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  1. Book ; Thesis: Role of the calcium/calmodulin-dependent protein kinase II splicing variant Delta-A in cardiac remodeling

    Xu, Chang

    2014  

    Author's details vorgelegt von Chang Xu
    Language English
    Size 70 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2014
    HBZ-ID HT018546983
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 340 order for loan Magazin

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  2. Article: O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells.

    Zhou, Xu-Chang / Ni, Guo-Xin

    World journal of stem cells

    2024  Volume 16, Issue 3, Page(s) 228–231

    Abstract: Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, ... ...

    Abstract Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated, the potential mechanisms of O-GlcNAcylation in bone metabolism, particularly, in the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs) remains unexplored. In this study, the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed, assuming that it could trigger more scholars to focus on research related to O-GlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v16.i3.228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Noise characteristics and seasonal variations of IGS site coordinate time series

    XU Chang

    Acta Geodaetica et Cartographica Sinica, Vol 48, Iss 4, Pp 535-

    2019  Volume 535

    Keywords Mathematical geography. Cartography ; GA1-1776
    Language Chinese
    Publishing date 2019-05-01T00:00:00Z
    Publisher Surveying and Mapping Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Innovative Approaches and Advances for Hair Follicle Regeneration.

    Zheng, Wei / Xu, Chang-Hua

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 5, Page(s) 2251–2276

    Abstract: Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of mechanisms in tissue engineering, the proliferation of HFs in vitro has achieved more ... ...

    Abstract Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors have posed an urgent requirement for HF regeneration. With the revelation of mechanisms in tissue engineering, the proliferation of HFs in vitro has achieved more promising trust for the treatments of alopecia and other skin impairments. Theoretically, HF organoids have great potential to develop into native HFs and attachments such as sweat glands after transplantation. However, since the rich extracellular matrix (ECM) deficiency, the induction characteristics of skin-derived cells gradually fade away along with their trichogenic capacity after continuous cell passaging in vitro. Therefore, ECM-mimicking support is an essential prelude before HF transplantation is implemented. This review summarizes the status of providing various epidermal and dermal cells with a three-dimensional (3D) scaffold to support the cell homeostasis and better mimic in vivo environments for the sake of HF regeneration. HF-relevant cells including dermal papilla cells (DPCs), hair follicle stem cells (HFSCs), and mesenchymal stem cells (MSCs) are able to be induced to form HF organoids in the vitro culture system. The niche microenvironment simulated by different forms of biomaterial scaffold can offer the cells a network of ordered growth environment to alleviate inductivity loss and promote the expression of functional proteins. The scaffolds often play the role of ECM substrates and bring about epithelial-mesenchymal interaction (EMI) through coculture to ensure the functional preservation of HF cells during in vitro passage. Functional HF organoids can be formed either before or after transplantation into the dermis layer. Here, we review and emphasize the importance of 3D culture in HF regeneration in vitro. Finally, the latest progress in treatment trials and critical analysis of the properties and benefits of different emerging biomaterials for HF regeneration along with the main challenges and prospects of HF regenerative approaches are discussed.
    MeSH term(s) Humans ; Hair Follicle/pathology ; Dermis/metabolism ; Dermis/pathology ; Regeneration ; Alopecia/metabolism ; Alopecia/pathology ; Alopecia/therapy ; Tissue Engineering
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c00028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Skeleton-Based Human Motion Prediction With Privileged Supervision.

    Dong, Minjing / Xu, Chang

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 12, Page(s) 10419–10432

    Abstract: Existing supervised methods have achieved impressive performance in forecasting skeleton-based human motion. However, they often rely on action class labels in both training and inference phases. In practice, it could be a burden to request action class ... ...

    Abstract Existing supervised methods have achieved impressive performance in forecasting skeleton-based human motion. However, they often rely on action class labels in both training and inference phases. In practice, it could be a burden to request action class labels in the inference phase, and even for the training phase, the collected labels could be incomplete for sequences with a mixture of multiple actions. In this article, we take action class labels as a kind of privileged supervision that only exists in the training phase. We design a new architecture that includes a motion classification as an auxiliary task with motion prediction. To deal with potential missing labels of motion sequence, we propose a new classification loss function to exploit their relationships with those observed labels and a perceptual loss to measure the difference between ground truth sequence and generated sequence in the classification task. Experimental results on the most challenging Human 3.6M dataset and the Carnegie Mellon University (CMU) dataset demonstrate the effectiveness of the proposed algorithm to exploit action class labels for improved modeling of human dynamics.
    MeSH term(s) Humans ; Neural Networks, Computer ; Skeleton ; Algorithms
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3166861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ordinal skills influence the transition in number line strategies for children in Grades 1 and 2.

