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Article: [The airway management and treatment of newborns with micrognathia and laryngomalacia].

Wang, Jing / Xu, Mengrou / Jin, Lei / Gu, Meizhen / Li, Xiaoyan

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2023 Volume 37, Issue 8, Page(s) 622–625;631

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Infant, Newborn ; Infant ; Micrognathism/surgery ; Laryngomalacia/surgery ; Treatment Outcome ; Mandible/surgery ; Airway Obstruction/surgery ; Intubation, Intratracheal ; Laryngeal Diseases ; Osteogenesis, Distraction ; Oxygen ; Retrospective Studies
Chemical Substances	Oxygen (S88TT14065)
Language	Chinese
Publishing date	2023-08-07
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2096-7993
ISSN	2096-7993
DOI	10.13201/j.issn.2096-7993.2023.08.004
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Article ; Online: Mechanisms of fibrosis in iatrogenic laryngotracheal stenosis: New discoveries and novel targets.

Xu, Mengrou / Hu, Bin / Chen, Jiarui / Wang, Jing / Li, Xiaoyan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 170, Page(s) 115995

Abstract: Iatrogenic laryngotracheal stenosis (iLTS) is a pathological condition characterized by the narrowing of the laryngeal and tracheal structures due to the formation of abnormal scar tissue. The core of iLTS lies in the fibrosis of the laryngotracheal ... ...

Abstract	Iatrogenic laryngotracheal stenosis (iLTS) is a pathological condition characterized by the narrowing of the laryngeal and tracheal structures due to the formation of abnormal scar tissue. The core of iLTS lies in the fibrosis of the laryngotracheal tissue, and recent research has unveiled novel discoveries regarding the underlying mechanisms of fibrosis. This review provides an overview of the recent advancements in understanding the mechanisms of fibrosis in iLTS. It encompasses various aspects, such as immune system dysregulation, changes in the extracellular matrix (ECM), metabolic alterations, and the role of microbial flora. The review also explores the interplay and relationships between these new mechanisms, establishing a theoretical foundation for the development of multi-target therapies and combination therapies for iLTS.
MeSH term(s)	Humans ; Constriction, Pathologic ; Laryngostenosis/etiology ; Laryngostenosis/metabolism ; Tracheal Stenosis/etiology ; Tracheal Stenosis/metabolism ; Fibrosis ; Iatrogenic Disease
Language	English
Publishing date	2023-12-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115995
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Article: CXCR7 promotes the migration of fibroblasts derived from patients with acquired laryngotracheal stenosis by NF-κB signaling.

Xu, Mengrou / Hu, Bin / Chen, Jiarui / Zhao, Limin / Wang, Jing / Li, Xiaoyan

Translational pediatrics

2023 Volume 12, Issue 9, Page(s) 1634–1645

Abstract: Background: Laryngotracheal stenosis (LTS) is a life-threatening disease that commonly results in airway obstruction in children. Traditional treatments such as laryngotracheal reconstruction and balloon dilation all have the risk of laryngotracheal ... ...

Abstract	Background: Laryngotracheal stenosis (LTS) is a life-threatening disease that commonly results in airway obstruction in children. Traditional treatments such as laryngotracheal reconstruction and balloon dilation all have the risk of laryngotracheal restenosis. It is of great importance to spare patients the morbidity of LTS and risks of restenosis associated with these treatments. Laboratory and clinical trials have focused on fibrosis, the crucial pathological process of LTS. This study was undertaken to investigate the function of CXC chemokine receptor-7 ( Methods: RNA sequencing was performed on acquired human LTS and normal trachea tissues to analyze differentially expressed genes. Fibroblasts from LTS and normal trachea tissues were isolated and cultured. Results: RNA sequencing showed that Conclusions: LTS had an increased
Language	English
Publishing date	2023-09-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-23-118
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Article: [Diagnosis and treatment of pediatric cervical bronchogenic cyst].

Chen, Wei / Xu, Mengrou / Wang, Qingyu / Chen, Jiarui / Sun, Guangbin / Li, Xiaoyan

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2023 Volume 37, Issue 11, Page(s) 916–919

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Female ; Humans ; Child ; Bronchogenic Cyst/diagnosis ; Bronchogenic Cyst/surgery ; Bronchogenic Cyst/pathology ; Retrospective Studies ; Neck/surgery ; Diagnosis, Differential ; Treatment Outcome
Language	Chinese
Publishing date	2023-10-31
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2096-7993
ISSN	2096-7993
DOI	10.13201/j.issn.2096-7993.2023.11.011
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Article ; Online: The value of MRI in the diagnosis of pediatric head and neck lymphatic malformations: A study of 46 surgical cases.

