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  1. AU="Xu, Ivana"
  2. AU="Linde, Lauren"
  3. AU="Brewer, Katlyn K"
  4. AU="Prow, Natalie A"
  5. AU=Venkatesan Arun
  6. AU="Russcher, H."
  7. AU="Chambino, Beatriz"
  8. AU="L'Abbé, Ericka N."
  9. AU=Moore Stephen M.
  10. AU="Gabriel, Berteșteanu Șerban Vifor" AU="Gabriel, Berteșteanu Șerban Vifor"
  11. AU="Gallo, Eduado"
  12. AU="Yurchenko, Maria"
  13. AU="Fabiana Giber"
  14. AU="Rajakumar, Gopal Suseela" AU="Rajakumar, Gopal Suseela"
  15. AU="Gutierrez, M. N"
  16. AU=Zhuo Jia L.
  17. AU=Miller Mark A
  18. AU="Dąbrowski, Leszek"
  19. AU="Röltgen, Katharina"
  20. AU="Tumanov, Alexey"
  21. AU="Berns, Lauren"
  22. AU="Elena A. Deshevaya"
  23. AU=Zhang Ruijuan
  24. AU="Mueller, Luke"
  25. AU=Barzon Luisa
  26. AU="Karunakaran, Denuja"
  27. AU="Figueroa-Rivera, Ivonne M"
  28. AU="Blackburn, Fran"
  29. AU="Lee, Hee-Kyung"
  30. AU=Kinoshita J H
  31. AU="Hernesniemi, Juha"
  32. AU="Evans, Matthew L"
  33. AU=Payne Thomas
  34. AU="Brown, Dexter"

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  1. Artikel: Dysregulation of β-Cell Proliferation in Diabetes: Possibilities of Combination Therapy in the Development of a Comprehensive Treatment.

    Eguchi, Natsuki / Toribio, Arvin John / Alexander, Michael / Xu, Ivana / Whaley, David Lee / Hernandez, Luis F / Dafoe, Donald / Ichii, Hirohito

    Biomedicines

    2022  Band 10, Heft 2

    Abstract: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia as a result of insufficient insulin levels and/or impaired function as a result of autoimmune destruction or insulin resistance. While Type 1 DM (T1DM) and Type 2 DM ( ... ...

    Abstract Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia as a result of insufficient insulin levels and/or impaired function as a result of autoimmune destruction or insulin resistance. While Type 1 DM (T1DM) and Type 2 DM (T2DM) occur through different pathological processes, both result in β-cell destruction and/or dysfunction, which ultimately lead to insufficient β-cell mass to maintain normoglycemia. Therefore, therapeutic agents capable of inducing β-cell proliferation is crucial in treating and reversing diabetes; unfortunately, adult human β-cell proliferation has been shown to be very limited (~0.2% of β-cells/24 h) and poorly responsive to many mitogens. Furthermore, diabetogenic insults result in damage to β cells, making it ever more difficult to induce proliferation. In this review, we discuss β-cell mass/proliferation pathways dysregulated in diabetes and current therapeutic agents studied to induce β-cell proliferation. Furthermore, we discuss possible combination therapies of proliferation agents with immunosuppressants and antioxidative therapy to improve overall long-term outcomes of diabetes.
    Sprache Englisch
    Erscheinungsdatum 2022-02-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10020472
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Comparison of Islet Characterization from Use of Standard Crude Collagenase to GMP-Grade Collagenase Enzyme Blends in Preweaned Porcine Islet Isolations.

    Corrales, Nicole / Park, Soomin / Lau, Hien / Xu, Ivana / Luong, Colleen / Rodriguez, Samuel / Mönch, Johanna / Alexander, Michael / Lakey, Jonathan Rt

    Cell transplantation

    2020  Band 29, Seite(n) 963689720977835

    Abstract: For the advancement of porcine xenotransplantation for clinical use in type 1 diabetes mellitus, the concerns of a sustainable and safe digestion enzyme blend must be overcome. Incorporating good manufacturing practices (GMP) can facilitate this through ... ...

