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Article ; Online: Centrifuge Modeling of Chloride Ions Completely Breakthrough Kaolin Clay Liner

Xing Zeng / Jia Su / Hengyu Wang / Tong Gao

Sustainability, Vol 14, Iss 6976, p

2022 Volume 6976

Abstract: The 2 m thick compacted clay liner with a permeability coefficient of 1 × 10 − 7 cm/s is required in the Chinese technical specifications about landfills. The processes of chloride ion completely breakthrough low permeability barriers ( k ≤ 1 × 10 − 7 cm/ ...

Abstract	The 2 m thick compacted clay liner with a permeability coefficient of 1 × 10 − 7 cm/s is required in the Chinese technical specifications about landfills. The processes of chloride ion completely breakthrough low permeability barriers ( k ≤ 1 × 10 − 7 cm/s) were modeled at 50 g in a geo-centrifuge. A measuring system was used to monitor solute velocity and conductivity. The entire process of chloride ion completely breaking through 2 m Kaolin clay liner was modeled successfully, which provided a valuable testing technology for centrifuge modeling of contaminant transport through low-permeable clay. The analyses results indicated the breakthrough time of conservative pollutant for the 2 m clay liner with a hydraulic conductivity of 1.0 × 10 −9 m/s under Δ h w of 40 m was 1.6 years. As for strongly adsorptive pollutants, the breakthrough time t 0.1 increased by 9 times when R d increased from 1 to 10, which indicates that the effect of R d on the performance of the liner was significant.
Keywords	centrifuge modeling ; kaolin clay liner ; chloride ion ; breakthrough time ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Polyporus umbellatus(Chinese medicine)on LPS-induced Viability and Cytokine Expression in RAW264.7 cells

Xing Zeng

Frontiers in Immunology, Vol

2013 Volume 4

Abstract: Polyporus umbellatus is a medicinal fungus with mild taste and neutral property. The investigations of immunological action of Polyporus umbellatus focus much more on ingredients than the compound of Polyporus umbellatus. The mechanism researches on ... ...

Abstract	Polyporus umbellatus is a medicinal fungus with mild taste and neutral property. The investigations of immunological action of Polyporus umbellatus focus much more on ingredients than the compound of Polyporus umbellatus. The mechanism researches on toxicity attenuation and efficacy potentiation effects of Polyporus umbellatus in recent years reveal that the interaction among the various ingredients from Polyporus umbellatus probably account for the bidirectional regulation of Polyporus umbellatus prescription on immunity. To investigate the immune regulatory function of Polyporus umbellatus by studying its impact on LPS-induced expression of cytokines (IL-1β, IL-6 and IL-10) in RAW264.7 cells, based on our previous studies. RESULTS: In comparison to LPS group, LPS-induced expression of IL-1β, IL-6 and IL-10 in RAW264.7 cells was inhibited by Polyporus umbellatus in a dose-response manner. IL-10 mRNA was promoted by 0.05μg/mL Polyporus umbellatus while inhibited by 0.5 and 5μg/mL.Polyporus umbellatus is capable of attenuating stimulation of LPS on RAW264.7 cells by suppressing the expression of cytokines like IL-1β and IL-6 as well as elevating the antiinflammatory cytokine IL-10. The correlation between the dose of Polyporus umbellatus and IL-10 expression indicates the bidirectional regulatory effect of Polyporus umbellatus on LPS-induced expression of cytokines in RAW264.7 cells.
Keywords	LPS ; Chinese medicine ; Cytokine expression ; Polyporus umbellatus ; RAW264.7 cells ; Immunologic diseases. Allergy ; RC581-607
Subject code	630
Language	English
Publishing date	2013-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of Factors for Compacted Clay Liner Performance Considering Isothermal Adsorption

Xing Zeng / Hengyu Wang / Jing Yao / Yuheng Li

Applied Sciences, Vol 11, Iss 9735, p

2021 Volume 9735

Abstract: The concentration profiles and breakthrough curves of the 2 m thick compacted clay liner (CCL) given in the specification were compared, considering three different adsorption isotherms (upper convex, linear, and lower concave). In addition, the effects ... ...

