protein levels of all tested genes increased significantly after a 40-days recovery. Transmission electron microscope demonstrated the occurrence of autolysosomes in the recovery groups but not in the exposure groups. These results suggest that exposure to ATR, CPF, or their combination promotes oxidative stress and autophagic responses in the brain of common carp.
    Keywords Western blotting ; messenger RNA ; genes ; oxidative stress ; antioxidant activity ; Cyprinus carpio ; atrazine ; carp ; transmission electron microscopes ; autophagy ; chlorpyrifos ; dynein ATPase ; brain ; quantitative polymerase chain reaction
    Language English
    Document type Article
    ISSN 0090-4341
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  10. Article: Effect of atrazine and chlorpyrifos exposure on cytochrome P450 contents and enzyme activities in common carp gills

    Fu, Yao / Li, Ming / Liu, Ci / Qu, Jian-Ping / Zhu, Wen-Jun / Xing, Hou-Juan / Xu, Shi-Wen / Li, Shu

    Ecotoxicology and environmental safety

    Volume v. 94

    Abstract: Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d ... ...

    Abstract Chlorpyrifos (CPF) and atrazine (ATR) are the most widely used organophosphate insecticides and triazine herbicides, respectively, worldwide. This study aimed at investigating the effects of ATR, CPF and mixture on common carp gills following 40-d exposure and 40-d recovery experiments. Cytochrome P450 content, activities of aminopyrine N-demethylase (APND) and erythromycin N-demethylase (ERND) and the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) were determined. In total, 220 common carps were divided into eleven groups, and each group was treated with a specific concentration of ATR (4.28, 42.8 and 428μg/L), CPF (1.16, 11.6 and 116μg/L) or ATR–CPF mixture (1.13, 11.3 and 113μg/L). The results showed that P450 content and activities of APND and ERND in fish exposed to ATR and mixture were significantly higher than those in the control group. After the 40-d recovery treatment (i.e., depuration), the P450 content and the activities of APND and ERND in fish decreased to the background levels. A similar tendency was also found in the mRNA levels of the CYP1 family (CYP1A, CYP1B, and CYP1C) in common carp gills. The CPF-treated fish showed no significant difference from the control groups, except for a significant CYP1C induction. These results indicated that CYP enzyme levels are induced by ATR but were only slightly affected by CPF in common carp gills. In addition, the ATR and CPF exposure showed an antagonistic effect on P450 enzymes in common carp gills.
    Keywords messenger RNA ; cytochrome P-450 ; carp ; atrazine ; Cyprinus carpio ; enzyme activity ; gills ; chlorpyrifos ; enzymes ; erythromycin
    Language English
    Document type Article
    ISSN 0147-6513
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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