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Article: Development of an Oncogenic Driver Alteration Associated Immune-Related Prognostic Model for Stage I-II Lung Adenocarcinoma.

Xu, Jian-Zhao / Gong, Chen / Xie, Zheng-Fu / Zhao, Hua

2021 Volume 10, Page(s) 593022

Abstract: Lung adenocarcinoma (LUAD) needs to be stratified for its heterogeneity. Oncogenic driver alterations such ... ...

Abstract	Lung adenocarcinoma (LUAD) needs to be stratified for its heterogeneity. Oncogenic driver alterations such as
Language	English
Publishing date	2021-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.593022
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Article ; Online: Effects of Depression, Anxiety, Stigma, and Disclosure on Health-Related Quality of Life among Chronic Hepatitis B Patients in Dalian, China.

Li, Ge / Wang, Gongchen / Hsu, Fang-Chi / Xu, Jianzhao / Pei, Xia / Zhao, Bo / Shetty, Avinash

The American journal of tropical medicine and hygiene

2020 Volume 102, Issue 5, Page(s) 988–994

Abstract: Chronic hepatitis B virus (HBV) infection is a major public health problem in China. We evaluated the impact of psychosocial factors (stigma, disclosure, depression, and anxiety) on health-related quality of life (HRQoL) among people living with chronic ... ...

Abstract	Chronic hepatitis B virus (HBV) infection is a major public health problem in China. We evaluated the impact of psychosocial factors (stigma, disclosure, depression, and anxiety) on health-related quality of life (HRQoL) among people living with chronic HBV infection (CHB) in the city of Dalian, Liaoning Province, China. In this hospital-based cross-sectional study, 401 patients living with chronic HBV infection were enrolled as study participants. Study measures included the Beck depression and anxiety inventory, the WHO Quality of Life (WHOQOL-BREF) assessment, the Toronto Chinese HBV Stigma Scale, and disclosure of HBV status to sexual partners. The primary outcome was HRQoL score as measured by the WHOQOL-BREF. A linear regression model was used to examine the association between HRQoL and the potential risk factors including stigma, disclosure, depression, anxiety, and sociodemographic variables. Stigma, disclosure, depression, and anxiety were the covariates of interest. A majority of the participants were females (
MeSH term(s)	Anxiety/epidemiology ; Anxiety/etiology ; Anxiety/psychology ; China/epidemiology ; Cross-Sectional Studies ; Depression/epidemiology ; Depression/etiology ; Depression/psychology ; Female ; Hepatitis B, Chronic/psychology ; Humans ; Linear Models ; Male ; Middle Aged ; Quality of Life/psychology ; Self Disclosure ; Sexual Partners/psychology ; Social Stigma
Language	English
Publishing date	2020-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.19-0007
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Article ; Online: Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.

Chevli, Parag Anilkumar / Freedman, Barry I / Hsu, Fang-Chi / Xu, Jianzhao / Rudock, Megan E / Ma, Lijun / Parks, John S / Palmer, Nicholette D / Shapiro, Michael D

Cardiovascular diabetology

2021 Volume 20, Issue 1, Page(s) 231

Abstract: Background: Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite ... ...

Abstract	Background: Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were investigated in the Diabetes Heart Study (DHS), a cohort enriched for type 2 diabetes (T2D). Methods: The analysis included 700 DHS participants, 438 African Americans (AAs), and 262 European Americans (EAs), in whom coronary artery calcium (CAC) was assessed using ECG-gated computed tomography. Plasma metabolomics using liquid chromatography-mass spectrometry identified 853 known metabolites. An ancestry-specific marginal model incorporating generalized estimating equations examined associations between metabolites and CAC (log-transformed (CAC + 1) as outcome measure). Models were adjusted for age, sex, BMI, diabetes duration, date of plasma collection, time between plasma collection and CT exam, low-density lipoprotein cholesterol (LDL-C), and statin use. Results: At an FDR-corrected p-value < 0.05, 33 metabolites were associated with CAC in AAs and 36 in EAs. The androgenic steroids, fatty acid, phosphatidylcholine, and bile acid metabolism subpathways were associated with CAC in AAs, whereas fatty acid, lysoplasmalogen, and branched-chain amino acid (BCAA) subpathways were associated with CAC in EAs. Conclusions: Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants.
MeSH term(s)	Black or African American ; Aged ; Asymptomatic Diseases ; Biomarkers/blood ; Chromatography, Reverse-Phase ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/ethnology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/ethnology ; Female ; Humans ; Male ; Metabolome ; Metabolomics ; Middle Aged ; North Carolina/epidemiology ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; White People
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-021-01419-y
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Article ; Online: Symptoms Suggestive of Gastroparesis in a Community-Based Cohort of European Americans and African Americans with Type 2 Diabetes Mellitus.

