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  1. Article ; Online: SARS-CoV-2 Omicron subvariant BA.2.86

    Xinling Wang / Lu Lu / Shibo Jiang

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    limited potential for global spread

    2023  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Plasma Proteomic Profiling Reveals the Regulatory Factors of Milk Protein Synthesis in Holstein Cows

    Xinling Wang / Jie Xu / Zhaoyu Han

    Biology, Vol 11, Iss 1239, p

    2022  Volume 1239

    Abstract: Milk protein concentrations in dairy cows are considered to be related to some plasma biomolecules. However, the characteristics of plasma biomolecules in dairy cows with different long-term milk protein concentrations are not fully elucidated. This ... ...

    Abstract Milk protein concentrations in dairy cows are considered to be related to some plasma biomolecules. However, the characteristics of plasma biomolecules in dairy cows with different long-term milk protein concentrations are not fully elucidated. This study was conducted to understand the mechanism of plasma proteins in milk protein synthesis by the comparative analysis of the plasma proteomics of cows with different milk protein concentrations. Three groups of Holstein cows (per group = 10) with low (LMP), medium (MMP), and high long-term milk protein concentrations (HMP) were selected for the experiment to determine plasma hormones, biochemical parameters, and proteome. We found that HMP cows had higher concentrations of plasma insulin-like growth factor 1 (IGF-1), glucose, prolactin, insulin, and growth hormone than LMP cows. Additionally, plasma proteomic identified 91 differential proteins, including IGF-1 between the LMP and HMP groups, and the mTOR pathway was enriched. In vitro, IGF-1 treatment increased β-casein expression and simultaneously activated S6K1 and mTOR phosphorylation in bovine mammary epithelial cells. Taken together, these data demonstrate the differences in plasma hormones, biochemical parameters, and proteome of cows with different milk protein concentrations and indicate that IGF-1 enhanced milk protein synthesis, associated with activation of the mTOR signaling pathway.
    Keywords milk protein ; plasma proteomic ; bovine mammary epithelial cells ; insulin-like growth factor 1 ; Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Impact of the Reform of Factor Market-oriented Allocation on Grid Companies and Related Suggestions

    Wei Zhu / Xinling Wang / Haolan Li

    E3S Web of Conferences, Vol 245, p

    2021  Volume 01013

    Abstract: On April 9, 2020, the CPC Central Committee and the State Council issued “Opinions on Building a More Complete System and Mechanism for Market-oriented Allocation of Factors” (hereinafter referred to as the Opinions), which made an important deployment ... ...

    Abstract On April 9, 2020, the CPC Central Committee and the State Council issued “Opinions on Building a More Complete System and Mechanism for Market-oriented Allocation of Factors” (hereinafter referred to as the Opinions), which made an important deployment to promote the five production factors to achieve a higher level of market-oriented allocation. As the key link of power allocation, Grid Companies are directly related to the economic and social development of the whole country. This paper analyzes the main contents of the opinions in detail, studies the impact of the opinions on power network planning and construction, labor employment, capital operation, technological innovation, the development of emerging industries of Grid Companies, and puts forward targeted suggestions to provide theoretical support for the development of Grid Companies.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Comparison of ruminal microbiota, metabolomics, and milk performance between Montbéliarde×Holstein and Holstein cattle

    Haomiao Chang / Xinling Wang / Hanfang Zeng / Yunfei Zhai / Ni Huang / Changjian Wang / Zhaoyu Han

    Frontiers in Veterinary Science, Vol

    2023  Volume 10

    Abstract: Holstein cattle are well known for their high average milk yield but are more susceptible to disease and have lower fecundity than other breeds of cattle. The purpose of this study was to explore the relationship between ruminal metabolites and both milk ...

    Abstract Holstein cattle are well known for their high average milk yield but are more susceptible to disease and have lower fecundity than other breeds of cattle. The purpose of this study was to explore the relationship between ruminal metabolites and both milk performance and ruminal microbiota composition as a means of assessing the benefits of crossbreeding Montbéliarde and Holstein cattle. This experiment crossbred Holstein with Montbéliarde cattle, aimed to act as a reference for producing high-quality dairy products and improving the overall efficiency of dairy cattle breeding. Based on similar age, parity and lactation time, 46 cows were selected and divided into two groups (n = 23 per group) for comparison experiment and fed the same formula: Montbéliarde×Holstein (MH, DIM = 33.23 ± 5.61 d), Holstein (H, DIM = 29.27 ± 4.23 d). Dairy herd improvement (DHI) data is an important basis for evaluating the genetic quality of bulls, understanding the quality level of milk, and improving feeding management. We collected the DHI data of these cows in the early lactation, middle lactation and late lactation period of 10 months. The results showed that the average milk production and protein content in Montbéliarde×Holstein were 1.76 kg (34.41 kg to 32.65 kg, p > 0.05) and 0.1% (3.54 to 3.44%, p < 0.05) higher than in Holstein cattle. Moreover, milk from Montbéliarde×Holstein cattle had lesser somatic cell score (1.66 to 2.02) than Holstein cattle (p < 0.01). A total of 10 experimental cattle in early lactation were randomly selected in the two groups (Lactation time = 92.70 ± 6.81), and ruminal fluid were collected by oral gastric tube. Using 16S rRNA microbial sequencing, we compared the ruminal microbiota composition and found that Montbéliarde×Holstein cattle had a lower abundance of Alphaproteobacteria (p < 0.05) and higher abundance of Selenomonas than Holstein cattle (p < 0.05). These bacteria play roles in protein degradation, nitrogen fixation and lactic acid degradation. The abundance of ...
    Keywords Montbéliarde×Holstein ; Holstein ; milk performance ; ruminal microbiota ; ruminal metabolomics ; Veterinary medicine ; SF600-1100
    Subject code 630
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Pharmacological inhibition of mTORC1 activity protects against inflammation-induced apoptosis of nucleus pulposus cells

