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Article: Towards the Clinical Translation of 3D PLGA/β-TCP/Mg Composite Scaffold for Cranial Bone Regeneration.

Zhou, Yongsen / Hu, Jingqi / Li, Binhan / Xia, Jingjing / Zhang, Ting / Xiong, Zhuo

2024 Volume 17, Issue 2

Abstract: Recent years have witnessed the rapid development of 3D porous scaffolds with excellent biocompatibility, tunable porosity, and pore interconnectivity, sufficient mechanical strength, controlled biodegradability, and favorable osteogenesis for improved ... ...

Abstract	Recent years have witnessed the rapid development of 3D porous scaffolds with excellent biocompatibility, tunable porosity, and pore interconnectivity, sufficient mechanical strength, controlled biodegradability, and favorable osteogenesis for improved results in cranioplasty. However, clinical translation of these scaffolds has lagged far behind, mainly because of the absence of a series of biological evaluations. Herein, we designed and fabricated a composite 3D porous scaffold composed of poly (lactic-co-glycolic) acid (PLGA), β-tricalcium phosphate (β-TCP), and Mg using the low-temperature deposition manufacturing (LDM) technique. The LDM-engineered scaffolds possessed highly porous and interconnected microstructures with a porosity of 63%. Meanwhile, the scaffolds exhibited mechanical properties close to that of cancellous bone, as confirmed by the compression tests. It was also found that the original composition of scaffolds could be maintained throughout the fabrication process. Particularly, two important biologic evaluations designed for non-active medical devices, i.e., local effects after implantation and subchronic systemic toxicity tests, were conducted to evaluate the local and systemic toxicity of the scaffolds. Additionally, the scaffolds exhibited significant higher mRNA levels of osteogenic genes compared to control scaffolds, as confirmed by an in vitro osteogenic differentiation test of MC3T3-E1 cells. Finally, we demonstrated the improved cranial bone regeneration performance of the scaffolds in a rabbit model. We envision that our investigation could pave the way for translating the LDM-engineered composite scaffolds into clinical products for cranial bone regeneration.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17020352
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps: A review

Fang, Yongcong / Sun, Wei / Zhang, Ting / Xiong, Zhuo

Biomaterials. 2022 Jan., v. 280

2022

Abstract: The field of cardiac tissue engineering has advanced over the past decades; however, most research progress has been limited to engineered cardiac tissues (ECTs) at the microscale with minimal geometrical complexities such as 3D strips and patches. ... ...

Abstract	The field of cardiac tissue engineering has advanced over the past decades; however, most research progress has been limited to engineered cardiac tissues (ECTs) at the microscale with minimal geometrical complexities such as 3D strips and patches. Although microscale ECTs are advantageous for drug screening applications because of their high-throughput and standardization characteristics, they have limited translational applications in heart repair and the in vitro modeling of cardiac function and diseases. Recently, researchers have made various attempts to construct engineered cardiac pumps (ECPs) such as chambered ventricles, recapitulating the geometrical complexity of the native heart. The transition from microscale ECTs to ECPs at a translatable scale would greatly accelerate their translational applications; however, researchers are confronted with several major hurdles, including geometrical reconstruction, vascularization, and functional maturation. Therefore, the objective of this paper is to review the recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps. We first review the bioengineering approaches to fabricate ECPs, and then emphasize the unmatched potential of 3D bioprinting techniques. We highlight key advances in bioprinting strategies with high cell density as researchers have begun to realize the critical role that the cell density of non-proliferative cardiomyocytes plays in the cell–cell interaction and functional contracting performance. We summarize the current approaches to engineering vasculatures both at micro- and meso-scales, crucial for the survival of thick cardiac tissues and ECPs. We showcase a variety of strategies developed to enable the functional maturation of cardiac tissues, mimicking the in vivo environment during cardiac development. By highlighting state-of-the-art research, this review offers personal perspectives on future opportunities and trends that may bring us closer to the promise of functional ECPs.
Keywords	biocompatible materials ; bioprinting ; cardiac output ; cardiomyocytes ; drugs
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121298
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Article ; Online: Advances in digital light processing of hydrogels.

Mo, Xingwu / Ouyang, Liliang / Xiong, Zhuo / Zhang, Ting

Biomedical materials (Bristol, England)

2022 Volume 17, Issue 4

Abstract: Hydrogels, three-dimensional (3D) networks of hydrophilic polymers formed in water, are a significant type of soft matter used in fundamental and applied sciences. Hydrogels are of particular interest for biomedical applications, owing to their soft ... ...

