Article ; Online: Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation.
American journal of respiratory cell and molecular biology
2024 Volume 70, Issue 1, Page(s) 26–38
Abstract: Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether coronavirus disease (COVID-19) affects BSC function is unknown. Here, we derived BSC lines from patients with COVID-19 using tracheal aspirates (TAs) to circumvent ... ...
Abstract | Airway basal stem cells (BSCs) play a critical role in epithelial regeneration. Whether coronavirus disease (COVID-19) affects BSC function is unknown. Here, we derived BSC lines from patients with COVID-19 using tracheal aspirates (TAs) to circumvent the biosafety concerns of live-cell derivation. We show that BSCs derived from the TAs of control patients are |
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MeSH term(s) | Humans ; Epithelial Cells ; COVID-19 ; Stem Cells ; Cell Differentiation/physiology ; Bronchi |
Language | English |
Publishing date | 2024-01-09 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1025960-0 |
ISSN | 1535-4989 ; 1044-1549 |
ISSN (online) | 1535-4989 |
ISSN | 1044-1549 |
DOI | 10.1165/rcmb.2023-0104OC |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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