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Article ; Online: Zuotai (β-HgS)-containing 70 Wei Zhen-Zhu-Wan differs from mercury chloride and methylmercury on hepatic cytochrome P450 in mice.

Nie, Yu / Xu, Shang-Fu / Lu, Yan-Liu / Zhao, Xiu-Rong / Li, Cen / Wei, Li-Xin / Liu, Jie

2021 Volume 10, Page(s) 203

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Chlorides ; Cytochrome P-450 Enzyme System ; Liver ; Mercuric Chloride ; Mercury ; Mercury Compounds ; Methylmercury Compounds ; Mice
Chemical Substances	Chlorides ; Mercury Compounds ; Methylmercury Compounds ; zuotai ; Mercuric Chloride (53GH7MZT1R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.40667.2
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Article: Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.

Xu, Shang-Fu / Hu, An-Ling / Xie, Lu / Liu, Jia-Jia / Wu, Qin / Liu, Jie

PeerJ

2019 Volume 7, Page(s) e7429

Abstract: Cytochrome P450s (CYPs) are phase-I metabolic enzymes playing important roles in drug metabolism, dietary chemicals and endogenous molecules. Age is a key factor influencing P450s expression. Thus, age-related changes of CYP 1-4 families and bile acid ... ...

Abstract	Cytochrome P450s (CYPs) are phase-I metabolic enzymes playing important roles in drug metabolism, dietary chemicals and endogenous molecules. Age is a key factor influencing P450s expression. Thus, age-related changes of CYP 1-4 families and bile acid homeostasis-related CYPs, the corresponding nuclear receptors and a few phase-II genes were examined. Livers from male Sprague-Dawley rats at fetus (-2 d), neonates (1, 7, and 14 d), weanling (21 d), puberty (28 and 35 d), adulthood (60 and 180 d), and aging (540 and 800 d) were collected and subjected to qPCR analysis. Liver proteins from 14, 28, 60, 180, 540 and 800 days of age were also extracted for selected protein analysis by western blot. In general, there were three patterns of their expression: Some of the drug-metabolizing enzymes and related nuclear receptors were low in fetal and neonatal stage, increased with liver maturation and decreased quickly at aging (AhR, Cyp1a1, Cyp2b1, Cyp2b2, Cyp3a1, Cyp3a2, Ugt1a2); the majority of P450s (Cyp1a2, Cyp2c6, Cyp2c11, Cyp2d2, Cyp2e1, CAR, PXR, FXR, Cyp7a1, Cyp7b1. Cyp8b1, Cyp27a1, Ugt1a1, Sult1a1, Sult1a2) maintained relatively high levels throughout the adulthood, and decreased at 800 days of age; and some had an early peak between 7 and 14 days (CAR, PXR, PPARα, Cyp4a1, Ugt1a2). The protein expression of CYP1A2, CYP2B1, CYP2E1, CYP3A1, CYP4A1, and CYP7A1 corresponded the trend of mRNA changes. In summary, this study characterized three expression patterns of 16 CYPs, five nuclear receptors, and four phase-II genes during development and aging in rat liver, adding to our understanding of age-related CYP expression changes and age-related disorders.
Language	English
Publishing date	2019-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.7429
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Article ; Online: Ginsenoside Re inhibits PDGF-BB-induced VSMC proliferation via the eNOS/NO/cGMP pathway.

Gao, Yang / Zhu, Ping / Xu, Shang-Fu / Li, Yi-Qi / Deng, Jiang / Yang, Dan-Li

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019 Volume 115, Page(s) 108934

Abstract: Ginsenoside Re (GS-Re), which is a major monomeric member of the ginseng trialcohol saponin family, is one of the main active components of ginseng and plays an important role in protecting the cardiovascular system. Here, we report a novel function by ... ...