Abstract	The concentration profiles and breakthrough curves of the 2 m thick compacted clay liner (CCL) given in the specification were compared, considering three different adsorption isotherms (upper convex, linear, and lower concave). In addition, the effects of transport parameters, sorption isotherms, and source concentrations on pollutant migration were analyzed. The results showed that the dimensionless breakthrough curves of different source concentrations considering the linear adsorption isotherm coincided with each other, as the partition coefficient of the linear adsorption isotherm was constant. For the lower concave isotherm, the migration of a large source concentration was slowest, because the partition coefficient of the lower concave isotherm increased with an increase in concentration. For the upper convex isotherm, the migration of a large source concentration was fastest, because the partition coefficient decreased with an increase in concentration. The effects of the nonlinear isotherms on the shape of the outflow curve were similar to the effects of a change in the hydrodynamic dispersion ( D h ): the concentration front of the upper convex isotherm was narrower, which was similar to the effect of a reduction in D h (i.e., P L ), and the concentration front of the lower concave isotherm was wider and similar to the effect of an increase D h (i.e., P L ). Therefore, the diffusion and adsorption parameters were fitted separately in the study, in case the nonlinear adsorption behavior was mistakenly defined as linear adsorption.
Keywords	CCL ; adsorption ; hydraulic conductivity ; numerical modeling ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	541
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Data-Driven Quasi-Dynamic Traffic Assignment Model Integrating Multi-Source Traffic Sensor Data on the Expressway Network

Xing Zeng / Xuefeng Guan / Huayi Wu / Heping Xiao

ISPRS International Journal of Geo-Information, Vol 10, Iss 3, p

2021 Volume 113

Abstract: Static traffic assignment (STA) models have been widely utilized in the field of strategic transport planning. However, STA models cannot fully represent the dynamic road conditions and suffer from inaccurate assignment during traffic congestion. At the ... ...

Abstract	Static traffic assignment (STA) models have been widely utilized in the field of strategic transport planning. However, STA models cannot fully represent the dynamic road conditions and suffer from inaccurate assignment during traffic congestion. At the same time, an increasing number of installed sensors have become an important means of detecting dynamic road conditions. To address the shortcomings of STA models, we integrate multi-source traffic sensor datasets and propose a novel data-driven quasi-dynamic traffic assignment model, named DQ-DTA. In this model, records of toll stations are used for time-varying travel demand estimation. GPS trajectory datasets of vehicles are further used to calculate the dynamic link costs of the road network, replacing the imprecise Bureau of Public Roads (BPR) function. Moreover, license plate recognition (LPR) data are used to design a statistical probability-based multipath assignment method to capture travelers’ route choices. The expressway network in the Hunan province is selected as the study area, and several classic STA models are also chosen for performance comparison. Experimental results demonstrate that the accuracy of the proposed DQ-DTA model is about 6% higher than that of the chosen STA models.
Keywords	traffic assignment ; multi-source data ; time-varying ; dynamic link cost ; expressway ; Geography (General) ; G1-922
Subject code	380
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neoadjuvant therapy with Disitamab vedotin in treating muscle-invasive bladder cancer

Haijun Huang / Yucong Zhang / Zhi Chen / Xing Zeng / Zhiquan Hu / Chunguang Yang

Heliyon, Vol 9, Iss 4, Pp e15157- (2023)

A case report

2023

Abstract: Purpose: Platinum-based regimens are regarded as the preferred alternative for neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC) patients. However, some patients cannot tolerate platinum-based regimens. We report an MIBC case with severe ...

Abstract	Purpose: Platinum-based regimens are regarded as the preferred alternative for neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC) patients. However, some patients cannot tolerate platinum-based regimens. We report an MIBC case with severe renal insufficiency treated by neoadjuvant therapy with gemcitabine and Disitamab Vedotin. Materials and Methods: A 68-year-old man with severe renal insufficiency was admitted to our department and diagnosed with cT3N0M0 MIBC. Immunohistochemical staining of the biopsy tissues showed human epidermal growth factor receptor 2 expression (1+). This patient received neoadjuvant therapy with gemcitabine 1600 mg and DV 120 mg intravenously every three weeks 3 times. We compared the imaging results of the patient before and after neoadjuvant therapy. In addition, the white blood cell count, alanine aminotransferase, aspartate aminotransferase, and serum creatinine were followed up during neoadjuvant therapy. Abnormal symptoms such as hair loss, fatigue, and hypoesthesia were also recorded. Results: According to the imaging examinations, the lesions were significantly reduced after receiving neoadjuvant therapy. Significant adverse side effects did not occur during neoadjuvant therapy. Conclusions: In this T3N0M0 cisplatin-ineligible patient, gemcitabine combined with DV as neoadjuvant therapy achieved radiological partial response, and no significant adverse events were observed during neoadjuvant therapy.
Keywords	Neoadjuvant therapy ; Muscle-invasive bladder cancer ; Disitamab vedotin ; HER2-Targeted ; Antibody‒drug conjugates ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610 ; 616
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effectiveness of GnRH Antagonists and Agonists in Patients with Hormone-Sensitive Prostate Cancer

