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Article ; Online: Benchmarking the Intrinsic Activity of Transition Metal Oxides for the Oxygen Evolution Reaction with Advanced Nanoelectrodes.

Gao, Han / Xu, Jianan / Zhang, Xueqi / Zhou, Min

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202404663

Abstract: The intrinsic activity assessment of transition metal oxides (TMOs) as key electrocatalysts for the oxygen evolution reaction (OER) has not been standardized due to uncertainties regarding their structure and composition, difficulties in accurately ... ...

Abstract	The intrinsic activity assessment of transition metal oxides (TMOs) as key electrocatalysts for the oxygen evolution reaction (OER) has not been standardized due to uncertainties regarding their structure and composition, difficulties in accurately measuring their electrochemically active surface area (ECSA), and deficiencies in mass-transfer (MT) rates in conventional measurements. To address these issues, we utilized an electrodeposition-thermal annealing method to precisely synthesize single-particle TMOs with well-defined structure and composition. Concurrently, we engineered low roughness, spherical surfaces for individual particles, enabling precise measurement of their ECSA. Furthermore, by constructing a conductor-core semiconductor-shell structure, we evaluated the inherent OER activity of perovskite-type semiconductor materials, broadening the scope beyond just conductive TMOs. Finally, using single-particle nanoelectrode technique, we systematically measured individual TMO particles of various sizes for OER, overcoming MT limitations seen in conventional approaches. These improvements have led us to propose a precise and reliable approach to evaluating the intrinsic activity of TMOs, not only validating the accuracy of theoretical calculations but also revealing a strong correlation of OER activity on the melting point of TMOs. This discovery holds significant importance for future high-throughput material research and applications, offering valuable insights in electrocatalysis.
Language	English
Publishing date	2024-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202404663
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advancements in NSCLC: From Pathophysiological Insights to Targeted Treatments.

Xu, Jianan / Tian, Lin / Qi, Wenlong / Lv, Qingguo / Wang, Tan

American journal of clinical oncology

2024

Abstract: With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, ... ...

Abstract	With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, particularly through the integration of genomic and epigenomic insights to enhance treatment outcomes for patients. We focus on the identification of key gene mutations and examine the evolution and impact of targeted therapies. These therapies have shown encouraging results in improving survival rates and quality of life. Despite numerous gene mutations being identified in association with NSCLC, targeted treatments are available for only a select few. This paper offers an exhaustive analysis of the pathogenesis of NSCLC and reviews the latest advancements in targeted therapeutic approaches. It emphasizes the ongoing necessity for research and development in this domain. In addition, we discuss the current challenges faced in the clinical application of these therapies and the potential directions for future research, including the identification of novel targets and the development of new treatment modalities.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604536-4
ISSN	1537-453X ; 0277-3732
ISSN (online)	1537-453X
ISSN	0277-3732
DOI	10.1097/COC.0000000000001088
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Article ; Online: Harnessing the LdCsm RNA Detection Platform for Efficient microRNA Detection.

Yu, Zhenxiao / Xu, Jianan / She, Qunxin

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: In cancer diagnosis, diverse microRNAs (miRNAs) are used as biomarkers for carcinogenesis of distinctive human cancers. Thus, the detection of these miRNAs and their quantification are very important in prevention of cancer diseases in human beings. ... ...

Abstract	In cancer diagnosis, diverse microRNAs (miRNAs) are used as biomarkers for carcinogenesis of distinctive human cancers. Thus, the detection of these miRNAs and their quantification are very important in prevention of cancer diseases in human beings. However, efficient RNA detection often requires RT-PCR, which is very complex for miRNAs. Recently, the development of CRISPR-based nucleic acid detection tools has brought new promises to efficient miRNA detection. Three CRISPR systems can be explored for miRNA detection, including type III, V, and VI, among which type III (CRISPR-Cas10) systems have a unique property as they recognize RNA directly and cleave DNA collaterally. In particular, a unique type III-A Csm system encoded by
MeSH term(s)	Humans ; MicroRNAs/genetics ; CRISPR-Cas Systems/genetics ; CRISPR-Associated Proteins/genetics
Chemical Substances	MicroRNAs ; CRISPR-Associated Proteins
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032857
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Article ; Online: MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.

Xu, Jianan / Sun, Yuanyuan / Fu, Weineng / Fu, Shuang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 165, Page(s) 115208

Abstract: Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development. While widely distributed in cells, its subcellular localization varies across different cancer types. As a novel c-Myc target gene, MYCT1 is subject to regulation by ... ...

