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Article ; Online: Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer.

Wu, Jiamei / Wang, Miao / Zhang, Yuechuan / Liu, Guohong / Xing, Yutong

2024 Volume 24, Issue 1, Page(s) 20

Abstract: Given the role of chondroitin polymerizing factor (CHPF) in several cancers, we investigated its role in the progression of colorectal cancer (CRC) and its association with NLRP3 inflammasome activation. High expression of CHPF in CRC predicted poor ... ...

Abstract	Given the role of chondroitin polymerizing factor (CHPF) in several cancers, we investigated its role in the progression of colorectal cancer (CRC) and its association with NLRP3 inflammasome activation. High expression of CHPF in CRC predicted poor patient prognosis. Using colony formation, EdU staining, wound healing, Transwell invasion, and flow cytometry assays, we revealed that the downregulation of CHPF inhibited the malignant behavior of CRC cells. CHPF promoted NLRP3 inflammasome activation by inducing the MAPK signaling pathway, as evidenced by enhanced expression of Phos-ERK1/2, Phos-MEK1, Phos-MEK2, and NLRP3. Additionally, nuclear factor 1 C-type (NFIC) was revealed as a potential upstream transcription factor of CHPF in the modulation of CRC, and the anti-tumor effects elicited through its knockdown were compromised by CHPF in vitro and in vivo. In summary, we demonstrated that NFIC promoted NLRP3 activation to support CRC development via the CHPF-mediated MAPK signaling.
MeSH term(s)	Humans ; Colorectal Neoplasms/genetics ; Down-Regulation ; Inflammasomes ; MAP Kinase Signaling System ; NFI Transcription Factors ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics
Chemical Substances	Inflammasomes ; NFI Transcription Factors ; NFIC protein, human ; NLR Family, Pyrin Domain-Containing 3 Protein ; chondroitin synthase (EC 2.4.1.175) ; NLRP3 protein, human
Language	English
Publishing date	2024-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-024-01299-x
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Article: Aging under endocrine hormone regulation.

Xing, Yutong / Xuan, Fan / Wang, Kaixi / Zhang, Huifeng

Frontiers in endocrinology

2023 Volume 14, Page(s) 1223529

Abstract: Aging is a biological process in which the environment interacts with the body to cause a progressive decline in effective physiological function. Aging in the human body can lead to a dysfunction of the vital organ systems, resulting in the onset of age- ...

Abstract	Aging is a biological process in which the environment interacts with the body to cause a progressive decline in effective physiological function. Aging in the human body can lead to a dysfunction of the vital organ systems, resulting in the onset of age-related diseases, such as neurodegenerative and cardiovascular diseases, which can seriously affect an individual's quality of life. The endocrine system acts on specific targets through hormones and related major functional factors in its pathways, which play biological roles in coordinating cellular interactions, metabolism, growth, and aging. Aging is the result of a combination of many pathological, physiological, and psychological processes, among which the endocrine system can achieve a bidirectional effect on the aging process by regulating the hormone levels in the body. In this paper, we explored the mechanisms of growth hormone, thyroid hormone, and estrogen in the aging process to provide a reference for the exploration of endocrine mechanisms related to aging.
MeSH term(s)	Humans ; Quality of Life ; Aging ; Estrogens ; Growth Hormone ; Endocrine System
Chemical Substances	Estrogens ; Growth Hormone (9002-72-6)
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1223529
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Article ; Online: m

Wu, Jiamei / Yi, Tingzhuang / Zhuo, Chenyi / Wang, Duanduan / Zhang, Ming / Hu, Rui / Wu, Dan / Hou, Guoxin / Xing, Yutong

Journal of cellular physiology

2024 Volume 239, Issue 5, Page(s) e31220

Abstract: Recent studies have indicated that dysregulation of the Hippo/Yes-associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of ... ...

