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  1. Article ; Online: Combination prediction method of students' performance based on ant colony algorithm.

    Xu, Huan / Kim, Min

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300010

    Abstract: Students' performance is an important factor for the evaluation of teaching quality in colleges. The prediction and analysis of students' performance can guide students' learning in time. Aiming at the low accuracy problem of single model in students' ... ...

    Abstract Students' performance is an important factor for the evaluation of teaching quality in colleges. The prediction and analysis of students' performance can guide students' learning in time. Aiming at the low accuracy problem of single model in students' performance prediction, a combination prediction method is put forward based on ant colony algorithm. First, considering the characteristics of students' learning behavior and the characteristics of the models, decision tree (DT), support vector regression (SVR) and BP neural network (BP) are selected to establish three prediction models. Then, an ant colony algorithm (ACO) is proposed to calculate the weight of each model of the combination prediction model. The combination prediction method was compared with the single Machine learning (ML) models and other methods in terms of accuracy and running time. The combination prediction model with mean square error (MSE) of 0.0089 has higher performance than DT with MSE of 0.0326, SVR with MSE of 0.0229 and BP with MSE of 0.0148. To investigate the efficacy of the combination prediction model, other prediction models are used for a comparative study. The combination prediction model with MSE of 0.0089 has higher performance than GS-XGBoost with MSE of 0.0131, PSO-SVR with MSE of 0.0117 and IDA-SVR with MSE of 0.0092. Meanwhile, the running speed of the combination prediction model is also faster than the above three methods.
    MeSH term(s) Humans ; Algorithms ; Neural Networks, Computer ; Machine Learning ; Students
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Occurrence, formation, and proteins perturbation of disinfection byproducts in indoor air resulting from chlorine disinfection.

    Xiang, Yangwei / Xu, Huan

    Chemosphere

    2023  Volume 343, Page(s) 140182

    Abstract: Increased amounts of chlorine disinfectant have been sprayed to inactivate viruses in the environment since the COVID-19 pandemic, and the health risk from chemicals, especially disinfection byproducts (DBPs), has unintentionally increased. In this study, ...

    Abstract Increased amounts of chlorine disinfectant have been sprayed to inactivate viruses in the environment since the COVID-19 pandemic, and the health risk from chemicals, especially disinfection byproducts (DBPs), has unintentionally increased. In this study, we characterized the occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in indoor air and evaluated their formation potential from typical indoor ingredients. Subsequently, the adverse effect of chloroacetic acid on A549 cells was depicted at the proteomic, transcriptional and silico levels. The results revealed that the total concentrations of HAAs and THMs ranged from 1.46 to 4.20 μg/m
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2023.140182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytokine expression patterns: A single-cell RNA sequencing and machine learning based roadmap for cancer classification.

    Ren, Zhixiang / Ren, Yiming / Liu, Pengfei / Xu, Huan

    Computational biology and chemistry

    2024  Volume 109, Page(s) 108025

    Abstract: Cytokines are small protein molecules that exhibit potent immunoregulatory properties, which are known as the essential components of the tumor immune microenvironment (TIME). While some cytokines are known to be universally upregulated in TIME, the ... ...

    Abstract Cytokines are small protein molecules that exhibit potent immunoregulatory properties, which are known as the essential components of the tumor immune microenvironment (TIME). While some cytokines are known to be universally upregulated in TIME, the unique cytokine expression patterns have not been fully resolved in specific types of cancers. To address this challenge, we develop a TIME single-cell RNA sequencing (scRNA-seq) dataset, which is designed to study cytokine expression patterns for precise cancer classification. The dataset, including 39 cancers, is constructed by integrating 684 tumor scRNA-seq samples from multiple public repositories. After screening and processing, the dataset retains only the expression data of immune cells. With a machine learning classification model, unique cytokine expression patterns are identified for various cancer categories and pioneering applied to cancer classification with an accuracy rate of 78.01%. Our method will not only boost the understanding of cancer-type-specific immune modulations in TIME but also serve as a crucial reference for future diagnostic and therapeutic research in cancer immunity.
    MeSH term(s) Humans ; Cytokines/genetics ; Neoplasms/diagnosis ; Neoplasms/genetics ; Sequence Analysis, RNA/methods ; Machine Learning ; Single-Cell Analysis/methods ; Tumor Microenvironment
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 1476-928X
    ISSN (online) 1476-928X
    DOI 10.1016/j.compbiolchem.2024.108025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The First Case Report of Inactive Nontuberculous Mycobacterial Pulmonary Disease (NTM-PD) in a Pneumoconiosis Patient Caused by

    Zhou, Jiaqing / Xu, Huan / Du, Wen / Peng, Lijun

    Infection and drug resistance

    2024  Volume 17, Page(s) 1515–1521

    Abstract: We reported a 51-year-old male electric welder with stage I pneumoconiosis, who had no significant cough, sputum, fever, chest pain, or other discomfort. However, regular physical examination at our hospital revealed bilateral pulmonary nodules with ... ...