Brown, Landon K / Xu, Jianzhao / Freedman, Barry I / Hsu, Fang-Chi / Bowden, Donald W / Koch, Kenneth L

Digestive diseases and sciences

2019 Volume 65, Issue 8, Page(s) 2321–2330

Abstract: Background: Although gastroparesis is seen in patients with type 2 diabetes mellitus (T2DM), the prevalence of symptoms suggestive of gastroparesis in patients with T2DM is unknown, particularly among African Americans.: Aims: To determine the ... ...

Abstract	Background: Although gastroparesis is seen in patients with type 2 diabetes mellitus (T2DM), the prevalence of symptoms suggestive of gastroparesis in patients with T2DM is unknown, particularly among African Americans. Aims: To determine the prevalence of symptoms associated with gastroparesis in a large community-based population of European Americans and African Americans with T2DM. Methods: Individuals with T2DM in the Diabetes Heart Study were asked to complete the gastroparesis cardinal symptom index (GCSI) and other GI-related questionnaires. GCSI total score ≥ 18 represented moderate or worse symptoms suggestive of gastroparesis. Results: A total of 1253 participants (700 female, 553 male) completed the GCSI: 750 were European American and 503 African American. GCSI scores ≥ 18 were recorded in 72 participants: 38 (5%) of European Americans and 34 (7%) of African Americans. The average GCSI was 24.1 in European Americans and 24.6 in African Americans, indicating moderate to severe symptoms. Compared to European Americans with GCSI scores ≥ 18, African Americans were younger (59.4 vs. 53.3 years, p = 0.004), had earlier onset of T2DM (46.3 vs. 40.1 years, p = 0.01), higher HbA1c (7.6 vs. 9.1, p = 0.0009), underwent fewer upper endoscopies (55.3% vs. 26.5%, p = 0.02), and had more anxiety and depression (p < 0.001). Conclusions: Moderate or greater symptoms suggestive of gastroparesis are present in 5-7% of European and African American patients with T2DM in community-based populations. Symptoms suggestive of gastroparesis may be underappreciated in patients with T2DM and account for upper gastrointestinal symptoms, unexplained glycemic control issues, and decreased quality of life.
MeSH term(s)	African Americans/statistics & numerical data ; Aged ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Female ; Gastroparesis/epidemiology ; Gastroparesis/etiology ; Humans ; Male ; Middle Aged ; North Carolina/epidemiology ; Prevalence ; Severity of Illness Index ; Whites/statistics & numerical data
Language	English
Publishing date	2019-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-019-05974-z
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Article ; Online: Predicting Mortality in African Americans With Type 2 Diabetes Mellitus: Soluble Urokinase Plasminogen Activator Receptor, Coronary Artery Calcium, and High-Sensitivity C-Reactive Protein.

Hayek, Salim S / Divers, Jasmin / Raad, Mohamad / Xu, Jianzhao / Bowden, Donald W / Tracy, Melissa / Reiser, Jochen / Freedman, Barry I

Journal of the American Heart Association

2018 Volume 7, Issue 9

Abstract: Background: Type 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow-derived signaling molecule associated with ... ...

Abstract	Background: Type 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow-derived signaling molecule associated with adverse cardiovascular and renal outcomes in many populations. We characterized the determinants of suPAR in African Americans with type 2 diabetes mellitus and assessed whether levels were useful for predicting mortality beyond clinical characteristics, coronary artery calcium (CAC), and high-sensitivity C-reactive protein (hs-CRP). Methods and results: We measured plasma suPAR levels in 500 African Americans with type 2 diabetes mellitus enrolled in the African American-Diabetes Heart Study. We used Kaplan-Meier curves and Cox proportional hazards models adjusting for clinical characteristics, CAC, and hs-CRP to examine the association between suPAR and all-cause mortality. Last, we report the change in C-statistics comparing the additive values of suPAR, hs-CRP, and CAC to clinical models for prediction of mortality. The suPAR levels were independently associated with female sex, smoking, insulin use, decreased kidney function, albuminuria, and CAC. After a median 6.8-year follow-up, a total of 68 deaths (13.6%) were recorded. In a model incorporating suPAR, CAC, and hs-CRP, only suPAR was significantly associated with mortality (hazard ratio 2.66, 95% confidence interval 1.63-4.34). Addition of suPAR to a baseline clinical model significantly improved the C-statistic for all-cause death (Δ0.05, 95% confidence interval 0.01-0.10), whereas addition of CAC or hs-CRP did not. Conclusions: In African Americans with type 2 diabetes mellitus, suPAR was strongly associated with mortality and improved risk discrimination metrics beyond traditional risk factors, CAC and hs-CRP. Studies addressing the clinical usefulness of measuring suPAR concentrations are warranted.
MeSH term(s)	African Americans ; Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Computed Tomography Angiography ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/ethnology ; Coronary Artery Disease/mortality ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/mortality ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Receptors, Urokinase Plasminogen Activator/blood ; Risk Assessment ; Risk Factors ; Time Factors ; United States/epidemiology ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/ethnology ; Vascular Calcification/mortality
Chemical Substances	Biomarkers ; PLAUR protein, human ; Receptors, Urokinase Plasminogen Activator ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2018-05-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.117.008194
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Article ; Online: Electrochemical Skin Conductance in Diabetic Kidney Disease.

