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  1. Article ; Online: DNA nanodevices map intracellular ions.

    Xu, Haoxing

    Nature biotechnology

    2023  

    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-02054-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2167: Show issues Location:
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  2. Article: Lysosomal Ion Channels and Lysosome-Organelle Interactions.

    Cai, Weijie / Li, Ping / Gu, Mingxue / Xu, Haoxing

    Handbook of experimental pharmacology

    2023  Volume 278, Page(s) 93–108

    Abstract: Intracellular organelles exchange their luminal contents with each other via both vesicular and non-vesicular mechanisms. By forming membrane contact sites (MCSs) with ER and mitochondria, lysosomes mediate bidirectional transport of metabolites and ions ...

    Abstract Intracellular organelles exchange their luminal contents with each other via both vesicular and non-vesicular mechanisms. By forming membrane contact sites (MCSs) with ER and mitochondria, lysosomes mediate bidirectional transport of metabolites and ions between lysosomes and organelles that regulate lysosomal physiology, movement, membrane remodeling, and membrane repair. In this chapter, we will first summarize the current knowledge of lysosomal ion channels and then discuss the molecular and physiological mechanisms that regulate lysosome-organelle MCS formation and dynamics. We will also discuss the roles of lysosome-ER and lysosome-mitochondria MCSs in signal transduction, lipid transport, Ca
    MeSH term(s) Humans ; Organelles/metabolism ; Ion Channels ; Lysosomes/metabolism ; Mitochondria/metabolism ; Biological Transport
    Chemical Substances Ion Channels
    Language English
    Publishing date 2023-02-02
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2023_640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
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  3. Article ; Online: Not just protons: Chloride also activates lysosomal acidic hydrolases.

    Feng, Xinghua / Liu, Siyu / Xu, Haoxing

    The Journal of cell biology

    2023  Volume 222, Issue 6

    Abstract: Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol.https://doi.org/10.1083/jcb.202210063) ... ...

    Abstract Lysosomal hydrolases require an acidic lumen for their optimal activities. In this issue, two independent groups (Wu et al. 2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208155; Zhang et al. 2023. J. Cell. Biol.https://doi.org/10.1083/jcb.202210063) report that hydrolase activation also requires high intralysosomal Cl-, which is established by the lysosomal Cl-/H+ exchanger ClC-7.
    MeSH term(s) Chlorides ; Lysosomes/enzymology ; Hydrolases/metabolism ; Chloride Channels/metabolism
    Chemical Substances Chlorides ; Hydrolases (EC 3.-) ; Chloride Channels
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202305007
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  4. Article ; Online: TRP channels in health and disease at a glance.

    Yue, Lixia / Xu, Haoxing

    Journal of cell science

    2021  Volume 134, Issue 13

    Abstract: The transient receptor potential (TRP) channel superfamily consists of a large group of non-selective cation channels that serve as cellular sensors for a wide spectrum of physical and environmental stimuli. The 28 mammalian TRPs, categorized into six ... ...

    Abstract The transient receptor potential (TRP) channel superfamily consists of a large group of non-selective cation channels that serve as cellular sensors for a wide spectrum of physical and environmental stimuli. The 28 mammalian TRPs, categorized into six subfamilies, including TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin) and TRPP (polycystin), are widely expressed in different cells and tissues. TRPs exhibit a variety of unique features that not only distinguish them from other superfamilies of ion channels, but also confer diverse physiological functions. Located at the plasma membrane or in the membranes of intracellular organelles, TRPs are the cellular safeguards that sense various cell stresses and environmental stimuli and translate this information into responses at the organismal level. Loss- or gain-of-function mutations of TRPs cause inherited diseases and pathologies in different physiological systems, whereas up- or down-regulation of TRPs is associated with acquired human disorders. In this Cell Science at a Glance article and the accompanying poster, we briefly summarize the history of the discovery of TRPs, their unique features, recent advances in the understanding of TRP activation mechanisms, the structural basis of TRP Ca2+ selectivity and ligand binding, as well as potential roles in mammalian physiology and pathology.
    MeSH term(s) Animals ; Humans ; Ion Transport ; Mammals/metabolism ; Signal Transduction ; TRPC Cation Channels ; TRPP Cation Channels/metabolism ; TRPV Cation Channels ; Transient Receptor Potential Channels/genetics ; Transient Receptor Potential Channels/metabolism
    Chemical Substances TRPC Cation Channels ; TRPP Cation Channels ; TRPV Cation Channels ; Transient Receptor Potential Channels
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.258372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 14: Show issues

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  5. Article ; Online: The Ion Channels of Endomembranes.