Zhenghao Liu / Chunguang Yang / Xing Zeng / Chunjin Ke / Jihua Tian / Zhihua Wang / Zhiquan Hu

Applied Bionics and Biomechanics, Vol

A Retrospective Study

2022 Volume 2022

Abstract: Objective. To assess the effectiveness of gonadotropin-releasing hormone (GnRH) antagonists and agonists in the treatment of patients with hormone-sensitive prostate cancer (HSPC), thus providing valid data support for their clinical treatment. Methods. ... ...

Abstract	Objective. To assess the effectiveness of gonadotropin-releasing hormone (GnRH) antagonists and agonists in the treatment of patients with hormone-sensitive prostate cancer (HSPC), thus providing valid data support for their clinical treatment. Methods. We collected 52 and 65 HSPC patients treated with GnRH antagonists and agonists, respectively, in Tongji Hospital, Tongji Medical College of HUST between May 2019 and April 2021. Prostate-specific antigen (PSA) levels before and after treatment were recorded and analyzed. Further, univariate and multivariate logistic regressions were used to analyze the influencing factors of PSA control rate in HSPC patients. Results. In patients receiving antagonist, the control rate of prostate-specific antigen (PSA) was 54.28% and 88% without and with abiraterone, respectively, and 47.91% and 72% in patients treated using agonist without and with abiraterone. In 32 pairs of patients obtained via propensity score matching, the PSA control rates were 84.38% and 53.13% for those receiving antagonists and agonists, respectively, and 66.67% and 50% for those without abiraterone, respectively. In addition, univariate logistic regression analysis showed that the type of androgen deprivation therapy (ADT) drugs and combined use of abiraterone had a significant effect on the control rate of PSA. Further multivariate logistic regression revealed that GnRH antagonists in ADT drugs were risk factors for PSA control rate. Conclusion. The PSA control rate of HSPC patients treated with GnRH antagonist is significantly higher than that of the agonist group, and the use of GnRH antagonist is an independent predictor of PSA control rate.
Keywords	Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gu-Ben-Hua-Shi (AESS) formula ameliorates atopic dermatitis via regulating NLRP3 signaling pathways

Xiong Li / Luyao Feng / Tingjing Zhong / Xiumei Mo / Dong Wang / Jiangyong Gu / Dacan Chen / Xing Zeng / Fenggen Yan

Saudi Pharmaceutical Journal, Vol 31, Iss 11, Pp 101792- (2023)

2023

Abstract: Background: Gu-ben-hua-shi (AESS) formula is a clinical experienced prescription from Guangdong Hospital of Traditional Chinese Medicine (TCM), which is used to treat atopic dermatitis (AD). Our previous work has shown that AESS has therapeutic effect on ...