Abstract	Hydrogels, three-dimensional (3D) networks of hydrophilic polymers formed in water, are a significant type of soft matter used in fundamental and applied sciences. Hydrogels are of particular interest for biomedical applications, owing to their soft elasticity and good biocompatibility. However, the high water content and soft nature of hydrogels often make it difficult to process them into desirable solid forms. The development of 3D printing (3DP) technologies has provided opportunities for the manufacturing of hydrogels, by adopting a freeform fabrication method. Owing to its high printing speed and resolution, vat photopolymerization 3DP has recently attracted considerable interest for hydrogel fabrication, with digital light processing (DLP) becoming a widespread representative technique. Whilst acknowledging that other types of vat photopolymerization 3DP have also been applied for this purpose, we here only focus on DLP and its derivatives. In this review, we first comprehensively outline the most recent advances in both materials and fabrication, including the adaptation of novel hydrogel systems and advances in processing (e.g. volumetric printing and multimaterial integration). Secondly, we summarize the applications of hydrogel DLP, including regenerative medicine, functional microdevices, and soft robotics. To the best of our knowledge, this is the first time that either of these specific review focuses has been adopted in the literature. More importantly, we discuss the major challenges associated with hydrogel DLP and provide our perspectives on future trends. To summarize, this review aims to aid and inspire other researchers investigatng DLP, photocurable hydrogels, and the research fields related to them.
MeSH term(s)	Drug Delivery Systems ; Hydrogels ; Polymers ; Printing, Three-Dimensional ; Water
Chemical Substances	Hydrogels ; Polymers ; Water (059QF0KO0R)
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ac6b04
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Article ; Online: Towards smart scanning probe lithography: a framework accelerating nano-fabrication process with in-situ characterization via machine learning.

Liu, Yijie / Li, Xuexuan / Pei, Ben / Ge, Lin / Xiong, Zhuo / Zhang, Zhen

Microsystems & nanoengineering

2023 Volume 9, Page(s) 128

Abstract: Scanning probe lithography (SPL) is a promising technology to fabricate high-resolution, customized and cost-effective features at the nanoscale. However, the quality of nano-fabrication, particularly the critical dimension, is significantly influenced ... ...

Abstract	Scanning probe lithography (SPL) is a promising technology to fabricate high-resolution, customized and cost-effective features at the nanoscale. However, the quality of nano-fabrication, particularly the critical dimension, is significantly influenced by various SPL fabrication techniques and their corresponding process parameters. Meanwhile, the identification and measurement of nano-fabrication features are very time-consuming and subjective. To tackle these challenges, we propose a novel framework for process parameter optimization and feature segmentation of SPL via machine learning (ML). Different from traditional SPL techniques that rely on manual labeling-based experimental methods, the proposed framework intelligently extracts reliable and global information for statistical analysis to fine-tune and optimize process parameters. Based on the proposed framework, we realized the processing of smaller critical dimensions through the optimization of process parameters, and performed direct-write nano-lithography on a large scale. Furthermore, data-driven feature extraction and analysis could potentially provide guidance for other characterization methods and fabrication quality optimization.
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ISSN	2055-7434
ISSN (online)	2055-7434
DOI	10.1038/s41378-023-00587-z
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Article ; Online: Two-dimensional heterostructures for photocatalytic CO

Zhao, Jiangting / Xiong, Zhuo / Zhao, Yongchun / Chen, Xiaobo / Zhang, Junying

Environmental research

2022 Volume 216, Issue Pt 3, Page(s) 114699

Abstract: The photocatalysis conversion of ... ...

Abstract	The photocatalysis conversion of CO
Language	English
Publishing date	2022-11-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.114699
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Article ; Online: Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.

Li, Ruyue / Xiong, Zhuo / Ma, Yuan / Li, Yongmei / Yang, Yu'e / Ma, Shaohan / Ha, Chunfang

World journal of surgical oncology

2024 Volume 22, Issue 1, Page(s) 81

Abstract: Background: This study aimed to develop a novel nomogram that can accurately estimate platinum resistance to enhance precision medicine in epithelial ovarian cancer(EOC).: Methods: EOC patients who received primary therapy at the General Hospital of ... ...

