Article ; Online: Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis.
Clinical journal of the American Society of Nephrology : CJASN
2019 Volume 14, Issue 3, Page(s) 411–420
Abstract: Background and objectives: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in ...
| Abstract | Background and objectives: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in part explained by inadequate excretion of the principal urinary buffer ammonium. The role of net acid excretion in the pathogenesis of uric acid nephrolithiasis is incompletely understood. Design, setting, participants, & measurements: We compared acid-base parameters of patients with idiopathic uric acid nephrolithiasis with matched control subjects under controlled diets in an inpatient metabolic unit. Measurements included fasting blood and 24-hour urine chemistries and 24-hour urine metabolomic analysis. Comparisons between groups included analysis of covariance models controlling for urine pH or body mass index. Results: Subjects with idiopathic uric acid nephrolithiasis had lower urine pH (5.5 versus 5.9; Conclusions: Higher acid load to the kidney, resulting in higher urinary net acid excretion, is an important factor in the pathogenesis of idiopathic uric acid nephrolithiasis. |
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| MeSH term(s) | Acid-Base Equilibrium ; Biomarkers/urine ; Body Mass Index ; Case-Control Studies ; Diet/adverse effects ; Female ; Humans ; Hydrogen-Ion Concentration ; Kidney/physiopathology ; Male ; Middle Aged ; Nephrolithiasis/diagnosis ; Nephrolithiasis/etiology ; Nephrolithiasis/physiopathology ; Nephrolithiasis/urine ; Pilot Projects ; Renal Elimination ; Risk Factors ; Uric Acid/urine | |||||
| Chemical Substances | Biomarkers ; Uric Acid (268B43MJ25) | |||||
| Language | English | |||||
| Publishing date | 2019-02-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2226665-3 | |||||
| ISSN | 1555-905X ; 1555-9041 | |||||
| ISSN (online) | 1555-905X | |||||
| ISSN | 1555-9041 | |||||
| DOI | 10.2215/CJN.10420818 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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