    Hu, Meiqin / Feng, Xinghua / Liu, Qiang / Liu, Siyu / Huang, Fangqian / Xu, Haoxing

    Physiological reviews

    2024  

    Abstract: The endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, ... ...

    Abstract The endomembrane system consists of organellar membranes in the biosynthetic pathway: endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles, as well as those in the degradative pathway: early endosomes, macropinosomes, phagosomes, autophagosomes, late endosomes, and lysosomes. These endomembrane organelles/vesicles work together to synthesize, modify, package, transport, and degrade proteins, carbohydrates, and lipids, regulating the balance between cellular anabolism and catabolism. Large ion concentration gradients exist across endomembranes - Ca
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209902-0
    ISSN 1522-1210 ; 0031-9333
    ISSN (online) 1522-1210
    ISSN 0031-9333
    DOI 10.1152/physrev.00025.2023
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    Uc I Zs.166: Show issues Location:
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  6. Article ; Online: Lysosomal solute and water transport.

    Hu, Meiqin / Zhou, Nan / Cai, Weijie / Xu, Haoxing

    The Journal of cell biology

    2022  Volume 221, Issue 11

    Abstract: Lysosomes mediate hydrolase-catalyzed macromolecule degradation to produce building block catabolites for reuse. Lysosome function requires an osmo-sensing machinery that regulates osmolytes (ions and organic solutes) and water flux. During hypoosmotic ... ...

    Abstract Lysosomes mediate hydrolase-catalyzed macromolecule degradation to produce building block catabolites for reuse. Lysosome function requires an osmo-sensing machinery that regulates osmolytes (ions and organic solutes) and water flux. During hypoosmotic stress or when undigested materials accumulate, lysosomes become swollen and hypo-functional. As a membranous organelle filled with cargo macromolecules, catabolites, ions, and hydrolases, the lysosome must have mechanisms that regulate its shape and size while coordinating content exchange. In this review, we discussed the mechanisms that regulate lysosomal fusion and fission as well as swelling and condensation, with a focus on solute and water transport mechanisms across lysosomal membranes. Lysosomal H+, Na+, K+, Ca2+, and Cl- channels and transporters sense trafficking and osmotic cues to regulate both solute flux and membrane trafficking. We also provide perspectives on how lysosomes may adjust the volume of themselves, the cytosol, and the cytoplasm through the control of lysosomal solute and water transport.
    MeSH term(s) Cytoplasm ; Cytosol ; Hydrolases/metabolism ; Ion Channels/metabolism ; Ions/metabolism ; Lysosomes/metabolism ; Water/metabolism
    Chemical Substances Ion Channels ; Ions ; Water (059QF0KO0R) ; Hydrolases (EC 3.-)
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202109133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ub I Zs.190: Show issues Location:
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  7. Article ; Online: The Acid Gate in the Lysosome.

    Hu, Meiqin / Chen, Jingzhi / Liu, Siyu / Xu, Haoxing

    Autophagy

    2022  Volume 19, Issue 4, Page(s) 1368–1370

    Abstract: The acidic environment within lysosomes is maintained within a narrow pH range (pH 4.5-5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building block metabolites can be reused. This pH homeostasis is a consequence of ... ...

    Abstract The acidic environment within lysosomes is maintained within a narrow pH range (pH 4.5-5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building block metabolites can be reused. This pH homeostasis is a consequence of proton influx produced by a V-type H
    MeSH term(s) Vacuolar Proton-Translocating ATPases/metabolism ; Autophagy/genetics ; Protons ; Acids/metabolism ; Lysosomes/metabolism ; Hydrogen-Ion Concentration
    Chemical Substances Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Protons ; Acids
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2022.2125629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6741: Show issues Location:
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  8. Article: Non-invasive evaluation of endometrial microvessels via in vivo intrauterine photoacoustic endoscopy.

    Xia, Qingrong / Lv, Shengmiao / Xu, Haoxing / Wang, Xiatian / Xie, Zhihua / Lin, Riqiang / Zhang, Jinke / Shu, Chengyou / Chen, Zhiyi / Gong, Xiaojing

    Photoacoustics

    2024  Volume 36, Page(s) 100589

    Abstract: The endometrium microvessel system, responsible for supplying oxygen and nutrients to the embryo, holds significant importance in evaluating endometrial receptivity (ER). Visualizing this system directly can significantly enhance ER evaluation. Currently, ...