Abstract	Recent studies have indicated that dysregulation of the Hippo/Yes-associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of Hippo signaling in LUAD is of great significance. Elevated levels of TRIB3, a pseudo kinase, have been observed in certain lung malignancies and are associated with an unfavorable prognosis. Our research aims to investigate whether increased TRIB3 levels enhance the malignant characteristics of LUAD cells and tumor progression through its interaction with the Hippo signaling pathway. In this study, we reported a positive correlation between elevated expression of TRIB3 and LUAD progression. Additionally, TRIB3 has the ability to enhance TEAD luciferase function and suppress Hippo pathway activity. Moreover, TRIB3 increases total YAP protein levels and promotes YAP nuclear localization. Mechanistic experiments revealed that TRIB3 directly interacts with large tumor suppressor kinase 1 (LATS1), thereby suppressing Hippo signaling. Moreover, the decrease in METTL3-mediated N6-methyladenosine modification of TRIB3 results in a substantial elevation of its expression levels in LUAD cells. Collectively, our research unveils a novel discovery that TRIB3 enhances the growth and invasion of LUAD cells by interacting with LATS1 and inhibiting the Hippo signaling pathway. TRIB3 may serve as a potential biomarker for an unfavorable prognosis and a target for novel treatments in YAP-driven lung cancer.
MeSH term(s)	Humans ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Hippo Signaling Pathway ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/metabolism ; Signal Transduction ; Lung Neoplasms/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Cell Proliferation/genetics ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Cell Line, Tumor ; Disease Progression ; Methyltransferases/metabolism ; Methyltransferases/genetics ; YAP-Signaling Proteins/metabolism ; YAP-Signaling Proteins/genetics ; A549 Cells ; Animals ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Female ; Cell Movement/genetics ; Male
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.31220
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Article ; Online: Improved Nitrogen Utilization of Faba Bean (Vicia faba L.) Roots and Plant Physiological Characteristics under the Combined Application of Organic and Inorganic Fertilizers

Liu, Zhenyu / Xing, Yutong / Jin, Dian / Liu, Yuting / Lu, Yi / Chen, Yuan / Chen, Dehua / Zhang, Xiang

Agriculture. 2022 Nov. 24, v. 12, no. 12

2022

Abstract: As one of the most important edible legumes worldwide, faba bean can be grown for grain, feed, vegetable, fertilizer, medicine and deep processing. In this study, experiments were designed to determine the combined effect of organic and inorganic ... ...

Abstract	As one of the most important edible legumes worldwide, faba bean can be grown for grain, feed, vegetable, fertilizer, medicine and deep processing. In this study, experiments were designed to determine the combined effect of organic and inorganic fertilizers on the growth and development of faba bean. Dabaipi (a cultivar of Vicia faba L.) was used for the experiments. Five treatments with different ratios of organic nitrogen (N) to total N were applied, including 0% organic fertilizer (0% OF), 25% OF, 50% OF, 75% OF, 100% OF and 0% OF. Chemical urea was used as an inorganic fertilizer. The experimental results showed that 50% OF resulted in the highest faba bean yield, up to 10,337.39 and 13,595.7 kg ha⁻¹ in 2018 and 2019, respectively. Compared with 0% OF, 50% OF increased the yield by 84.47% and 183.17%, respectively. The regression analysis showed that the yield could be maximized when ROT accounted for 51.1%. The 50% OF treatment significantly increased N accumulation in seeds, resulting in higher N partial factor productivity and N harvest index (NHI). N accumulation in green seeds and aboveground plant parts had a significantly positive linear correlation with the yield and NHI, respectively. The 50% OF treatment maintained appropriate N accumulation in vegetative organs and higher N accumulation in reproductive organs and whole plants. Compared to 0% OF, the 50% OF treatment increased the total nodule number per plant (52.5%), fresh nodule weight (55.8%), nitrate reductase activity (70.7%), glutamine synthetase (18.2%) and glutamate synthase activity (42.4%). Therefore, the combined application of 50% OF and 50% inorganic fertilizer can be recommended for faba bean cultivation. This study will provide a theoretical basis for high-yield cultivation of faba bean.
Keywords	Vicia faba ; agriculture ; cultivars ; faba beans ; glutamate-ammonia ligase ; glutamic acid ; growth and development ; harvest index ; medicine ; mineral fertilizers ; nitrate reductase ; organic fertilizers ; organic nitrogen ; regression analysis ; roots ; total nitrogen ; urea ; vegetables
Language	English
Dates of publication	2022-1124
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture12121999
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The complete mitochondrial genome of the Thomas's horseshoe bat (

Xing, Yutong / Mao, Xiuguang

Mitochondrial DNA. Part B, Resources

2016 Volume 1, Issue 1, Page(s) 964–965

Abstract: The Thomas's horseshoe bat ( ...

Abstract	The Thomas's horseshoe bat (
Language	English
Publishing date	2016-12-23
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2016.1266707
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Article ; Online: Gut microbial diversity in two insectivorous bats: Insights into the effect of different sampling sources.

