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  1. Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

    Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2023  Volume 54, Issue 1, Page(s) 161–164

    Abstract: Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods: A retrospective study was conducted and the data of RCIT ... ...

    Abstract Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.
    Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment.
    Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment (
    Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
    MeSH term(s) Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
    Chemical Substances Antineoplastic Agents
    Language Chinese
    Publishing date 2023-01-16
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20230160506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review.

    Sun, Sheng / Wang, Ye-Hui / Gao, Xiang / Wang, He-Yong / Zhang, Lu / Wang, Na / Li, Chun-Mei / Xiong, Shao-Quan

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1253048

    Abstract: The treatment of breast cancer (BC) is a serious challenge due to its heterogeneous nature, multidrug resistance (MDR), and limited therapeutic options. Nanoparticle-based drug delivery systems (NDDSs) represent a promising tool for overcoming toxicity ... ...

    Abstract The treatment of breast cancer (BC) is a serious challenge due to its heterogeneous nature, multidrug resistance (MDR), and limited therapeutic options. Nanoparticle-based drug delivery systems (NDDSs) represent a promising tool for overcoming toxicity and chemotherapy drug resistance in BC treatment. No bibliometric studies have yet been published on the research landscape of NDDS-based treatment of BC. In this review, we extracted data from 1,752 articles on NDDS-based treatment of BC published between 2012 and 2022 from the Web of Science Core Collection (WOSCC) database. VOSviewer, CiteSpace, and some online platforms were used for bibliometric analysis and visualization. Publication trends were initially observed: in terms of geographical distribution, China and the United States had the most papers on this subject. The highest contributing institution was Sichuan University. In terms of authorship and co-cited authorship, the most prolific author was Yu Zhang. Furthermore, Qiang Zhang and co-workers have made tremendous achievements in the field of NDDS-based BC treatment. The article titled "Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications" had the most citations. The
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1253048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [The Anti-virus Effect of

    Li, Guang-Ping / Ke, Jian-Long / Lü, Pan-Pan / Zhu, Xi / Wang, Cui / Wang, Jin-Yang / Shen, Xian-Ying / Xiong, Shao-Quan

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2019  Volume 50, Issue 4, Page(s) 540–545

    Abstract: Objective: To explore the anti-virus effect of : Methods: HEK293 cells were stably transfected by the : Results: ① Virus titer:The virus titer in the liquid supernatant of pcDNA-3.1-: Conclusion: ... ...

    Abstract Objective: To explore the anti-virus effect of
    Methods: HEK293 cells were stably transfected by the
    Results: ① Virus titer:The virus titer in the liquid supernatant of pcDNA-3.1-
    Conclusion: AY
    MeSH term(s) Animals ; Carrier Proteins/genetics ; Cytokines ; HEK293 Cells ; Humans ; Interferons ; Plasmids ; Transfection ; Vesicular Stomatitis/immunology ; Vesiculovirus
    Chemical Substances Carrier Proteins ; Cytokines ; UQCC3 protein, human ; Interferons (9008-11-1)
    Language Chinese
    Publishing date 2019-10-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
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  4. Article: Usage of Chinese Herbs in Cancer Patients in Southern China: A Survey.

    Xiong, Shao-Quan / Chen, Yu / Wang, Li-Juan / Lyu, Pan-Pan / Liao, Wan / Wang, Cui / Ke, Jian-Long / Zhu, Xi / Wang, Jin-Yang / Shen, Xian-Ying / Li, Guang-Ping / Lin, Li-Zhu

    Chinese journal of integrative medicine

    2020  Volume 27, Issue 7, Page(s) 502–508

    Abstract: Objective: To study the use of Chinese medicine (CM) in cancer patients in southern China.: Methods: A total of 1,950 cancer patients finished questionnaires in four provinces in southern China. The survey included socio-demographic and clinical ... ...