Freedman, Barry I / Smith, Susan Carrie / Bagwell, Benjamin M / Xu, Jianzhao / Bowden, Donald W / Divers, Jasmin

American journal of nephrology

2015 Volume 41, Issue 6, Page(s) 438–447

Abstract: Background: There is a need to identify patients with diabetic kidney disease (DKD) using noninvasive, cost-effective screening tests. Sudoscan®, a device using electrochemical skin conductance (ESC) to measure sweat gland dysfunction, is valuable for ... ...

Abstract	Background: There is a need to identify patients with diabetic kidney disease (DKD) using noninvasive, cost-effective screening tests. Sudoscan®, a device using electrochemical skin conductance (ESC) to measure sweat gland dysfunction, is valuable for detecting peripheral neuropathy. ESC was tested for association with DKD (estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)) in 383 type 2 diabetes mellitus (T2D)-affected patients; diagnostic thresholds were determined in 540 patients. Methods: Relationships between ESC with eGFR and urine albumin:creatinine ratio (UACR) were assessed in 202 European Americans and 181 African Americans with T2D. Results: In 92 European American DKD cases and 110 T2D non-nephropathy controls, respectively, mean (SD) ages were 69 (9.7) and 61 (10.8) years, hemoglobin A1c (HbA1c) 7.4 (1.2) and 7.4 (1.3)%, eGFR 29.6 (12.2) and 87.8 (14.2) ml/min/1.73 m(2), and UACR 1,214 (1,705) and 7.5 (5.8) mg/g. In 57 African American cases and 124 controls, respectively, mean (SD) ages were 64.0 (11.9) and 59.5 (9.7) years, HbA1c 7.4 (1.3) and 7.5 (1.7)%, eGFR 29.6 (13.3) and 90.2 (16.2) ml/min/1.73 m(2), and UACR 1,172 (1,564) and 7.8 (7.1) mg/g. Mean (SD) ESC (μS) was lower in cases than controls (European Americans: case/control hands 49.5 (18.5)/62.3 (16.2); feet 62.1 (17.9)/73.6 (13.8), both p < 1.3 × 10(-6); African Americans: case/control hands 39.8 (19.0)/48.5 (17.1); feet 53.2 (21.3)/63.5 (19.4), both p ≤ 0.01). Adjusting for age, sex, body mass index and HbA1c, hands and feet ESC associated with eGFR <60 ml/min/1.73 m(2) (p ≤ 7.2 × 10(-3)), UACR >30 mg/g (p ≤ 7.0 × 10(-3)), UACR >300 mg/g (p ≤ 8.1 × 10(-3)), and continuous traits eGFR and UACR (both p ≤ 5.0 × 10(-9)). HbA1c values were not useful for risk stratification. Conclusions: ESC measured using Sudoscan® is strongly associated with DKD in African Americans and European Americans. ESC is a useful screening test to identify DKD in patients with T2D.
MeSH term(s)	African Americans ; Aged ; Albuminuria/urine ; Case-Control Studies ; Creatinine/urine ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/physiopathology ; Diabetic Nephropathies/urine ; European Continental Ancestry Group ; Female ; Foot ; Galvanic Skin Response ; Glomerular Filtration Rate ; Glycated Hemoglobin A/metabolism ; Hand ; Humans ; Male ; Middle Aged ; Sweat Glands/physiopathology
Chemical Substances	Glycated Hemoglobin A ; hemoglobin A1c protein, human ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2015
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000437342
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Article: Bone Mineral Density of the Radius Predicts All-Cause Mortality in Patients With Type 2 Diabetes: Diabetes Heart Study.