Abstract	Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development. While widely distributed in cells, its subcellular localization varies across different cancer types. As a novel c-Myc target gene, MYCT1 is subject to regulation by multiple transcription factors. Studies have revealed aberrant expression of MYCT1 in various cancers, impacting pivotal biological processes such as proliferation, apoptosis, migration, genomic instability, and differentiation in cancer cells. Additionally, MYCT1 plays a critical role in modulating tumor angiogenesis and remodeling tumor immune responses within the tumor microenvironment. Despite certain debated functions, MYCT1 undeniably holds significance in cancer development. In this review, we comprehensively examine the relationship between MYCT1 and cancer, encompassing gene structure, regulation of gene expression, gene mutation, and biological function, with the aim of providing valuable insights for cancer diagnosis and treatment.
MeSH term(s)	Cell Line, Tumor ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Proto-Oncogene Proteins c-myc/metabolism ; Humans ; Nuclear Proteins/genetics
Chemical Substances	Proto-Oncogene Proteins c-myc ; MYCT1 protein, human ; Nuclear Proteins
Language	English
Publishing date	2023-07-25
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115208
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Article ; Online: Comparison of Artificial Feed and Natural Food by the Growth and Blood Biochemistry in Chinese Sturgeon Acipenser sinensis

Zheng, Yueping / Liu, Jiehao / Xu, Jianan / Fan, Houyong / Wang, Youji / Zhuang, Ping / Hu, Menghong

Fishes. 2023 Jan. 10, v. 8, no. 1

2023

Abstract: As an endangered animal species, the Chinese sturgeon (Acipenser sinensis) has been artificially cultured during recent years. In the present experiment, the performance of a common formulated feed and a mixed natural feed on the growth and blood ... ...

Abstract	As an endangered animal species, the Chinese sturgeon (Acipenser sinensis) has been artificially cultured during recent years. In the present experiment, the performance of a common formulated feed and a mixed natural feed on the growth and blood physiology of Chinese sturgeon were compared during one year of indoor culture. In terms of specific growth rate, the formulated diet group showed a higher value (4.2%) compared with the natural food group (−1.8%) during one year of indoor culture. Alanine aminotransferase activities of the sturgeons in formulated diet group was significantly higher than that in the natural food group throughout whole experiment period (p < 0.05). The total protein albumin, albumin and globulin contents of the natural food group were significantly higher than that of the formulated diet group in February and May (p < 0.05). The C-reactive protein contents of the formulated diet group were significantly higher than that of natural food group in May and August (p < 0.05). The activities of total cholesterol, high-density cholesterol, and low-density cholesterol were significantly higher in the natural food group than those in the formulated diet group (p < 0.05). The activities of triglycerides were significantly higher in the natural food group than those in the formulated diet group in February and May (p < 0.05). Almost half of the biochemical indicators examined show significant seasonal fluctuations, indicating that seasons have a substantial impact on the Chinese sturgeon. Overall, these results indicate that natural food exerted a positive impact on physiological indicators compared to the formulated diet.
Keywords	Acipenser sinensis ; C-reactive protein ; alanine transaminase ; albumins ; animals ; blood ; cholesterol ; diet ; feed formulation ; food groups ; globulins ; protein content ; specific growth rate
Language	English
Dates of publication	2023-0110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ISSN	2410-3888
DOI	10.3390/fishes8010045
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Electrochemical Visualization of an Ion-Selective Membrane Using a Carbon Nanoelectrode.

Wu, Shengquan / Xu, Jianan / Gao, Han / An, Qingbo / Wang, Fei / Li, Liang

ACS sensors

2023 Volume 8, Issue 7, Page(s) 2713–2720

Abstract: Molecular and physical probes have been widely employed to investigate physicochemical properties and mechanisms of interfaces due to their ability to provide accurate measurements with temporal and spatial resolution. However, the direct measurement of ... ...

