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  1. Article: Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction.

    Jiang, Yuwei / Xu, Jiaoya / Huang, Ping / Yang, Lili / Liu, Yang / Li, Yiping / Wang, Jue / Song, Haiyan / Zheng, Peiyong

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 863756

    Abstract: The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether mitochondrial dysfunction induced by the JNK/Sab signaling pathway plays a ... ...

    Abstract The activated c-Jun N-terminal kinase (JNK) specifically combined with SH3 domain-binding protein 5 (Sab) may mediate damage to the mitochondrial respiratory chain. Whether mitochondrial dysfunction induced by the JNK/Sab signaling pathway plays a pivotal role in the lipotoxic injury of nonalcoholic steatohepatitis (NASH) remains a lack of evidence. Scoparone, a natural compound from Traditional Chinese Medicine herbs, has the potential for liver protection and lipid metabolism regulation. However, the effect of scoparone on NASH induced by a high-fat diet (HFD) as well as its underlying mechanism remains to be elucidated. The HepG2 and Huh7 cells with/without Sab-knockdown induced by palmitic acid (PA) were used to determine the role of JNK/Sab signaling in mitochondrial dysfunction and cellular lipotoxic injury. To observe the effect of scoparone on the lipotoxic injured hepatocytes, different dose of scoparone together with PA was mixed into the culture medium of HepG2 and AML12 cells to incubate for 24 h. In addition, male C57BL/6J mice were fed with an HFD for 22 weeks to induce the NASH model and were treated with scoparone for another 8 weeks to investigate its effect on NASH. Molecules related to JNK/Sab signaling, mitochondrial function, and lipotoxic injury were detected in
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.863756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Study on the Therapeutic Efficacy of San Zi Yang Qin Decoction for Non-Alcoholic Fatty Liver Disease and the Underlying Mechanism Based on Network Pharmacology.

    Li, Yiping / Liu, Yang / Yang, Ming / Wang, Qianlei / Zheng, Yu / Xu, Jiaoya / Zheng, Peiyong / Song, Haiyan

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 8819245

    Abstract: Objective: This study aims to explore the therapeutic efficacy of San Zi Yang Qin Decoction (SZ) and its potential mechanism in the treatment of non-alcoholic fatty liver disease (NAFLD) based on network pharmacology and : Methods: Effective ... ...

    Abstract Objective: This study aims to explore the therapeutic efficacy of San Zi Yang Qin Decoction (SZ) and its potential mechanism in the treatment of non-alcoholic fatty liver disease (NAFLD) based on network pharmacology and
    Methods: Effective chemicals and targets of SZ were searched in online databases, according to the drug-likeness of compounds and the binomial distribution of targets. A disease-target-chemical network was established using NAFLD-associated genes screened through GeneCards database, Gene Ontology (GO) terms, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Furthermore, animal experiments were conducted to verify the efficacy and mechanism of SZ predicted by network pharmacology. The NAFLD mouse model was established with C57BL/6J mice fed with a high-fat diet for 22 weeks. The mice in the control group were fed with a chow diet. From the 23
    Results: A total of 27 effective compounds and 20 targets of SZ were screened. GO analysis uncovered a significant correlation between the targets of SZ and those of NAFLD. KEGG analysis presented the signaling pathways enriched in SZ and NAFLD, including NAFLD, TNF-
    Conclusions: According to the network pharmacology analysis and
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/8819245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Natural Products on Nonalcoholic Fatty Liver Disease.

    Xu, Jiao-Ya / Zhang, Li / Li, Zhong-Ping / Ji, Guang

    Current drug targets

    2015  Volume 16, Issue 12, Page(s) 1347–1355

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis dysregulation, and inflammation at cellular and molecular levels. Use of ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis dysregulation, and inflammation at cellular and molecular levels. Use of currently available anti-hyperlipidemia, hypoglycemia, or anti-inflammation drugs to treat NAFLD has not achieved desirable outcomes. A growing attention thus has been paid towards natural products as an alternative means in treating NALFD. Some of the natural products apparently possess the properties of ameliorating symptoms of NAFLD through restoration of lipid and carbohydrate metabolism and energy homeostasis. Data from recent animal and human studies concerning the use of natural products in the treatment of NAFLD are analyzed, and the potential underlying mechanisms are discussed.
    MeSH term(s) Animals ; Biological Products/therapeutic use ; Carbohydrate Metabolism/drug effects ; Carbohydrate Metabolism/physiology ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Glucose/metabolism ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Lipid Metabolism/drug effects ; Lipid Metabolism/physiology ; Mitochondria, Liver/drug effects ; Mitochondria, Liver/physiology ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/physiopathology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology
    Chemical Substances Biological Products ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2015-05-21
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450116666150531155711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.

    Xu, Jiao-Ya / Li, Zhong-Ping / Zhang, Li / Ji, Guang

    World journal of gastroenterology

    2014  Volume 20, Issue 37, Page(s) 13493–13500

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular carcinoma. However, the pathogenesis of NAFLD is complex, and no efficient pharmaceutic treatments have yet been established for NAFLD. Accumulating data have shown that the farnesoid X receptor (FXR) plays important roles not only in bile acid metabolism, but also in lipid and carbohydrate homeostasis, inflammatory responses, among others. In this review, we aim to highlight the role of FXR in the pathogenesis and treatment of NAFLD.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Bile Acids and Salts/metabolism ; Carbohydrate Metabolism ; Disease Progression ; Hepatitis/etiology ; Hepatitis/metabolism ; Humans ; Hypolipidemic Agents/therapeutic use ; Inflammation Mediators/metabolism ; Lipid Metabolism ; Liver/drug effects ; Liver/metabolism ; Liver Cirrhosis/etiology ; Liver Cirrhosis/metabolism ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Receptors, Cytoplasmic and Nuclear/agonists ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction
    Chemical Substances Anti-Inflammatory Agents ; Bile Acids and Salts ; Hypolipidemic Agents ; Inflammation Mediators ; Receptors, Cytoplasmic and Nuclear ; farnesoid X-activated receptor (0C5V0MRU6P)
    Language English
    Publishing date 2014-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i37.13493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity.