    Abstract The endometrium microvessel system, responsible for supplying oxygen and nutrients to the embryo, holds significant importance in evaluating endometrial receptivity (ER). Visualizing this system directly can significantly enhance ER evaluation. Currently, clinical methods like Narrow-band hysteroscopy and Color Doppler ultrasound are commonly used for uterine blood vessel examination, but they have limitations in depth or resolution. Endoscopic Photoacoustic Imaging (PAE) has proven effective in visualizing microvessels in the digestive tract, while its adaptation to uterine imaging faces challenges due to the uterus's unique physiological characteristics. This paper for the first time that uses high-resolution PAE in vivo to capture a comprehensive network of endometrial microvessels non-invasively. Followed by continuous observation and quantitative analysis in the endometrial injury model, we further corroborated that PAE detection of endometrial microvessels stands as a valuable indicator for evaluating ER. The PAE system showcases its promising potential for integration into reproductive health assessments.
    Language English
    Publishing date 2024-01-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2716706-9
    ISSN 2213-5979
    ISSN 2213-5979
    DOI 10.1016/j.pacs.2024.100589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Saliency enhancement method for photoacoustic molecular imaging based on Grüneisen relaxation nonlinear effect.

    Wang, Xiatian / Xie, Zhihua / Lin, Riqiang / Shu, Chengyou / Lv, Shengmiao / Guo, Pengkun / Xu, Haoxing / Zhang, Jinke / Dong, Liquan / Gong, Xiaojing

    Journal of biophotonics

    2024  , Page(s) e202400004

    Abstract: Photoacoustic molecular imaging technology has a wide range of applications in biomedical research. In practical scenarios, both the probes and blood generate signals, resulting in the saliency of the probes in the blood environment being diminished, ... ...

    Abstract Photoacoustic molecular imaging technology has a wide range of applications in biomedical research. In practical scenarios, both the probes and blood generate signals, resulting in the saliency of the probes in the blood environment being diminished, impacting imaging quality. Although several methods have been proposed for saliency enhancement, they inevitably suffer from moderate generality and detection speed. The Grüneisen relaxation (GR) nonlinear effect offers an alternative for enhancing saliency and can improve generality and speed. In this article, the excitation and detection efficiencies are optimized to enhance the GR signal amplitude. Experimental studies show that the saliency of the probe is enhanced. Moreover, the issue of signal aliasing is studied to ensure the accuracy of enhancement results in the tissues. In a word, the feasibility of the GR-based imaging method in saliency enhancement is successfully demonstrated in the study, showing the superiorities of good generality and detection speed.
    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202400004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6723: Show issues Location:
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  10. Article: MoS2-Catalyzed Aerobic Synthesis of Tetraethylthiuram Disulfide in Batch and Continuous Flow

    Zhao, Ze-Run / Xu, Hao-Xing / Wang, Xiao

    Synlett

    2022  Volume 34, Issue 05, Page(s) 488–492

    Abstract: Tetraethylthiuram disulfide (TETD) is one of the most important thiuram-class rubber vulcanization accelerators and a ‘star molecule’ in other areas. The development of a mild, efficient, low-cost, safe, and sustainable approach to produce TETD is ... ...

    Abstract Tetraethylthiuram disulfide (TETD) is one of the most important thiuram-class rubber vulcanization accelerators and a ‘star molecule’ in other areas. The development of a mild, efficient, low-cost, safe, and sustainable approach to produce TETD is extremely desirable. Here, we developed a much-improved route to synthesize TETD using MoS 2 as the catalyst and ethanol as the solvent. A packed-bed microflow strategy was implemented to accelerate the catalytic process. TETD was obtained with an excellent yield and purity within a short residence time. Besides, this continuous process did not generate any waste salts, rendering it a sustainable method for producing thiuram-type compounds.
    Keywords tetraethylthiuram disulfide ; molybdenum disulfide ; packed-bed microflow reactor ; green solvent ; aerobic oxidation ; sustainability
    Language English
    Publishing date 2022-12-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2042012-2
    ISSN 1437-2096 ; 0936-5214
    ISSN (online) 1437-2096
    ISSN 0936-5214
    DOI 10.1055/a-2000-0442
    Database Thieme publisher's database

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