Abstract	Molecular and physical probes have been widely employed to investigate physicochemical properties and mechanisms of interfaces due to their ability to provide accurate measurements with temporal and spatial resolution. However, the direct measurement of electroactive species diffusion in ion-selective electrode (ISE) membranes and quantification of the water layer have been challenging due to the high impedance and optical opacity of polymer membranes. In the present work, carbon nanoelectrodes with ultrathin insulating encapsulation and good geometrical structure are reported as physical probes for direct electrochemical measurement of the water layer. The scanning electrochemical microscopy experiment exhibits positive feedback at the interface of the fresh ISE, and negative feedback after conditioning for 3 h. The thickness of the water layer was estimated to be ca. 13 nm. For the first time, we provide direct evidence that, during conditioning, the water molecules diffuse through the chloride ion selective membrane (Cl-ISM) until a water layer establishes at almost 3 h. Furthermore, the diffusion coefficient and concentration of oxygen molecules in the Cl-ISM are also directly electrochemical measured by introducing ferrocene (Fc) as a redox molecule probe. The oxygen concentration in the Cl-ISM decreases during conditioning, suggesting the diffusion of oxygen from ISM to the water layer. The proposed method can be used for the electrochemical measurement of solid contact, providing theoretical guidance and advice for the performance optimization of ISEs.
MeSH term(s)	Carbon/chemistry ; Ion-Selective Electrodes ; Polymers/chemistry ; Oxidation-Reduction ; Water/chemistry
Chemical Substances	Carbon (7440-44-0) ; Polymers ; Water (059QF0KO0R)
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c00574
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transcriptome analysis reveals dysfunction of the endoplasmic reticulum protein processing in the sonic muscle of small yellow croaker (Larimichthys polyactis) following noise exposure.

Zhang, Xuguang / Tang, Xianming / Xu, Jianan / Zheng, Yueping / Lin, Jun / Zou, Huafeng

Marine environmental research

2023 Volume 194, Page(s) 106299

Abstract: Noise pollution is increasingly prevalent in aquatic ecosystems, causing detrimental effects on growth and behavior of marine fishes. The physiological responses of fish to underwater noise are poorly understood. In this study, we used RNA-sequencing ( ... ...

Abstract	Noise pollution is increasingly prevalent in aquatic ecosystems, causing detrimental effects on growth and behavior of marine fishes. The physiological responses of fish to underwater noise are poorly understood. In this study, we used RNA-sequencing (RNA-seq) to study the transcriptome of the sonic muscle in small yellow croaker (Larimichthys polyactis) after exposure to a 120 dB noise for 30 min. The behavioral experiment revealed that noise exposure resulted in accelerated tail swimming behavior at the beginning of the exposure period, followed by loss of balance at the end of experiment. Transcriptomic analysis found that most highly expressed genes in the sonic muscle, including parvalbumin, slc25a4, and troponin C were related with energy metabolism and locomotor function. Further, a total of 1261 differentially expressed genes (DEGs) were identified, including 284 up-regulated and 977 down-regulated genes in the noise exposure group compared with the control group. Gene ontology (GO) analysis indicated that the most enriched categories of DEGs included protein folding and response to unfolding protein. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis found over-represented pathways including protein processing in the endoplasmic reticulum, chaperones and folding catalysts, as well as arginine and proline metabolism. Specifically, many genes related to fatty acid and collagen metabolism were up-regulated in the noise exposure group. Taken together, our results indicate that exposure to noise stressors alters the swimming behavior of croaker, inducing endoplasmic reticulum stress, disrupting lipid metabolism, and causing collagen degradation in the sonic muscle of L. polyactis.
MeSH term(s)	Animals ; Ecosystem ; Gene Expression Profiling/methods ; Transcriptome ; Muscles ; Perciformes/genetics ; Collagen/genetics
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2023.106299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Investigating the technology of UV nanosecond laser milling for cutting CFRP laminates.

Lu, Yao / Gao, PeiYing / Xu, Jianan / Wang, Yang / Yang, LiJun

Applied optics

2023 Volume 62, Issue 10, Page(s) 2656–2660

Abstract: An enhanced ultraviolet (UV) nanosecond laser milling cutting method is innovatively adopted to cut carbon fiber reinforced plastic (CFRP) composites. This paper aims to achieve a more efficient and facile way to cut the thicker sheet cutting mode. The ... ...

Abstract	An enhanced ultraviolet (UV) nanosecond laser milling cutting method is innovatively adopted to cut carbon fiber reinforced plastic (CFRP) composites. This paper aims to achieve a more efficient and facile way to cut the thicker sheet cutting mode. The technology of UV nanosecond laser milling cutting is studied in detail. The effects of milling mode and filling spacing on the cutting effect are explored in milling mode cutting. Cutting with the milling method can obtain a smaller heat-affected zone at the slit entrance and a shorter effective processing time. When the longitudinal milling method is adopted, the machining effect of the lower side of the slit is better when the filling spacing is 20 µm and 50 µm, with no burr or other defects. Additionally, the filling spacing below 50 µm can obtain a better machining effect. The coupled photochemical and photothermal effects of UV laser cutting CFRP are elucidated, and the experiments verify this phenomenon successfully. Overall, it is anticipated that this study can offer a practical reference for UV nanosecond laser milling cutting CFRP composites and make contributions to military fields.
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.485656
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Article ; Online: Effects of Citrobacter freundii on sturgeon: Insights from skin mucosal immunology and microbiota.

