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  1. Article: [Drug resistance of

    Xu, C F / Xu, W

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2021  Volume 59, Issue 8, Page(s) 651–657

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Acinetobacter Infections/drug therapy ; Acinetobacter Infections/epidemiology ; Acinetobacter baumannii/genetics ; Anti-Bacterial Agents/pharmacology ; Child ; China/epidemiology ; Drug Resistance, Multiple, Bacterial/genetics ; Female ; Humans ; Infant ; Intensive Care Units, Pediatric ; Male ; Microbial Sensitivity Tests ; Retrospective Studies ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language Chinese
    Publishing date 2021-07-31
    Publishing country China
    Document type Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20210117-00053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3292: Show issues Location:
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  2. Article ; Online: Elevated venous lactate level as an early predictive marker of organ failure in acute pancreatitis: a retrospective study.

    Xu, S-X / Wang, N-Z / Yao, G-H / Ding, Y-B / Xu, C-F

    European review for medical and pharmacological sciences

    2024  Volume 28, Issue 6, Page(s) 2179–2185

    Abstract: Objective: The aim of this study was to elucidate the relationship between venous lactate levels and the severity of acute pancreatitis (AP).: Patients and methods: Retrospective data analysis was conducted on patients diagnosed with acute ... ...

    Abstract Objective: The aim of this study was to elucidate the relationship between venous lactate levels and the severity of acute pancreatitis (AP).
    Patients and methods: Retrospective data analysis was conducted on patients diagnosed with acute pancreatitis. The comparative assessment encompassed baseline characteristics, laboratory data, illness severity, local consequences, and organ failure instances. This comparison was performed between patients exhibiting normal serum lactic acid levels (HL) and those displaying elevated HL levels. The association between serum HL levels and other pertinent clinical markers was investigated using linear regression. Logistic regression analysis was employed to evaluate the utility of elevated serum lactate levels in identifying high-risk groups.
    Results: Significantly elevated serum HL levels were observed in patients with moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP) in contrast to those with mild acute pancreatitis (MAP) (p<0.01). Multivariate logistic analysis demonstrated that higher lactate levels independently predicted organ failure (95% CI 0.738-0.902, p<0.05). Receiver operating characteristic (ROC) curve analysis indicated that the lactate (LAC) cut-off value of 2.45 mmol/L yielded sensitivity and specificity values of 76.5% and 79.1%, respectively, for predicting AP-associated organ failure. The corresponding area under the curve (AUC) was 0.820.
    Conclusions: In AP patients, elevated serum HL levels signify disease severity and hold predictive potential for assessing the risk of organ failure.
    MeSH term(s) Humans ; Pancreatitis/diagnosis ; Retrospective Studies ; Acute Disease ; Prognosis ; Biomarkers ; ROC Curve ; Severity of Illness Index
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-04-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202403_35721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: [Characteristics of serum bile acids among healthy children in Zhejiang province].

    Liu, A N / Shen, H Q / Xu, C F / Jiang, L / Shao, J / Shu, Q / Fu, J F / Ni, Y

    Zhonghua er ke za zhi = Chinese journal of pediatrics

    2023  Volume 61, Issue 6, Page(s) 509–514

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Child ; Female ; Male ; Cross-Sectional Studies ; Bile Acids and Salts ; Hospitals, Pediatric ; Laboratories
    Chemical Substances Bile Acids and Salts
    Language Chinese
    Publishing date 2023-06-14
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 784523-6
    ISSN 0578-1310
    ISSN 0578-1310
    DOI 10.3760/cma.j.cn112140-20230127-00056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long noncoding RNA LINC00052 suppressed the proliferation, migration and invasion of glioma cells by upregulating KLF6.

    Xu, C-F / Liu, P / Tan, J / Hu, D-F

    European review for medical and pharmacological sciences

    2019  Volume 23, Issue 11, Page(s) 4822–4827

    Abstract: Objective: Recent studies have discovered a class of dysregulated long noncoding RNAs (lncRNAs) related to carcinogenesis. This study aims to uncover the molecular functions of lncRNA LINC00052 in the tumorigenesis of glioma.: Patients and methods: ... ...

