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Article ; Online: Roles of HIF-1α signaling in Mycobacterium tuberculosis infection: New targets for anti-TB therapeutics?

Li, Chaowei / Wang, Jiajun / Xu, Jun-Fa / Pi, Jiang / Zheng, Biying

Biochemical and biophysical research communications

2024 Volume 711, Page(s) 149920

Abstract: Tuberculosis (TB), a deadly infectious disease induced by Mycobacterium tuberculosis (Mtb), continues to be a global public health issue that kill millions of patents every year. Despite significant efforts have been paid to identify effective TB ... ...

Abstract	Tuberculosis (TB), a deadly infectious disease induced by Mycobacterium tuberculosis (Mtb), continues to be a global public health issue that kill millions of patents every year. Despite significant efforts have been paid to identify effective TB treatments, the emergence of drug-resistant strains of the disease and the presence of comorbidities in TB patients urges us to explore the detailed mechanisms involved in TB immunity and develop more effective innovative anti-TB strategies. HIF-1α, a protein involved in regulating cellular immune responses during TB infection, has been highlighted as a promising target for the development of novel strategies for TB treatment due to its critical roles in anti-TB host immunity. This review provides a summary of current research progress on the roles of HIF-1α in TB infection, highlighting its importance in regulating the host immune response upon Mtb infection and summarizing the influences and mechanisms of HIF-1α on anti-TB immunological responses of host cells. This review also discusses the various challenges associated with developing HIF-1α as a target for anti-TB therapies, including ensuring specificity and avoiding off-target effects on normal cell function, determining the regulation and expression of HIF-1α in TB patients, and developing drugs that can inhibit HIF-1α. More deep understanding of the molecular mechanisms involved in HIF-1α signaling, its impact on TB host status, and systematic animal testing and clinical trials may benefit the optimization of HIF-1α as a novel therapeutic target for TB.
MeSH term(s)	Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Mycobacterium tuberculosis/drug effects ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/immunology ; Signal Transduction/drug effects ; Tuberculosis/drug therapy ; Tuberculosis/immunology ; Tuberculosis/metabolism ; Tuberculosis/microbiology ; Animals ; Antitubercular Agents/therapeutic use ; Antitubercular Agents/pharmacology ; Molecular Targeted Therapy/methods
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; Antitubercular Agents ; HIF1A protein, human
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149920
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emerging Role of Exosomes in Tuberculosis: From Immunity Regulations to Vaccine and Immunotherapy.

Sun, Yin-Fu / Pi, Jiang / Xu, Jun-Fa

Frontiers in immunology

2021 Volume 12, Page(s) 628973

Abstract: Exosomes are cell-derived nanovesicles carrying protein, lipid, and nucleic acid for secreting cells, and act as significant signal transport vectors for cell-cell communication and immune modulation. Immune-cell-derived exosomes have been found to ... ...

Abstract	Exosomes are cell-derived nanovesicles carrying protein, lipid, and nucleic acid for secreting cells, and act as significant signal transport vectors for cell-cell communication and immune modulation. Immune-cell-derived exosomes have been found to contain molecules involved in immunological pathways, such as MHCII, cytokines, and pathogenic antigens. Tuberculosis (TB), caused by
MeSH term(s)	Adaptive Immunity ; Animals ; Autophagy ; Exosomes/immunology ; Exosomes/microbiology ; Exosomes/transplantation ; Humans ; Immune Evasion ; Immunotherapy ; Mycobacterium tuberculosis/immunology ; Mycobacterium tuberculosis/pathogenicity ; Tuberculosis/immunology ; Tuberculosis/microbiology ; Tuberculosis/therapy ; Tuberculosis Vaccines/therapeutic use
Chemical Substances	Tuberculosis Vaccines
Language	English
Publishing date	2021-04-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.628973
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Advancing of Selenium Nanoparticles Against Infectious Diseases.

