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  1. AU="Xu, Linhao"
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  1. Article: Drug therapy for myocarditis induced by immune checkpoint inhibitors.

    Wu, Yihao / Xu, Yizhou / Xu, Linhao

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1161243

    Abstract: Immune checkpoint inhibitors (ICIs), including cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and its ligand 1 (PD-L1), have improved the survival in multiple types of cancers; however, ICIs may cause cardiovascular toxicity. ... ...

    Abstract Immune checkpoint inhibitors (ICIs), including cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death 1 (PD-1), and its ligand 1 (PD-L1), have improved the survival in multiple types of cancers; however, ICIs may cause cardiovascular toxicity. Although rare, ICI-mediated cardiotoxicity is an extremely serious complication with a relatively high mortality. In this review, we discuss the underlying mechanism and clinical manifestations of cardiovascular toxicity induced by ICIs. According to previous studies, multiple signaling pathways are involved in myocarditis induced by ICIs. Further, we summarize the clinical trials of drugs for the treatment of ICI-associated myocarditis. Although these drugs have shown the beneficial effects of alleviating cardiac function and reducing mortality rates, their efficacy is not optimal. Finally, we discuss the therapeutic potential of some novel compounds as well as the underlying mechanisms of their action.
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1161243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea.

    He, Daqiang / Chen, Jian / Du, Xiaoxue / Xu, Linhao

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1222626

    Abstract: Obstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cognitive impairment is a signifi- cant and common OSA complication often described in such patients. The most commonly utilized ... ...

    Abstract Obstructive sleep apnea (OSA) is a severe sleep disorder associated with intermittent hypoxia and sleep fragmentation. Cognitive impairment is a signifi- cant and common OSA complication often described in such patients. The most commonly utilized methods in clinical OSA treatment are oral appliances and continuous positive airway pressure (CPAP). However, the current therapeutic methods for improving cognitive function could not achieve the expected efficacy in same patients. Therefore, further understanding the molecular mechanism behind cognitive dysfunction in OSA disease will provide new treatment methods and targets. This review briefly summarized the clinical manifestations of cognitive impairment in OSA disease. Moreover, the pathophysiological molecular mechanism of OSA was outlined. Our study concluded that both SF and IH could induce cognitive impairment by multiple signaling pathways, such as oxidative stress activation, inflammation, and apoptosis. However, there is a lack of effective drug therapy for cognitive impairment in OSA. Finally, the therapeutic potential of some novel compounds and herbal medicine was evaluated on attenuating cognitive impairment based on certain preclinical studies.
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1222626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines.

    Xu, Linhao / Yan, Hui / Tang, Yiling / Liu, Yu / Xiang, Ping / Hang, Taijun

    Journal of analytical toxicology

    2024  

    Abstract: Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-keto-arylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances ... ...

    Abstract Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-keto-arylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances have rapidly increasing illicit recreational use, the lack of detailed toxicity data are of particular concern. Therefore, analysis of their metabolites can help forensic personnel provide references and suggestions on whether a suspect has taken an illicit new psychoactive β-keto-arylcyclohexylamine. The present study investigated the in vitro and in vivo metabolism and metabolites of three β-keto-arylcyclohexylamines: deschloro-N-ethyl-ketamine, fluoro-N-ethyl-ketamine and bromoketamine. In vitro and in vivo models were established using zebrafish and human liver microsomes for analysis of Phase I and Phase II metabolites by liquid chromatography-high-resolution mass spectrometry. Altogether, 49 metabolites were identified. The results were applied for the subject urine samples of known fluoro-N-ethyl-ketamine consumer screen analysis in forensic cases. Hydroxy-deschloro-N-ethyl-ketamine, hydroxy-fluoro-N-ethyl-ketamine and hydroxy-bromoketamine were recommended as potential biomarkers for documenting intake in clinical and forensic cases.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 752391-9
    ISSN 1945-2403 ; 0146-4760
    ISSN (online) 1945-2403
    ISSN 0146-4760
    DOI 10.1093/jat/bkae020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Hydrothermal synthesis of mesoporous tobermorite from fly ash with enhanced removal performance towards Pb2+ from wastewater

    Wang, Zehua / Xu, Linhao / Wu, Daishe / Zheng, Shili

    Colloids and surfaces. 2022 Jan. 02, v. 632

    2022  

    Abstract: The mesoporous tobermorite with high removal efficiency of Pb²⁺ was hydrothermally synthesized from fly ash (FA). The physicochemical characteristics of the synthesized tobermorite were measured by X-ray diffraction (XRD), scanning electron microscopy ( ... ...