Abstract	Background: Gu-ben-hua-shi (AESS) formula is a clinical experienced prescription from Guangdong Hospital of Traditional Chinese Medicine (TCM), which is used to treat atopic dermatitis (AD). Our previous work has shown that AESS has therapeutic effect on AD by regulating yes-associated protein (YAP). AESS formula has multi-component and multi-target characteristic, and need to be analyzed by systematic chemical profiling and network pharmacology technology, as well as verification of key signaling pathways. Therefore, this study aimed at investigating the efficacy and effect of AESS formula in the treatment of AD and its effect on NLRP3 signaling pathway. Methods: The components of AESS formula were analyzed and identified by ultra high performance liquid chromatography/tandem mass spectrometry (UHPLC- MS/MS), and the potential mechanism of AESS formula in the treatment of AD was predicted by network pharmacology approach, with detected main components, and the potential components targeted NOD-like receptor thermal protein domain associated protein (NLRP3) signaling pathway [Direct binding with NLRP3, apoptosis-associated speck-like protein (ASC) and Caspase-1] were assessed using molecular docking. AD-like symptoms were constructed by DNCB induced BALB/c mice. The effect of AESS formula on dorsal skin structure in AD-like mice was observed using H&E staining. Furthermore, the western blotting experiment explored the expression of the NLRP3 pathway protein. Results: By UHPLC-MS/MS analysis, 91 compounds were detected in AESS formula, and 76 of them were identified, while by network pharmacological analysis, 1500 component targets were obtained, and 257 of them were obtained by intersection with eczema targets. Then one of the key pathways, nucleotide-binding oligomerization domain (NOD)-like signaling pathway was obtained by KEGG enrichment analysis. Molecular docking results showed 24 main components could effectively combine with ASC and Caspase-1 (≤−7 kcal/mol). The animal experiment results further ...
Keywords	Atopic dermatitis ; Traditional Chinese medicine ; UHPLC-MS/MS ; NLRP3 signaling pathway ; Therapeutics. Pharmacology ; RM1-950
Subject code	570
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Study of the Adsorption and Removal of Sb(III) from Aqueous Solution by Fe(III) Modified Proteus cibarius with Mechanistic Insights Using Response Surface Methodology

Xiaojian Li / Renjian Deng / Zhie Tang / Saijun Zhou / Xing Zeng / Jianqun Wang / Andrew Hursthouse

Processes, Vol 9, Iss 933, p

2021 Volume 933

Abstract: Environmental pollution caused by excessive Sb(III) in the water environment is a global issue. We investigated the effect of processing parameters, their interaction and mechanistic details for the removal of Sb(III) using an iron salt-modified ... ...

Abstract	Environmental pollution caused by excessive Sb(III) in the water environment is a global issue. We investigated the effect of processing parameters, their interaction and mechanistic details for the removal of Sb(III) using an iron salt-modified biosorbent (Fe(III)-modified Proteus cibarius (FMPAs)). Our study evaluated the optimisation of the adsorption time, adsorbent dose, pH, temperature and the initial concentration of Sb(III). We use response surface methodology to optimize this process, determining optimal processing conditions and the adsorption mechanism evaluated based on isotherm model and adsorption kinetics. The results showed that—(1) the optimal conditions for the adsorption of Sb(III) by FMPAs were an adsorption time of 2.2 h, adsorbent dose of 3430 mg/L, at pH 6.0 and temperature 44.0 °C. For the optimum initial concentration of Sb(III) 27.70 mg/L, the removal efficiency of Sb(III) reached 97.60%. (2) The adsorption process for Sb(III) removal by FMPAs conforms to the Langmuir adsorption isotherm model, and its maximum adsorption capacity ( q max ) is as high as 30.612 mg/g. A pseudo-first-order kinetic model provided the best fit to the adsorption process, classified as single layer adsorption and chemisorption mechanism. (3) The adsorption of Sb(III) takes place via the hydroxyl group in Fe–O–OH and EPS–Polyose–O–Fe(OH) 2 , which forms a new complex Fe–O–Sb and X≡Fe–OH. The study showed that FMPAs have higher adsorption capacity for Sb(III) than other previously studied sorbents and with low environmental impact, it has a great potential as a green adsorbent for Sb(III) in water.
Keywords	Fe(III) modified Proteus cibarius adsorbent (FMPAs) ; surface method ; Sb(III) ; the adsorption mechanism ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment

Wenyu Jia / Siwan Luo / Gena Lai / Shiqi Li / Shuai Huo / Meifang Li / Xing Zeng

BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-

2021 Volume 12

Abstract: Abstract Background Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities. The purpose of this ...

