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  1. AU="Xiong, Zhuo-Chao"
  2. AU="Mu, Dezhi"
  3. AU="Kaiser, Steffen"
  4. AU=Garlepp M J
  5. AU=Yang Zhenwei
  6. AU="Guillot, Loic"
  7. AU=Pocrnic Ivan
  8. AU="Rackova, Sylva"
  9. AU="Jordan Denizeau"
  10. AU="Alexandra J. Corbett"
  11. AU="Felderman, Howard E"
  12. AU="Chen, Fuxing"
  13. AU="Soekadar, Surjo R"
  14. AU="Pagotto, Sara"
  15. AU="Dominguez, Georgina Cutillas"
  16. AU=Barabutis Nektarios
  17. AU="Rumalla, Kavelin"
  18. AU=Meares Gordon P.
  19. AU="Gawron, Lori M"
  20. AU=Guettari Moez
  21. AU=Ma Xingcong
  22. AU="Greene, Kerrie" AU="Greene, Kerrie"
  23. AU="Adebayo, Abe"
  24. AU=Amoako Yaw Ampem
  25. AU="Khanna, Sakshum"

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  1. Artikel ; Online: Cardiovascular health metrics defined by Life's Essential 8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study.

    Huang, Ze-Gui / Gao, Jing-Wei / Zhang, Hai-Feng / You, Si / Xiong, Zhuo-Chao / Wu, Yu-Biao / Guo, Da-Chuan / Wang, Jing-Feng / Chen, Yang-Xin / Zhang, Shao-Ling / Liu, Pin-Ming

    Diabetes, obesity & metabolism

    2024  

    Abstract: Aim: To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D).: Materials and methods: This prospective study included 11 ... ...

    Abstract Aim: To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D).
    Materials and methods: This prospective study included 11 033 participants with T2D, all devoid of macrovascular diseases (including cardiovascular and peripheral artery disease) and microvascular complications (e.g. diabetic retinopathy, neuropathy and nephropathy) at baseline from the UK Biobank. The LE8 score comprised eight metrics: smoking, body mass index, physical activity, non-high-density lipoprotein cholesterol, blood pressure, glycated haemoglobin, diet and sleep duration. Cox proportional hazards models were established to assess the associations of LE8 scores with incident macrovascular and microvascular complications.
    Results: During a median follow-up of 12.1 years, we identified 1975 cases of incident macrovascular diseases and 1797 cases of incident microvascular complications. After adjusting for potential confounders, each 10-point increase in the LE8 score was associated with an 18% lower risk of macrovascular diseases and a 15% lower risk of microvascular complications. Comparing individuals in the highest and lowest quartiles of LE8 scores revealed hazard ratios of 0.55 (95% confidence interval 0.47-0.62) for incident macrovascular diseases, and 0.61 (95% confidence interval 0.53-0.70) for incident microvascular complications. This association remained robust across a series of sensitivity analyses and nearly all subgroups.
    Conclusion: Higher LE8 scores were associated with a lower risk of incident macrovascular and microvascular complications among individuals with T2D. These findings underscore the significance of adopting fundamental strategies to maintain optimal cardiovascular health and curtail the risk of developing diabetic vascular complications.
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15583
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Potential ferroptosis key genes in calcific aortic valve disease.

    Li, Xiong-Zhi / Xiong, Zhuo-Chao / Zhang, Shao-Ling / Hao, Qing-Yun / Gao, Ming / Wang, Jing-Feng / Gao, Jing-Wei / Liu, Pin-Ming

    Frontiers in cardiovascular medicine

    2022  Band 9, Seite(n) 916841

    Abstract: Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodeling, culminating in aortic stenosis, heart failure, and ultimately ... ...

