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  1. Article ; Online: Upper Semicontinuity of Pullback Attractors for the 3D Nonautonomous Benjamin-Bona-Mahony Equations

    Xinguang Yang / Xiaosong Wang / Juntao Li / Lingrui Zhang

    The Scientific World Journal, Vol

    2014  Volume 2014

    Keywords Science ; Q ; Science (General) ; Q1-390
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Upper Semicontinuity of Pullback Attractors for the 3D Nonautonomous Benjamin-Bona-Mahony Equations

    Xinguang Yang / Xiaosong Wang / Juntao Li / Lingrui Zhang

    The Scientific World Journal, Vol

    2014  Volume 2014

    Abstract: We will study the upper semicontinuity of pullback attractors for the 3D nonautonomouss Benjamin-Bona-Mahony equations with external force perturbation terms. Under some regular assumptions, we can prove the pullback attractors ε(t) of equation ut-Δut- ... ...

    Abstract We will study the upper semicontinuity of pullback attractors for the 3D nonautonomouss Benjamin-Bona-Mahony equations with external force perturbation terms. Under some regular assumptions, we can prove the pullback attractors ε(t) of equation ut-Δut-νΔu+∇·F→(u)=ɛg(x,t), x∈Ω, converge to the global attractor of the above-mentioned equation with ε=0 for any t∈ℝ.
    Keywords Technology ; T ; Medicine ; R ; Science ; Q
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants.

    Yuanli Liu / Jinan Zhou / Yilin Qu / Xinguang Yang / Guojing Shi / Xiuhong Wang / Yuzhi Hong / Karl Drlica / Xilin Zhao

    PLoS ONE, Vol 11, Iss 4, p e

    2016  Volume 0153023

    Abstract: Reactive oxygen species (ROS; superoxide, peroxide, and hydroxyl radical) are thought to contribute to the rapid bactericidal activity of diverse antimicrobial agents. The possibility has been raised that consumption of antioxidants in food may interfere ...

    Abstract Reactive oxygen species (ROS; superoxide, peroxide, and hydroxyl radical) are thought to contribute to the rapid bactericidal activity of diverse antimicrobial agents. The possibility has been raised that consumption of antioxidants in food may interfere with the lethal action of antimicrobials. Whether nutritional supplements containing antioxidant activity are also likely to interfere with antimicrobial lethality is unknown. To examine this possibility, resveratrol, a popular antioxidant dietary supplement, was added to cultures of Escherichia coli and Staphylococcus aureus that were then treated with antimicrobial and assayed for bacterial survival and the recovery of mutants resistant to an unrelated antimicrobial, rifampicin. Resveratrol, at concentrations likely to be present during human consumption, caused a 2- to 3-fold reduction in killing during a 2-hr treatment with moxifloxacin or kanamycin. At higher, but still subinhibitory concentrations, resveratrol reduced antimicrobial lethality by more than 3 orders of magnitude. Resveratrol also reduced the increase in reactive oxygen species (ROS) characteristic of treatment with quinolone (oxolinic acid). These data support the general idea that the lethal activity of some antimicrobials involves ROS. Surprisingly, subinhibitory concentrations of resveratrol promoted (2- to 6-fold) the recovery of rifampicin-resistant mutants arising from the action of ciprofloxacin, kanamycin, or daptomycin. This result is consistent with resveratrol reducing ROS to sublethal levels that are still mutagenic, while the absence of resveratrol allows ROS levels to high enough to kill mutagenized cells. Suppression of antimicrobial lethality and promotion of mutant recovery by resveratrol suggests that the antioxidant may contribute to the emergence of resistance to several antimicrobials, especially if new derivatives and/or formulations of resveratrol markedly increase bioavailability.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effect of bile pigments on the compromised gut barrier function in a rat model of bile duct ligation.

    Kangkang Zhou / Mingshan Jiang / Yuanli Liu / Yilin Qu / Guojing Shi / Xinguang Yang / Xiaofa Qin / Xiuhong Wang

    PLoS ONE, Vol 9, Iss 6, p e

    2014  Volume 98905

    Abstract: BACKGROUND: Studies have shown that the absence of bile in the gut lumen, either by bile duct ligation or bile diversion, induces mucosal injury. However, the mechanism remains elusive. In this study, the role of bile pigments in gut barrier function was ...

    Abstract BACKGROUND: Studies have shown that the absence of bile in the gut lumen, either by bile duct ligation or bile diversion, induces mucosal injury. However, the mechanism remains elusive. In this study, the role of bile pigments in gut barrier function was investigated in a rat model of bile duct ligation. METHODS: Male Sprague Dawley (SD) rats were used in this study. After ligation of bile duct, the animals were administrated with free bilirubin, bilirubin ditaurate, or biliverdin by intragastric gavage. 1, 2, or 3 days later, the animals were sacrificed and the damage of mucosa was assessed by histological staining as well as biochemical parameters such as changes of diamine oxidase (DAO) and D-lactate (D-Lac) in the blood. Trypsin and chymotrypsin of the gut were also measured to determine how these digestive proteases may relate to the observed effects of bile pigments. RESULTS: Bile duct ligation (BDL) caused significant increases in gut trypsin and chymotrypsin along with damage of the mucosa as demonstrated by the histological findings under microscope, the reduced expression of tight junction molecules like occludin, and significant changes in DAO and D-lac in the blood. Free bilirubin but not bilirubin ditaurate or biliverdin showed significant inhibitions on trypsin and chymotrypsin as well as alleviated changes of histological and biochemical parameters related to gut barrier disruption. CONCLUSION: Bile may protect the gut from damage through inhibiting digestive proteases like trypsin and chymotrypsin by free bilirubin.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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