    Abstract Objective: To study the use of Chinese medicine (CM) in cancer patients in southern China.
    Methods: A total of 1,950 cancer patients finished questionnaires in four provinces in southern China. The survey included socio-demographic and clinical characteristics of participants, dosage forms, efficacy, and side effects.
    Results: The study results showed that cancer patients with higher education (>12 years) were more likely to accept the treatment of Chinese herbs. There were 54.61% (1,065 cases) of patients chose Chinese herbs for the initial treatment and 14.46% (282 cases) chose Chinese herbs as monotherapy. Most patients (54.51%, 1,063 cases) continuously used CM for more than 6 months, and a few of them (212 cases) used CM for up to 3 years. All kinds of dosage forms of CM had been used, including CM decoction, CM patent prescription and CM injection. Concerning the efficacy in the view of patients, 40.31% (786 cases) believed that it would be effective to take Chinese herbs before they starting the anti-cancer treatment, and the percentage increased to 81.08% after 1-month CM treatment. The effect of Chinese herbs was mainly demonstrated by symptom relief and improvement of quality of life, and 8.31% (162 cases) of patients experienced control of tumor growth and decreased tumor markers. Furthermore, only 14.31% (279 cases) participants reported that they experienced side effects during CM treatment.
    Conclusion: This large scale investigation reflects the current situation of domestic CM usage objectively and comprehensively, which might provide new ways for cancer treatment.
    MeSH term(s) China ; Drugs, Chinese Herbal/adverse effects ; Humans ; Medicine, Chinese Traditional ; Neoplasms/drug therapy ; Quality of Life ; Surveys and Questionnaires
    Chemical Substances Drugs, Chinese Herbal
    Keywords covid19
    Language English
    Publishing date 2020-05-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-019-3184-6
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  5. Article: [Proteomics in Chinese medicine researches: current status, problems and strategies].

    Xiong, Shao-quan / Zhou, Dai-han / Long, Qi-da

    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

    2010  Volume 30, Issue 2, Page(s) 197–200

    Abstract: Proteomics plays important roles in Chinese medicine research at post-genomics era. Its research idea and methods are beneficial for elucidating some elemental features of Chinese medicine. At present, Chinese medicine proteomic studies are mainly ... ...

    Abstract Proteomics plays important roles in Chinese medicine research at post-genomics era. Its research idea and methods are beneficial for elucidating some elemental features of Chinese medicine. At present, Chinese medicine proteomic studies are mainly focusing on the syndromatology and medical herbal pharmacology. However, there are still some problems, the most important matter was that most of the results were merely the superficial delineations. Further research should put emphasize on the unremitting and penetrating study of proteomics, molecular biology and bioinformatics integrally for illuminating Chinese medicine theory deeply to promote the modernization of Chinese medicine research.
    MeSH term(s) Computational Biology ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional/methods ; Proteomics ; Research
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2010-02
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1195456-5
    ISSN 1003-5370
    ISSN 1003-5370
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  6. Article: [Apoptosis inducing effect of Hechanpian on human lung adenocarcinoma A549 cells].

    Xiong, Shao-Quan / Zhou, Dai-Han / Lin, Li-Zhu

    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

    2010  Volume 30, Issue 6, Page(s) 607–610

    Abstract: Objective: To study the apoptosis inducing effects of Hechanpian (HCP) on human lung adenocarcinoma A549 cells.: Methods: HCP containing rat serum was prepared and applied on A549 cells. The cell growth inhibition rate was tested by MTT assay; the ... ...

    Abstract Objective: To study the apoptosis inducing effects of Hechanpian (HCP) on human lung adenocarcinoma A549 cells.
    Methods: HCP containing rat serum was prepared and applied on A549 cells. The cell growth inhibition rate was tested by MTT assay; the effect of HCP on cell apoptosis was observed with Propidium iodide (PI) staining and flow cytometry analysis; the mRNA expression of epidermal growth factor receptor (EGFR) was detected through RT-PCR.
    Results: The growth of A549 cells was obviously inhibited after being treated by HCP containing serum, and the cells presented an apoptotic change. The cell apoptosis rate after treated by serum containing 10% and 20% HCP was 20.5% and 33.2%, respectively, significantly higher than that in the control (6.1% in cells didn't treated with HCP, P < 0.05). Compared with control, EGFR mRNA expression in HCP treated cells was significantly lower (P < 0.05).
    Conclusion: HCP has apoptosis inducing effect on A549 cell, and its molecular mechanism is probably correlated with the inhibition of EGFR gene transcription.
    MeSH term(s) Adenocarcinoma/pathology ; Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Down-Regulation ; Drugs, Chinese Herbal/pharmacology ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, Epidermal Growth Factor/genetics ; Receptor, Epidermal Growth Factor/metabolism
    Chemical Substances Antineoplastic Agents, Phytogenic ; Drugs, Chinese Herbal ; RNA, Messenger ; EGFR protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1)
    Language Chinese
    Publishing date 2010-06
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1195456-5
    ISSN 1003-5370
    ISSN 1003-5370
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  7. Article: [Bioinformatics analysis and function prediction of the novel gene AY358935].