    Abstract We reported a 51-year-old male electric welder with stage I pneumoconiosis, who had no significant cough, sputum, fever, chest pain, or other discomfort. However, regular physical examination at our hospital revealed bilateral pulmonary nodules with cavity formation. Blood routine, liver or kidney function, and infection-related biomarkers, including interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and procalcitonin (PCT), were normal. Sputum and alveolar lavage fluid (BALF) acid-fast bacilli (AFB) smears, BALF
    Language English
    Publishing date 2024-04-16
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S448805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Design and optimization of haze prediction model based on particle swarm optimization algorithm and graphics processor.

    Liu, Zuhan / Zhao, Kexin / Liu, Xuehu / Xu, Huan

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9650

    Abstract: With the rapid expansion of industrialization and urbanization, fine Particulate Matter ( ... ...

    Abstract With the rapid expansion of industrialization and urbanization, fine Particulate Matter (PM
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60486-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 5α-HA inhibits VEGF164-induced proliferation, migration and angiogenesis of choroidal vascular endothelial cells

    LEI Wulong / YAO Hao / XU Huan / ZHOU Xiyuan

    陆军军医大学学报, Vol 45, Iss 14, Pp 1501-

    2023  Volume 1508

    Abstract: Objective To investigate the role and underlying mechanism of 5α-hydroxycostic acid (5α-HA) in inhibiting choroidal neovascularization (CNV) model in vitro. Methods Rat choroidal vascular endothelial cells (CECs) were randomly grouped into blank control ... ...

    Abstract Objective To investigate the role and underlying mechanism of 5α-hydroxycostic acid (5α-HA) in inhibiting choroidal neovascularization (CNV) model in vitro. Methods Rat choroidal vascular endothelial cells (CECs) were randomly grouped into blank control group, model group (30 ng/mL VEGF164), 5α-HA treatment group (30 ng/mL VEGF164+100 μmol/L 5α-HA) and inhibition group (30 ng/mL VEGF164+5 μmol/L semaxanib) (n=3). CCK-8 assay was used to detect the proliferation of CECs in each group. Cell scratch assay, Transwell assay and Matrigel tube formation assay were used to observe the proliferation, migration and tube formation of the CECs. RT-qPCR was employed to detect the mRNA expression of leakage-related factors angiopoietin 2 (Ang 2), VE-Cadherin and ZO-1. Western blotting was performed to measure the expression of p-VEGFR2, p-Tie2, p-FAK, VE-Cadherin, ZO-1 and occudin. Cell immunofluorescence assay was conducted to observe the expression of Ang 2 protein in the cells. Results CCK-8 assay showed that 5α-HA treatment inhibited the abnormal proliferation of CECs in the model group (P < 0.01). Cell scratch assay, Transwell assay and Matrigel tube formation assay displayed that 5α-HA treatment also reversed the migration and tube formation of CECs induced by VEGF164 in the model group (P < 0.01). RT-qPCR indicated that the treatment also inhibited the up-regulation of Ang 2 mRNA and the down-regulation of VE-Cadherin and ZO-1 in the model group (P < 0.01). Western blotting results showed that 5α-HA significantly reduced the protein levels of p-VEGFR2, p-Tie2 and p-FAK in the model group (P < 0.01), and up-regulated the levels of VE-Cadherin, ZO-1 and occudin (P < 0.05). The results of cell immunofluorescence showed 5α-HA reduced the expression of Ang 2 protein in the model group (P < 0.01). Conclusion 5α-HA inhibits VEGF164-induced proliferation, migration and tube formation in CECs, possibly by inhibiting the phosphorylation of VEGFR2 and Tie2 and VEGFR2/FAK signaling pathway.
    Keywords sesquiterpeneseudesmane ; choroidal neovascularization ; angiopoietin-2 vascular endothelial growth factor a ; Medicine (General) ; R5-920
    Subject code 570
    Language Chinese
    Publishing date 2023-07-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Letter to the Editor from Han and Xu: "Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes".