Lin, Wensen / Zhang, Junai / Xu, Jun-Fa / Pi, Jiang

Frontiers in pharmacology

2021 Volume 12, Page(s) 682284

Abstract: Infectious diseases, caused by the direct exposure of cellular or acellular pathogens, are found to be closely associated with multiple inflammation and immune responses, keeping one of the top threats to human health. As an indispensable trace element, ... ...

Abstract	Infectious diseases, caused by the direct exposure of cellular or acellular pathogens, are found to be closely associated with multiple inflammation and immune responses, keeping one of the top threats to human health. As an indispensable trace element, Selenium (Se) plays important roles in antioxidant defence and redox state regulation along with a variety of specific metabolic pathways. In recent decades, with the development of novel nanotechnology, Selenium nanoparticles (Se NPs) emerged as a promising agent for biomedical uses due to their low toxicity, degradability and high bioavailability. Taking the advantages of the strong ability to trigger apoptosis or autophagy by regulating reactive oxygen species (ROS), Se NPs have been widely used for direct anticancer treatments and pathogen killing/clearance in host cells. With excellent stability and drug encapsulation capacity, Se NPs are now serving as a kind of powerful nano-carriers for anti-cancer, anti-inflammation and anti-infection treatments. Notably, Se NPs are also found to play critical roles in immunity regulations, such as macrophage and T effector cell activation, which thus provides new possibilities to achieve novel nano-immune synergetic strategy for anti-cancer and anti-infection therapies. In this review, we summarized the progress of preparation methods for Se NPs, followed by the advances of their biological functions and mechanisms for biomedical uses, especially in the field of anti-infection treatments. Moreover, we further provide some prospects of Se NPs in anti-infectious diseases, which would be helpful for facilitating their future research progress for anti-infection therapy.
Language	English
Publishing date	2021-07-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.682284
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advances of Long Non-Coding RNAs as Potential Biomarkers for Tuberculosis: New Hope for Diagnosis?

Xia, Jiaojiao / Liu, Yilin / Ma, Yuhe / Yang, Fen / Ruan, Yongdui / Xu, Jun-Fa / Pi, Jiang

Pharmaceutics

2023 Volume 15, Issue 8

Abstract: Tuberculosis (TB), one of the top ten causes of death globally induced by the infection of Mycobacterium tuberculosis (Mtb), remains a grave public health issue worldwide. With almost one-third of the world's population getting infected by Mtb, between 5% ...

Abstract	Tuberculosis (TB), one of the top ten causes of death globally induced by the infection of Mycobacterium tuberculosis (Mtb), remains a grave public health issue worldwide. With almost one-third of the world's population getting infected by Mtb, between 5% and 10% of these infected individuals are predicted to develop active TB disease, which would not only result in severe tissue damage and necrosis, but also pose serious threats to human life. However, the exact molecular mechanisms underlying the pathogenesis and immunology of TB remain unclear, which significantly restricts the effective control of TB epidemics. Despite significant advances in current detection technologies and treatments for TB, there are still no appropriate solutions that are suitable for simultaneous, early, rapid, and accurate screening of TB. Various cellular events can perturb the development and progression of TB, which are always associated with several specific molecular signaling events controlled by dysregulated gene expression patterns. Long non-coding RNAs (lncRNAs), a kind of non-coding RNA (ncRNA) with a transcript of more than 200 nucleotides in length in eukaryotic cells, have been found to regulate the expression of protein-coding genes that are involved in some critical signaling events, such as inflammatory, pathological, and immunological responses. Increasing evidence has claimed that lncRNAs might directly influence the susceptibility to TB, as well as the development and progression of TB. Therefore, lncRNAs have been widely expected to serve as promising molecular biomarkers and therapeutic targets for TB. In this review, we summarized the functions of lncRNAs and their regulatory roles in the development and progression of TB. More importantly, we widely discussed the potential of lncRNAs to act as TB biomarkers, which would offer new possibilities in novel diagnostic strategy exploration and benefit the control of the TB epidemic.
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15082096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures.