Lenchik, Leon / Register, Thomas C / Hsu, Fang-Chi / Xu, Jianzhao / Smith, S Carrie / Carr, J Jeffrey / Freedman, Barry I / Bowden, Donald W

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2017 Volume 21, Issue 3, Page(s) 347–354

Abstract: This study aimed to determine the association between areal and volumetric bone mineral density (BMD) with all-cause mortality in patients with type 2 diabetes (T2D). Associations between BMD and all-cause mortality were examined in 576 women and 517 men ...

Abstract	This study aimed to determine the association between areal and volumetric bone mineral density (BMD) with all-cause mortality in patients with type 2 diabetes (T2D). Associations between BMD and all-cause mortality were examined in 576 women and 517 men with T2D in the Diabetes Heart Study. Volumetric BMD in the thoracic and lumbar spine was measured with quantitative computed tomography. Areal BMD (aBMD) in the lumbar spine, total hip, femoral neck, ultradistal radius, mid radius, and whole body was measured using dual X-ray absorptiometry. Association of BMD with all-cause mortality was determined using sequential models, stratified by sex: (1) unadjusted; (2) adjusted for age, race, smoking, alcohol, estrogen use; (3) model 2 plus history of cardiovascular disease, hypertension, and coronary artery calcification; (4) model 3 plus lean mass; and (5) model 3 plus fat mass. At baseline, mean age was 61.2 years for women and 62.7 years for men. At mean 11.0 ± 3.7 years' follow-up, 221 (36.4%) women and 238 (43.6%) men were deceased. In women, BMD at all skeletal sites (except spine aBMD and whole body aBMD) was inversely associated with all-cause mortality in the unadjusted model. These associations remained significant in the mid radius (hazard ratio per standard deviation = 0.79; p = 0.0057) and distal radius (hazard ratio per standard deviation = 0.76; p = 0.0056) after adjusting for all covariates, including lean mass. In men, volumetric BMD measurements but not aBMD were inversely associated with mortality and only in the unadjusted model. In this longitudinal study, lower baseline aBMD in the radius was associated with increased all-cause mortality in women with T2D, but not men, independent of other risk factors for death.
MeSH term(s)	Absorptiometry, Photon ; Aged ; Bone Density ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Femur Neck/diagnostic imaging ; Humans ; Longitudinal Studies ; Lumbar Vertebrae/diagnostic imaging ; Male ; Middle Aged ; Mortality ; Radius/diagnostic imaging ; Sex Factors ; Thoracic Vertebrae/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2017.11.003
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Zs.A 5425: Show issues

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Article ; Online: Plasma apoM and S1P levels are inversely associated with mortality in African Americans with type 2 diabetes mellitus.

Liu, Mingxia / Frej, Cecilia / Langefeld, Carl D / Divers, Jasmin / Bowden, Donald W / Carr, J Jeffrey / Gebre, Abraham K / Xu, Jianzhao / Larsson, Benny / Dahlbäck, Björn / Freedman, Barry I / Parks, John S

Journal of lipid research

2019 Volume 60, Issue 8, Page(s) 1425–1431

Abstract: apoM is a minor HDL apolipoprotein and carrier for sphingosine-1-phosphate (S1P). HDL apoM and S1P concentrations are inversely associated with atherosclerosis progression in rodents. We evaluated associations between plasma concentrations of S1P, plasma ...

Abstract	apoM is a minor HDL apolipoprotein and carrier for sphingosine-1-phosphate (S1P). HDL apoM and S1P concentrations are inversely associated with atherosclerosis progression in rodents. We evaluated associations between plasma concentrations of S1P, plasma concentrations of apoM, and HDL apoM levels with prevalent subclinical atherosclerosis and mortality in the African American-Diabetes Heart Study participants (N = 545). Associations between plasma S1P, plasma apoM, and HDL apoM with subclinical atherosclerosis and mortality were assessed using multivariate parametric, nonparametric, and Cox proportional hazards models. At baseline, participants' median (25th percentile, 75th percentile) age was 55 (49, 62) years old and their coronary artery calcium (CAC) mass score was 26.5 (0.0, 346.5). Plasma S1P, plasma apoM, and HDL apoM were not associated with CAC. After 64 (57.6, 70.3) months of follow-up, 81 deaths were recorded. Higher concentrations of plasma S1P [odds ratio (OR) = 0.14,
MeSH term(s)	African Americans ; Apolipoproteins M/blood ; Biomarkers/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/mortality ; Disease-Free Survival ; Female ; Humans ; Lysophospholipids/blood ; Male ; Middle Aged ; Sphingosine/analogs & derivatives ; Sphingosine/blood ; Survival Rate
Chemical Substances	APOM protein, human ; Apolipoproteins M ; Biomarkers ; Lysophospholipids ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42)
Language	English
Publishing date	2019-05-27
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1194/jlr.P089409
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Zs.A 175: Show issues

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Article ; Online: Genome-wide association study of vitamin D concentrations and bone mineral density in the African American-Diabetes Heart Study.

