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  1. Article ; Online: Serratus anterior plane block catheter for hepatectomy: A method to decrease opioid use perioperatively.

    Tao, Kun-Ming / Xu, Hui-Hong / Zhu, Cheng-Cheng / Lu, Zhi-Jie

    Journal of clinical anesthesia

    2019  Volume 61, Page(s) 109682

    MeSH term(s) Analgesics, Opioid/adverse effects ; Catheters/adverse effects ; Hepatectomy/adverse effects ; Humans ; Nerve Block ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-12-16
    Publishing country United States
    Document type Letter
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2019.109682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2622: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus.

    Shen, Ling / Qiu, Hai-Bo / Xu, Hui-Hong / Wei, Kai / Zhao, Liang / Zhu, Cheng-Cheng / Li, Cheng-Jian / Lu, Zhi-Jie

    Neuropharmacology

    2021  Volume 189, Page(s) 108515

    Abstract: Patients deprived of cigarettes exhibit increased pain sensitivity during perioperative periods, yet the underlying neuroanatomical and molecular bases of this hypersensitivity are unclear. The present study showed that both the mechanical withdrawal ... ...

    Abstract Patients deprived of cigarettes exhibit increased pain sensitivity during perioperative periods, yet the underlying neuroanatomical and molecular bases of this hypersensitivity are unclear. The present study showed that both the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were significantly decreased in a rat model of nicotine withdrawal. These rats showed less tryptophan hydroxylase 2 (TPH2) positive neurons and reduced TPH2 expression in the nucleus raphe magnus (NRM), and thus resulted in decreased 5-hydroxytryptamine (5-HT) levels in cerebrospinal fluid. Intrathecal injection of 5-HT or NRM microinjection of TPH-overexpression adeno-associated virus alleviated nicotine withdrawal-induced hyperalgesia, whereas 5-HT receptor pharmacological blockade by methysergide (a 5-HT receptor antagonist) exacerbated hypersensitivity and diminished the difference between the two groups. Together, these data indicate that hyperalgesia after nicotine withdrawal is mediated by declined descending serotonergic pathways in the NRM. This provides a new perspective to improve the postoperative pain management of patients, especially the smokers.
    MeSH term(s) Animals ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Injections, Spinal ; Injections, Subcutaneous ; Male ; Nicotine/administration & dosage ; Nicotine/adverse effects ; Nucleus Raphe Magnus/drug effects ; Nucleus Raphe Magnus/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Serotonin/metabolism ; Serotonergic Neurons/drug effects ; Serotonergic Neurons/metabolism ; Serotonin/administration & dosage ; Serotonin/metabolism ; Substance Withdrawal Syndrome/drug therapy ; Substance Withdrawal Syndrome/metabolism
    Chemical Substances Receptors, Serotonin ; Serotonin (333DO1RDJY) ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2021.108515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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