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Article ; Online: Red blood cell distribution width is an inflammatory but not a nutritional biomarker.

Wang, Jialu / Xu, Renying

Clinical nutrition (Edinburgh, Scotland)

2024 Volume 43, Issue 4, Page(s) 1090–1091

MeSH term(s)	Humans ; Biomarkers ; Erythrocyte Indices ; Erythrocytes
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2024.02.013
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Article ; Online: Comments on "Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity".

Zhou, Yiquan / Xu, Renying

JACC. Cardiovascular imaging

2023 Volume 16, Issue 8, Page(s) 1126

MeSH term(s)	Humans ; Adult ; Obesity, Metabolically Benign/diagnosis ; Predictive Value of Tests ; Obesity/diagnosis ; Obesity/epidemiology ; Risk Factors ; Body Mass Index
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2023.05.022
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Article ; Online: Comments on "Preconception paternal/maternal body mass index and risk of small/large for gestational age infant in over 4.7 million Chinese women aged 20-49 years: a population-based cohort study in China".

Zhao, Weixiu / Xu, Renying

The British journal of nutrition

2022 , Page(s) 1–3

Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114522001167
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Article: Association Between Dietary Behaviors and Weight Gain During City-Wide Quarantine.

Tang, Molian / Chen, Zhiqi / Wang, Jialu / Song, Anqi / Wu, I-Ting / Xu, Renying

International journal of general medicine

2023 Volume 16, Page(s) 5743–5750

Abstract: Background: The impact of quarantine-induced changes in dietary behavior on weight gain remained unclear. This study aimed to evaluate the association between changes in dietary behavior and body weight during quarantine and to identify the risk factors ...

Abstract	Background: The impact of quarantine-induced changes in dietary behavior on weight gain remained unclear. This study aimed to evaluate the association between changes in dietary behavior and body weight during quarantine and to identify the risk factors of weight gain. Methods: This was a pilot observational cross-sectional study. All the potential participants were those who underwent body weight management program in one teaching hospital in China from 26th April 2021 to 31st March 2022. An online self-reported questionnaire was sent to collect information on sex, age, self-reported body weight before and after quarantine, dietary quality, meal time, food consumption, physical activities, and sleep quality. Weight gain was defined as an increase of 1 kilogram or more. The study has been performed in accordance with the Declaration of Helsinki and approved by the Ethics Committee (KY2020-204). The participants were informed about the objectives of the study and electronic informed consent was obtained from each participant. Results: Finally, 79 participants (22.8% male and 77.2% female, aged 33.3 ± 7.1 years) was included in the analysis. During quarantine, the mean body weight gain was 0.8 (interquartile range: -1.0~3.0) kg. The proportion of weight gain among the participants was 45.6%. Increased cooked white rice (OR=16.93; 95% CI: 2.66-108.00), convenient food (OR=11.69; 95% CI: 2.00-68.26), and snack consumption (OR=5.56; 95% CI: 1.08-28.56), delayed dinner time (OR=6.64; 95% CI: 1.20-36.74) and house working time less than 30 minutes (OR=12.80; 95% CI: 2.01-81.44) were risk factors for body weight gain. Conclusion: During the quarantine, weight gain was observed even in participants who were previously on body weight management. Increased consumption of cooked white rice, convenient food, and snack, as well as delayed dinner time and reduced house working time (less than 30 minutes), were found to be associated with body weight gain.
Language	English
Publishing date	2023-12-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S439750
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Article ; Online: The Association Between Chronological Age and Dyslipidemia: A Cross-Sectional Study in Chinese Aged Population.

Li, Qingyao / Jiang, Ying / Song, Anqi / Li, Yun / Xu, Xinyi / Xu, Renying

Clinical interventions in aging

2023 Volume 18, Page(s) 667–675

Abstract: Background and aims: Dyslipidemia is obviously an important risk factor for cardiovascular diseases, which might further lead to disability and death in aged population. We thus performed the current study to evaluate the association between ... ...