Wu, Haonan / Xing, Yutong / Sun, Haijian / Mao, Xiuguang

MicrobiologyOpen

2018 Volume 8, Issue 4, Page(s) e00670

Abstract: The gut microbiota is now known as a key factor in mammalian physiology and health. Our understanding of the gut microbial communities and their effects on ecology and evolution of their hosts is extremely limited in bats which represent the second ... ...

Abstract	The gut microbiota is now known as a key factor in mammalian physiology and health. Our understanding of the gut microbial communities and their effects on ecology and evolution of their hosts is extremely limited in bats which represent the second largest mammalian order. In the current study, gut microbiota of three sampling sources (small intestine, large intestine, and feces) were characterized in two sympatric and insectivorous bats (Rhinolophus sinicus and Myotis altarium) by high-throughput sequencing of the V3-V4 region of the 16S rRNA gene. Combining with published studies, this work reveals that Gammaproteobacteria may be a dominant class in the whole Chiroptera and Fusobacteria is less observed in bats although it has been proven to be dominant in other mammals. Our results reveal that the sampling source influences alpha diversity of the microbial community in both studied species although no significant variations of beta diversity were observed, which support that fecal samples cannot be used as a proxy of the microbiota in other gut regions in wild animals.
MeSH term(s)	Animals ; Animals, Wild/microbiology ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Biodiversity ; Chiroptera/microbiology ; DNA, Bacterial/genetics ; Feces/microbiology ; Gastrointestinal Microbiome ; Phylogeny ; RNA, Ribosomal, 16S/genetics
Chemical Substances	DNA, Bacterial ; RNA, Ribosomal, 16S
Keywords	covid19
Language	English
Publishing date	2018-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661368-2
ISSN	2045-8827 ; 2045-8827
ISSN (online)	2045-8827
ISSN	2045-8827
DOI	10.1002/mbo3.670
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Article: Gut transcriptomic changes during hibernation in the greater horseshoe bat (

Sun, Haijian / Wang, Jiaying / Xing, Yutong / Pan, Yi-Hsuan / Mao, Xiuguang

Frontiers in zoology

2020 Volume 17, Page(s) 21

Abstract: Background: The gut is the major organ for nutrient absorption and immune response in the body of animals. Although effects of fasting on the gut functions have been extensively studied in model animals (e.g. mice), little is known about the response of ...

Abstract	Background: The gut is the major organ for nutrient absorption and immune response in the body of animals. Although effects of fasting on the gut functions have been extensively studied in model animals (e.g. mice), little is known about the response of the gut to fasting in a natural condition (e.g. hibernation). During hibernation, animals endure the long term of fasting and hypothermia. Results: Here we generated the first gut transcriptome in a wild hibernating bat ( Conclusion: This is the first gut transcriptome of a hibernating mammal. Our study identified candidate genes associated with regulation of food intake and enhance of innate immunity in the gut during hibernation. By comparing with previous studies, we found that two DEGs (
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2164409-3
ISSN	1742-9994
ISSN	1742-9994
DOI	10.1186/s12983-020-00366-w
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Article: TRIB3 Promotes Lung Adenocarcinoma Progression via an Enhanced Warburg Effect.

Xing, Yutong / Luo, Peng / Hu, Rui / Wang, Duanduan / Zhou, Gang / Jiang, Jie

Cancer management and research

2020 Volume 12, Page(s) 13195–13206

Abstract: Background: The pseudokinase Tribbles 3 (TRIB3) is involved in many cellular processes and various cancers. In recent years, the importance of metabolic transformation in the maintenance of malignant tumors has become increasingly prominent. Abnormal ... ...