    Xiong, Shao-quan / Yang, Han-shuo / Long, Qi-da

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2010  Volume 30, Issue 2, Page(s) 232–235

    Abstract: Objective: To obtain the functional information of AY358935 gene.: Methods: The properties, subcellular location, and structure of AY358935 protein, and the expression profile of AY358935 gene were analyzed by bioinformatics software and the ... ...

    Abstract Objective: To obtain the functional information of AY358935 gene.
    Methods: The properties, subcellular location, and structure of AY358935 protein, and the expression profile of AY358935 gene were analyzed by bioinformatics software and the biological functions of the gene were predicted. AY358935 expression was detected by Western blot analysis in early virus infection.
    Results: AY358935 was evolutionally conserved. The human AY358935 protein had an amino acid similarity of 74%, 60%, 38% and 33% with its counterpart in horses, mice, zebrafish and Xenopus laevis, respectively. Bioinformatics analysis indicated that AY358935 protein was located likely in the mitochondria. There was a N-terminal signal peptide and single transmembrane structure in AY358935 protein, which contained several phosphorylation sites. The secondary structure mainly comprised of alpha helices and random coils. AY358935 was ubiquitously expressed in normal tissues and carcinomas and regulated by the expression of double-stranded RNA-dependent protein kinase. AY358935 protein expression was obviously upregulated in cells 2 h after infection by vesicular stomatitis virus.
    Conclusion: As a predicted secretary protein with a small molecular weight, AY358935 might have important functions in cellular proliferation and anti-viral innate immune regulation.
    MeSH term(s) Amino Acid Sequence ; Chromosomes, Human, Pair 11/genetics ; Computational Biology/methods ; Humans ; Molecular Sequence Data ; Proteins/genetics ; Proteins/metabolism ; Sequence Homology, Amino Acid ; Software ; Vesicular Stomatitis/metabolism
    Chemical Substances Proteins
    Language Chinese
    Publishing date 2010-02
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
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  8. Article: Expression of prolyl 4-hydroxylase beta-polypeptide in non-small cell lung cancer treated with Chinese medicines.

    Wang, Shu-mei / Lin, Li-zhu / Zhou, Dai-han / Zhou, Jing-xu / Xiong, Shao-quan

    Chinese journal of integrative medicine

    2014  Volume 21, Issue 9, Page(s) 689–696

    Abstract: Objectives: To investigate the role of prolyl 4-hydroxylase beta polypeptide (P4HB) expressed in lung carcinoma and the intervention effect of Yiqi Chutan Formula (, YQCTF).: Methods: Lung carcinoma model was established by subcutaneously inoculating ...

    Abstract Objectives: To investigate the role of prolyl 4-hydroxylase beta polypeptide (P4HB) expressed in lung carcinoma and the intervention effect of Yiqi Chutan Formula (, YQCTF).
    Methods: Lung carcinoma model was established by subcutaneously inoculating LEWIS lung carcinoma cells in C57BL/6J mice. The differential expression of P4HB protein between the YQCTF (3.0 g/kg, gavage, once daily, 21 days) group and the control group was acquired by a 2 fluorescence difference gel electrophoresis (2D-DIGE), verified by Western blotting and identified by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF/TOF-MS). The expression of P4HB and P4HB mRNA in cultured A549 cells from cisplatin (DDP) 1.5 µg/mL group and 15% serum combined with DDP 1.5 µg/mL group were detected by cellular immunohistochemistry and reverse transcription-polymerase chain reaction, respectively.
    Results: The proteomics research discovered that one-third of differential proteins including P4HB were decreased in the YQCTF group (P<0.01). Clinical pathology and tissue microarray studies showed that P4HB expression in lung cancer tissue was stronger than adjacent tissues and normal lung epithelial (P<0.01). In the YQCTF and DDP combined groups, the expression of P4HB and P4HB mRNA in A549 cell were decreased significantly (P<0.01).
    Conclusion: YQCTF could inhibit the LEWIS lung carcinoma's growth, decrease the expression of P4HB in LEWIS lung carcinoma and A549 cells. YQCTF might take effect through regulating P4HB in endoplasmic reticulum to inhibit the incidence and growth process of lung carcinoma.
    MeSH term(s) Animals ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Progression ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Electrophoresis, Gel, Two-Dimensional ; Gene Expression Regulation, Neoplastic/drug effects ; Immunohistochemistry ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mice, Inbred C57BL ; Peptide Mapping ; Peptides/pharmacology ; Peptides/therapeutic use ; Prolyl Hydroxylases/genetics ; Prolyl Hydroxylases/metabolism ; Proteomics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction ; Tissue Array Analysis
    Chemical Substances Drugs, Chinese Herbal ; Peptides ; RNA, Messenger ; Prolyl Hydroxylases (EC 1.14.11.-)
    Language English
    Publishing date 2014-01-02
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-013-1535-2
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  9. Article: [Cohort Study of EGFR-TKIs Combined with Traditional Chinese Medicine and Single EGFR-TKIs for Advanced NSCLC (Non₋small Cell Lung Cancer)].

