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  1. Article ; Online: Targeting the Complement Pathway in Malignant Glioma Microenvironments

    Hongtao Zhu / Xingjiang Yu / Suojun Zhang / Kai Shu

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Malignant glioma is a highly fatal type of brain tumor, and its reoccurrence is largely due to the ordered interactions among the components present in the complex microenvironment. Besides its role in immune surveillance and clearance under ... ...

    Abstract Malignant glioma is a highly fatal type of brain tumor, and its reoccurrence is largely due to the ordered interactions among the components present in the complex microenvironment. Besides its role in immune surveillance and clearance under physiological conditions, the complement system is expressed in a variety of tumor types and mediates the interactions within the tumor microenvironments. Recent studies have uncovered the broad expression spectrum of complement signaling molecules in the tumor microenvironment and various tumor cells, in particular, malignant glioma cells. Involvement of the complement system in tumor growth, immunosuppression and phenotype transition have also been elucidated. In this review, we enumerate the expression and function of complement molecules in multiple tumor types reported. Moreover, we elaborate the complement pathways in glioma cells and various components of malignant glioma microenvironments. Finally, we summarize the possibility of the complement molecules as prognostic factors and therapeutic targets in the treatment of malignant glioma. Specific targeting of the complement system maybe of great significance and value in the future treatment of multi-type tumors including malignant glioma.
    Keywords glioblastoma microenvironments ; malignant glioma ; complement pathway ; immunotherapy ; tumor immunity ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

    Cuifang Ye / Huan Li / Yachao Li / Yang Zhang / Guohao Liu / Hailong Mi / Honglian Li / Qungen Xiao / Li Niu / Xingjiang Yu

    iScience, Vol 25, Iss 9, Pp 104872- (2022)

    2022  

    Abstract: Summary: Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from tumor cells, promoting the development of tumor. ... ...

    Abstract Summary: Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from tumor cells, promoting the development of tumor. Here, we report that HMGB1 is overexpressed in human GBM specimens. Hypoxia promotes the expression and secretion of HMGB1 in GSCs. Furthermore, silencing HMGB1 results in the loss of stem cell markers and a reduction in self-renewal ability of GSCs. Additionally, HMGB1 knockdown inhibits the activation of RAGE-dependent ERK1/2 signaling pathway and arrests the cell cycle in GSCs. Consistently, FPS-ZM1, an inhibitor of RAGE, downregulates HMGB1 expression and the phosphorylation of ERK1/2, leading to a reduction in the proliferation of GSCs. In xenograft mice of GBM, HMGB1 knockdown inhibits tumor growth and promotes mouse survival. Collectively, these findings uncover a vital function for HMGB1 in regulating GSC self-renewal potential and tumorigenicity.
    Keywords Biological sciences ; Cancer ; Cell biology ; Microenvironment ; Molecular biology ; Science ; Q
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells

    Qiuhong Zhu / Panpan Liang / Hao Meng / Fangzhen Li / Wei Miao / Cuiying Chu / Wei Wang / Dongxue Li / Cong Chen / Yu Shi / Xingjiang Yu / Yifang Ping / Chaoshi Niu / Hai-bo Wu / Aili Zhang / Xiu-wu Bian / Wenchao Zhou

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 19

    Abstract: Abstract The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma ... ...

    Abstract Abstract The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glioma stem cells (GSCs), but the underlying mechanisms remain elusive. Here we demonstrate that Pin1 is deubiquitinated and stabilized by USP34, which promotes isomerization of the sole SUMO E2 enzyme Ubc9, leading to SUMO1-modified hypersumoylation to support GSC maintenance. Pin1 interacts with USP34, a deubiquitinase with preferential expression and oncogenic function in GSCs. Such interaction is facilitated by Plk1-mediated phosphorylation of Pin1. Disruption of USP34 or inhibition of Plk1 promotes poly-ubiquitination and degradation of Pin1. Furthermore, Pin1 isomerizes Ubc9 to upregulate Ubc9 thioester formation with SUMO1, which requires CDK1-mediated phosphorylation of Ubc9. Combined inhibition of Pin1 and CDK1 with sulfopin and RO3306 most effectively suppresses orthotopic tumor growth. Our findings provide multiple molecular targets to induce Pin1 degradation and suppress hypersumoylation for cancer treatment.
    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Levenberg-Marquardt Algorithm for Mackey-Glass Chaotic Time Series Prediction

    Junsheng Zhao / Yongmin Li / Xingjiang Yu / Xingfang Zhang

    Discrete Dynamics in Nature and Society, Vol

    2014  Volume 2014

    Keywords Social sciences (General) ; H1-99 ; Social Sciences ; H ; Mathematics ; QA1-939 ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Levenberg-Marquardt Algorithm for Mackey-Glass Chaotic Time Series Prediction

    Junsheng Zhao / Yongmin Li / Xingjiang Yu / Xingfang Zhang

    Discrete Dynamics in Nature and Society, Vol

    2014  Volume 2014

    Abstract: For decades, Mackey-Glass chaotic time series prediction has attracted more and more attention. When the multilayer perceptron is used to predict the Mackey-Glass chaotic time series, what we should do is to minimize the loss function. As is well known, ... ...

    Abstract For decades, Mackey-Glass chaotic time series prediction has attracted more and more attention. When the multilayer perceptron is used to predict the Mackey-Glass chaotic time series, what we should do is to minimize the loss function. As is well known, the convergence speed of the loss function is rapid in the beginning of the learning process, while the convergence speed is very slow when the parameter is near to the minimum point. In order to overcome these problems, we introduce the Levenberg-Marquardt algorithm (LMA). Firstly, a rough introduction is given to the multilayer perceptron, including the structure and the model approximation method. Secondly, we introduce the LMA and discuss how to implement the LMA. Lastly, an illustrative example is carried out to show the prediction efficiency of the LMA. Simulations show that the LMA can give more accurate prediction than the gradient descent method.
    Keywords Mathematics ; QA1-939 ; Social sciences (General) ; H1-99
    Subject code 518
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

    Weiwei Tao / Chengwei Chu / Wenchao Zhou / Zhi Huang / Kui Zhai / Xiaoguang Fang / Qian Huang / Aili Zhang / Xiuxing Wang / Xingjiang Yu / Haidong Huang / Qiulian Wu / Andrew E. Sloan / Jennifer S. Yu / Xiaoxia Li / George R. Stark / Jeremy N. Rich / Shideng Bao

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 16

    Abstract: The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages. ...

    Abstract The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.
    Keywords Science ; Q
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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