Abstract	Background: The pseudokinase Tribbles 3 (TRIB3) is involved in many cellular processes and various cancers. In recent years, the importance of metabolic transformation in the maintenance of malignant tumors has become increasingly prominent. Abnormal metabolism of cancer cells is considered a hallmark of cancer. However, the exact role and molecular mechanism of TRIB3 in lung adenocarcinoma (LUAD) cell reprogramming is largely unknown. Methods: The oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of cells were examined with a Seahorse XF Extracellular Flux Analyzer. In vitro and in vivo RT-qPCR, Western blotting, and functional assays were performed to explore the functional roles of TRIB3 in LUAD. Results: In the present study, we demonstrated that TRIB3 is remarkably upregulated in LUAD cell lines as well as tissues. TRIB3 knockdown significantly inhibited LUAD cell growth and suppressed LUAD cell invasion, while TRIB3 overexpression conferred the opposite effects. Moreover, silencing TRIB3 suppressed the tumorigenesis and metastatic ability of LUAD cells. Mechanistically, we demonstrated that silencing TRIB3 significantly impaired aerobic glycolysis ability in LUAD cells. Furthermore, our data indicated that TRIB3 knockdown decreased hypoxia-inducible factor (HIF)1α levels and targeted the glycolytic genes regulated by HIF1α. Conclusion: Together, our findings revealed a previously unappreciated function of TRIB3 in cancer cell metabolism and tumor progression, illustrating that TRIB3 could be considered a valuable therapeutic target for LUAD patients.
Language	English
Publishing date	2020-12-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S287956
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Article ; Online: Anti-HER2 Affibody-Conjugated Photosensitizer for Tumor Targeting Photodynamic Therapy.

Li, Shuang / Jin, Yingying / Su, Yao / Li, Wenjing / Xing, Yutong / Wang, Fengwei / Hong, Zhangyong

Molecular pharmaceutics

2020 Volume 17, Issue 5, Page(s) 1546–1557

Abstract: Antibody-coupled photosensitive molecules can achieve an ideal tumor-specific photodynamic therapy (PDT) and show strong clinical application potential. However, some inherent disadvantages, such as long circulation half-life, poor permeation into solid ... ...

Abstract	Antibody-coupled photosensitive molecules can achieve an ideal tumor-specific photodynamic therapy (PDT) and show strong clinical application potential. However, some inherent disadvantages, such as long circulation half-life, poor permeation into solid tumors, and difficulty in obtaining uniform coupling products, present potential problems to clinical applications. In this study, we propose a novel design of targeting photosensitizers, based on a very small targeting protein (an affibody molecule) coupled with photosensitive compounds, to address these problems. In the synthesis, photosensitive pyropheophorbide-a (Pyro) is modified with a PEG linker (molecular weight of 727 Da) and then site specifically coupled to the anti-HER2 Z
MeSH term(s)	Animals ; Antibodies/metabolism ; Cell Line, Tumor ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Neoplasms, Experimental/drug therapy ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Reactive Oxygen Species/metabolism ; Receptor, ErbB-2/analysis ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/metabolism
Chemical Substances	Antibodies ; Photosensitizing Agents ; Reactive Oxygen Species ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.9b01247
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Article ; Online: The little brown bat nuclear genome contains an entire mitochondrial genome: Real or artifact?

Shi, Huizhen / Xing, Yutong / Mao, Xiuguang

Gene

2017 Volume 629, Page(s) 64–67

Abstract: Nuclear mitochondrial DNA sequences (NUMTs) have been documented in almost all eukaryotic genomes studied. Recently, with the number of sequenced genomes increasing, extremely large NUMTs, even a nearly entire mitochondrial genome, have been reported in ... ...

Abstract	Nuclear mitochondrial DNA sequences (NUMTs) have been documented in almost all eukaryotic genomes studied. Recently, with the number of sequenced genomes increasing, extremely large NUMTs, even a nearly entire mitochondrial genome, have been reported in some plants and animals. However, few such studies provided strong experimental evidences for these important discoveries. In this study using a computer-based search method an entire mitochondrial genome (NUMT-1) was found in the nuclear genome of a bat species (Myotis lucifugus). This super-large NUMT shared a same scaffold with a 754bp nuclear genomic sequence and a second NUMT (NUMT-2, 3292bp). If NUMT-1 was real, it will be the largest NUMT found in animals and this finding will provide valuable insights into the mode of generation of NUMTs in the nuclear genome. Unfortunately, although the initial sequencing technology of the published M. lucifugus genome makes the possibility of artifact less likely, our results from both the PCR amplification followed by Sanger sequencing and mapping method based on the whole-genome resequencing datasets suggested that the scaffold containing the entire mitochondrial genome was artifact possibly due to a misassembly of mitochondrial and the nuclear DNA sequences. Our current study highlights the necessity to validate the authenticity of extremely large NUMTs identified in previous searches on whole-genome sequence assemblies.
MeSH term(s)	Animals ; Cell Nucleus/genetics ; Chiroptera/genetics ; DNA, Mitochondrial/genetics ; Genome ; Genome, Mitochondrial
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2017-09-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2017.07.065
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