    Xu, Chang

    Journal of experimental child psychology

    2019  Volume 185, Page(s) 109–127

    Abstract: How do children place numbers on a line where only the endpoints are marked? Previous researchers have shown that the differential estimation patterns on the number line task reflect different strategies used by children. What factors influence their ... ...

    Abstract How do children place numbers on a line where only the endpoints are marked? Previous researchers have shown that the differential estimation patterns on the number line task reflect different strategies used by children. What factors influence their transition from less efficient to more efficient strategies? Children in Grade 1 (n = 66) and Grade 2 (n = 80) completed a 0-100 number line task at two time points of the school year. Their ordinal skills (i.e., number ordering) and spatial skills (i.e., mental rotation) were also measured. A latent transition analysis revealed two types of profiles. Children showing a variable profile were more accurate at estimating the numbers that are close to the endpoints and the middle of the line than other numbers, and their performance did not fit any of the linear, exponential, or logarithmic functions. In contrast, children showing a uniform profile were accurate across all target numbers (i.e., linear performance). Children's verbal strategy reports provided support for the latent profile classification; children showing a uniform profile were more likely to use relational strategies, suggesting they were considering the number line as a whole, whereas children showing a variable profile were more likely to count from one of the three common reference points (i.e., endpoints or the imagined midpoint). Transition between the variable and uniform profiles was predicted by children's ordinal skills, suggesting that children need to understand the ordinal associations among numbers to refine their solution strategies on the number line task.
    MeSH term(s) Aptitude/physiology ; Child ; Comprehension/physiology ; Female ; Humans ; Male ; Mathematics ; Psychological Tests
    Language English
    Publishing date 2019-05-24
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 218137-x
    ISSN 1096-0457 ; 0022-0965
    ISSN (online) 1096-0457
    ISSN 0022-0965
    DOI 10.1016/j.jecp.2019.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 670: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Clear cell renal cell carcinoma with small intestine invasion mimicking intestinal tumor.

    Yu, Mengmeng / Li, Jun / Xu, Chang

    Revista espanola de enfermedades digestivas

    2024  

    Abstract: A 65-year-old man presented with asymptomatic retroperitoneal mass that had been detected on ultrasonography performed during a physical screening. He had no hematochezia, hematuria or any other symptoms. Tumor markers were normal, including alpha ... ...

    Abstract A 65-year-old man presented with asymptomatic retroperitoneal mass that had been detected on ultrasonography performed during a physical screening. He had no hematochezia, hematuria or any other symptoms. Tumor markers were normal, including alpha fetoprotein, carcinoembryonic antigen, neuron-specific enolase and cancer antigen 199. Abdominal CT demonstrated a retroperitoneal mass (white arrow) accompanied by significant thickening of the jejunal wall, involving the left kidney. After enhancement, the mass showed rapid enhancement at arterial phase and venous phase, showed washout at delayed phase. Multi-planar reformation revealed the mass involving the pancreatic tail and the left renal pelvis. Surgical resection was performed and pathological examination confirmed clear cell renal cell carcinoma involving pancreas and jejunum, with immunohistochemical results as follows: CK (partly +), Vimentin (partly +), Pax-8 (+), CD10 (+), P505s (partly +), CA-IX (+), TFE-3 (-), Syn (-), CgA (-), CD56 (+), S-100 (-), SOX-10 (-), HMB-45 (-), Desmin (-),CD117 (-), DOG-1 (-), Melan-A (-), SMA (-), CD34 (+), CD31 (+), CD68 (+), Ki67 (5%+). Discussion.
    Language English
    Publishing date 2024-01-23
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2024.10226/2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 199: Show issues Location:
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  8. Article ; Online: Multi-tailed vision transformer for efficient inference.