    Rigao Chen / Fei Yang / Yong Wang / Xinling Wang / Xiaohong Fan

    Brazilian Journal of Medical and Biological Research, Vol 54, Iss

    2021  Volume 5

    Abstract: Lumbar disc herniation is a common disease characterized by the degeneration of intervertebral discs (IVDs), accompanied by imbalance of metabolic and inflammatory homeostasis. Current studies establish that IVD degeneration is induced by increased ... ...

    Abstract Lumbar disc herniation is a common disease characterized by the degeneration of intervertebral discs (IVDs), accompanied by imbalance of metabolic and inflammatory homeostasis. Current studies establish that IVD degeneration is induced by increased apoptosis of nucleus pulposus (NP) cells. However, the underlying mechanisms of NP cell survival/apoptosis are not well elucidated. Here, we reveal a novel mechanism by which mTORC1 signaling controls NP cell survival through regulating metabolic homeostasis. We demonstrated that hyperactivated mTORC1 activity induced by inflammatory cytokines engenders the apoptosis of NP cells, whereas pharmacological inhibition of mTORC1 activity promotes NP cell survival. Using an integrative approach spanning metabolomics and biochemical approaches, we showed that mTORC1 activation enhanced glucose metabolism and lactic acid production, and therefore caused NP cell apoptosis. Our study identified mTORC1 in NP cells as a novel target for IVD degeneration, and provided potential strategies for clinical intervention of lumbar disc herniation.
    Keywords Intervertebral disc degeneration ; Nucleus pulposus cells ; mTORC1 ; Lactic acid ; Apoptosis ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Associação Brasileira de Divulgação Científica
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Corrigendum to “Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS”

    Ming Qiao / Jianhua Yang / Yao Zhao / Yi Zhu / Xiaomei Wang / Xinling Wang / Junping Hu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Volume 2022

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comprehensive Profiling of ceRNA (circRNA-miRNA-mRNA) Networks in Hypothalamic-Pituitary-Mammary Gland Axis of Dairy Cows under Heat Stress

    Hanfang Zeng / Haibin Xia / Xinling Wang / Yue Wang / Jian Fang / Shujie Li / Yunfei Zhai / Zhaoyu Han

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    2023  Volume 888

    Abstract: Heat stress (HS) is directly correlated with mammary gland dysfunction and the hypothalamic-pituitary-mammary gland (HPM) axis is involved in regulating stress responses and lactation in dairy cows. Circular RNAs (circRNAs) play major roles in regulating ...

    Abstract Heat stress (HS) is directly correlated with mammary gland dysfunction and the hypothalamic-pituitary-mammary gland (HPM) axis is involved in regulating stress responses and lactation in dairy cows. Circular RNAs (circRNAs) play major roles in regulating transcription and post-transcription but their expression in the HPM axis of dairy cows under HS is still unclear. In the present study, we performed RNA sequencing to identify diferentially expressed (DE) circRNAs, DE microRNAs(miRNAs) and DEmRNAs, and performed bioinformatics analysis on those in HPM axis-related tissues of heat-stressed and normal cows. A total of 1680, 1112 and 521 DEcircRNAs, 120, 493 and 108 DEmiRNAs, 274, 6475 and 3134 DEmRNAs were identified in the hypothalamic, pituitary, and mammary gland tissues, respectively. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses indicated that the MAPK signaling pathway is potentially a key pathway. Competitive endogenous RNA (ceRNA) networks related to HS response and lactation regulation were established in three tissues. In conclusion, our results indicate that HS induces differential circRNA expression profiles in HPM axis-related tissues, and the predicted ceRNA network provides a molecular basis for regulating the stress response and lactation regulation in heat-stressed dairy cows.
    Keywords heat stress ; hypothalamic-pituitary-mammary gland axis ; circRNA ; ceRNA network ; dairy cow ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 630
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The Expression of VISTA on CD4+ T Cells Associate with Poor Prognosis and Immune Status in Non-small Cell Lung Cancer Patients

    Shengyao Ma / Liya Qin / Xinling Wang / Weiyu Wang / Jinfeng Li / Huaijie Wang / Hanyue Li / Xiaoshan Cai / Yang Yang / Meihua Qu

    Bosnian Journal of Basic Medical Sciences (2022)

    2022  

    Abstract: Besides the two main histologic types of papillary thyroid carcinoma (PTC), the classical PTC (CL-PTC) and the follicular variant PTC (FV-PTC), several other variants are described. The encapsulated FV-PTC variant was recently reclassified as noninvasive ...