    Abstract Objective: Recent studies have discovered a class of dysregulated long noncoding RNAs (lncRNAs) related to carcinogenesis. This study aims to uncover the molecular functions of lncRNA LINC00052 in the tumorigenesis of glioma.
    Patients and methods: Quantitative Real-time polymerase chain reaction (qRT-PCR) was performed to detect LINC00052 expression in 40 glioma samples and 4 glioma cell lines. Besides, regulatory effects of LINC00052 on the in vitro behaviors of glioma cells were evaluated by the proliferation assay, transwell assay and wound healing assay. Furthermore, the interaction between LINC00052 and kruppel-like factor 6 (KLF6) in mediating the progression of glioma was studied by performing qRT-PCR and Western blot.
    Results: LINC00052 expression was remarkably downregulated in glioma samples compared with that in adjacent samples. Moreover, cell proliferation, invasion, and migration of glioma were inhibited after overexpression of LINC00052 in vitro. Besides, LINC00052 overexpression upregulated mRNA and protein level of KLF6. Besides, the expression of KLF6 in tumor tissues was positively correlated to the expression of LINC00052.
    Conclusions: These results suggested that LINC00052 could repress cell migration, invasion and proliferation in glioma through upregulating KLF6, which may offer a new therapeutic intervention for glioma patients.
    MeSH term(s) Cell Movement ; Cell Proliferation ; Gene Expression Profiling ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; Kruppel-Like Factor 6/genetics ; Kruppel-Like Factor 6/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Tumor Cells, Cultured ; Up-Regulation
    Chemical Substances KLF6 protein, human ; Kruppel-Like Factor 6 ; RNA, Long Noncoding ; RNA, Messenger
    Language English
    Publishing date 2019-06-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201906_18068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1887: Show issues Location:
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  5. Article: [Determination of the block range of ultrasound-guided lumbar erector spinal plane and its application in lumbar spine surgery].

    Chen, L Q / Xu, C F / Zhai, Z X / Hong, A M / Nan, Y / Liu, R H / Zhu, L J / Li, J

    Zhonghua yi xue za zhi

    2021  Volume 101, Issue 37, Page(s) 2993–2998

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Lumbosacral Region ; Nerve Block ; Pain, Postoperative ; Ultrasonography ; Ultrasonography, Interventional
    Language Chinese
    Publishing date 2021-10-12
    Publishing country China
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20210220-00444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2011: Show issues Location:
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  6. Article: [Association between serum apolipoprotein B level and nonalcoholic fatty liver disease].

    Liu, X / Xu, C F / Xu, L / Miao, M / Cao, Q F / Yu, C H / Li, Y M

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2017  Volume 25, Issue 1, Page(s) 44–46

    Language Chinese
    Publishing date 2017-01-20
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2017.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [The frequencies of sister chromatid exchanges and chromosomal aberrations in the peripheral lymphocytes in patients with cervical carcinoma].

    Xu, C F

    Zhonghua fu chan ke za zhi

    1993  Volume 28, Issue 8, Page(s) 496–7, 508

    Abstract: The study of the SCE frequencies and chromosome aberrations in 20 patients with cervical carcinoma and 20 cases of healthy women was carried out. The result showed that the SCE frequencies were as high as 9.28 +/- 0.34/cell in the patients with cervical ... ...

    Abstract The study of the SCE frequencies and chromosome aberrations in 20 patients with cervical carcinoma and 20 cases of healthy women was carried out. The result showed that the SCE frequencies were as high as 9.28 +/- 0.34/cell in the patients with cervical cancer. They were significantly higher than those of the normal control group (P < 0.001). The chromosomal numerical changes and structural aberrations of the patients were much more than those of the normal women (P < 0.01). The important structural aberrations included ring chromosome, chromosomal restituation and breakage. Genetic instability and DNA repair level significantly suppressed in cancer patients were detected.
    MeSH term(s) Adult ; Aged ; Carcinoma, Squamous Cell/genetics ; Chromosome Aberrations ; DNA Repair ; Female ; Humans ; Lymphocytes/ultrastructure ; Middle Aged ; Ring Chromosomes ; Sister Chromatid Exchange ; Uterine Cervical Neoplasms/genetics
    Language Chinese
    Publishing date 1993-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604570-4
    ISSN 0529-567X
    ISSN 0529-567X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1619: Show issues Location:
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    Zs.MO 324: Show issues