Abstract	Abstract Background Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities. The purpose of this study was to investigate the mechanism of homogeneous polyporus polysaccharide (HPP) activated macrophages in the treatment of bladder cancer. Methods 100 ng/mL Phorbol myristate acetate (PMA) was used to induce THP-1 human leukemic cells as a macrophage model. Then macrophages derived from THP-1 were treated with different concentrations of HPP (1, 10 and 100 μg/mL). Flow cytometry and RT-PCR were used to detected the expression of CD16, CD23, CD86, CD40 and interleukin (IL)-Iβ, iNOS mRNA. ELISA was used to test the change of IL-1β and TNF-α in macrophage after the treatment with HPP. The conditioned medium from HPP-polarized macrophages was used to detect the effect of activated macrophages on bladder cancer. MTT assay, 5-ethynyl-2′-deoxyuridine assay, flow cytometry, Transwell assay, and Western blot analysis were used to detect the effects of polarized macrophages on the viability, proliferation, apoptosis, and migration of bladder cancer cells. Western blot was also used to analysis the change of JAK2/NF-κB pathway protein. Results HPP promoted the expression of pro-inflammatory factors, such as IL-Iβ, TNF-α and iNOS, and surface molecules CD86, CD16, CD23, and CD40 in macrophages and then polarized macrophages to M1 type. Results demonstrated that activated macrophages inhibited the proliferation of bladder cancer cells, regulated their apoptosis, and inhibited migration and epithelial–mesenchymal transformation (EMT). JAK2/NF-κB pathways were downregulated in the anti-bladder cancer process of activated macrophages. Conclusion The findings indicated that HPP inhibited the proliferation and progression of bladder cancer by the polarization of macrophages to M1 type, and JAK2/NF-κB pathway was downregulated in the process of anti-bladder cancer.
Keywords	Bladder cancer ; Homogeneous polyporus polysaccharide ; THP-1-derived macrophage ; Tumor microenvironment ; JAK2/NF-κB pathway ; Other systems of medicine ; RZ201-999
Subject code	616 ; 610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Functional types of long trichoid sensilla responding to sex pheromone components in Plutella xylostella.

Li, Xiao-Fei / Qie, Xing-Tao / Mo, Bao-Tong / Wang, Cai-Feng / Xing, Zeng-Hua / Zhao, Jin-Yu / Wang, Chen-Zhu / Hao, Chi / Ma, Li / Yan, Xi-Zhong

Insect science

2024

Abstract: Sex pheromones, which consist of multiple components in specific ratios promote intraspecific sexual communications of insects. Plutella xylostella (L.) is a worldwide pest of cruciferous vegetables, the mating behavior of which is highly dependent on ... ...

Abstract	Sex pheromones, which consist of multiple components in specific ratios promote intraspecific sexual communications of insects. Plutella xylostella (L.) is a worldwide pest of cruciferous vegetables, the mating behavior of which is highly dependent on its olfactory system. Long trichoid sensilla on male antennae are the main olfactory sensilla that can sense sex pheromones. However, the underlying mechanisms remain unclear. In this study, 3 sex pheromone components from sex pheromone gland secretions of P. xylostella female adults were identified as Z11-16:Ald, Z11-16:Ac, and Z11-16:OH in a ratio of 9.4 : 100 : 17 using gas chromatography - mass spectrometry and gas chromatography with electroantennographic detection. Electrophysiological responses of 581 and 385 long trichoid sensilla of male adults and female adults, respectively, to the 3 components were measured by single sensillum recording. Hierarchical clustering analysis showed that the long trichoid sensilla were of 6 different types. In the male antennae, 52.32%, 5.51%, and 1.89% of the sensilla responded to Z11-16:Ald, Z11-16:Ac, and Z11-16:OH, which are named as A type, B type, and C type sensilla, respectively; 2.93% named as D type sensilla responded to both Z11-16:Ald and Z11-16:Ac, and 0.34% named as E type sensilla were sensitive to both Z11-16:Ald and Z11-16:OH. In the female antennae, only 7.53% of long trichoid sensilla responded to the sex pheromone components, A type sensilla were 3.64%, B type and C type sensilla were both 0.52%, D type sensilla were 1.30%, and 1.56% of the sensilla responded to all 3 components, which were named as F type sensilla. The responding long trichoid sensilla were located from the base to the terminal of the male antennae and from the base to the middle of the female antennae. The pheromone mixture (Z11-16:Ald : Z11-16:Ac : Z11-16:OH = 9.4 : 100 : 17) had a weakly repellent effect on female adults of P. xylostella. Our results lay the foundation for further studies on sex pheromone communications in P. xylostella.
Language	English
Publishing date	2024-04-14
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2179775-4
ISSN	1744-7917 ; 1672-9609
ISSN (online)	1744-7917
ISSN	1672-9609
DOI	10.1111/1744-7917.13367
Database	MEDical Literature Analysis and Retrieval System OnLINE

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