Yao, Hanbo / Wang, Xiaodong / Chi, Jiaxin / Chen, Haorong / Liu, Yilin / Yang, Jiayi / Yu, Jiaqi / Ruan, Yongdui / Xiang, Xufu / Pi, Jiang / Xu, Jun-Fa

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 5

Abstract: Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of ... ...

Abstract	Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of monoamine hypothesis, resulting in slow progress. Traditional ADs have undesirable traits like delayed onset of action, limited efficacy, and severe side effects. Recently, two categories of fast-acting antidepressant compounds have surfaced, dissociative anesthetics S-ketamine and its metabolites, as well as psychedelics such as lysergic acid diethylamide (LSD). This has led to structural research and drug development of the receptors that they target. This review provides breakthroughs and achievements in the structure of depression-related receptors and novel ADs based on these. Cryo-electron microscopy (cryo-EM) has enabled researchers to identify the structures of membrane receptors, including the N-methyl-D-aspartate receptor (NMDAR) and the 5-hydroxytryptamine 2A (5-HT
MeSH term(s)	Humans ; Depressive Disorder, Major/drug therapy ; Serotonin ; Molecular Structure ; Cryoelectron Microscopy ; Antidepressive Agents/pharmacology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
Chemical Substances	Serotonin (333DO1RDJY) ; Antidepressive Agents ; Receptors, G-Protein-Coupled ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29050964
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics.

Huang, Huanshao / Wang, Jiajun / Zhang, Junai / Cai, Jiye / Pi, Jiang / Xu, Jun-Fa

Pharmaceutics

2021 Volume 13, Issue 10

Abstract: Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and ... ...

Abstract	Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects and low efficiency for a long time, which urges us to develop new technologies for more effective and much safer anticancer therapies. Novel nanotechnologies, based on different kinds of functional nanomaterials, have been proved to act as effective and promising strategies for anticancer treatment. Based on the important biological roles of cobalt, cobalt oxide nanoparticles (NPs) have been widely developed for their attractive biomedical applications, especially their potential for anticancer treatments due to their selective inhibition of cancer cells. Thus, more and more attention has been attracted to the preparation, characterization and anticancer investigation of cobalt oxide nanoparticles in recent years, which is expected to introduce novel anticancer treatment strategies. In this review, we summarize the synthesis methods of cobalt oxide nanoparticles to discuss the advantages and restrictions for their preparation. Moreover, we emphatically discuss the anticancer functions of cobalt oxide nanoparticles as well as their underlying mechanisms to promote the development of cobalt oxide nanoparticles for anticancer treatments, which might finally benefit the current anticancer therapeutics based on functional cobalt oxide nanoparticles.
Language	English
Publishing date	2021-10-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13101599
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies.

Fan, Shuhao / Lin, Wensen / Huang, Yifan / Xia, Jiaojiao / Xu, Jun-Fa / Zhang, Junai / Pi, Jiang

Frontiers in pharmacology

2022 Volume 13, Page(s) 829712

Abstract: Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy ( ...

Abstract	Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.829712
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Promising Roles of Circular RNAs as Biomarkers and Targets for Potential Diagnosis and Therapy of Tuberculosis.

Huang, Yifan / Li, Ying / Lin, Wensen / Fan, Shuhao / Chen, Haorong / Xia, Jiaojiao / Pi, Jiang / Xu, Jun-Fa

Biomolecules

2022 Volume 12, Issue 9

Abstract: Tuberculosis (TB), caused ... ...

Abstract	Tuberculosis (TB), caused by
MeSH term(s)	Biomarkers/metabolism ; Humans ; MicroRNAs/metabolism ; RNA Splicing ; RNA, Circular/genetics ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/genetics
Chemical Substances	Biomarkers ; MicroRNAs ; RNA, Circular
Language	English
Publishing date	2022-09-04
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12091235
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Article: Ferroptosis: A mixed blessing for infectious diseases.