    Abstract The mesoporous tobermorite with high removal efficiency of Pb²⁺ was hydrothermally synthesized from fly ash (FA). The physicochemical characteristics of the synthesized tobermorite were measured by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller specific surface area analyzer, and Fourier transform infrared spectroscopy (FTIR). It was found that the specific surface area and pore volume of the mesoporous tobermorite were 29.98 m²/g and 0.1325 cm³/g, respectively, which were much higher than those of FA. The tobermorite showed high removal efficiency for Pb²⁺ of 99.93%, and the adsorption kinetic data for Pb²⁺ adsorption on tobermorite were better fitted with the pseudo-second-order model. Besides, the Langmuir isotherm model provided better description of the Pb²⁺ adsorption isotherm, and the maximum adsorption capacity for Pb²⁺ adsorption on tobermorite was 266.67 mg/g, which was much higher than that on FA (86.13 mg/g). What’s more, the adsorption mechanisms of the tobermorite towards Pb²⁺ were analyzed by XRD, SEM-energy dispersive spectroscopy, and FTIR. It was found that the high adsorption capacity of the tobermorite towards Pb²⁺ was ascribed to its mesoporous structure, a mass of –OH, the ion-exchange of Ca²⁺ with Pb²⁺, and the precipitation of 2PbCO₃·Pb(OH)₂. This work presents the tobermorite synthesized from FA as an effective and low-cost adsorbent towards Pb²⁺, and provides a potential application method of FA in treatment of industrial wastewater containing Pb²⁺.
    Keywords Fourier transform infrared spectroscopy ; X-ray diffraction ; adsorbents ; adsorption ; calcium ; fly ash ; industrial wastewater ; ion exchange ; models ; porous media ; sorption isotherms ; surface area
    Language English
    Dates of publication 2022-0102
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2021.127775
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  5. Article ; Online: Metabolism of dipentylone in zebrafish and human liver microsomes determined by liquid chromatography-high resolution mass spectrometry.

    Tang, Yiling / Xu, Linhao / Zhao, Junbo / Xiang, Ping / Yan, Hui

    Journal of pharmaceutical and biomedical analysis

    2023  Volume 236, Page(s) 115710

    Abstract: The consumption of novel psychoactive substances (NPS) is exceedingly prevalent in society, as these substances are sold and distributed as "legal highs." One novel synthetic cathinone emerging in the market is 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino) ... ...

    Abstract The consumption of novel psychoactive substances (NPS) is exceedingly prevalent in society, as these substances are sold and distributed as "legal highs." One novel synthetic cathinone emerging in the market is 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino) pentan-1-one (dipentylone). The goal of this work was to study the in vivo and in vitro metabolism of dipentylone in zebrafish and human liver microsomes (HLMs) by liquid chromatography-high resolution mass spectrometry (LC-HRMS). The zebrafish and HLM samples contained 14 dipentylone metabolites, specifically 12 phase Ⅰ metabolites and 2 phase Ⅱ metabolites. The main metabolic pathways included monohydroxylation (M1 and M2), N-dealkylation (M3), hydroxylation of the aromatic ring and dealkoxylation of M3 (M4), O-dealkylation (M5), N-dealkylation of M5 (M6), reduction of carboxide (M7), monohydroxylation of M5 (M8), dehydrogenation (M9), dealkoxylation (M10), N-dealkylation of M10 (M11), dealkoxylation of M9 (M12), glucuronidation of M5 (M13), and sulfation (M14). The monohydroxylated metabolite (M2) can be recommended as metabolic markers for dipentylone. This study is the first to identify a target compound for monitoring the abuse of dipentylone and to determine the essential chemical structure of the metabolites for further toxicological research.
    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115710
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Penpulimab-induced complete atrioventricular block in a patient with metastatic renal cancer.

    Shen, Lishui / Xu, Linhao / Wang, Yongmei / Wu, Yihao / Duan, Xu

    HeartRhythm case reports

    2023  Volume 9, Issue 7, Page(s) 451–455

    Language English
    Publishing date 2023-04-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.04.007
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  7. Article ; Online: Preparation of amino-functionalized fly ash based tobermorite for enhanced removal of Cr(VI).

    Wang, Zehua / Xu, Linhao / Su, Ningning / Zhu, Shuhan / Wu, Daishe

    Environmental science and pollution research international

    2023  Volume 30, Issue 19, Page(s) 54547–54555

    Abstract: Amino-functionalized fly ash based tobermorite ( ... ...