    Abstract Besides the two main histologic types of papillary thyroid carcinoma (PTC), the classical PTC (CL-PTC) and the follicular variant PTC (FV-PTC), several other variants are described. The encapsulated FV-PTC variant was recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) due to its similarities to benign lesions. Specific molecular signatures, however, are still unavailable. It is well known that improper DNA repair of dysfunctional telomeres may cause telomere-related genome instability. The mechanisms involved in the damaged telomere repair processing may lead to detrimental outcomes, altering the three-dimensional (3D) nuclear telomere and genome organization in cancer cells. This pilot study aimed to evaluate whether a specific 3D nuclear telomere architecture might characterize NIFTP, potentially distinguishing it from other PTC histologic variants. Our findings demonstrate that 3D telomere profiles of CL-PTC and FV-PTC were different from NIFTP and that NIFTP more closely resembles follicular thyroid adenoma (FTA). NIFTP has longer telomeres than CL-PTC and FV-PTC samples, and the telomere length of NIFTP overlaps with that of the FTA histotype. In contrast, there was no association between BRAF expression and telomere length in all tested samples. These preliminary findings reinforce the view that NIFTP is closer to non-malignant thyroid nodules and confirm that PTC features short telomeres.
    Keywords VISTA ; CD4 T cells ; Non-small cell lung cancer ; Prognosis ; Immune status ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: AgBr/(Sr 0.6 Bi 0.305 ) 2 Bi 2 O 7 Heterostructured Composites

    Xinling Wang / Di Zhu / Yan Zhong / Dianhui Wang / Chaohao Hu

    Catalysts, Vol 9, Iss 5, p

    Fabrication, Characterization, and Significantly Enhanced Photocatalytic Activity

    2019  Volume 394

    Abstract: The pyrochlore-type (Sr 0.6 Bi 0.305 ) 2 Bi 2 O 7 (SBO) containing Bi 3+ and Bi 5+ mixed valent states was first investigated as a photocatalyst in our very recent work. To further improve the photocatalytic performance, AgBr/SBO heterostructured ... ...

    Abstract The pyrochlore-type (Sr 0.6 Bi 0.305 ) 2 Bi 2 O 7 (SBO) containing Bi 3+ and Bi 5+ mixed valent states was first investigated as a photocatalyst in our very recent work. To further improve the photocatalytic performance, AgBr/SBO heterostructured composites were synthesized by using a deposition-precipitation method. The characterization of phase structure, morphology, microstructure, elemental composition, and optical properties of the obtained products were performed using X-ray diffractometer (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM)TEM, X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance spectroscopy (UV-vis DRS). The photocatalytic activity of samples was evaluated by degrading methylene blue under visible light illumination. AgBr/SBO composites possess high stability and significantly enhanced photocatalytic performance. The improvement of photocatalytic activity is due to the enhanced light absorption and the separation of photoinduced electrons and holes on the interface of AgBr/SBO heterostructured composites.
    Keywords (Sr 0.6 Bi 0.305 ) 2 Bi 2 O 7 ; AgBr/(Sr 0.6 Bi 0.305 ) 2 Bi 2 O 7 ; Heterojunction ; Photocatalytic activity ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Identification of potential diagnostic gene biomarkers in patients with osteoarthritis

    Xinling Wang / Yang Yu / Yong Huang / Mingshuang Zhu / Rigao Chen / Zhanghui Liao / Shipeng Yang

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 11

    Abstract: Abstract The current study was aimed to identify diagnostic gene signature for osteoarthritis (OA). The differentially expressed genes (DEGs) in synovial membrane samples and blood samples were respectively identified from the GEO dataset. The ... ...

    Abstract Abstract The current study was aimed to identify diagnostic gene signature for osteoarthritis (OA). The differentially expressed genes (DEGs) in synovial membrane samples and blood samples were respectively identified from the GEO dataset. The intersection DEGs between synovial membrane and blood were further screened out, followed by the functional annotation of these common DEGs. The optimal intersection gene biomarkers for OA diagnostics were determined. The GSE51588 dataset of articular cartilage was used for expression validation and further diagnostic analysis validation of identified gene biomarkers for OA diagnostics. There were 379 intersection DEGs were obtained between the synovial membrane and blood samples of OA. 22 DEGs had a diagnostic value for OA. After further screening, a total of 9 DEGs including TLR7, RTP4, CRIP1, ZNF688, TOP1, EIF1AY, RAB2A, ZNF281 and UIMC1 were identified for OA diagnostic. The identified DEGs could be considered as potential diagnostic biomarkers for OA.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Publishing Group
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