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Article ; Online: Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids.

Xing, Zhimin / Fang, Bowen / Luo, Shangwen / Xie, Xingang / Wang, Xiaolei

Organic letters

2022 Volume 24, Issue 22, Page(s) 4034–4039

Abstract: Seven-membered polycyclic architectures, widely present in natural products and molecular drugs, are challenging synthetic targets. However, methods for synthesizing fused medium-sized bicyclo[ ...

Abstract	Seven-membered polycyclic architectures, widely present in natural products and molecular drugs, are challenging synthetic targets. However, methods for synthesizing fused medium-sized bicyclo[
MeSH term(s)	Biological Products ; Sesquiterpenes
Chemical Substances	Biological Products ; Sesquiterpenes
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c01401
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Article ; Online: Association between migraine and vasomotor rhinitis.

Liu, Yan / Xing, Zhimin / Ma, Xin / Yu, Lisheng

International forum of allergy & rhinology

2021 Volume 11, Issue 9, Page(s) 1378–1380

MeSH term(s)	Humans ; Migraine Disorders/epidemiology ; Nasal Mucosa ; Rhinitis/epidemiology ; Rhinitis, Vasomotor/epidemiology
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625826-2
ISSN	2042-6984 ; 2042-6976
ISSN (online)	2042-6984
ISSN	2042-6976
DOI	10.1002/alr.22790
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Zs.A 6927: Show issues

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Article: Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids

Xing, Zhimin / Fang, Bowen / Luo, Shangwen / Xie, Xingang / Wang, Xiaolei

Organic letters. 2022 June 01, v. 24, no. 22

2022

Abstract	Seven-membered polycyclic architectures, widely present in natural products and molecular drugs, are challenging synthetic targets. However, methods for synthesizing fused medium-sized bicyclo[m.n.0] ring systems, including the benzo-cycloheptane systems, are still urgent. Herein we describe a base-induced ring expansion as a general strategy to construct a wide range of fused seven-membered ring systems. The application of this method was demonstrated by the efficient total syntheses of two sesquiterpenoids, plecarpenene and plecarpenone, both bearing a fused bicyclo[5.3.0]decane skeleton.
Keywords	decane ; sesquiterpenoids ; skeleton
Language	English
Dates of publication	2022-0601
Size	p. 4034-4039.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.2c01401
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Article ; Online: Accidental migration of a dental implant into the nasal cavity.

Li, Shichang / Xing, Zhimin / Yu, Lisheng

The Journal of international medical research

2020 Volume 48, Issue 8, Page(s) 300060520948736

Abstract: The accidental migration (i.e., displacement) of dental implants into the maxillary sinus is a relatively common complication in dental clinical practice. Here, we report the extremely rare nasal cavity migration of a dental implant in a 23-year-old man. ...

Abstract	The accidental migration (i.e., displacement) of dental implants into the maxillary sinus is a relatively common complication in dental clinical practice. Here, we report the extremely rare nasal cavity migration of a dental implant in a 23-year-old man. Considering the superficial location of the dental implant and the absence of oronasal fistula formation, we attempted to remove the implant via endoscopy, nasal bayonet forceps, curved hooks, and suction in an ambulatory surgery setting with the patient under local anesthesia. Importantly, we were able to extract the implant with only minor complications. The patient received medication for 2 weeks and exhibited uneventful healing. Our findings may be useful for physicians and dentists who encounter similar situations in clinical practice.
MeSH term(s)	Adult ; Dental Implants/adverse effects ; Endoscopy ; Foreign-Body Migration/diagnostic imaging ; Foreign-Body Migration/etiology ; Foreign-Body Migration/surgery ; Humans ; Male ; Maxillary Sinus ; Nasal Cavity/diagnostic imaging ; Nasal Cavity/surgery ; Young Adult
Chemical Substances	Dental Implants
Language	English
Publishing date	2020-09-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/0300060520948736
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Zs.A 925: Show issues

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Article ; Online: Onodi cell mucocele with cholesterol granuloma is more likely to cause serious optic neuropathy, compared with simple Onodi cell mucocele.

