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Article ; Online: Does CSR performance improve corporate immunity to the COVID-19 pandemic? Evidence from China's stock market

Jing Tian / Xiuxiu Wang / Yanqiu Wei

Frontiers in Public Health, Vol

2022 Volume 10

Abstract: This paper studies the role of corporate social responsibility (CSR) performance on corporate financial performance during the COVID-19 by examining a sample of Chinese listed firms. Based on the PSM-DID methodology, we find that the pandemic-induced ... ...

Abstract	This paper studies the role of corporate social responsibility (CSR) performance on corporate financial performance during the COVID-19 by examining a sample of Chinese listed firms. Based on the PSM-DID methodology, we find that the pandemic-induced decline in stock returns is stronger with more CSR engagement. The results remain robust even after the dynamic effect test and placebo test. It means CSR performance does not improve Chinese corporate immunity to the pandemic. This inadequate response of CSR could be due to the “relatively few good things effect”. Furthermore, our study indicates that increasing awareness of responsible investment and improving the quality of CSR disclosure could facilitate CSR engagement in China.
Keywords	CSR ; corporate immunity ; stock return ; COVID-19 pandemic ; PSM-DID ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pan-cancer analyses reveal the immunotherapeutic value of klotho

Jinghao Liang / Xin Zhang / Xiuxiu Wang / Weiqiang Yin / Zhihua Guo

Heliyon, Vol 8, Iss 11, Pp e11510- (2022)

2022

Abstract: Klotho (KL) was initially thought to be a typical ''ageing suppressor'' gene, but recent studies have suggested that KL is involved in the progression of several types of human cancer. This study aims to analyse whether the expression level of KL could ... ...

Abstract	Klotho (KL) was initially thought to be a typical ''ageing suppressor'' gene, but recent studies have suggested that KL is involved in the progression of several types of human cancer. This study aims to analyse whether the expression level of KL could impact patient prognosis, clinical parameters, and tumour immunity in different tumour patients. KL activity was utilized to determine differences between the KL transcript and KL protein. Expression levels were detected by single-sample gene enrichment analysis (GSEA). To explore the inherent mechanisms of KL in tumour immunotherapy, we investigated the possible impact of KL on the tumour microenvironment, immune processes and immune components. GO and KEGG analysis showed that KL was significantly involved in immune response, Inflammation, and calcium signaling pathway. We also found that KL was significantly correlated with multiple immunotherapeutic biomarkers (TMB, MSI, CD274, PDCD1, CTLA4 and TIGIT) in a variety of tumours. Furthermore, increased KL expression was closely associated with the non-response of anti-PD-1 immunotherapy, indicating that KL might affect the response sensitivity of tumour patients to anti-PD-1 immunotherapy. This study will provide a basis for further research on how KL regulates tumour immune cells and may lead to the development of more effective target tumour immunotherapy.
Keywords	Klotho ; Pan-cancer ; Immune ; Immunotherapy ; Biomarkers ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	616
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Near‐Infrared Fluorogenic Probe for Rapid, Specific, and Ultrasensitive Detection of Sphingosine in Living Cells and In Vivo

Yanyan Chen / Tingting Hao / Jing Wang / Yiming Chen / Xiuxiu Wang / Wei Wei / Jing Zhao / Yong Qian

Advanced Science, Vol 11, Iss 2, Pp n/a-n/a (2024)

2024

Abstract: Abstract Sphingosine (Sph) plays important roles in various complex biological processes. Abnormalities in Sph metabolism can result in various diseases, including neurodegenerative disorders. However, due to the lack of rapid and accurate detection ... ...