    Xiong, Shao-Quan / Li, Ya-Ling / Wang, Shu-Mei / Jin, Shuai / Luo, Qiu-Yue / Ding, Qian / Song, Ting-Ting / Wang, Li-Juan / Cai, Rui / Lü, Pan-Pan / He, Cheng-Shi / Xiang, Jie

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2018  Volume 49, Issue 4, Page(s) 566–569

    Abstract: Objective: To explore the curative effect of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) combined with Traditional Chinese Medicine (TCM) versus single EGFR-TKIs for Advanced non-small-cell lung cancer (NSCLC).: Methods: A ... ...

    Abstract Objective: To explore the curative effect of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) combined with Traditional Chinese Medicine (TCM) versus single EGFR-TKIs for Advanced non-small-cell lung cancer (NSCLC).
    Methods: A total of 59 NSCLC patients with EGFR mutation were divided (2:1) into treatment group and control group. Patients in treatment group (39 cases) take EGFR-TKIs plus TCM and control group (20 cases) take EGFR-TKIs. Analysis the progression-free survival (PFS), disease control rate (DCR) and treatment-related adverse events of two groups.
    Results: The DCR of the treatment group and control group was 94.1% and 84.2% respectively (
    Conclusion: For NSCLC patients with EGFR mutation, EGFR-TKIs combined with TCM has a certain effect to prolong PFS, especially for the patients with L858R.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Medicine, Chinese Traditional ; Mutation ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language Chinese
    Publishing date 2018-10-31
    Publishing country China
    Document type Controlled Clinical Trial ; Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
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  10. Article: [Effects of ShenFu Injection on Peripheral Neurotoxicity of Paclitaxel].

    Xiong, Shao-Quan / Zou, Xiao-Ling / Zheng, Qiao / Jin, Shuai / Xie, Mei / Wang, Li-Juan / Song, Ting-Ting / He, Cheng-Shi / Wan, Li

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2018  Volume 49, Issue 1, Page(s) 44–47

    Abstract: Objective: To investigate the effects and the underlying mechanisms of ShenFu Injection on paclitaxel-induced peripheral neuropathy.: Methods: Twenty-eight adult male Wister rats were randomized into 4 groups (: Results: The MWT and TWL of 14 d in ...

    Abstract Objective: To investigate the effects and the underlying mechanisms of ShenFu Injection on paclitaxel-induced peripheral neuropathy.
    Methods: Twenty-eight adult male Wister rats were randomized into 4 groups (
    Results: The MWT and TWL of 14 d in paclitaxel group significantly increased compared with those of 0 d and control group (
    Conclusion: Shenfu Injection can reduce the peripheral neurotoxicity of paclitaxel by promoting the expression of NGF in serum.
    MeSH term(s) Animals ; Drugs, Chinese Herbal/pharmacology ; Male ; Neurotoxins/adverse effects ; Paclitaxel/adverse effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/drug effects ; Sciatic Nerve/ultrastructure
    Chemical Substances Drugs, Chinese Herbal ; Neurotoxins ; Shen-Fu ; Paclitaxel (P88XT4IS4D)
    Language Chinese
    Publishing date 2018-05-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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