    Han, Qianqian / Xu, Huan

    The Journal of clinical endocrinology and metabolism

    2022  Volume 108, Issue 4, Page(s) e56–e57

    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Incidence ; Hypoglycemic Agents ; Liver Cirrhosis/epidemiology ; Neoplasms/epidemiology ; Kidney Failure, Chronic/epidemiology ; Diabetes Mellitus
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Hypoglycemic Agents
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Application of valence-variable transition-metal-oxide-based nanomaterials in electrochemical analysis: A review.

    Xu, Huan / Wang, Qiu-Yu / Jiang, Min / Li, Shan-Shan

    Analytica chimica acta

    2024  Volume 1295, Page(s) 342270

    Abstract: The construction of materials with rapid electron transfer is considered an effective method for enhancing electrochemical activity in electroanalysis. It has been widely demonstrated that valence changes in transition metal ions can promote electron ... ...

    Abstract The construction of materials with rapid electron transfer is considered an effective method for enhancing electrochemical activity in electroanalysis. It has been widely demonstrated that valence changes in transition metal ions can promote electron transfer and thus increase electrochemical activity. Recently, valence-variable transition metal oxides (TMOs) have shown popular application in electrochemical analysis by using their abundant valence state changes to accelerate electron transfer during electrochemical detection. In this review, we summarize recent research advances in valence changes of TMOs and their application in electrochemical analysis. This includes the definition and mechanism of valence change, the association of valence changes with electronic structure, and their applications in electrochemical detection, along with the use of density functional theory (DFT) to simulate the process of electron transfer during valence changes. Finally, the challenges and opportunities for developing and applying valence changes in electrochemical analysis are also identified.
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Demographic distribution analysis of different glomerular diseases in Southwest China from 2008 to 2022.

    Han, Qianqian / Xu, Huan / Li, Lin / Lei, Song / Yang, Mei

    International urology and nephrology

    2024  

    Abstract: Background: Environmental and lifestyle factors play an etiological role in the pathogenesis of different glomerular diseases. Thus, exploring the epidemic characteristics of renal disease in different nationalities and regions is important.: ... ...

    Abstract Background: Environmental and lifestyle factors play an etiological role in the pathogenesis of different glomerular diseases. Thus, exploring the epidemic characteristics of renal disease in different nationalities and regions is important.
    Materials and methods: Patients who underwent renal biopsy from October 2008 to October 2022 were included. The proportion and change tendency of glomerular diseases and the differences between the sexes and different ages and races were analyzed.
    Results: There were 15,146 cases of glomerular diseases (98.5%), involving 7538 males (49.8%) and 7608 females (50.2%). The mean age was 37.0 years (range 0-80 years). The proportion of membranous nephropathy (MN) and diabetic nephropathy (DN) showed an increased trend. The most common primary glomerulonephritis (PGN) was IgA nephropathy (IgAN, 44.6%), followed by minimal-change disease (MCD, 24.3%) and MN (15.4%). Lupus nephritis (LN, 30%) accounted for the largest proportion of SGNs, followed by Henoch-Schonlein purpura nephritis (HSPN, 20.9%) and DN (19.8%). Compared with adults aged 18-60 years old, MCD and HSPN were more common in children and MN and DN in elderly individuals, statistically significant differences. Additionally, the sex and age distribution of PGN and SGN between the Tibetan and Han populations differed significantly, whereby LN was higher in the Han population and HSPN in the Tibetan population.
    Conclusion: The distribution of glomerular diseases showed age, sex and race differences. This research will be beneficial for providing epidemiological evidence for clinical diagnosis, disease prevention and public health decision-making.
    Language English
    Publishing date 2024-01-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-023-03902-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The association of the prothrombin A19911G single-nucleotide polymorphism and the risk of venous thromboembolism: A systematic review and meta-analysis.

    Xiang, Kehong / Xu, Huan / Zhang, Yamei / Leng, Qiuju / Zhang, Feng

    Phlebology

    2024  , Page(s) 2683555241247095

    Abstract: Background: The study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE).: Method: The databases were searched to ...

    Abstract Background: The study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE).
    Method: The databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software.
    Results: A total of five literature studies were included, involving 14,001 participants. Meta-analysis demonstrated that prothrombin A19911G polymorphism increased the risk of VTE (G vs A: OR = 1.17, 95% CI = 1.11-1.22,
    Conclusion: The polymorphism of prothrombin A19911G enhances the susceptibility to VTE.
    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 645172-x
    ISSN 1758-1125 ; 0268-3555
    ISSN (online) 1758-1125
    ISSN 0268-3555
    DOI 10.1177/02683555241247095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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