    Abstract Amino-functionalized fly ash based tobermorite (NH
    MeSH term(s) Coal Ash ; Water Pollutants, Chemical/analysis ; Chromium/analysis ; Adsorption ; Kinetics
    Chemical Substances Coal Ash ; chromium hexavalent ion (18540-29-9) ; tobermorite (1319-31-9) ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB)
    Language English
    Publishing date 2023-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-26269-x
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  8. Article ; Online: Mutation of histone H3 serine 28 to alanine influences H3K27me3-mediated gene silencing in Arabidopsis thaliana.

    Xu, Linhao / Cheng, Jinping / Jiang, Hua

    Plant physiology

    2022  Volume 190, Issue 4, Page(s) 2417–2429

    Abstract: Histone modifications are essential for chromatin activity and play an important role in many biological processes. Trimethylation of histone H3K27 (H3K27me3) is a repressive modification established by Polycomb Repressive Complex 2 (PRC2). Although the ... ...

    Abstract Histone modifications are essential for chromatin activity and play an important role in many biological processes. Trimethylation of histone H3K27 (H3K27me3) is a repressive modification established by Polycomb Repressive Complex 2 (PRC2). Although the presence of the histone H3 serine 28 phosphorylation (H3S28ph) modification at adjacent amino acid residues has both positive and negative effects on Polycomb silencing in mammals, little is known about the effect of H3S28ph on H3K27me3-mediated gene silencing in plants. In this study, we show that mutating H3S28A in Arabidopsis (Arabidopsis thaliana) causes a dominant-negative effect that leads to an early-flowering phenotype by promoting the expression of flowering-promoting genes independently of abnormal cell division. While H3S28ph levels decreased due to the H3S28A mutation, H3K27me3 levels at the same loci did not increase. Moreover, we observed decreased H3K27me3 levels at some known PRC2 target genes in H3.3S28A transgenic lines, rather than the expected enhanced H3K27me3-mediated silencing. In line with the reduced H3K27me3 levels, the expression of the PRC2 catalytic subunits CURLY LEAF and SWINGER decreased. Taken together, these data demonstrate that H3.3S28 is required for PRC2-dependent H3K27me3-mediated silencing in Arabidopsis, suggesting that H3S28 has a noncanonical function in H3K27me3-mediated gene silencing.
    MeSH term(s) Animals ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Histones/genetics ; Histones/metabolism ; Serine/genetics ; Serine/metabolism ; Alanine/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism ; Gene Silencing ; Mutation/genetics ; Gene Expression Regulation, Plant ; Mammals/metabolism ; Transcription Factors/metabolism
    Chemical Substances Histones ; Serine (452VLY9402) ; Alanine (OF5P57N2ZX) ; Arabidopsis Proteins ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; SWINGER protein, Arabidopsis ; Transcription Factors
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiac409
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  9. Article: Writing and Reading Histone H3 Lysine 9 Methylation in

    Xu, Linhao / Jiang, Hua

    Frontiers in plant science

    2020  Volume 11, Page(s) 452

    Abstract: In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. ... ...

    Abstract In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.00452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: Towards High Performance One-Stage Human Pose Estimation

    Li, Ling / Zhao, Lin / Xu, Linhao / Xu, Jie

    2023  

    Abstract: Making top-down human pose estimation method present both good performance and high efficiency is appealing. Mask RCNN can largely improve the efficiency by conducting person detection and pose estimation in a single framework, as the features provided ... ...

    Abstract Making top-down human pose estimation method present both good performance and high efficiency is appealing. Mask RCNN can largely improve the efficiency by conducting person detection and pose estimation in a single framework, as the features provided by the backbone are able to be shared by the two tasks. However, the performance is not as good as traditional two-stage methods. In this paper, we aim to largely advance the human pose estimation results of Mask-RCNN and still keep the efficiency. Specifically, we make improvements on the whole process of pose estimation, which contains feature extraction and keypoint detection. The part of feature extraction is ensured to get enough and valuable information of pose. Then, we introduce a Global Context Module into the keypoints detection branch to enlarge the receptive field, as it is crucial to successful human pose estimation. On the COCO val2017 set, our model using the ResNet-50 backbone achieves an AP of 68.1, which is 2.6 higher than Mask RCNN (AP of 65.5). Compared to the classic two-stage top-down method SimpleBaseline, our model largely narrows the performance gap (68.1 AP vs. 68.9 AP) with a much faster inference speed (77 ms vs. 168 ms), demonstrating the effectiveness of the proposed method. Code is available at: https://github.com/lingl_space/maskrcnn_keypoint_refined.

    Comment: 5 pages, 5 figures, accepted at ACM Multimedia Asia (MMAsia) 2022
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 004
    Publishing date 2023-01-12
    Publishing country us
    Document type Book ; Online
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