Abstract	Background and aims: Dyslipidemia is obviously an important risk factor for cardiovascular diseases, which might further lead to disability and death in aged population. We thus performed the current study to evaluate the association between chronological age and dyslipidemia. Subjects and methods: A total number of 59,716 Chinese aged population (31,174 men and 28,542 women, average age 67.8y) were included in the current study. Age and sex were abstracted from medical records. Height, body weight, and blood pressure were measured by trained nurses. Serum concentration of total cholesterol (TC) and total triglycerides were performed by enzyme-linked immunosorbent method after at least 8-h fast. Dyslipidemia was defined if total cholesterol≥5.7 mmol/L, or total triglycerides≥1.7 mmol/L, or self-reported history of dyslipidemia. Results: The prevalence of dyslipidemia was 50.4% in the current study population. Compared to the youngest age group (60-64y), the adjusted odds ratio was 0.88 (95% CI: 0.84, 0.92), 0.77 (95% CI: 0.73, 0.81), 0.66 (95% CI: 0.61, 0.70), 0.55 (95% CI: 0.50, 0.59) for the participants who were 65 to 69, 70-74, 75-79, and ≥80 years old (p trend <0.001). Excluding participants with low body weight and with overweight and obesity, with high blood pressure and history of hypertension, with high fasting blood glucose and history of diabetes, generated similar results with main analysis. Conclusion: Chronological age was closely associated with the risk of dyslipidemia in Chinese aged population.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; East Asian People ; Risk Factors ; Triglycerides ; Dyslipidemias/epidemiology ; Hypertension/epidemiology ; Body Weight ; Cholesterol ; Cholesterol, HDL ; Prevalence ; China/epidemiology
Chemical Substances	Triglycerides ; Cholesterol (97C5T2UQ7J) ; Cholesterol, HDL
Language	English
Publishing date	2023-04-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364924-0
ISSN	1178-1998 ; 1176-9092
ISSN (online)	1178-1998
ISSN	1176-9092
DOI	10.2147/CIA.S406237
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Article: Osteocalcin has a muscle-protective effect during weight loss in men without metabolic syndrome: a multicenter, prospective, observational study.

Xiang, Yi / Lu, Wenyi / Mao, Xiaomeng / Zou, Jing / Wang, Jialu / Xu, Renying / Tang, Qingya

Frontiers in endocrinology

2023 Volume 14, Page(s) 1308452

Abstract: Objective: Weight reduction often accompanies muscle loss. Existing studies highlight the involvement of osteocalcin (OC) in energy metabolism and its potential to prevent age-related muscle loss. Nevertheless, these studies predominantly involve ... ...

Abstract	Objective: Weight reduction often accompanies muscle loss. Existing studies highlight the involvement of osteocalcin (OC) in energy metabolism and its potential to prevent age-related muscle loss. Nevertheless, these studies predominantly involve individuals with hyperglycemia, yielding conflicting research outcomes. This study investigated the protective role of OC against muscle loss during weight reduction in individuals without metabolic syndrome (MetS). Measures: We enrolled 130 overweight or obese individuals without MetS in a 4-month high-protein, energy-restricted dietary weight management program conducted at two clinic centers. Body composition and laboratory tests were assessed both before and after weight loss. Correlation and regression analysis were made between the changes in metabolic indicators and muscle mass during weight loss. Results: Following weight loss, there was a decrease in body mass index (BMI), percentage of body fat (PBF), visceral fat area (VFA), fasting insulin (FINS), homeostasis model assessment insulin resistance (HOMA-IR), glycated haemoglobin (HbA1c), and lipid profile, and increase in the percentage of skeletal muscle (PSM) and vitamin D. There was no change in osteocalcin (OC) during the intervention. Correlation analysis of the relative changes in all metabolic indicators revealed a positive correlation between OC and PSM (r=0.383, p=0.002). Multiple linear regression analysis found that OC has a significant protective effect on muscles during weight loss in males after adjusting for confounding factors (β=0.089, p=0.017). Conclusion: High-protein, energy-restricted diets demonstrate efficacy in enhancing metabolic indicators within the weight-loss population. Furthermore, OC exhibits a protective effect on muscle mass during weight reduction in individuals without MetS, with this effect being particularly evident in males.
MeSH term(s)	Humans ; Male ; Metabolic Syndrome/epidemiology ; Muscle, Skeletal/metabolism ; Osteocalcin/metabolism ; Prospective Studies ; Weight Loss
Chemical Substances	Osteocalcin (104982-03-8) ; BGLAP protein, human
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1308452
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Article ; Online: The applicability of a commercial 3DO body scanner in measuring body composition in Chinese adults with overweight and obesity: a secondary analysis based on a weight-loss clinical trial.