Geng, Congli / Tong, Qizhe / Wang, Yi / Huang, Shien / Wang, Min / Xing, Zhimin / Sun, Kunkun

Ear, nose, & throat journal

2022 , Page(s) 1455613221080069

Abstract: Objective: The objective is to describe the clinical features, treatments, and outcomes of a case series of patients with Onodi cell mucocele, with or without cholesterol granuloma (CG).: Material and methods: We retrospectively reviewed the medical ... ...

Abstract	Objective: The objective is to describe the clinical features, treatments, and outcomes of a case series of patients with Onodi cell mucocele, with or without cholesterol granuloma (CG). Material and methods: We retrospectively reviewed the medical records of eight patients diagnosed with Onodi cell mucocele at a single tertiary care university hospital in Beijing, China, between January 2017 and September 2020. Data regarding nasal symptoms, ocular symptoms, sinus computed tomography findings, treatments, histopathological results, and clinical outcomes were extracted. Results: We identified eight patients (six men and two women) of an average age of 48.1 (range, 26-70) years. Four patients presented nasal symptoms. Three patients presented ocular symptoms. Among them, one patient experienced concurrent nasal and ocular symptoms. Two patients were diagnosed based on a physical examination in the absence of nasal or ocular symptoms. All patients underwent endoscopic sinus surgery. The pathological specimens showed mucocele in four cases and mucocele with CG in the other four cases. Among the four cases with CG, three cases presented with decreased vision. After endoscopic sinus surgery, one patient recovered completely, and two patients showed significant improvement. Conclusion: If Onodi cell opacity is observed, especially with optic neuropathy, mucocele and CG are important differential diagnoses. The combination of mucocele and CG is more likely to promote bone destruction and cause serious optic neuropathy than simple mucocele. Endoscopic sinus surgery is appropriate. Diagnoses, treatments, and follow-up should be performed by a multidisciplinary team.
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/01455613221080069
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Zs.B 107: Show issues

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Article ; Online: A novel mutation in COL1A1 causing osteogenesis imperfecta/hearing loss.

Pan, Ti-Ti / Han, Lin / Zheng, Hong-Wei / Xing, Zhi-Min / Yu, Li-Sheng / Liu, Yuan-Jun

Brazilian journal of otorhinolaryngology

2023 Volume 89, Issue 5, Page(s) 101312

Abstract: Objectives: To screen the COL1A1 and COL1A2 gene mutation sites in a family with type I osteogenesis imperfecta (OI)/hearing loss and analyze the characteristics and recovery of hearing loss in patients with osteogenesis imperfecta.: Methods: The ... ...

Abstract	Objectives: To screen the COL1A1 and COL1A2 gene mutation sites in a family with type I osteogenesis imperfecta (OI)/hearing loss and analyze the characteristics and recovery of hearing loss in patients with osteogenesis imperfecta. Methods: The basic clinical data of OI proband and her parents were collected, and the COL1A1 and COL1A2 genes were detected in peripheral blood by PCR amplification and generation Sanger sequencing. Literature of stapedial surgery in patients with osteogenesis imperfecta was collected. Results: The heterozygous mutation of the 26 exon c.1922_1923 ins C in the OI progenitor COL1A1 gene led to the amino acid frameshift mutation of p.Pro 601FS, which was not detected in the phenotypic parents. The homozygous of exon 28 c.1782>G in COL1A2 was detected in the proband and her parents, resulting in changes in the protein p.Pro 549Ala. Conclusion: The clinical symptoms of the OI proband is caused by heterozygous mutation of the 26 exon c.1922_1923 ins C in COL1A1 gene. Stapedial surgery can provide short-term and long-term hearing benefits for OI patients with hearing loss. Level of evidence: Level 4.
MeSH term(s)	Female ; Humans ; Collagen Type I, alpha 1 Chain ; Deafness ; Hearing Loss/genetics ; Mutation ; Osteogenesis Imperfecta/complications ; Osteogenesis Imperfecta/genetics
Chemical Substances	Collagen Type I, alpha 1 Chain ; Collagen Type I, alpha2 Subunit ; COL1A1 protein, human
Language	English
Publishing date	2023-08-25
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2023.101312
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Zs.A 6641: Show issues

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Article ; Online: The circadian timing of noise exposure influences noise-induced inflammatory responses in the mouse cochlea.