    Abstract Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodeling, culminating in aortic stenosis, heart failure, and ultimately premature death. Ferroptosis has been hypothesized to contribute to the pathogenesis of CAVD. We aimed to study the association between ferroptosis genes and CAVD and reveal the potential roles of ferroptosis in CAVD. CAVD-related differentially expressed genes (DEGs) were identified
    Sprache Englisch
    Erscheinungsdatum 2022-08-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.916841
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Predictors of long-term absence of coronary artery calcium in individuals with high blood pressure: results from the MESA study.

    You, Si / Gao, Jing-Wei / Zhang, Hai-Feng / Xiong, Zhuo-Chao / Hao, Qing-Yun / Han, Jia-Jin / Wang, Jing-Feng / Zhang, Shao-Ling / Liu, Pin-Ming

    Annals of medicine

    2023  Band 55, Heft 1, Seite(n) 2209334

    Abstract: Background & aims: Individuals with high blood pressure (BP) have varying risks of cardiovascular events due to other coexisting factors. We aimed to identify the predictors of long-term absence of coronary artery calcium (CAC) in individuals with high ... ...

    Abstract Background & aims: Individuals with high blood pressure (BP) have varying risks of cardiovascular events due to other coexisting factors. We aimed to identify the predictors of long-term absence of coronary artery calcium (CAC) in individuals with high BP, which is an indicator of healthy arterial aging and can guide preventive strategies.
    Methods: We analyzed data from participants with high BP (≥120/80 mm Hg) in the Multi-Ethnic Study of Atherosclerosis who had baseline CAC = 0 and underwent a second CAC scanning after 10 years. We used multivariable logistic regression to evaluate the association between various risk factors for atherosclerotic cardiovascular disease (ASCVD) and long-term CAC = 0. We also calculated the area under the receiver operating characteristic curve (AUC) to predict the phenotype of healthy arterial aging in this population.
    Results: We included 830 participants (37.6% male, mean ± SD age of 59.4 ± 8.7 years). During follow-up, 46.5% of participants (
    Conclusion: In individuals with high BP and initial CAC = 0, over 40% maintained CAC = 0 during a 10-year follow-up, which was associated with fewer ASCVD risk factors. These findings may have implications for preventive strategies in individuals with high BP.
    Mesh-Begriff(e) Female ; Humans ; Male ; Atherosclerosis ; Calcium ; Cardiovascular Diseases/epidemiology ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Vessels/diagnostic imaging ; Hypertension/epidemiology ; Risk Assessment/methods ; Risk Factors ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2023-05-06
    Erscheinungsland England
    Dokumenttyp Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2209334
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.

    Li, Xiong-Zhi / Xiong, Zhuo-Chao / Zhang, Shao-Ling / Hao, Qing-Yun / Liu, Zhao-Yu / Zhang, Hai-Feng / Wang, Jing-Feng / Gao, Jing-Wei / Liu, Pin-Ming

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Band 43, Heft 9, Seite(n) 1684–1699

    Abstract: Background: Excess aldosterone is implicated in vascular calcification (VC), but the mechanism by which aldosterone-MR (mineralocorticoid receptor) complex promotes VC is unclear. Emerging evidence indicates that long-noncoding RNA H19 (H19) plays a ... ...

