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Article ; Online: A software and hardware design scheme of intelligent valve positioner

Xu Haiming / Zhang Lanzhu

E3S Web of Conferences, Vol 268, p

2021 Volume 01067

Abstract: Valve positioner is the core component of the pneumatic control valve. A new software and hardware design scheme of intelligent valve positioner is presented in this paper. The circuit composition of each part of the intelligent valve positioner is ... ...

Abstract	Valve positioner is the core component of the pneumatic control valve. A new software and hardware design scheme of intelligent valve positioner is presented in this paper. The circuit composition of each part of the intelligent valve positioner is introduced in hardware part. Based on it, a hardware solution to realize HART ‘multi-point’ communication is proposed in this research. In the software design, a novel combined PID control algorithm is proposed to solve the nonlinear problem caused by the friction between the valve stem and the packing during the control process. Simulation results show that the method proposed in this paper is better than traditional PID method and fuzzy PID method. The software and hardware design scheme of the valve positioner proposed in this paper has certain guiding significance for the development of related products.
Keywords	valve positioner ; pneumatic control valve ; combined pid ; hart ; nonlinear control ; Environmental sciences ; GE1-350
Subject code	621
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined application of multiple biomarkers for early auxiliary diagnosis of silicosis.

Liu, Keliang / Sun, Linqing / Li, Sirui / Xu, Haiming

Toxicology and industrial health

2023 Volume 39, Issue 3, Page(s) 138–145

Abstract: Silicosis is an important industrial health problem for those workers exposed to silica. The present study aimed to investigate the sensitivity and specificity of combined detection of biomarkers in early auxiliary diagnosis of silicosis, the risk ... ...

Abstract	Silicosis is an important industrial health problem for those workers exposed to silica. The present study aimed to investigate the sensitivity and specificity of combined detection of biomarkers in early auxiliary diagnosis of silicosis, the risk factors of silicosis were also studied. The study sample comprised 65 workers who had clinical silicosis and 70 matched control subjects who were exposed to silica but did not have clinical silicosis. The levels of superoxide dismutase, malondialdehyde, interleukin 6 (IL-6), tumor necrosis factor-alpha, and cholinesterases in the serum of 135 subjects were measured. After completing the biochemical assays, a logistic regression model based on the above biochemical determination results was established, and the receiver operating characteristic curve was used for judging the discrimination ability of different statistical indexes. The expression levels of MDA, IL-6, and TNF-alpha in serum samples of patients with stage I silicosis and MDA and IL-6 in serum samples of patients with stage II silicosis were all significantly higher. Results from logistic regression analysis showed that ChEs were protective factors for silicosis, while age, chronic respiratory symptoms, IL-6, and MDA were risk factors. The areas under the ROC curve (AUC) were 0.86 (IL-6), 0.81 (MDA), and 0.65 (TNF-alpha or ChEs). AUC-ROC = 0.90 (95%CI:0.84-0.95). The diagnostic efficiency of IL-6 combined with MDA and TNF-alpha was better than that of any single biomarker.
MeSH term(s)	Humans ; Tumor Necrosis Factor-alpha/metabolism ; Interleukin-6 ; Silicosis/diagnosis ; Silicon Dioxide ; Biomarkers
Chemical Substances	Tumor Necrosis Factor-alpha ; Interleukin-6 ; 2-(N-cyclohexylamino)ethanesulfonic acid (103-47-9) ; Silicon Dioxide (7631-86-9) ; Biomarkers
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/07482337231154636
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Article ; Online: Evaluation and future projections of wind energy resources over the Northern Hemisphere in CMIP5 and CMIP6 models

Miao, Haozeyu / Xu, Haiming / Huang, Gang / Yang, Kai

Renewable Energy. 2023 July, v. 211 p.809-821

2023

Abstract: Understanding how the wind energy resources will change in a future climate under different greenhouse gas (GHG) emission scenarios is critical for global energy safety and economy. In this study, we evaluate the simulated wind speed over the Northern ... ...