Li, Shichang / Zheng, Hongwei / Xing, Zhimin / Liu, Yan / Han, Lin / Wang, Zijing / Yu, Lisheng

Brazilian journal of otorhinolaryngology

2021 Volume 88 Suppl 3, Page(s) S1–S8

Abstract: Introduction: Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss. Nevertheless, the mechanisms of noise-induced hearing loss are still not fully understood.: Objective: To investigate the dynamics of inflammatory ...

Abstract	Introduction: Noise-induced hearing loss is one of the most common forms of sensorineural hearing loss. Nevertheless, the mechanisms of noise-induced hearing loss are still not fully understood. Objective: To investigate the dynamics of inflammatory responses in the mammalian cochlea following noise trauma at two different times, once during the light cycle and once during the dark. Methods: We challenged C57BL/6J mice with moderate, continuous noise trauma at either 9 a.m. or 9 p.m. Auditory function, histological changes in hair cells, and modifications in gene expression levels of inflammatory mediators were assessed at specific time points. Shifts in auditory brainstem response thresholds were measured at 1, 3, 7 and 14 days after noise exposure to measure potential noise-induced hearing loss. Cochlear basilar-membrane immunofluorescent staining was performed at 3 and 14 days after noise exposure. The mRNA levels of several inflammatory mediators were measured via quantitative real-time polymerase chain reaction before (pre) and after (0, 3, 12, 24 and 72 h) noise exposure. Results: We found that all noise-exposed mice developed a temporary threshold shift and that there were no significant differences between daytime and nighttime noise exposures in terms of inducing hearing-threshold shifts. Similarly, we did not detect significant histological changes in hair cells between these two groups. However, we discovered an interesting phenomenon in that the peak mRNA levels of IL-1β, IL-6, CCL2 and TNF-α were higher in day noise-exposed mice compared to those in night noise-exposed mice, and these mRNA levels subsided more slowly in day noise-exposed mice. Conclusion: Overall, these observations suggest that the circadian timing of noise exposure has a significant effect on noise-induced inflammatory responses in the mouse cochlea and that a greater inflammatory response might occur after daytime exposure.
Language	English
Publishing date	2021-06-12
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2021.05.010
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Article ; Online: Salivary Immunoglobulin A, E, and G4 Levels Specific to Dermatophagoides pteronyssinus in Allergic Rhinitis Patients Treated With Subcutaneous Immunotherapy.

Liu, Yan / Xing, Zhimin / Wang, Junge / Geng, Congli

American journal of rhinology & allergy

2018 Volume 32, Issue 6, Page(s) 458–464

Abstract: Background: Allergen-specific immunotherapy (AIT) is an effective treatment for allergic rhinitis (AR). During the course of AIT, many biomarkers in body fluids change. It is necessary to find effective indicators of AIT.: Objective: To examine ... ...