Abstract	Abstract Sphingosine (Sph) plays important roles in various complex biological processes. Abnormalities in Sph metabolism can result in various diseases, including neurodegenerative disorders. However, due to the lack of rapid and accurate detection methods, understanding sph metabolic in related diseases is limited. Herein, a series of near‐infrared fluorogenic probes DMS‐X (X = 2F, F, Cl, Br, and I) are designed and synthesized. The fast oxazolidinone ring formation enables the DMS‐2F to detect Sph selectively and ultrasensitively, and the detection limit reaches 9.33 ± 0.41 nm. Moreover, it is demonstrated that DMS‐2F exhibited a dose‐ and time‐dependent response to Sph and can detect sph in living cells. Importantly, for the first time, the changes in Sph levels induced by Aβ42 oligomers and H2O2 are assessed through a fluorescent imaging approach, and further validated the physiological processes by which Aβ42 oligomers and reactive oxygen species (ROS)‐induce changes in intracellular Sph levels. Additionally, the distribution of Sph in living zebrafish is successfully mapped by in vivo imaging of a zebrafish model. This work provides a simple and efficient method for probing Sph in living cells and in vivo, which will facilitate investigation into the metabolic process of Sph and the connection between Sph and disease pathologies.
Keywords	endogenous sphingosine imaging ; fluorogenic probe ; low background interference ; rapid ; specific and ultrasensitive detection ; sphingosine detection ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ZnCDs/ZnO@ZIF-8 Zeolite Composites for the Photocatalytic Degradation of Tetracycline

Yong Cheng / Xiuxiu Wang / Yu Mei / Dan Wang / Changchun Ji

Catalysts, Vol 11, Iss 934, p

2021 Volume 934

Abstract: Considering the photocatalytic performance of CDs, ZnO, and the unique porous nanostructure and stability of ZIF-8, we prepared ZnCDs/ZnO@ZIF-8 zeolite composites. The resultant material represented an enhanced ability for the photodegradation of TC ... ...

Abstract	Considering the photocatalytic performance of CDs, ZnO, and the unique porous nanostructure and stability of ZIF-8, we prepared ZnCDs/ZnO@ZIF-8 zeolite composites. The resultant material represented an enhanced ability for the photodegradation of TC compared with that of ZnCDs and ZnO. The photocatalytic degradation efficiency reached over 85%. The catalytic activity of the composites was maintained after four cycles. The experimental result indicated that ⋅O 2 radical was the active species in the reaction.
Keywords	carbon dots ; zeolite composites ; photocatalytic ; tetracycline ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cyclin L1 controls cardiomyocyte proliferation and heart repair after injury

Rui Gong / Xinlu Gao / Yu Liu / Yifu Shen / Zuke Jiang / Xiuxiu Wang / Naufal Zagidullin / Wenya Ma / Ning Wang / Benzhi Cai

Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

2023 Volume 4

Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Programmable Complex Shape Changing of Polysiloxane Main-Chain Liquid Crystalline Elastomers

Yuhe Zhang / Xiuxiu Wang / Wenlong Yang / Huixuan Yan / Xinyu Zhang / Dongxu Han / Yifan He / Chensha Li / Liguo Sun

Molecules, Vol 28, Iss 4858, p

2023 Volume 4858

Abstract: Liquid crystal elastomers (LCEs) are shape-morphing materials whose large and reversible shape transformations are caused by the coupling between the mobile anisotropic properties of liquid crystal (LC) units and the rubber elastic of polymer networks. ... ...

Abstract	Liquid crystal elastomers (LCEs) are shape-morphing materials whose large and reversible shape transformations are caused by the coupling between the mobile anisotropic properties of liquid crystal (LC) units and the rubber elastic of polymer networks. Their shape-changing behaviors under certain stimuli are largely directed by the LC orientation; therefore, various strategies have been developed to spatially modulate the LC alignments. However, most of these methods are limited as they require complex fabrication technologies or have intrinsic limitations in applicability. To address this issue, programmable complex shape changes in some LCE types, such as polysiloxane side-chain LCEs, thiol-acrylate main-chain LCEs, etc., were achieved by using a mechanical alignment programming process coupled with two-step crosslinking. Here, we report a polysiloxane main-chain LCE with programmable 2- and 3D shape-changing abilities that were created by mechanically programming the polydomain LCE with two crosslinking steps. The resulting LCEs exhibited a reversible thermal-induced shape transformation between the initial and programmed shapes due to the two-way memory between the first and second network structures. Our findings expand on the applications of LCE materials in actuators, soft robotics, and smart structures where arbitrary and easily programmed shape morphing is needed.
Keywords	polysiloxane liquid crystalline elastomer ; programmable shape morphing ; two-way network memory ; mechanical programming process ; two-step crosslinking ; Organic chemistry ; QD241-441
Subject code	612
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Expansion of CRISPR Targeting Sites Using an Integrated Gene-Editing System in Apis mellifera