Wang, Jialu / Song, Anqi / Tang, Molian / Xiang, Yi / Zhou, Yiquan / Chen, Zhiqi / Heber, David / Tang, Qingya / Xu, Renying

Journal of the International Society of Sports Nutrition

2024 Volume 21, Issue 1, Page(s) 2307963

Abstract: Background: A commercial three-dimensional optical (3DO) scanning system was reported to be used in body composition assessment. However, the applicability in Chinese adults has yet to be well-studied.: Methods: This secondary analysis was based on a ...

Abstract	Background: A commercial three-dimensional optical (3DO) scanning system was reported to be used in body composition assessment. However, the applicability in Chinese adults has yet to be well-studied. Methods: This secondary analysis was based on a 16-week weight-loss clinical trial with an optional extension to 24 weeks. Waist and hip circumference and body composition were measured by 3DO scanning at each follow-up visit during the study. Bioelectrical impedance analysis (BIA) was also performed to confirm the reliability of 3DO scanning at each visit. We used Lin's concordance correlation coefficients (CCC) to evaluate the correlation between the two methods above-mentioned. Bland-Altman analysis was also performed to evaluate the agreement and potential bias between different methods. Results: A total number of 70 Chinese adults overweight and obese (23 men and 47 women, aged 31.8 ± 5.8 years) were included in the analysis, which resulted in 350 3DO scans and corresponding 350 BIA measurements. The percent body fat, fat mass, and fat-free mass were 33.9 ± 5.4%, 26.7 ± 4.6 kg, and 50.3 ± 8.7 kg before the trial by 3DO scanning. And they were 30.5 ± 5.8%, 22.5 ± 4.7 kg, and 49.4 ± 8.3 kg after 16 weeks of the trial. Compared with BIA, 3DO scanning performed best in the assessment of fat-free mass (CCC = 0.89, 95%CI: 0.86, 0.90), then followed by fat mass (CCC = 0.76, 95%CI: 0.71, 0.80) and percent body fat (CCC = 0.70, 95%CI: 0.64, 0.75). Subgroup analysis showed that 3DO scanning and BIA correlated better in women than that in men, and correlated better in measuring fat-free mass in participants with larger body weight (BMI ≥28.0 kg/m Conclusions: 3DO scanning is an effective technology to monitor changes in body composition in Chinese adults overweight and obese. However its accuracy and reliability in different ethnicities needs further exploration.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Body Composition ; Body Weight ; China ; Obesity ; Overweight ; Reproducibility of Results ; Weight Loss ; Clinical Trials as Topic
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2162810-5
ISSN	1550-2783 ; 1550-2783
ISSN (online)	1550-2783
ISSN	1550-2783
DOI	10.1080/15502783.2024.2307963
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Article ; Online: The Association between Serum Level of Vitamin D and Inflammatory Biomarkers in Hospitalized Adult Patients: A Cross-Sectional Study Based on Real-World Data.

Zhang, Xiaomin / Chen, Zhiqi / Xiang, Yi / Zhou, Yiquan / Tang, Molian / Cai, Jun / Xu, Xinyi / Cui, Hongyuan / Feng, Yi / Xu, Renying

Mediators of inflammation

2024 Volume 2024, Page(s) 8360538

Abstract: Objective: The association between vitamin D status and inflammation remains unclear in hospitalized patients.: Materials and methods: We performed the current study based on real-world data from two teaching hospitals. Serum level of vitamin D ( ... ...