Chen, Wei / Xu, Hongming / Lina, Zhang / Xu, Mengrou / Li, Xiaoyan / Sun, Guangbin

European journal of radiology

2023 Volume 170, Page(s) 111260

Abstract: Objective To discuss the value of MRI in diagnosing and evaluating the pediatric head and neck lymphatic malformations (HNLMs). Methods We performed a retrospective review of 46 children who were referred to our hospital in the last decade for the ... ...

Abstract	Objective To discuss the value of MRI in diagnosing and evaluating the pediatric head and neck lymphatic malformations (HNLMs). Methods We performed a retrospective review of 46 children who were referred to our hospital in the last decade for the treatment of HNLMs. Results About 34 cases confirmed with intralesional hemorrhage while the capsule contents were dark red or light bloody liquid. The remaining 12 pure HNLMs were filled with yellow clear or watery liquid. The multilocular HNLMs accounted for 95.7 % (44/46). The accuracy of contrast enhanced MRI (CE-MRI) diagnosis of HNLMs was 100 %. On MRI, the HNLMs appeared as irregular shape [95.7 % (44/46)], clear boundary [91.3 % (42/46)], infiltrative growth [91.3 % (42/46)] cystic masses. The cystic wall and septa were hyperintense on T1WI and hypointense on T2WI (100 %), and displayed enhancement. The capsule contents had hypointense on T1WI and hyperintense on T2WI in 18 cases (pure HNLMs,12; intracystic hemorrhage,6), while that of mixed signal in 28 cases (pure HNLMs,0; intracystic hemorrhage,28). Capsule contents were enhanced in 22 cases (pure HNLMs,1; intracystic hemorrhage,21), while the remaining 24 without enhancement (pure HNLMs,11; intracystic hemorrhage,13). Liquid-liquid levers were found in 21 cases (pure HNLMs,0; intracystic hemorrhage,21). There were statistical differences in capsule contents signal, enhancement, and liquid-liquid levels between the two groups (P < 0.05). Conclusions On MRI, HNLMs typically show a thin-walled, well-circumscribed, irregularly shaped, infiltrative, unenhanced, multilocular cystic mass with hypointense on T1WI and hyperintense on T2WI. The capsule wall and septa are hyperintense on T1WI, hypointense on T2WI, and display enhancement. Changes in the signal of capsule contents or appearance of liquid-liquid levels indicate intracystic hemorrhage.
MeSH term(s)	Humans ; Child ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Hemorrhage
Language	English
Publishing date	2023-12-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2023.111260
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Article ; Online: Management of the head and neck lymphatic malformations in children: A 7-year experience of 91 surgical cases.

Chen, Wei / Xu, Hongming / Chen, Fang / Xu, Mengrou / Xu, Rong / Wang, Qingyu / Li, Xiaoyan

American journal of otolaryngology

2023 Volume 44, Issue 4, Page(s) 103897

Abstract: Objective: To review the clinical characteristics and treatment outcomes of head and neck lymphatic malformations (HNLMs) in children.: Methods: A retrospective study of 91 patients with HNLMs was performed.: Results: The age ranged from 1 day to ... ...

Abstract	Objective: To review the clinical characteristics and treatment outcomes of head and neck lymphatic malformations (HNLMs) in children. Methods: A retrospective study of 91 patients with HNLMs was performed. Results: The age ranged from 1 day to 14 years, of which 82.4 % (75/91) were under 2 years old and 45.1 % (41/91) were diagnosed at birth. The diagnostic rates of ultrasound, CT and MRI were 80.2 % (73/91), 90.1 % (82/91) and 100 % (8/8) respectively. There were 2 cases of complete excision, 8 of bleomycin sclerotherapy, and 81 of subtotal resection combined with bleomycin irrigation. Followed up for 3-93 months, all 91 cases were cured. Conclusions: HNLMs mostly occur within 2 years old, and nearly half of them are present at birth. Characteristic imaging findings can assist clinicians in diagnosis and treatment plan. Subtotal resection combined with bleomycin irrigation may be an appropriate first-line therapy for HNLMs involving the vital anatomical structures.
MeSH term(s)	Infant, Newborn ; Humans ; Child ; Child, Preschool ; Retrospective Studies ; Head ; Neck ; Bleomycin/therapeutic use ; Sclerotherapy ; Lymphatic Abnormalities/diagnostic imaging ; Lymphatic Abnormalities/surgery ; Treatment Outcome
Chemical Substances	Bleomycin (11056-06-7)
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2023.103897
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Article: Pediatric bronchogenic cysts in the head and neck region: A study of 10 surgical cases and a review of the literature.