PloS one

2021 Volume 16, Issue 5, Page(s) e0251423

Abstract: Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically ... ...

Abstract	Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals were detected for VDBP on chromosome 4; variants rs7041 (β = 0.44, SE = 0.019, P = 9.4x10-86) and rs4588 (β = 0.17, SE = 0.021, P = 3.5x10-08) in the group-specific component (vitamin D binding protein) gene (GC). These variants were found to be independently associated. In addition, rs7041 was also associated with bioavailable vitamin D (BAVD; β = 0.16, SE = 0.02, P = 3.3x10-19). Six rare variants were significantly associated with 25OHD, including a non-synonymous variant in HSPG2 (rs116788687; β = -1.07, SE = 0.17, P = 2.2x10-10) and an intronic variant in TNIK (rs143555701; β = -1.01, SE = 0.18, P = 9.0x10-10), both biologically related to bone development. Variants associated with 25OHD failed to replicate in African Americans from the Insulin Resistance Atherosclerosis Family Study (IRASFS). Evaluation of vitamin D metabolism and bone mineral density phenotypes in an African American population enriched for T2D could provide insight into ethnic specific differences in vitamin D metabolism and bone mineral density.
MeSH term(s)	African Americans/genetics ; Aged ; Bone Density ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/genetics ; Vitamin D-Binding Protein/blood ; Vitamin D-Binding Protein/genetics
Chemical Substances	Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-05-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0251423
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Article ; Online: Relationships between electrochemical skin conductance and kidney disease in Type 2 diabetes.

Freedman, Barry I / Bowden, Donald W / Smith, Susan Carrie / Xu, Jianzhao / Divers, Jasmin

Journal of diabetes and its complications

2013 Volume 28, Issue 1, Page(s) 56–60

Abstract: Background: SUDOSCAN® non-invasively measures peripheral small fiber and autonomic nerve activity using electrochemical skin conductance. Since neuropathy and nephropathy are microvascular Type 2 diabetes (T2D) complications, relationships between skin ... ...

Abstract	Background: SUDOSCAN® non-invasively measures peripheral small fiber and autonomic nerve activity using electrochemical skin conductance. Since neuropathy and nephropathy are microvascular Type 2 diabetes (T2D) complications, relationships between skin conductance, estimated glomerular filtration rate (eGFR), and urine albumin:creatinine ratio (UACR) were assessed. Methods: Two hundred five African Americans (AA) with T2D, 93 AA non-diabetic controls, 185 European Americans (EA) with T2D, and 73 EA non-diabetic controls were evaluated. Linear models were fitted stratified by population ancestry and T2D, adjusted for covariates. Results: Relative to EA, AA had lower skin conductance (T2D cases p<0.0001; controls p<0.0001). Skin conductance was also lower in T2D cases vs. controls in each population (p<0.0001, AA and EA). Global skin conductance was significantly associated with eGFR in AA and EA with T2D; adjusting for age, gender, BMI, and HbA1c, positive association was detected between skin conductance and eGFR in AA T2D cases (parameter estimate 3.38, standard error 1.2; p=5.2E(-3)), without association in EA T2D cases (p=0.22). Conclusions: Noninvasive measurement of skin conductance strongly associated with eGFR in AA with T2D, replicating results in Hong Kong Chinese. SUDOSCAN® may prove useful as a low cost, non-invasive screening tool to detect undiagnosed diabetic kidney disease in populations of African ancestry.
MeSH term(s)	Adult ; African Americans ; Aged ; Albuminuria/complications ; Albuminuria/ethnology ; Albuminuria/physiopathology ; Albuminuria/urine ; Case-Control Studies ; Creatinine/urine ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/ethnology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/urine ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/ethnology ; Diabetic Nephropathies/physiopathology ; Diabetic Nephropathies/urine ; European Continental Ancestry Group ; Female ; Galvanic Skin Response/physiology ; Glomerular Filtration Rate ; Humans ; Male ; Middle Aged ; Prognosis
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2013-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2013.09.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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