Xiao, Leyao / Huang, Huanshao / Fan, Shuhao / Zheng, Biying / Wu, Jianguo / Zhang, Junai / Pi, Jiang / Xu, Jun-Fa

Frontiers in pharmacology

2022 Volume 13, Page(s) 992734

Abstract: To date, it has been confirmed that the occurrence and development of infectious diseases are tightly associated with regulatory cell death processes, such as apoptosis, autophagy, and necroptosis. Ferroptosis, as a newly discovered form of regulatory ... ...

Abstract	To date, it has been confirmed that the occurrence and development of infectious diseases are tightly associated with regulatory cell death processes, such as apoptosis, autophagy, and necroptosis. Ferroptosis, as a newly discovered form of regulatory cell death characterized by iron-dependent lipid peroxidation, is not only closely associated with tumor progression, but is also found to be tightly related to the regulation of infectious diseases, such as Tuberculosis, Cryptococcal meningitis, Malaria and COVID-2019. The emerging critical roles of ferroptosis that has been found in infectious disease highlight ferroptosis as a potential therapeutic target in this field, which is therefore widely expected to be developed into new therapy strategy against infectious diseases. Here, we summarized the underlying mechanisms of ferroptosis and highlighted the intersections between host immunity and ferroptosis. Moreover, we illuminated the roles of ferroptosis in the occurrence and progression of different infectious diseases, which might provide some unique inspiration and thought-provoking perspectives for the future research of these infectious diseases, especially for the development of ferroptosis-based therapy strategy against infectious diseases.
Language	English
Publishing date	2022-09-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.992734
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy.

Liu, Jianxin / Fan, Shuhao / Xiang, Yinhong / Xia, Jiaojiao / Jin, Hua / Xu, Jun-Fa / Yang, Fen / Cai, Jiye / Pi, Jiang

Scanning

2022 Volume 2022, Page(s) 1422185

Abstract: Gambogic acid (GA), a kind of polyprenylated xanthone derived from Garcinia hanburyi tree, has showed spectrum anticancer effects both in vitro and in vivo with low toxicity. However, up to now, there is little information about the effects of GA on ... ...

Abstract	Gambogic acid (GA), a kind of polyprenylated xanthone derived from Garcinia hanburyi tree, has showed spectrum anticancer effects both in vitro and in vivo with low toxicity. However, up to now, there is little information about the effects of GA on esophageal cancer. In this study, we aim to test the anticancer effects of GA on esophageal cancer EC9706 cells. We established a nanoscale imaging method based on AFM to evaluate the reactive oxygen species- (ROS-) mediated anticancer effects of GA on esophageal cancer regarding the morphological and ultrastructural changes of esophageal cancer cells. The obtained results demonstrated that GA could inhibit cell proliferation, induce apoptosis, induce cell cycle arrest, and induce mitochondria membrane potential disruption in a ROS-dependent way. And using AFM imaging, we also found that GA could induce the damage of cellular morphology and increase of membrane height distribution and membrane roughness in EC9706 cells, which could be reversed by the removal of GA-induced excessive intracellular ROS. Our results not only demonstrated the anticancer effects of GA on EC9706 cells in ROS-dependent mechanism but also strongly suggested AFM as a powerful tool for the detection of ROS-mediated cancer cell apoptosis on the basis of imaging.
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Esophageal Neoplasms/drug therapy ; Humans ; Microscopy, Atomic Force ; Reactive Oxygen Species/metabolism ; Xanthones/pharmacology
Chemical Substances	Reactive Oxygen Species ; Xanthones ; gambogic acid (8N585K83U2)
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	391900-6
ISSN	1932-8745 ; 0161-0457
ISSN (online)	1932-8745
ISSN	0161-0457
DOI	10.1155/2022/1422185
Database	MEDical Literature Analysis and Retrieval System OnLINE

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