    Abstract For the advancement of porcine xenotransplantation for clinical use in type 1 diabetes mellitus, the concerns of a sustainable and safe digestion enzyme blend must be overcome. Incorporating good manufacturing practices (GMP) can facilitate this through utilizing GMP-grade enzymes. In conjunction, still taking into account the cost-effectiveness, a wide concern. We evaluated how GMP-grade enzyme blends impact our piglet islets and their long-term effects.  Preweaned porcine islets (PPIs) were isolated from 8- to 10-day-old pigs. Digestion enzyme blends, collagenase type V (Type V), collagenase AF-1 GMP-grade with collagenase NB 6 GMP-grade (AF-1 and NB 6), and collagenase AF-1 GMP-grade with collagenase neutral protease AF GMP-grade (AF-1 and NP AF) were compared. Islet quality control assessments, islet yield, viability, and function, were performed on days 3 and 7, and cell content was performed on day 7.  GMP-grade AF-1 and NB 6 (17,209 ± 2,730 islet equivalent per gram of pancreatic tissue [IE/g] on day 3, 9,001 ± 1,034 IE/g on day 7) and AF-1 and NP AF (17,214 ± 3,901 IE/g on day 3, 8,833 ± 2,398 IE/g on day 7) showed a significant increase in islet yield compared to Type V (4,618 ± 1,240 IE/g on day 3, 1,923 ± 704 IE/g on day 7). Islet size, viability, and function showed comparable results in all enzyme blends. There was no significant difference in islet cellular content between enzyme blends.  This study demonstrated a comparison of GMP-grade collagenase enzyme blends and a standard crude collagenase enzyme in preweaned-aged porcine, a novel topic in this age. GMP-grade enzyme blends of AF-1 and NB 6 and AF-1 and NP AF resulted in substantially higher yields and as effective PPIs compared to Type V. In the long run, considering costs, integrity, and sustainability, GMP-grade enzyme blends are more favorable for clinical application due to high reproducibility in comparison to undefined manufacturing processes of standard enzymes.
    Mesh-Begriff(e) Animals ; Collagenases/pharmacology ; Islets of Langerhans/drug effects ; Islets of Langerhans/metabolism ; Islets of Langerhans/physiology ; Islets of Langerhans Transplantation ; Pancreas ; Swine ; Tissue Survival/physiology
    Chemische Substanzen Collagenases (EC 3.4.24.-)
    Sprache Englisch
    Erscheinungsdatum 2020-12-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1135816-6
    ISSN 1555-3892 ; 0963-6897
    ISSN (online) 1555-3892
    ISSN 0963-6897
    DOI 10.1177/0963689720977835
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network.