Chen, Wei / Xu, MengRou / Wang, Qingyu / Xu, Hongming / Chen, Jiarui / Li, Xiaoyan

Frontiers in pediatrics

2022 Volume 10, Page(s) 1030692

Abstract: Objective: To explore the clinical characteristics and surgical treatment of children with bronchogenic cysts (BCs) in the head and neck region.: Methods: A retrospective study of 10 pediatric patients with BCs in the head and neck region treated in ... ...

Abstract	Objective: To explore the clinical characteristics and surgical treatment of children with bronchogenic cysts (BCs) in the head and neck region. Methods: A retrospective study of 10 pediatric patients with BCs in the head and neck region treated in Shanghai Children's Hospital during 2011 to 2022 was performed. Results: Based on their pathological diagnosis, 10 patients with BCs in the head and neck were identified. The most common location was the neck (8 patients, 80%; 2 midline neck, 6 lateral neck), followed by the ventral tip of tongue (1 patient), and the posterior pharyngeal wall (1 patient). Misdiagnosed as lymphangioma in 5 cases, cyst in 3 cases, thyroglossal duct cyst (TGDC) in 2 cases and congenital pyriform sinus fistula (CPSF) in 1 case preoperative. The median follow-up period after surgery was 4.68 (range, 0.67-9.25) years. All 10 patients underwent complete resection without recurrence or other complications. Conclusions: Although extremely rare, BCs should be considered in the differential diagnosis of midline and lateral neck masses or intraoral cysts in children. Surgical excision is recommended in BCs, and the diagnosis is definitively confirmed by histopathology.
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.1030692
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Article ; Online: Congenital first branchial cleft anomalies in children: a study of 100 surgical cases and a review of the literature.

Chen, Wei / Xu, Mengrou / Wang, Qingyu / Xu, Rong / Chen, Jiarui / Xu, Hongming / Li, Xiaoyan

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2022

Abstract: Objective: To investigate the clinical features and surgical outcomes of pediatric congenital first branchial cleft anomalies (CFBCAs).: Methods: We conducted a retrospective analysis of 100 children who were referred to Shanghai Children's Hospital ... ...

Abstract	Objective: To investigate the clinical features and surgical outcomes of pediatric congenital first branchial cleft anomalies (CFBCAs). Methods: We conducted a retrospective analysis of 100 children who were referred to Shanghai Children's Hospital from March 2014 to March 2022 for the treatment of CFBCAs. Results: This study included 100 patients (33 males, 67 females) with an average age of 4.0 ± 2.7 years. 64 cases were type I FBCAs and 36 were type II. The main clinical manifestations included having a skin pit or discharge from it (62%), painless masses (5%), mucopurulent otorrhea (8%) and recurrent swelling with pain (90%) in the Pochet's triangle area. 92% had infection histories, 84% had incision and drainage histories, and 18% had surgical histories. 6 cases of tympanic membranous attachment were found by auricular endoscopy. Ultrasonography (US) was 55.6% (30/54) accurate and enhanced CT was 75% (75/100) accurate in diagnosing CFBCAs. We dissected the facial nerve (FN) in 46% cases. Lesions ended in the external auditory canal (EAC) wall in 86 cases. 69 exhibited close relationship with the parotid. The patients were followed up 0.25-8.2 years. 11 had postoperative temporary facial paralysis and all improved within 6 months. 3 had recurrence and they were secondarily successfully retreated. No EAC stenosis were found. Conclusions: CFBCAs often presented with repeated swelling and purulence in Pochet's triangle. CT, US and auricular endoscopy can assist in diagnosis and planning the surgical strategy. Complete excision in non-infection stage as soon as possible is the first choice for the treatment of CFBCAs.
Language	English
Publishing date	2022-08-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-022-07607-0
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Article: Congenital second branchial cleft anomalies in children: A report of 52 surgical cases, with emphasis on characteristic CT findings.