Abstract	Objective: The association between vitamin D status and inflammation remains unclear in hospitalized patients. Materials and methods: We performed the current study based on real-world data from two teaching hospitals. Serum level of vitamin D (assessed by 25-hydroxyvitamin D) was evaluated within 2 days after admission. All the patients were further classified into three groups: deficiency (<12 ng/mL), insufficiency (12-20 ng/mL), and adequate (≥20 ng/mL). White blood cell (WBC) count, serum level of C-reactive protein (CRP), and procalcitonin were also measured and used to evaluate inflammation. Other potential covariates were abstracted from medical records. Charlson comorbidity index (CCI) was calculated to assess the severity of disease. Results: A total number of 35,528 hospitalized adult patients (21,171 men and 14,357 women) were included. The average age and BMI were 57.5 ± 16.2 years and 23.4 ± 3.7 kg/m Conclusions: The deficiency and insufficiency of vitamin D in the hospitalized adult patients was very common. However, the results should be interpreted with caution for limited representation of the whole inpatients. Low level of vitamin D was associated with inflammatory biomarkers, which provide the evidences to early intervention for lower the risk of infection.
MeSH term(s)	Male ; Adult ; Humans ; Female ; Cross-Sectional Studies ; Vitamin D Deficiency ; Procalcitonin ; Vitamin D ; Biomarkers ; C-Reactive Protein/metabolism ; Inflammation
Chemical Substances	Procalcitonin ; Vitamin D (1406-16-2) ; Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2024/8360538
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Article ; Online: Response by Xu and Fan to Letter Regarding Article, "High-Sensitivity CRP (C-Reactive Protein) Is Associated With Incident Carotid Artery Plaque in Chinese Aged Adults".

Xu, Renying / Fan, Zhuping

Stroke

2019 Volume 50, Issue 11, Page(s) e324

MeSH term(s)	Adult ; Biomarkers ; C-Reactive Protein ; Carotid Artery Diseases ; Carotid Stenosis ; Humans ; Middle Aged
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2019-10-18
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.119.027041
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Article ; Online: Association between non-alcoholic fatty liver disease and silent carotid plaque in Chinese aged population: a cross-sectional study.

Zhang, Yanan / Xu, Renying / Ai, Luoyan / Fan, Zhuping

Annals of palliative medicine

2020 Volume 9, Issue 2, Page(s) 182–189

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for carotid plaque in the general population; however, whether NAFLD is associated with carotid plaque in aged population remains unknown. This cross-sectional study was conducted to ...

Abstract	Background: Non-alcoholic fatty liver disease (NAFLD) is a risk factor for carotid plaque in the general population; however, whether NAFLD is associated with carotid plaque in aged population remains unknown. This cross-sectional study was conducted to evaluate the association between NAFLD and carotid plaque in a Chinese aged population. Methods: A total number of 12,990 Chinese aged adults (7,685 men and 5,305 women) were included. NAFLD was diagnosed based on the recommendation of Asia-Pacific Working Party on NAFLD and Chinese Association for the Study of Liver Disease and excessive alcohol consumption (weekly alcohol consumption ≤210 g in men and ≤140 g in women) was excluded. Carotid plaque was confirmed by ultrasonography. Potential confounders and biochemical findings were collected at baseline. Logistic regression model was employed to evaluate the association between NAFLD and carotid plaque. Results: The prevalence of carotid plaque was significantly higher in aged participants with NAFLD than in those without NAFLD (22.4% vs. 16.3%, P<0.001). NAFLD is associated with carotid plaque [odd ratio (OR) =1.89, 95% confidence interval (CI): 1.59-2.24], after adjusting for age, gender, BMI, liver and kidney function, glucose level, lipid profiles, and white blood cell (WBC) count. The association between NAFLD and carotid plaque was attenuated when participants with elevated ALT (≥75 IU/L), a history of cardiovascular diseases (CVDs) and obesity were censored although the significant association remained. Conclusions: NAFLD is associated with carotid plaque in Chinese aged population.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group/statistics & numerical data ; Carotid Artery Diseases/epidemiology ; Carotid Artery Diseases/etiology ; China/epidemiology ; Cross-Sectional Studies ; Female ; Frail Elderly/statistics & numerical data ; Humans ; Male ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Prevalence ; Risk Factors
Language	English
Publishing date	2020-03-02
Publishing country	China
Document type	Comparative Study ; Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5820
ISSN (online)	2224-5839
ISSN	2224-5820
DOI	10.21037/apm.2020.02.07
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