Liqiang Liang / Zhenghanqing Li / Qiufang Li / Xiuxiu Wang / Songkun Su / Hongyi Nie

Insects, Vol 12, Iss 954, p

2021 Volume 954

Abstract: CRISPR/Cas9, a predominant gene-editing tool, has been utilised to dissect the gene function in Apis mellifera . However, only the genomic region containing NGG PAM could be recognised and edited in A. mellifera , seriously hampering the application of ... ...

Abstract	CRISPR/Cas9, a predominant gene-editing tool, has been utilised to dissect the gene function in Apis mellifera . However, only the genomic region containing NGG PAM could be recognised and edited in A. mellifera , seriously hampering the application of CRISPR technology in honeybees. In this study, we carried out the bioinformatics analysis for genome-wide targeting sites of NGG, TTN, and NNGRRT to determine the potential expansion of the SpCas9, SaCas9, Cpf1, and it was found that the targetable spectrum of the CRISPR editing system could be markedly extended via the integrated gene manipulation system. Meanwhile, the single guide RNA (sgRNA)/crRNA of different novel gene editing systems and the corresponding CRISPR proteins were co-injected into honeybee embryos, and their feasibility was tested in A. mellifera . The sequencing data revealed that both SaCas9 and Cpf1 are capable of mediating mutation in A. mellifera , albeit with relatively lower mutagenesis rates for Cpf1 and unstable editing for SaCas9. To our knowledge, our results provide the first demonstration that SaCas9 and Cpf1 can function to induce genome sequence alternation, which extended the editing scope to the targets with TTN and NNGRRT and enabled CRISPR-based genome research in a broader range in A . mellifera .
Keywords	CRISPR/Cas9 ; gene editing ; Apis mellifera ; editing scope ; NGG ; Science ; Q
Subject code	572
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptional Profiles of Diploid Mutant Apis mellifera Embryos after Knockout of csd by CRISPR/Cas9

Xiuxiu Wang / Yan Lin / Liqiang Liang / Haiyang Geng / Meng Zhang / Hongyi Nie / Songkun Su

Insects, Vol 12, Iss 704, p

2021 Volume 704

Abstract: In honey bees, complementary sex determiner ( csd ) is the primary signal of sex determination. Its allelic composition is heterozygous in females, and hemizygous or homozygous in males. To explore the transcriptome differences after sex differentiation ... ...

Abstract	In honey bees, complementary sex determiner ( csd ) is the primary signal of sex determination. Its allelic composition is heterozygous in females, and hemizygous or homozygous in males. To explore the transcriptome differences after sex differentiation between males and females, with genetic differences excluded, csd in fertilized embryos was knocked out by CRISPR/Cas9. The diploid mutant males at 24 h, 48 h, 72 h, and 96 h after egg laying (AEL) and the mock-treated females derived from the same fertilized queen were investigated through RNA-seq. Mutations were detected in the target sequence in diploid mutants. The diploid mutant drones had typical male morphological characteristics and gonads. Transcriptome analysis showed that several female-biased genes, such as worker-enriched antennal ( Wat ), vitellogenin ( Vg ), and some venom-related genes, were down-regulated in the diploid mutant males. In contrast, some male-biased genes, such as takeout and apolipophorin-III-like protein ( A4 ), had higher expressions in the diploid mutant males. Weighted gene co-expression network analysis (WGCNA) indicated that there might be interactions between csd and fruitless ( fru ), feminizer ( fem ) and hexamerin 70c ( hex70c ), transformer-2 ( tra2 ) and troponin T ( TpnT ). The information provided by this study will benefit further research on the sex dimorphism and development of honey bees and other insects in Hymenoptera.
Keywords	Apis mellifera ; sex determination ; CRISPR/cas9 ; transcriptome ; Science ; Q
Subject code	590
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diversity, Composition, and Activities of Nano- and Pico-Eukaryotes in the Northern South China Sea With Influences of Kuroshio Intrusion

Feipeng Wang / Bangqin Huang / Yuyuan Xie / Shujie Cai / Xiuxiu Wang / Jingli Mu

Frontiers in Marine Science, Vol

2021 Volume 8

Abstract: Nano- and pico-eukaryotes play important roles in the diversity and functions of marine ecosystems. Warm, saline, and nutrient-depleted water that originates in the Kuroshio Current seasonally intrudes into the northern South China Sea (NSCS) from autumn ...