Abstract	Background: Allergen-specific immunotherapy (AIT) is an effective treatment for allergic rhinitis (AR). During the course of AIT, many biomarkers in body fluids change. It is necessary to find effective indicators of AIT. Objective: To examine levels of salivary immunoglobulin A, E, and G4 (IgA, IgE, and IgG4, respectively) specific to Dermatophagoides pteronyssinus (Dp-IgA, Dp-IgE, and Dp-IgG4, respectively) and their changes in AR patients undergoing subcutaneous immunotherapy (SCIT). Methods: This study included 82 patients with AR sensitized only to Dp and 14 healthy controls. Among patients with AR, 30 patients were not treated with specific immunotherapy (group A), while the remainder (n = 52) received house dust mite SCIT in the up-dosing phase (n = 27; group B) or the maintenance treatment phase (n = 25; group C). Dp-IgA, Dp-IgE, and Dp-IgG4 levels in the saliva were measured using the enzyme-linked immunosorbent assay. Clinical symptoms, concomitant medication, and the Rhinoconjunctivitis Quality of Life Questionnaire score were recorded and correlated with immunoglobulin levels. Results: Salivary Dp-IgG4 and Dp-IgA levels were significantly lower in AR patients than in healthy controls ( P < .001 for both), while Dp-IgE levels were significantly higher ( P < .001). SCIT resulted in sustained increases in Dp-IgG4 and Dp-IgA in the maintenance phase compared to the up-dosing phase ( P < .001 for both), whereas Dp-IgE only increased in the up-dosing phase ( P = .004, P < .0125). There was no correlation between the different salivary immunoglobulins and clinical scores during SCIT. Conclusions: This study shows that allergen-specific IgE levels are increased in the saliva of sensitized patients, suggesting that measuring salivary IgE testing should be further considered for the diagnosis of AR. Moreover, allergen-specific IgA and IgG4 in the saliva, which may play protective roles against allergy, may serve as objective indicators for evaluating treatment response to SCIT. However, none of the immunoglobulin reflects subjective symptoms.
MeSH term(s)	Adolescent ; Adult ; Aged ; Animals ; Antigens, Dermatophagoides/immunology ; Antigens, Dermatophagoides/therapeutic use ; Biomarkers/metabolism ; Child ; Dermatophagoides pteronyssinus/immunology ; Desensitization, Immunologic/methods ; Female ; Humans ; Immunoglobulin A/metabolism ; Immunoglobulin E/metabolism ; Immunoglobulin G/metabolism ; Injections, Subcutaneous ; Male ; Middle Aged ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/therapy ; Saliva/metabolism ; Young Adult
Chemical Substances	Antigens, Dermatophagoides ; Biomarkers ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2018-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2482804-X
ISSN	1945-8932 ; 1945-8924
ISSN (online)	1945-8932
ISSN	1945-8924
DOI	10.1177/1945892418793470
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Zs.A 2542: Show issues

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Article ; Online: Visible light photoredox catalyzed deprotection of 1,3-oxathiolanes.

Yang, Mingyang / Xing, Zhimin / Fang, Bowen / Xie, Xingang / She, Xuegong

Organic & biomolecular chemistry

2019 Volume 18, Issue 2, Page(s) 288–291

Abstract: An efficient visible light photoredox catalyzed aerobic deprotection of 1,3-oxathiolanes using organic dye Eosin Y as a photocatalyst is disclosed. The deprotection procedure features the use of a metal-free catalyst, mild conditions, a broad range of ... ...

Abstract	An efficient visible light photoredox catalyzed aerobic deprotection of 1,3-oxathiolanes using organic dye Eosin Y as a photocatalyst is disclosed. The deprotection procedure features the use of a metal-free catalyst, mild conditions, a broad range of substrate scope, and good functional group tolerance. 35 examples were tested under the standard conditions and most of them afforded the deprotected products in modest to high yields.
Language	English
Publishing date	2019-12-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/c9ob02517k
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Article ; Online: Comparison Between Multiple and Solitary Fungus Balls: A Retrospective Analysis.

Li, Hui / Wu, Yu-Xiao / Wang, Min / Xing, Zhi-Min / Han, Lin

Ear, nose, & throat journal

2020 Volume 101, Issue 10, Page(s) NP459–NP467

Abstract: Objectives: The most common type of noninvasive fungal rhinosinusitis is fungus ball (FB), which usually involves a solitary paranasal sinus. Multiple fungus balls (MFBs) are rarely reported in literature. The purpose of this study was to analyze and ... ...

Abstract	Objectives: The most common type of noninvasive fungal rhinosinusitis is fungus ball (FB), which usually involves a solitary paranasal sinus. Multiple fungus balls (MFBs) are rarely reported in literature. The purpose of this study was to analyze and compare the clinical features of MFBs and solitary fungus ball (SFB). Methods: We retrospectively investigated consecutive cases of FB between 2001 and 2018 and compared the clinical records of SFB with MFBs with respect to demographics, clinical features, location, radiological findings, and operative outcome. Results: A total of 440 SFB and 43 MFBs cases were included in the study. The mean age was 55.3 ± 13.3 and 60.6 ± 10.9 years, respectively ( Conclusions: Compared with SFB, MFBs showed some special characteristics. The MFBs affected older patients showed wide range of lesions and complex anatomy. Surgical technique is very important. Much more attention should be paid to this not so uncommon disease during the perioperative period.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Retrospective Studies ; Sinusitis/microbiology ; Paranasal Sinuses/pathology ; Nose Deformities, Acquired ; Fungi
Language	English
Publishing date	2020-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/0145561320982188
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