Liu, Jiehao / Pan, Yiting / Jin, Shen / Zheng, Yueping / Xu, Jianan / Fan, Houyong / Khalid, Mansoor / Wang, Youji / Hu, Menghong

Fish & shellfish immunology

2024 Volume 149, Page(s) 109527

Abstract: Skin mucus analysis has recently been used as a non-invasive method to evaluate for fish welfare. The present research study was conducted to examine the skin mucosal immunity and skin microbiota profiles of sturgeons infected with Citrobacter freundii. ... ...

Abstract	Skin mucus analysis has recently been used as a non-invasive method to evaluate for fish welfare. The present research study was conducted to examine the skin mucosal immunity and skin microbiota profiles of sturgeons infected with Citrobacter freundii. Our histology results showed that the thickness of the epidermal layer of skin remained thinner, and the number of mucous cells was significantly decreased in sturgeons after infection (p < 0.05). Total protein, alanine aminotransferase, aspartate aminotransferase, superoxide dismutase, and creatine kinase levels in the mucus showed biphasic pattern (decrease and then increase). Lactate dehydrogenase, lysozyme, and acid phosphatase activities in the mucus showed an increasing trend after infection. Furthermore, 16S rRNA sequencing also revealed that C. freundii infection also affected the diversity and community structure of the skin mucus microbiota. An increase in microbial diversity (p > 0.05) and a decrease in microbial abundance (p < 0.05) after infection were noted. The predominant bacterial phyla in the skin mucus were Proteobacteria, Fusobacteria, Bacteroidetes, Firmicutes, and Actinobacteria. Specifically, the relative abundance of Fusobacteria increased after infection. The predominant bacterial genera in the skin mucus were Cetobacterium, Pelomonas, Bradyrhizobium, Flavobacterium, and Pseudomonas. The relative abundance of Cetobacterium, Pseudomonas, and Flavobacterium increased after infection. Our current research findings will provide new insights into the theoretical basis for future research studies exploring the mechanism of sturgeon infection with C. freundii.
Language	English
Publishing date	2024-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2024.109527
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Article ; Online: Indexing serum and mucous biochemical parameters of endangered Chinese sturgeon Acipenser sinensis with implications for health assessment.

Liu, Jiehao / UllahKhan, Fahim / Jin, Shen / Zheng, Yueping / Xu, Jianan / Fan, Houyong / Wang, Youji / Hu, Menghong

Journal of fish biology

2024 Volume 104, Issue 4, Page(s) 1180–1192

Abstract: The Chinese sturgeon (Acipenser sinensis) is a critically endangered aquatic fish. Health monitoring and welfare assessments are critical for the conservation of Chinese sturgeon. In this study, biochemical parameters of serum and skin mucus in Chinese ... ...

Abstract	The Chinese sturgeon (Acipenser sinensis) is a critically endangered aquatic fish. Health monitoring and welfare assessments are critical for the conservation of Chinese sturgeon. In this study, biochemical parameters of serum and skin mucus in Chinese sturgeon were examined to evaluate the potential biomarkers. Serum and mucous samples were obtained from Chinese sturgeon, and the levels of total protein (TP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), lactic acid (LD), acid phosphatase (ACP), lysozyme (LYZ), glucose (GLU), and cortisol were determined. The concentrations of ALT, AST, cortisol, and LYZ were significantly higher in the mucous group than those in the serum group (p < 0.05). In addition, the concentrations of ALP, ACP, LD, LDH, CK, and TP were significantly higher level in the serum group than those in the mucous group (p < 0.05). Moreover, the correlations between serum and mucous biochemical parameters were established. Statistical analysis showed a positive correlation between serum and skin mucous markers (ACP, cortisol, and LYZ). AST versus ALT in serum and mucus showed a significant positive correlation (p < 0.01). A significant positive correlation was found between cortisol and CK in mucus (p < 0.01). Moreover, LD versus LDH in serum showed a significant but weak positive correlation (p < 0.01). Principal component analysis revealed a complete separation between the serum and mucous groups, with the biomarkers that contributed the most being ALP, TP, ALT, and AST. This study provides baseline data and reference intervals for serum and mucous biochemical parameters in presumably healthy Chinese sturgeons. The current study has important implications for the development of conservation strategies and the conservation status of critically endangered species.
MeSH term(s)	Animals ; Hydrocortisone ; Fishes ; Biomarkers
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Biomarkers
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	410564-3
ISSN	1095-8649 ; 0022-1112
ISSN (online)	1095-8649
ISSN	0022-1112
DOI	10.1111/jfb.15662
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