    Zhang, Li / Xu, Jiaoya / Song, Haiyan / Yao, Zemin / Ji, Guang

    Journal of translational medicine

    2014  Volume 12, Page(s) 236

    Abstract: Background: Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndromes. The mechanism of SNN action ...

    Abstract Background: Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndromes. The mechanism of SNN action is unknown.
    Methods: HepG2 cells were cultured in lipid-rich media supplemented with chemical components of SNN. Male Wistar rats (6 weeks of age) were fed a high calorie diet (15% fat, 15% sucrose, and 2% cholesterol) for eight weeks, and then treated with SNN for four weeks. Body and liver weight, lipids profiles, insulin and glucose levels, glucose and insulin tolerance were evaluated, the mRNA and protein expression of insulin receptor (InsR), insulin receptor substrate (IRS) 1/2, protein kinase B (PKB/Akt), protein expression of suppressor of cytokine signaling 3 (SOCS3), protein kinase C epsilon (PKC ε) in liver tissue were analysed.
    Results: Treatment with SNN components in lipid-laden HepG2 cells decreased lipid accumulation. Rats fed with a HC diet developed hepatosteatosis and accompanied hyperglycemia, hyperinsulinemia, hyperleptinemia, and diabetic dyslipidemia. Prolonged HC diet feeding resulted in parabolic response in plasma triglyceride (TG) concentrations, indicative of compromised hepatic production of TG-rich lipoproteins. HC diet feeding also resulted in impaired insulin sensitivity and hepatic insulin signalling. Administration of SNN extracts alleviated hepatosteatosis and conferred to a normolipoproteinemia profile in the HC diet-fed rats. The efficacy of SNN extract in improving liver function and insulin sensitivity was comparable to that of simvastatin or pioglitazone. The improved insulin signaling by SNN treatment was associated with increased IRS and Akt phosphorylation and decreased SOCS3 expression. However, SNN failed to inhibit the PKC ε expression in the liver.
    Conclusions: SNN is effective in reducing lipid accumulation in HepG2 cells and attenuating hepatosteatosis in HC diet-fed rats. Reduced hepatic lipid content in the rat liver was associated with improved insulin signalling.
    MeSH term(s) Animals ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Fatty Liver/drug therapy ; Fatty Liver/metabolism ; Hep G2 Cells ; Humans ; Insulin Resistance ; Liver/drug effects ; Liver/metabolism ; Male ; Phytotherapy ; Rats ; Rats, Wistar ; Salvia/chemistry
    Chemical Substances Drugs, Chinese Herbal ; jiangzhi
    Language English
    Publishing date 2014-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-014-0236-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.

    Li, Zhongping / Xu, Jiaoya / Zheng, Peiyong / Xing, Lianjun / Shen, Hongyi / Yang, Lili / Zhang, Li / Ji, Guang

    International journal of clinical and experimental medicine

    2015  Volume 8, Issue 10, Page(s) 17295–17307

    Abstract: Hawthorn (Crataeguspinnatifida) belongs to the genus Rosaceae family of plants. The hawthorn leaf, Crataeguspinnatifida Bunge, is used for both condiment and medicinal purposes to prevent and treat metabolic dysfunctions, such as hyperlipidemia, ... ...

    Abstract Hawthorn (Crataeguspinnatifida) belongs to the genus Rosaceae family of plants. The hawthorn leaf, Crataeguspinnatifida Bunge, is used for both condiment and medicinal purposes to prevent and treat metabolic dysfunctions, such as hyperlipidemia, hypertension, and cardiovascular disease in traditional Chinese medicine. However, its effects on nonalcoholic fatty liver disease (NAFLD) remain obscure. The purpose of the present study was to investigate the protective effect of hawthorn leaf flavonoids (HLF), the dominant bioactive extracts of hawthorn leaves, on high fat diet (HFD)-induced hepatic steatosis and to elucidate its underlying mechanisms. HLF supplementation significantly lowered body weight, liver weight, liver/body weight ratio, improved serum parameters and liver dysfunction and markedly decreased hepatic lipid accumulation in HFD-fed rats. In addition, HLF intervention dramatically increased circulating adiponectin levels and up-regulated the expression of adiponectin receptors, particularly adiponectin receptor 2 (AdipoR2) in the liver. Moreover, adenosine monophosphate (AMP)-activated protein kinase (AMPK) was also activated, as well as AMPK-mediated alteration of sterol regulatory element binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor α (PPARα) and their downstream targets. Taken together, our data suggest that HLF ameliorates hepatic steatosis by enhancing the adiponectin/AMPK pathway in the liver of HFD-induced NAFLD rats.
    Language English
    Publishing date 2015-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2418305-2
    ISSN 1940-5901
    ISSN 1940-5901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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