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  8. Article ; Online: Hyperbilirubinemia in pazopanib- or sunitinib-treated patients in COMPARZ is associated with UGT1A1 polymorphisms.

    Motzer, R J / Johnson, T / Choueiri, T K / Deen, K C / Xue, Z / Pandite, L N / Carpenter, C / Xu, C F

    Annals of oncology : official journal of the European Society for Medical Oncology

    2013  Volume 24, Issue 11, Page(s) 2927–2928

    MeSH term(s) Bilirubin/isolation & purification ; Bilirubin/metabolism ; Biomarkers, Pharmacological ; Genetic Association Studies ; Genotype ; Gilbert Disease/chemically induced ; Gilbert Disease/genetics ; Gilbert Disease/pathology ; Glucuronosyltransferase/genetics ; Humans ; Hyperbilirubinemia/drug therapy ; Hyperbilirubinemia/genetics ; Hyperbilirubinemia/pathology ; Indoles/administration & dosage ; Indoles/adverse effects ; Liver/drug effects ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Pyrroles/administration & dosage ; Pyrroles/adverse effects ; Randomized Controlled Trials as Topic ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sunitinib
    Chemical Substances Biomarkers, Pharmacological ; Indoles ; Pyrimidines ; Pyrroles ; Sulfonamides ; pazopanib (7RN5DR86CK) ; UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17) ; Bilirubin (RFM9X3LJ49) ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2013-10-09
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdt394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  9. Article: The rapid establishment and implications of a melamine-induced standardized bladder stone model in mice

    Xu, C.-F. / Gao, X.-L. / Du, Y.-X. / Ren, S.-T.

    Food and chemical toxicology

    2011  Volume 49, Issue 12, Page(s) 3013–3017

    Language English
    Document type Article
    ZDB-ID 782617-5
    ISSN 0278-6915
    Database Current Contents Nutrition, Environment, Agriculture

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    Z 4035: Show issues

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  10. Article: Mutations of the BRCA1 gene in human cancer.

    Xu, C F / Solomon, E

    Seminars in cancer biology

    1996  Volume 7, Issue 1, Page(s) 33–40

    Abstract: BRCA1 is a putative tumour suppressor gene located on chromosome 17q21. It spans 100kb of genomic DNA and encodes a protein of 200kD consisting of 1863 amino acids. Sixty-three distinct germline mutations of BRCA1 have now been identified in more than ... ...

    Abstract BRCA1 is a putative tumour suppressor gene located on chromosome 17q21. It spans 100kb of genomic DNA and encodes a protein of 200kD consisting of 1863 amino acids. Sixty-three distinct germline mutations of BRCA1 have now been identified in more than 100 patients with breast and/or ovarian cancer. These mutations are distributed across the entire coding region of the BRCA1 gene, and the majority (87%) are predicted to result in truncated proteins or loss of a BRCA1 transcript. No somatic mutations of the BRCA1 gene have been identified in sporadic breast cancers, though five mutations have been found in sporadic ovarian tumours. This suggests that mutations in the BRCA1 gene may play a significant role in the tumorigenesis of familial breast cancer but not of sporadic breast cancer.
    MeSH term(s) BRCA1 Protein ; Base Sequence ; Breast Neoplasms/genetics ; Female ; Genes, Tumor Suppressor ; Humans ; Molecular Sequence Data ; Mutation ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/genetics ; Transcription Factors/genetics
    Chemical Substances BRCA1 Protein ; Neoplasm Proteins ; Transcription Factors
    Language English
    Publishing date 1996-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1006/scbi.1996.0005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2922: Show issues Location:
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