Abstract	Understanding how the wind energy resources will change in a future climate under different greenhouse gas (GHG) emission scenarios is critical for global energy safety and economy. In this study, we evaluate the simulated wind speed over the Northern Hemisphere in global climate models that participate in the Coupled Model Intercomparison Project Phase 5 (CMIP5) and Phase 6 (CMIP6) using observation, and further show the future change of wind speed and wind energy in the Northern Hemisphere under four different GHG emission scenarios using superior models. We find that the CMIP6 models are generally better in simulating surface wind speeds over the Northern Hemisphere than CMIP5 models, in terms of spatial pattern and long-term trend. For future projection of wind speed at the end of the 21st century, models generally show a continued decreasing trend, except in SSP3-7.0 scenario. The change in wind energy and emissions are non-linearly related in different regions, as wind speed exhibits the fastest drop over Europe and Asia while shows the flattest trend over North America under SSP3-7.0. Our results suggest that higher emission scenario will undermine the magnitude of the wind energy resources and more importantly, reshape its spatial distribution over the Northern Hemisphere.
Keywords	climate ; energy ; greenhouse gas emissions ; greenhouse gases ; models ; wind power ; wind speed ; Asia ; Europe ; North America ; Wind energy resource ; Greenhouse warming ; The Northern Hemisphere ; Climate model
Language	English
Dates of publication	2023-07
Size	p. 809-821.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2023.05.007
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Article ; Online: Comparative and functional analysis unveils the contribution of photoperiod to DNA methylation, sRNA accumulation, and gene expression variations in short-day and long-day grasses.

Wu, Xia / Chen, Siyi / Lin, Feng / Muhammad, Fahad / Xu, Haiming / Wu, Liang

The Plant journal : for cell and molecular biology

2024

Abstract: Photoperiod employs complicated networks to regulate various developmental processes in plants, including flowering transition. However, the specific mechanisms by which photoperiod affects epigenetic modifications and gene expression variations in ... ...

Abstract	Photoperiod employs complicated networks to regulate various developmental processes in plants, including flowering transition. However, the specific mechanisms by which photoperiod affects epigenetic modifications and gene expression variations in plants remain elusive. In this study, we conducted a comprehensive analysis of DNA methylation, small RNA (sRNA) accumulation, and gene expressions under different daylengths in facultative long-day (LD) grass Brachypodium distachyon and short-day (SD) grass rice. Our results showed that while overall DNA methylation levels were minimally affected by different photoperiods, CHH methylation levels were repressed under their favorable light conditions, particularly in rice. We identified numerous differentially methylated regions (DMRs) that were influenced by photoperiod in both plant species. Apart from differential sRNA clusters, we observed alterations in the expression of key components of the RNA-directed DNA methylation pathway, DNA methyltransferases, and demethylases, which may contribute to the identified photoperiod-influenced CHH DMRs. Furthermore, we identified many differentially expressed genes in response to different daylengths, some of which were associated with the DMRs. Notably, we discovered a photoperiod-responsive gene MYB11 in the transcriptome of B. distachyon, and further demonstrated its role as a flowering inhibitor by repressing FT1 transcription. Together, our comparative and functional analysis sheds light on the effects of daylength on DNA methylation, sRNA accumulation, and gene expression variations in LD and SD plants, thereby facilitating better designing breeding programs aimed at developing high-yield crops that can adapt to local growing seasons.
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16721
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Article ; Online: Unique regulatory roles of ncRNAs changed by PM

He, Bo / Xu, Hai-Ming / Liu, Hao-Wen / Zhang, Yin-Feng

Ecotoxicology and environmental safety

2023 Volume 255, Page(s) 114812

Abstract: ... ...

Abstract	PM
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Circular/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Inflammation ; Biomarkers ; Particulate Matter/toxicity
Chemical Substances	RNA, Long Noncoding ; RNA, Circular ; MicroRNAs ; Biomarkers ; Particulate Matter
Language	English
Publishing date	2023-03-22
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114812
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Article: Eye-Tracking in Interpreting Studies: A Review of Four Decades of Empirical Studies.

Hu, Ting / Wang, Xinyu / Xu, Haiming

Frontiers in psychology

2022 Volume 13, Page(s) 872247

Abstract: It has been four decades since eye-tracking was first used in interpreting studies, and recent years has witnessed a growing interest in the application of this method, which holds great potential for offering a look into the "black box" of interpreting ... ...