Chen, Wei / Zhou, Yilong / Xu, Mengrou / Xu, Rong / Wang, Qingyu / Xu, Hongming / Chen, Jiarui / Li, Xiaoyan

Frontiers in pediatrics

2023 Volume 11, Page(s) 1088234

Abstract: Objective: The objectives of this study was to review the clinical features and surgical treatment outcomes of congenital second branchial cleft anomalies (CSBCAs) and to investigate the characteristic computed tomography (CT) findings of CSBCAs.: ... ...

Abstract	Objective: The objectives of this study was to review the clinical features and surgical treatment outcomes of congenital second branchial cleft anomalies (CSBCAs) and to investigate the characteristic computed tomography (CT) findings of CSBCAs. Methods: We conducted a retrospective study of 52 children who were referred to Shanghai Children's Hospital from October 2014 to December 2021 diagnosed as CSBCAs. Results: There were 36 males and 16 females. Of them, 35 patients were presented as having a skin pit at birth or discharge from the skin opening on the lateral neck, and 17 patients presented with an asymptomatic or painful mass. The typical CT features of CSBCAs included isolated and homogeneously hypodense cystic lesions surrounded by a uniformly thin, smooth wall. CSBCAs were generally located at the anteromedial border of the sternocleidomastoid muscle, posterior to the submandibular gland, and lateral to the carotid sheath. All patients were treated surgically and only one case underwent ipsilateral tonsillectomy. After a median follow-up of 30 (range 4-90) months, no recurrence or complications were observed. Conclusions: The CSBCAs show some characteristic CT findings, which can help clinicians diagnose and plan surgical strategies. High ligation of the lesions is sufficient for complete excision of CSBCAs.
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1088234
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Article ; Online: Diagnosis of infantile subglottic hemangioma and the effect of oral propranolol.

Chen, Wei / Zhu, Peng / Xu, Mengrou / Chen, Shumei / Wang, Ying / Shen, Chenling / Xu, Hongming / Chen, Jiarui / Li, Xiaoyan

American journal of otolaryngology

2022 Volume 43, Issue 6, Page(s) 103610

Abstract: Objectives: To investigate the clinical characteristics of infantile subglottic hemangioma (SGH), and to observe the safety and efficacy of propranolol in the treatment of SGH.: Methods: The data of 21 children diagnosed with SGH and treated with ... ...

Abstract	Objectives: To investigate the clinical characteristics of infantile subglottic hemangioma (SGH), and to observe the safety and efficacy of propranolol in the treatment of SGH. Methods: The data of 21 children diagnosed with SGH and treated with propranolol in our hospital from March 2013 to January 2021 were retrospectively analyzed and followed up. Results: Among the 21 cases, there were 7 males and 14 females. SGH was found 11 left-sided, 9 right-sided and 1 bilateral-sided. The clinical manifestations included stridor (13/21), respiratory distress (6/21), barking cough (5/21), feeding difficulty (4/21), three concave sign (4/21), cyanosis (2/21) and hoarseness (1/21). 8 patients had multiple cutaneous hemangiomas. The age of presentation ranged from 1 to 8 months, with a median of 1.1 months. 18 cases (85.7 %) had a history of misdiagnosis, 14 bronchitis/pneumonia, 5 laryngomalacia, 2 laryngeal obstruction and 1 asthma. The median ages at diagnosis were 3 months, with a range of 1.2-28 months. The treatment duration ranged from 6 to 25.6 months, with an average of (14.3 ± 4.9) months. Age at termination of treatment ranged from 9 to 38 months, with a median of 18.6 months, and only 2 cases were beyond 2 years old at that time. No adverse side effects from propranolol therapy occurred and all 21 cases were cured. Conclusions: We advocate a strong index of suspicion for SGH presenting with respiratory symptoms under 2 years old who has poor effect or repeated condition after routine treatment. Laryngoscopy combined with contrast-enhanced CT can confirm the diagnosis of SGH. Oral propranolol is safe and effective, and that early diagnosis and intervention of propranolol without further delay are crucial to the successful management. We advocate continue propranolol treatment beyond 18 months of age, furthermore, 2 years old may be the best time for therapy termination.
MeSH term(s)	Male ; Female ; Child ; Humans ; Infant ; Child, Preschool ; Propranolol/therapeutic use ; Retrospective Studies ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/drug therapy ; Hemangioma/diagnosis ; Hemangioma/drug therapy ; Laryngoscopy ; Treatment Outcome ; Administration, Oral
Chemical Substances	Propranolol (9Y8NXQ24VQ)
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2022.103610
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