    Kim, Ella S / Rajan, Arjun / Chang, Kathleen / Govindarajan, Sanath / Gulick, Clara / English, Eva / Rodriguez, Bianca / Bloomfield, Orion / Nakada, Stella / Beard, Charlotte / O'Connor, Sarah / Mastroianni, Sophia / Downey, Emma / Feigenbaum, Matthew / Tolentino, Caitlin / Pace, Abigail / Khan, Marina / Moon, Soyoun / DiPrima, Jordan /
    Syed, Amber / Lin, Flora / Abukhadra, Yasmina / Bacon, Isabella / Beckerle, John / Cho, Sophia / Donkor, Nana Esi / Garberg, Lucy / Harrington, Ava / Hoang, Mai / Lawani, Nosa / Noori, Ayush / Park, Euwie / Parsons, Ella / Oravitan, Philip / Chen, Matthew / Molina, Cristian / Richmond, Caleb / Reddi, Adith / Huang, Jason / Shugrue, Cooper / Coviello, Rose / Unver, Selma / Indelicarto, Matthew / Islamovic, Emir / McIlroy, Rosemary / Yang, Alana / Hamad, Mahdi / Griffin, Elizabeth / Ahmed, Zara / Alla, Asha / Fitzgerald, Patricia / Choi, Audrey / Das, Tanya / Cheng, Yuchen / Yu, Joshua / Roderiques, Tabor / Lee, Ethan / Liu, Longchao / Harper, Jaekeb / Wang, Jason / Suhr, Chris / Tan, Max / Luque, Jacqueline / Tam, A Russell / Chen, Emma / Triff, Max / Zimmermann, Lyric / Zhang, Eric / Wood, Jackie / Clark, Kaitlin / Kpodonu, Nat / Dey, Antar / Ecker, Alexander / Chuang, Maximilian / López, Ramón Kodi Suzuki / Sun, Harry / Wei, Zijing / Stone, Henry / Chi, Chia Yu Joy / Silvestri, Aiden / Orloff, Petra / Nedumaran, Neha / Zou, Aletheia / Ünver, Leyla / Page, Oscair / Kim, Minseo / Chan, Terence Yan Tao / Tulloch, Akili / Hernandez, Andrea / Pillai, Aruli / Chen, Caitlyn / Chowdhury, Neil / Huang, Lina / Mudide, Anish / Paik, Garrett / Wingate, Alexandra / Quinn, Lily / Conybere, Chris / Baumgardt, Luca Laiza / Buckley, Rollo / Kolberg, Zara / Pattison, Ruth / Shazli, Ashlyn Ahmad / Ganske, Pia / Sfragara, Luca / Strub, Annina / Collier, Barney / Tamana, Hari / Ravindran, Dylan / Howden, James / Stewart, Madeleine / Shimizu, Sakura / Braniff, Julia / Fong, Melanie / Gutman, Lucy / Irvine, Danny / Malholtra, Sahil / Medina, Jillian / Park, John / Yin, Alicia / Abromavage, Harrison / Barrett, Breanna / Chen, Jacqueline / Cho, Rachelle / Dilatush, Mac / Gaw, Gabriel / Gu, Caitlin / Huang, Jupiter / Kilby, Houston / Markel, Ethan / McClure, Katie / Phillips, William / Polaski, Benjamin / Roselli, Amelia / Saint-Cyr, Soleil / Shin, Ellie / Tatum, Kylan / Tumpunyawat, Tai / Wetherill, Lucia / Ptaszynska, Sara / Zeleznik, Maddie / Pesendorfer, Alexander / Nolan, Anna / Tao, Jeffrey / Sammeta, Divya / Nicholson, Laney / Dinh, Giao Vu / Foltz, Merrin / Vo, An / Ross, Maggie / Tokarski, Andrew / Hariharan, Samika / Wang, Elaine / Baziuk, Martha / Tay, Ashley / Wong, Yuk Hung Maximus / Floyd, Jax / Cui, Aileen / Pierre, Kieran / Coppisetti, Nikita / Kutam, Matthew / Khurjekar, Dhruv / Gadzi, Anthony / Gubbay, Ben / Pedretti, Sophia / Belovich, Sofiya / Yeung, Tiffany / Fey, Mercy / Shaffer, Layla / Li, Arthur / Beritela, Giancarlo / Huyghue, Kyle / Foster, Greg / Durso-Finley, Garrett / Thierfelder, Quinn / Kiernan, Holly / Lenkowsky, Andrew / Thomas, Tesia / Cheng, Nicole / Chao, Olivia / L'Etoile-Goga, Pia / King, Alexa / McKinley, Paris / Read, Nicole / Milberg, David / Lin, Leila / Wong, Melinda / Gilman, Io / Brown, Samantha / Chen, Lila / Kosai, Jordyn / Verbinsky, Mark / Belshaw-Hood, Alice / Lee, Honon / Zhou, Cathy / Lobo, Maya / Tse, Asia / Tran, Kyle / Lewis, Kira / Sonawane, Pratmesh / Ngo, Jonathan / Zuzga, Sophia / Chow, Lillian / Huynh, Vianne / Yang, Wenyi / Lim, Samantha / Stites, Brandon / Chang, Shannon / Cruz-Balleza, Raenalyn / Pelta, Michaela / Kujawski, Stella / Yuan, Christopher / Standen-Bloom, Elio / Witt, Oliver / Anders, Karina / Duane, Audrey / Huynh, Nancy / Lester, Benjamin / Fung-Lee, Samantha / Fung, Melanie / Situ, Mandy / Canigiula, Paolo / Dijkgraaf, Matijs / Romero, Wilbert / Baula, Samantha Karmela / Wong, Kimberly / Xu, Ivana / Martinez, Benjamin / Nuygen, Reena / Norris, Lucy / Nijensohn, Noah / Altman, Naomi / Maajid, Elise / Burkhardt, Olivia / Chanda, Jullian / Doscher, Catherine / Gopal, Alex / Good, Aaron / Good, Jonah / Herrera, Nate / Lanting, Lucas / Liem, Sophia / Marks, Anila / McLaughlin, Emma / Lee, Audrey / Mohr, Collin / Patton, Emma / Pyarali, Naima / Oczon, Claire / Richards, Daniel / Good, Nathan / Goss, Spencer / Khan, Adeeb / Madonia, Reagan / Mitchell, Vivian / Sun, Natasha / Vranka, Tarik / Garcia, Diogo / Arroyo, Frida / Morales, Eric / Camey, Steven / Cano, Giovanni / Bernabe, Angelica / Arroyo, Jennifer / Lopez, Yadira / Gonzalez, Emily / Zumba, Bryan / Garcia, Josue / Vargas, Esmeralda / Trinidad, Allen / Candelaria, Noel / Valdez, Vanessa / Campuzano, Faith / Pereznegron, Emily / Medrano, Jenifer / Gutierrez, Jonathan / Gutierrez, Evelyn / Abrego, Ericka Taboada / Gutierrez, Dayanara / Ortiz, Cristian / Barnes, Angelica / Arms, Eleanor / Mitchell, Leo / Balanzá, Ciara / Bradford, Jake / Detroy, Harrison / Ferguson, Devin / Guillermo, Ethel / Manapragada, Anusha / Nanula, Daniella / Serna, Brigitte / Singh, Khushi / Sramaty, Emily / Wells, Brian / Wiggins, Matthew / Dowling, Melissa / Schmadeke, Geraldine / Cafferky, Samantha / Good, Stephanie / Reese, Margaret / Fleig, Miranda / Gannett, Alex / Cain, Cory / Lee, Melody / Oberto, Paul / Rinehart, Jennifer / Pan, Elaine / Mathis, Sallie Anne / Joiner, Jessica / Barr, Leslie / Evans, Cory J / Baena-Lopez, Alberto / Beatty, Andrea / Collette, Jeanette / Smullen, Robert / Suttie, Jeanne / Chisholm, Townley / Rotondo, Cheryl / Lewis, Gareth / Turner, Victoria / Stark, Lloyd / Fox, Elizabeth / Amirapu, Anjana / Park, Sangbin / Lantz, Nicole / Rankin, Anne E / Kim, Seung K / Kockel, Lutz

    G3 (Bethesda, Md.)

    2023  Band 13, Heft 9

    Abstract: Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present ... ...

    Abstract Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic, and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II, and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons. A subset of enhancer traps was expressed in CNS neurons known to produce and secrete insulin, an essential regulator of growth, development, and metabolism. Fly lines described here were generated and characterized through studies by students and teachers in an international network of genetics classes at public, independent high schools, and universities serving a diversity of students, including those underrepresented in science. Thus, a unique partnership between secondary schools and university-based programs has produced and characterized novel resources in Drosophila, establishing instructional paradigms devoted to unscripted experimental science.
    Mesh-Begriff(e) Animals ; Drosophila/genetics ; Drosophila/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Gene Expression Regulation ; Enhancer Elements, Genetic
    Chemische Substanzen Drosophila Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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