Abstract	It has been four decades since eye-tracking was first used in interpreting studies, and recent years has witnessed a growing interest in the application of this method, which holds great potential for offering a look into the "black box" of interpreting processing. However, little attention has been paid to comprehensively illustrating what has been done, what can be done, and what needs to be done with this method in this discipline. With this in view, this paper sets out to understand contributions of previous studies-key themes discussed, eye-tracking measures used, their limitations and implications, and future directions. To this end, we conduct a review of a total of 26 empirical papers from peer-reviewed journals within a time span of 4 decades ranging from 1981 to 2021. This study, as the first attempt of its kind at a comprehensive review on using eye-tracking in interpreting studies, should have implications for researchers, educators, and practitioners.
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.872247
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Article ; Online: Retraction notice to "LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122" [Experimental and Molecular Pathology 111 (2019) 104325].

Gong, Licheng / Chang, Hong / Xu, Haiming

Experimental and molecular pathology

2022 Volume 126, Page(s) 104778

Language	English
Publishing date	2022-05-23
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	207655-x
ISSN	1096-0945 ; 0014-4800
ISSN (online)	1096-0945
ISSN	0014-4800
DOI	10.1016/j.yexmp.2022.104778
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Article: Why is the mid-tropospheric North Atlantic subtropical high much stronger than the North Pacific subtropical high in boreal summer?

Chen, Hongli / Xu, Haiming / Ma, Jing / Deng, Jiechun

Climate dynamics. 2022 Sept., v. 59, no. 5-6

2022

Abstract: Evidence clearly shows that the mid-tropospheric North Atlantic subtropical high (NASH) is much stronger than the North Pacific subtropical high (NPSH) in summer, but the mechanism is unknown. To understand the mechanism for such zonal difference between ...

Abstract	Evidence clearly shows that the mid-tropospheric North Atlantic subtropical high (NASH) is much stronger than the North Pacific subtropical high (NPSH) in summer, but the mechanism is unknown. To understand the mechanism for such zonal difference between the two systems, we perform a series of sensitivity simulations using a community atmosphere model (CAM) and a linear baroclinic model (LBM). The CAM results indicate that the zonal variation of tropical sea-surface temperatures (SSTs), followed by Tibetan Plateau (TP), play leading roles in the formation of these mid-level subtropical high differences through modulating precipitation-related heating sources. The impacts of such heat sources are then investigated using the LBM. The tropical SST variation-related convective heating over the northeastern equatorial Pacific acts to enhance the NASH via exciting an eastward-propagating wave pattern resembling the Pacific-North American teleconnection; the TP-induced large-scale latent heating can also cause the NASH-NPSH difference by exciting a circumglobal teleconnection (CGT)-like wave pattern with westward-propagating part and eastward-propagating part along the westerly jet stream. Thus, their combined effect makes the NASH much stronger than the NPSH in the mid troposphere during summertime.
Keywords	climate ; dynamics ; heat ; models ; summer ; troposphere ; China
Language	English
Dates of publication	2022-09
Size	p. 1883-1895.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-021-06074-3
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Article ; Online: Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice.

Lin, Yu-Jia / Li, Hong-Mei / Gao, Yan-Rong / Wu, Ping-Fan / Cheng, Bin / Yu, Chen-Long / Sheng, Yu-Xin / Xu, Hai-Ming

Environmental pollution (Barking, Essex : 1987)

2024 Volume 350, Page(s) 123948

Abstract: The aim of this study is to investigate the adverse effects of benzophenones (BPs) on the intestinal tract of mice and the potential mechanism. F1-generation ICR mice were exposed to BPs (benzophenone-1, benzophenone-2, and benzophenone-3) by ... ...