Abstract	Nano- and pico-eukaryotes play important roles in the diversity and functions of marine ecosystems. Warm, saline, and nutrient-depleted water that originates in the Kuroshio Current seasonally intrudes into the northern South China Sea (NSCS) from autumn to spring. To clarify the mechanisms in shaping the community structure of nano- and pico-eukaryotes as well as impacts of the Kuroshio intrusion on the NSCS ecosystem, genomic DNA and RNA were co-extracted from samples collected at two depths from nine stations, and then the V9 region of 18S rDNA and rRNA was sequenced with high-throughput sequencing. Our results showed that Dinophyceae was the most diverse and abundant nanoeukaryotic group during the study period revealed by both DNA and RNA surveys. In contrast, the relative read abundance of MAST, Pelagophyceae, and Dinophyceae in the size fraction of picoeukaryotes might be largely underestimated by the DNA survey. The RNA survey was the more reliable method to investigate the eukaryotic community structure. Environmental filtering played an important role in shaping the community structure, and the sampling depth became the governing factor of the beta diversity under the environmental setting of stratification during the study period. The spatial variations in the diversity of nanoeukaryotes were subject to the dispersal limitation under the size rule. The effects of the Kuroshio intrusion on the nanoeukaryotic community structure might also be explained by the dispersal limitation. Overall, neutral processes are critical in shaping the community structure of nanoeukaryotes. The relative metabolic activities of nanoeukaryotes were relatively stable in accordance with the high similarity of community structure between sampling sites. The responses of the relative metabolic activities of picoeukaryotes to environmental factors displayed two distinct patterns: positive correlations with salinity and nutrients and negative with temperature for Dinophyceae, MAST, and Pelagophyceae, while reversed patterns for ...
Keywords	nano- and pico-eukaryotes ; RNA/DNA comparison ; neutral process ; Kuroshio intrusion ; northern South China Sea ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	333
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation

Lin Cao / Yurong Wu / Xiuxiu Wang / Xiang Li / Zengqi Tan / Feng Guan

International Journal of Molecular Sciences, Vol 22, Iss 4, p

2021 Volume 1770

Abstract: Integrin β1 plays an essential role in the crosstalk between tumor cells and their microenvironment. Aberrant N-glycosylation of integrin β1 was documented to alter integrin β1 expression, dimerization, and biological function. However, the biological ... ...

Abstract	Integrin β1 plays an essential role in the crosstalk between tumor cells and their microenvironment. Aberrant N-glycosylation of integrin β1 was documented to alter integrin β1 expression, dimerization, and biological function. However, the biological function of site-specific N-glycosylation of integrin β1 on extracellular vesicles is not fully understood. In this study, we mutated putative N-glycosylation sites in different domains of integrin β1. Removal of the N-glycosylation sites on the I-like domain of integrin β1 (termed the Δ4–6 β1 mutant) suppressed focal adhesion kinase (FAK) signaling, cell migration, and adhesion compared with other β1 mutants. Cell adhesion, migration, and activation of FAK were suppressed in recipient MCF7 cells co-cultured with Δ4–6 mutant cells and treated with small extracellular vesicles (sEVs) from Δ4–6 mutant cells. Notably, the wild-type and β1 mutant were both present in sEVs, and could be transferred to recipient cells via sEVs, resulting in changes of cell behavior. Our findings demonstrate the important roles of N-glycosylation of the I-like domain of integrin β1. Moreover, the vesicular Δ4–6 β1 mutant can regulate integrin-mediated functions in recipient cells via sEVs.
Keywords	integrin β1 ; N-glycosylation ; sEVs ; FAK ; migration ; adhesion ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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