Abstract	Background: This study aimed to develop a novel nomogram that can accurately estimate platinum resistance to enhance precision medicine in epithelial ovarian cancer(EOC). Methods: EOC patients who received primary therapy at the General Hospital of Ningxia Medical University between January 31, 2019, and June 30, 2021 were included. The LASSO analysis was utilized to screen the variables which contained clinical features and platinum-resistance gene immunohistochemistry scores. A nomogram was created after the logistic regression analysis to develop the prediction model. The consistency index (C-index), calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) were used to assess the nomogram's performance. Results: The logistic regression analysis created a prediction model based on 11 factors filtered down by LASSO regression. As predictors, the immunohistochemical scores of CXLC1, CXCL2, IL6, ABCC1, LRP, BCL2, vascular tumor thrombus, ascites cancer cells, maximum tumor diameter, neoadjuvant chemotherapy, and HE4 were employed. The C-index of the nomogram was found to be 0.975. The nomogram's specificity is 95.35% and its sensitivity, with a cut-off value of 165.6, is 92.59%, as seen by the ROC curve. After the nomogram was externally validated in the test cohort, the coincidence rate was determined to be 84%, and the ROC curve indicated that the nomogram's AUC was 0.949. Conclusion: A nomogram containing clinical characteristics and platinum gene IHC scores was developed and validated to predict the risk of EOC platinum resistance.
MeSH term(s)	Female ; Humans ; Precision Medicine ; Carcinoma, Ovarian Epithelial/drug therapy ; Nomograms ; Platinum/therapeutic use ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics
Chemical Substances	Platinum (49DFR088MY)
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-024-03359-9
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Article ; Online: Electrical Stimulation Promotes the Vascularization and Functionalization of an Engineered Biomimetic Human Cardiac Tissue.

Lu, Bingchuan / Ye, Min / Xia, Jingjing / Zhang, Zhenrui / Xiong, Zhuo / Zhang, Ting

Advanced healthcare materials

2023 Volume 12, Issue 19, Page(s) e2300607

Abstract: The formation of multiscale vascular networks is essential for the in vitro construction of large-scale biomimetic cardiac tissues/organs. Although a variety of bioprinting processes have been developed to achieve the construction of mesoscale and large- ... ...

Abstract	The formation of multiscale vascular networks is essential for the in vitro construction of large-scale biomimetic cardiac tissues/organs. Although a variety of bioprinting processes have been developed to achieve the construction of mesoscale and large-scale blood vessels, the formation of microvascular networks still mainly depends on the self-assembly behavior of endothelial cells (ECs), which is inefficient and demanding without appropriate stimulus. To address this problem, the elongation and connection of endothelial cells in engineered cardiac tissue (ECT) are sought to promote by electrical stimulation (ES) to achieve vascularization. As proof of the concept, bio-inks are composed of GelMA/fibrin hydrogel, human pluripotent stem cells induced cardiomyocytes (iPSC-CM), and human umbilical vein endothelial cells (HUVEC) are used for the bioprinting of ECTs. It is demonstrated that electrical stimulation significantly promotes the elongation, migration, and interconnection of HUVECs in ECT and increases the expression of related genes. Moreover, ES also enhances the secretion of signal factors interacting between CMs and HUVECs. It seems that the HUVECs further strengthen the contractility of cardiac tissue. Taken together, electrical stimulation promotes vascularization and CMs functionalization in ECT, which has important application potential in the fabrication of vascularized ECT and its clinical transplantation.
MeSH term(s)	Humans ; Tissue Engineering ; Biomimetics ; Human Umbilical Vein Endothelial Cells/metabolism ; Myocytes, Cardiac ; Electric Stimulation ; Tissue Scaffolds
Language	English
Publishing date	2023-04-14
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202300607
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Article ; Online: Recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps: A review.

Fang, Yongcong / Sun, Wei / Zhang, Ting / Xiong, Zhuo

Biomaterials

2021 Volume 280, Page(s) 121298

Abstract	The field of cardiac tissue engineering has advanced over the past decades; however, most research progress has been limited to engineered cardiac tissues (ECTs) at the microscale with minimal geometrical complexities such as 3D strips and patches. Although microscale ECTs are advantageous for drug screening applications because of their high-throughput and standardization characteristics, they have limited translational applications in heart repair and the in vitro modeling of cardiac function and diseases. Recently, researchers have made various attempts to construct engineered cardiac pumps (ECPs) such as chambered ventricles, recapitulating the geometrical complexity of the native heart. The transition from microscale ECTs to ECPs at a translatable scale would greatly accelerate their translational applications; however, researchers are confronted with several major hurdles, including geometrical reconstruction, vascularization, and functional maturation. Therefore, the objective of this paper is to review the recent advances on bioengineering approaches for fabrication of functional engineered cardiac pumps. We first review the bioengineering approaches to fabricate ECPs, and then emphasize the unmatched potential of 3D bioprinting techniques. We highlight key advances in bioprinting strategies with high cell density as researchers have begun to realize the critical role that the cell density of non-proliferative cardiomyocytes plays in the cell-cell interaction and functional contracting performance. We summarize the current approaches to engineering vasculatures both at micro- and meso-scales, crucial for the survival of thick cardiac tissues and ECPs. We showcase a variety of strategies developed to enable the functional maturation of cardiac tissues, mimicking the in vivo environment during cardiac development. By highlighting state-of-the-art research, this review offers personal perspectives on future opportunities and trends that may bring us closer to the promise of functional ECPs.
MeSH term(s)	Bioengineering ; Bioprinting/methods ; Myocytes, Cardiac ; Printing, Three-Dimensional ; Tissue Engineering/methods
Language	English
Publishing date	2021-11-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2021.121298
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Article ; Online: Evaluation of the kinetics of direct aqueous mineral carbonation of wood combustion ash using modified shrinking core models