Abstract	The aim of this study is to investigate the adverse effects of benzophenones (BPs) on the intestinal tract of mice and the potential mechanism. F1-generation ICR mice were exposed to BPs (benzophenone-1, benzophenone-2, and benzophenone-3) by breastfeeding from birth until weaning, and by drinking water after weaning until maturity. The offspring mice were executed on postnatal day 56, then their distal colons were sampled. AB-PAS staining, HE staining, immunofluorescence, Transmission Electron Microscope, immunohistochemistry, Western Blot and RT-qPCR were used to study the effects of BPs exposure on the colonic tissues of offspring mice. The results showed that colonic microvilli appeared significantly deficient in the high-dose group, and the expression of tight junction markers Zo-1 and Occludin was significantly down-regulated and the number of goblet cells and secretions were reduced in all dose groups, and the expression of secretory cell markers MUC2 and KI67 were decreased, as well as the expression of intestinal stem cell markers Lgr5 and Bmi1, suggesting that BPs exposure caused disruption of intestinal barrier and imbalance in the composition of the intestinal stem cell pool. Besides, the expression of cellular inflammatory factors such as macrophage marker F4/80 and tumor necrosis factor TNF-α was elevated in the colonic tissues of all dose groups, and the inflammatory infiltration was observed, which means the exposure of BPs caused inflammatory effects in the intestinal tract of F1-generation mice. In addition, the contents of Notch/Wnt signaling pathway-related genes, such as Dll-4, Notch1, Hes1, Ctnnb1and Sfrp2 were significantly decreased in each high-dose group (P < 0.05), suggesting that BPs may inhibit the regulation of Notch/Wnt signaling pathway. In conclusion, exposure to BPs was able to imbalance colonic homeostasis, disrupt the intestinal barrier, and trigger inflammation in the offspring mice, which might be realized through interfering with the Notch/Wnt signaling pathway.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123948
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Zs.A 2599: Show issues

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Article ; Online: Identification of key miRNAs and mRNAs related to coronary artery disease by meta-analysis.

Liu, Long / Zhang, Jingze / Wu, Mei / Xu, Haiming

BMC cardiovascular disorders

2021 Volume 21, Issue 1, Page(s) 443

Abstract: Background: To illustrate the mechanism of miRNA and mRNA in coronary artery diseasen (CAD), differentially expressed microRNAs (DEmiRNAs) and genes (DEGs) were analyzed.: Methods: The mRNA transcription profiles of GSE20680 (including 87 blood ... ...

Abstract	Background: To illustrate the mechanism of miRNA and mRNA in coronary artery diseasen (CAD), differentially expressed microRNAs (DEmiRNAs) and genes (DEGs) were analyzed. Methods: The mRNA transcription profiles of GSE20680 (including 87 blood samples of CAD and 52 blood samples of control), GSE20681 (including 99 blood samples of CAD and 99 blood samples of control) and GSE12288 (including 110 blood samples of CAD and 112 blood samples of control) and the miRNA transcription profiles of GSE59421 (including 33 blood samples of CAD and 37 blood samples of control), GSE49823 (including 12 blood samples of CAD and 12 blood samples of control) and GSE28858 (including 13 blood samples of CAD and 13 blood samples of control) were downloaded from Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/ ). Then, the homogenous expressed mRNAs and miRNAs across the three mRNA transcription profiles and three miRNA transcription profiles were screened using the Fishers exact test in MetaDE. ES package. The weighted gene co-expression network analysis (WGCNA) was used to analyze gene modules. Additionally, the integrated miRNAs-targets regulatory network using the DEmiRNA and their targets was constructed using Cytoscape. Results: A total of 1201 homogenously statistically significant DEGs were identified including 879 up-regulated and 322 down-regulated DEGs, while a total of 47 homogenously statistically significant DEmiRNAs including 37 up-regulated and 10 down-regulated DEmiRNAs in CAD compared with the controls across the three mRNA transcription profiles and the three miRNA transcription profiles. A total of 5067 genes were clustered into 9 modules in the training dataset, among which, 8 modules were validated. In the miRNAs-targets network, there existed 267 interaction relationships among 5 miRNAs (hsa-miR-361-5p, hsa-miR-139-5p, hsa-miR-146b-5p, hsa-miR-502-5p and hsa-miR-501-5p) and 213 targets. CAV1 could be the target of hsa-miR-361-5 while HSF2 was the target of both hsa-miR-361-5p and hsa-miR-146b-5p. CAV1 was significantly enriched in the GO term of regulation of cell proliferation. Conclusion: hsa-miR-361-5p, has-miR-146b-5p, CAV1 and HSF2 could play an important role in CAD.
MeSH term(s)	Adult ; Aged ; Case-Control Studies ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/genetics ; Databases, Genetic ; Female ; Gene Expression Profiling ; Gene Regulatory Networks ; Genetic Association Studies ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcriptome
Chemical Substances	CAV1 protein, human ; Caveolin 1 ; Heat-Shock Proteins ; MIRN146 microRNA, human ; MIRN361 microRNA, human ; MicroRNAs ; RNA, Messenger ; Transcription Factors ; HSF2 protein, human (142297-91-4)
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-021-02211-2
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