    Wang, Yunke / Du, Bo / Wang, Wenyuan / Xu, Chang

    Neural networks : the official journal of the International Neural Network Society

    2024  Volume 174, Page(s) 106235

    Abstract: Recently, Vision Transformer (ViT) has achieved promising performance in image recognition and gradually serves as a powerful backbone in various vision tasks. To satisfy the sequential input of Transformer, the tail of ViT first splits each image into a ...

    Abstract Recently, Vision Transformer (ViT) has achieved promising performance in image recognition and gradually serves as a powerful backbone in various vision tasks. To satisfy the sequential input of Transformer, the tail of ViT first splits each image into a sequence of visual tokens with a fixed length. Then, the following self-attention layers construct the global relationship between tokens to produce useful representation for the downstream tasks. Empirically, representing the image with more tokens leads to better performance, yet the quadratic computational complexity of self-attention layer to the number of tokens could seriously influence the efficiency of ViT's inference. For computational reduction, a few pruning methods progressively prune uninformative tokens in the Transformer encoder, while leaving the number of tokens before the Transformer untouched. In fact, fewer tokens as the input for the Transformer encoder can directly reduce the following computational cost. In this spirit, we propose a Multi-Tailed Vision Transformer (MT-ViT) in the paper. MT-ViT adopts multiple tails to produce visual sequences of different lengths for the following Transformer encoder. A tail predictor is introduced to decide which tail is the most efficient for the image to produce accurate prediction. Both modules are optimized in an end-to-end fashion, with the Gumbel-Softmax trick. Experiments on ImageNet-1K demonstrate that MT-ViT can achieve a significant reduction on FLOPs with no degradation of the accuracy and outperform compared methods in both accuracy and FLOPs.
    MeSH term(s) Recognition, Psychology
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2024.106235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Superatomic Aromaticity in Cyclic Superatomic Molecules: Ligand-Protected Penta-Icosahedral [M@Au

    Gao, Jiahao / Zhou, Yichun / Xu, Chang / Cheng, Longjiu

    The journal of physical chemistry. A

    2024  Volume 128, Issue 15, Page(s) 2982–2988

    Abstract: Pure or doped gold icosahedra, which can be generally viewed as superatoms, are promising candidates for cluster-assembled structures. As the first large-scale ring-like gold cluster, the report of [ ... ...

    Abstract Pure or doped gold icosahedra, which can be generally viewed as superatoms, are promising candidates for cluster-assembled structures. As the first large-scale ring-like gold cluster, the report of [Au
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.4c00229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MTKSVCR: A novel multi-task multi-class support vector machine with safe acceleration rule.

    Pang, Xinying / Xu, Chang / Xu, Yitian

    Neural networks : the official journal of the International Neural Network Society

    2024  Volume 175, Page(s) 106317

    Abstract: Regularized multi-task learning (RMTL) has shown good performance in tackling multi-task binary problems. Although RMTL can be used to handle multi-class problems based on "one-versus-one" and "one-versus-rest" techniques, the information of the samples ... ...

    Abstract Regularized multi-task learning (RMTL) has shown good performance in tackling multi-task binary problems. Although RMTL can be used to handle multi-class problems based on "one-versus-one" and "one-versus-rest" techniques, the information of the samples is not fully utilized and the class imbalance problem occurs. Motivated by the regularization technique in RMTL, we propose an original multi-task multi-class model termed MTKSVCR based on "one-versus-one-versus-rest" strategy to achieve better testing accuracy. Due to the utilization of the idea of RMTL, the related information included in multiple tasks is mined by setting different penalty parameters before task-common and task-specific regularization terms. However, the proposed MTKSVCR is time-consuming since it employs all samples in each optimization problem. Therefore, a multi-parameter safe acceleration rule termed SA is further presented to reduce the time consumption. It identifies and deletes most of the superfluous samples corresponding to 0 elements in the dual optimal solution before solving. Then, only a reduced dual problem is to be solved and the computational efficiency is improved accordingly. The biggest advantage of the proposed SA lies in safety. Namely, it derives an identical optimal solution to the primal problem without SA. In addition, our method remains effective when multiple parameters change simultaneously. Experiments on different artificial datasets and benchmark datasets verify the validity of the proposed methods.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2024.106317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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