Miao, Endong / Du, Yi / Wang, Hongyue / Zheng, Xufan / Zhang, Xuguang / Xiong, Zhuo / Zhao, Yongchun / Zhang, Junying

Environ Sci Pollut Res. 2023 Mar., v. 30, no. 12 p.34009-34021

2023

Abstract: The direct aqueous mineral carbonation of wood combustion ash (WCA), which is a representative high-calcium waste from combustion process, was systematically investigated by varying complex operating conditions, including reaction time, liquid-to-solid ... ...

Abstract	The direct aqueous mineral carbonation of wood combustion ash (WCA), which is a representative high-calcium waste from combustion process, was systematically investigated by varying complex operating conditions, including reaction time, liquid-to-solid ratio (L/S), CO₂ concentration, and particle size. The WCA exhibited high CO₂ sequestration characteristics with an optimal carbonation efficiency of 76.4%, corresponding to a CO₂ sequestration capacity of 0.314 g CO₂/g WCA. In addition to solid carbonates, dry residues from liquid products with high potassium contents are potential feedstocks for quality potash fertilizer. Modified shrinking core models based on diffusion-controlled mechanism were proposed to evaluate the carbonation process. The theoretical framework assumes a contracting interface mechanism where active CaO reacts with CO₂ to form a product layer. The effective diffusion coefficient of CO₂ through the product layer decreases over time, giving deficient carbonation efficiency. The newly proposed models corresponding to different geometrical dimensions provided more perfect fit to the experimental data when compared with the most commonly used kinetic equations. The low apparent activation energy of the carbonation reaction demonstrated the diffusion-controlled mechanism. This work is useful for improving the economics and feasibility of bioenergy carbon capture and storage (CCS) technology chain.
Keywords	activation energy ; bioenergy ; calcium oxide ; carbon dioxide ; carbon sequestration ; carbonation ; combustion ; diffusivity ; economics ; feedstocks ; fertilizers ; liquids ; particle size ; potassium ; wastes ; wood
Language	English
Dates of publication	2023-03
Size	p. 34009-34021.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-24603-3
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Article ; Online: A Multifunctional 3D Bioprinting System for Construction of Complex Tissue Structure Scaffolds: Design and Application.

Xu, Yuanyuan / Wang, Chengjin / Yang, Yang / Liu, Hui / Xiong, Zhuo / Zhang, Ting / Sun, Wei

International journal of bioprinting

2022 Volume 8, Issue 4, Page(s) 617

Abstract: Three-dimensional (3D) bioprinting offers a potentially powerful new approach to reverse engineering human pathophysiology to address the problem of developing more biomimetic experimental systems. Human tissues and organs are multiscale and multi- ... ...

Abstract	Three-dimensional (3D) bioprinting offers a potentially powerful new approach to reverse engineering human pathophysiology to address the problem of developing more biomimetic experimental systems. Human tissues and organs are multiscale and multi-material structures. The greatest challenge for organ printing is the complexity of the structural elements, from the shape of the macroscopic structure to the details of the nanostructure. A highly bionic tissue-organ model requires the use of multiple printing processes. Some printers with multiple nozzles and multiple processes are currently reported. However, the bulk volume, which is inconvenient to move, and the high cost of these printing systems limits the expansion of their applications. Scientists urgently need a multifunctional miniaturized 3D bioprinter. In this study, a portable multifunctional 3D bioprinting system was built based on a modular design and a custom written operating application. Using this platform, constructs with detailed surface structures, hollow structures, and multiscale complex tissue analogs were successfully printed using commercial polymers and a series of hydrogel-based inks. With further development, this portable, modular, low-cost, and easy-to-use Bluetooth-enabled 3D printer promises exciting opportunities for resource-constrained application scenarios, not only in biomedical engineering but also in the education field, and may be used in space experiments.
Language	English
Publishing date	2022-09-19
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2834694-4
ISSN	2424-8002 ; 2424-8002
ISSN (online)	2424-8002
ISSN	2424-8002
DOI	10.18063/ijb.v8i4.617
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