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  1. Article: Population genetic differentiation and phenotypic plasticity of Ambrosia artemisiifolia under different nitrogen levels.

    Xiong, Yunqi / Oduor, Ayub M O / Zhao, Caiyun

    Ecological applications : a publication of the Ecological Society of America

    2023  Volume 34, Issue 1, Page(s) e2903

    Abstract: Rapid adaptive evolution and phenotypic plasticity are two mechanisms that often underlie invasiveness of alien plant species, but whether they can co-occur within invasive plant populations under altered environmental conditions such as nitrogen (N) ... ...

    Abstract Rapid adaptive evolution and phenotypic plasticity are two mechanisms that often underlie invasiveness of alien plant species, but whether they can co-occur within invasive plant populations under altered environmental conditions such as nitrogen (N) enrichment has seldom been explored. Latitudinal clines in plant trait responses to variation in environmental factors may provide evidence of local adaptation. Here, we inferred the relative contributions of phenotypic plasticity and local adaptation to the performance of the invasive plant Ambrosia artemisiifolia under different soil N levels, using a common garden approach. We grew A. artemisiifolia individuals raised from seeds that were sampled from six invasive populations along a wide latitudinal cline in China (23°42' N to 45°43' N) under three N (0, 5, and 10 g N m
    MeSH term(s) Humans ; Ambrosia/genetics ; Nitrogen ; Adaptation, Physiological/genetics ; Phenotype ; Plants ; Genetics, Population ; Introduced Species
    Chemical Substances Nitrogen (N762921K75)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1074505-1
    ISSN 1939-5582 ; 1051-0761
    ISSN (online) 1939-5582
    ISSN 1051-0761
    DOI 10.1002/eap.2903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification of the Active Compound of Liu Wei Di Huang Wan for Treatment of Gestational Diabetes Mellitus via Network Pharmacology and Molecular Docking.

    Xiong, Yunqi / Li, Qiutong / Chen, Xiuhui / Zhu, Ting / Lu, Qitian / Jiang, Guojing

    Journal of diabetes research

    2022  Volume 2022, Page(s) 4808303

    Abstract: Liu Wei Di Huang Wan (LWDHW) is a well-known Chinese herbal compound, which has been prescribed for the treatment of gestational diabetes mellitus (GDM). We sought to clarify the potential therapeutic effects of LWDHW against GDM. Differentially ... ...

    Abstract Liu Wei Di Huang Wan (LWDHW) is a well-known Chinese herbal compound, which has been prescribed for the treatment of gestational diabetes mellitus (GDM). We sought to clarify the potential therapeutic effects of LWDHW against GDM. Differentially expressed genes (DEGs) in GDM were firstly identified from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to reveal the biological functions of the DEGs. Subsequently, the LWDHW-compound-target network was constructed based on public databases to identify the relationship between the active components in LWDHW and the corresponding targets. Furthermore, gene functional analysis and protein-protein interaction (PPI) network construction were applied to investigate the function of potential targets and to evaluate hub genes. Finally, molecular docking was used to verify the binding activities between active ingredients and hub targets. Thirteen active components and 39 corresponding therapeutic target genes were obtained via network pharmacology analysis. The enrichment analysis demonstrated that the anti-GDM effect of LWDHW included oxidoreductase activity, involvement in renal system process, and regulation of blood pressure, which may be achieved through regulation of serotonergic synapses, vascular smooth muscle contraction, and neuroactive ligand-receptor interaction pathways. Additionally, molecular docking revealed that the main active component, Mu Dan Pi, exhibited the best affinity for proteins encoded by hub genes. This study applied network pharmacology analysis and molecular docking to display the multicomponent and multitarget characteristics of LWDHW in the treatment of GDM. Our findings provide novel insights into the pathogenesis of GDM and the therapeutic mechanisms of LWDHW against GDM.
    MeSH term(s) Diabetes, Gestational/drug therapy ; Diabetes, Gestational/genetics ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Network Pharmacology ; Pregnancy ; Protein Interaction Maps
    Chemical Substances Drugs, Chinese Herbal ; Liuwei Dihuang Decoction
    Language English
    Publishing date 2022-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2022/4808303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outcomes of ureteroscopy and internal ureteral stent for pregnancy with urolithiasis: a systematic review and meta-analysis.

    Jin, Xingwei / Liu, Boke / Xiong, Yunqi / Wang, Yuanchun / Tu, Weichao / Shao, Yuan / Zhang, Lin / Wang, Dawei

    BMC urology

    2022  Volume 22, Issue 1, Page(s) 150

    Abstract: Objectives: To investigate the outcomes of internal ureteral stents in comparison with ureteroscopy (URS) for pregnant women with urolithiasis.: Data sources: Relevant studies published from January 1980 to June 2022 were identified through ... ...

    Abstract Objectives: To investigate the outcomes of internal ureteral stents in comparison with ureteroscopy (URS) for pregnant women with urolithiasis.
    Data sources: Relevant studies published from January 1980 to June 2022 were identified through systematic literature searches of MEDLINE, EMBASE, Web of Science and the Cochrane Library.
    Methods of study selection: A total of 499 studies were initially identified. We included pregnant women in any stages of gestation who underwent double-J (D-J) stent insertion only or ureteroscopy for the treatment of urolithiasis; for a study to be included, the number of participants needed to exceed 10. This systematic review was registered on the PROSPERO website (Reference: CRD42020195607).
    Results: A total of 25 studies were identified with 131 cases undergoing serial stenting and 789 cases undergoing URS. The pooled operative success rate was 97% for D-J stent insertion and 99% for URS. Only a few patients passed stones spontaneously after serial D-J stenting. The pooled stone free rate (SFR) in URS operations was about 91%. For internal ureteral stent therapy, the rate of normal fertility outcomes was 99%, although the pooled incidence of complications was approximately 45%. For group receiving URS treatment, the rate of normal fertility outcome was 99% and the pooled incidence of complications was approximately 1%. However, the pooled rate of premature birth and abortion were the similar between the two groups (< 1%); the rate of serious complications was also similar between the two groups.
    Conclusions: Although internal ureteral stents may cause more minor complications, both ureteroscopy and internal ureteral stents showed had low rates of adverse effects on fertility outcomes when used to treat pregnant women with symptomatic urolithiasis. Evidence suggests that URS may have a greater advantage for pregnant patients with urinary stones when conditions permit. Since, it has been proven to be safe and effective, internal ureteral stents could be considered in emergency or other special situations.
    MeSH term(s) Female ; Humans ; Pregnancy ; Stents/adverse effects ; Ureter/surgery ; Ureteral Calculi/therapy ; Ureteroscopy/methods ; Urolithiasis/complications ; Urolithiasis/surgery
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-022-01100-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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