    Abstract Background: Excess aldosterone is implicated in vascular calcification (VC), but the mechanism by which aldosterone-MR (mineralocorticoid receptor) complex promotes VC is unclear. Emerging evidence indicates that long-noncoding RNA H19 (H19) plays a critical role in VC. We examined whether aldosterone-induced osteogenic differentiation of vascular smooth muscle cells (VSMCs) through H19 epigenetic modification of Runx2 (runt-related transcription factor-2) in a MR-dependent manner.
    Methods: We induced in vivo rat model of chronic kidney disease using a high adenine and phosphate diet to explore the relationship among aldosterone, MR, H19, and VC. We also cultured human aortic VSMCs to explore the roles of H19 in aldosterone-MR complex-induced osteogenic differentiation and calcification of VSMCs.
    Results: H19 and Runx2 were significantly increased in aldosterone-induced VSMC osteogenic differentiation and VC, both in vitro and in vivo, which were significantly blocked by the MR antagonist spironolactone. Mechanistically, our findings reveal that the aldosterone-activated MR bound to H19 promoter and increased its transcriptional activity, as determined by chromatin immunoprecipitation, electrophoretic mobility shift assay, and luciferase reporter assay. Silencing H19 increased microRNA-106a-5p (miR-106a-5p) expression, which subsequently inhibited aldosterone-induced Runx2 expression at the posttranscriptional level. Importantly, we observed a direct interaction between H19 and miR-106a-5p, and downregulation of miR-106a-5p efficiently reversed the suppression of Runx2 induced by H19 silencing.
    Conclusions: Our study clarifies a novel mechanism by which upregulation of H19 contributes to aldosterone-MR complex-promoted Runx2-dependent VSMC osteogenic differentiation and VC through sponging miR-106a-5p. These findings highlight a potential therapeutic target for aldosterone-induced VC.
    Mesh-Begriff(e) Humans ; Rats ; Animals ; MicroRNAs/metabolism ; Aldosterone/toxicity ; RNA, Long Noncoding/metabolism ; Osteogenesis ; Vascular Calcification/chemically induced ; Vascular Calcification/genetics ; Vascular Calcification/metabolism ; Myocytes, Smooth Muscle/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism
    Chemische Substanzen MicroRNAs ; Aldosterone (4964P6T9RB) ; RNA, Long Noncoding ; Runx2 protein, rat ; Core Binding Factor Alpha 1 Subunit
    Sprache Englisch
    Erscheinungsdatum 2023-07-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.319308
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Lung Function Decline in Young Adulthood and Coronary Artery Calcium Progression in Midlife.

    Gao, Jing-Wei / Han, Jia-Jin / Xiong, Zhuo-Chao / Hao, Qing-Yun / You, Si / Zhang, Hai-Feng / Wang, Jing-Feng / Zhang, Shao-Ling / Liu, Pin-Ming

    The American journal of medicine

    2023  Band 136, Heft 9, Seite(n) 910–917.e4

    Abstract: Background: Reduced lung function has been linked to cardiovascular disease, but population-based evidence on the relationship between lung function decline and coronary artery calcium (CAC) progression is rare.: Methods: A total of 2694 participants ...

    Abstract Background: Reduced lung function has been linked to cardiovascular disease, but population-based evidence on the relationship between lung function decline and coronary artery calcium (CAC) progression is rare.
    Methods: A total of 2694 participants (44.7% men) with a mean ± standard deviation age of 40.4 ± 3.6 years from the Coronary Artery Risk Development in Young Adults (CARDIA) were included. The rates of decline in forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) over a 20-year period were calculated for each participant and categorized into quartiles. The primary outcome was CAC progression.
    Results: During a mean follow-up of 8.9 years, 455 (16.9%) participants had CAC progression. After adjusting for traditional cardiovascular risk factors, the hazard ratios (95% confidence intervals [CIs]) for CAC progression were higher for participants in the 2nd (Q2), 3rd (Q3), and highest quartiles (Q4) of FVC decline compared with those in the lowest quartile (Q1): 1.366 (1.003-1.861), 1.412 (1.035-1.927), and 1.789 (1.318-2.428), respectively. Similar trends were observed for the association between FEV1 and CAC progression. The association remained robust across a series of sensitivity analyses and all subgroups.
    Conclusions: A faster decline in FVC or FEV1 during young adulthood is independently associated with an increased risk of CAC progression in midlife. Maintaining optimal lung function during young adulthood may improve future cardiovascular health.
    Mesh-Begriff(e) Male ; Young Adult ; Humans ; Adult ; Female ; Calcium ; Lung/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Vital Capacity ; Risk Factors ; Forced Expiratory Volume
    Chemische Substanzen Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2023-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.05.004
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