Abstract	Ginsenoside Re (GS-Re), which is a major monomeric member of the ginseng trialcohol saponin family, is one of the main active components of ginseng and plays an important role in protecting the cardiovascular system. Here, we report a novel function by which GS-Re regulates the eNOS/NO/cGMP pathway, which affects the platelet-derived growth factor-BB (PDGF-BB)-induced proliferation of vascular smooth muscle cells (VSMCs). GS-Re inhibited PDGF-BB-induced VSMC proliferation in a concentration-dependent manner without cytotoxicity, and the endothelial nitric oxide synthase (eNOS) inhibitor NG-nitro-L-arginine methyl ester (L-NAME) antagonized the antiproliferative effect of GS-Re. The flow cytometry analysis suggested that GS-Re regulates VSMC proliferation by influencing the cell cycle transition from G0/G1 to S phase and decreasing the expression of G0/G1-specific regulatory proteins, including proliferating cell nuclear antigen (PCNA), cyclin D1, and CDK4, in PDGF-BB-treated VSMCs, consequently upregulating the protein expression of p21. After GS-Re treatment, the levels of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) and the phos-eNOS
MeSH term(s)	Animals ; Aorta, Thoracic/drug effects ; Aorta, Thoracic/metabolism ; Aorta, Thoracic/pathology ; Becaplermin ; Cell Proliferation/drug effects ; Cells, Cultured ; Cyclic GMP/metabolism ; Ginsenosides/pharmacology ; Male ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/metabolism ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/pathology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Rats, Sprague-Dawley ; Signal Transduction
Chemical Substances	Ginsenosides ; Becaplermin (1B56C968OA) ; Nitric Oxide (31C4KY9ESH) ; ginsenoside Re (46F3R0BL3I) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, rat (EC 1.14.13.39) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2019-05-10
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2019.108934
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Article: GC-MS Profile of Hua-Feng-Dan and RNA-Seq Analysis of Induced Adaptive Responses in the Liver.

Liu, Jia-Jia / Liang, Yan / Zhang, Ya / Wu, Rui-Xia / Song, Ying-Lian / Zhang, Feng / Shi, Jing-Shan / Liu, Jie / Xu, Shang-Fu / Wang, Zhang

Frontiers in pharmacology

2022 Volume 13, Page(s) 730318

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.730318
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Article ; Online: Sodium Ferulate Inhibits Rat Cardiomyocyte Hypertrophy Induced by Angiotensin II Through Enhancement of Endothelial Nitric Oxide Synthase/Nitric Oxide/Cyclic Guanosine Monophosphate Signaling Pathway.

Luo, Min / Lin, Hui-Cai / Wen, Zhao-Qin / Chen, Pan-Pan / Shi, Wan-Lan / Li, Ying-Ying / Gao, Yang / Xu, Shang-Fu / Xu, Rui-Xia / Gong, Qi-Hai / Deng, Jiang

Journal of cardiovascular pharmacology

2022 Volume 80, Issue 2, Page(s) 251–260

Abstract: Abstract: Sodium ferulate (SF) is the sodium salt of ferulic acid, which is one of the effective components of Angelica sinensis and Lignsticum chuanxiong , and plays an important role in protecting the cardiovascular system. In this study, myocardial ... ...

Abstract	Abstract: Sodium ferulate (SF) is the sodium salt of ferulic acid, which is one of the effective components of Angelica sinensis and Lignsticum chuanxiong , and plays an important role in protecting the cardiovascular system. In this study, myocardial hypertrophy was induced by angiotensin II 0.1 μmol/L in neonatal Sprague-Dawley rat ventricular myocytes. Nine groups were designed, that is, normal, normal administration, model, L-arginine (L-arg 1000 μmol/L), SF (50, 100, 200 μmol/L) group, and N G -nitro-L-arg-methyl ester 1500 μmol/L combined with SF 200 μmol/L or L-arg 1000 μmol/L group, respectively. Cardiomyocyte hypertrophy was confirmed by observing histological changes and measurements of cell diameter, protein content and atrial natriuretic factor, and β-myosin heavy chain levels of the cells. Notably, SF could inhibit significantly myocardial hypertrophy of neonatal rat cardiomyocytes in a concentration-dependent manner without producing cytotoxicity, and the levels of nitric oxide, NO synthase (NOS), endothelial NOS, and cyclic guanosine monophosphate were increased, but the level of cyclic adenosine monophosphate was decreased in cardiomyocytes. Simultaneously, levels of protein kinase C beta, Raf-1, and extracellular regulated protein kinase 1/2 (ERK1/2) were downregulated, whereas levels of mitogen-activated protein kinase phosphatase-1 were significantly upregulated. All the beneficial effects of SF were blunted by N G -nitro-L-arg-methyl ester. Overall, these findings reveal that SF can inhibit angiotensin II-induced myocardial hypertrophy of neonatal rat cardiomyocytes, which is closely related to activation of endothelial NOS/NO/cyclic guanosine monophosphate, and inhibition of protein kinase C and mitogen-activated protein kinase signaling pathways.
MeSH term(s)	Angiotensin II/metabolism ; Animals ; Cardiomegaly/chemically induced ; Cardiomegaly/drug therapy ; Cardiomegaly/prevention & control ; Coumaric Acids ; Cyclic GMP/metabolism ; Esters ; Guanosine Monophosphate/metabolism ; Guanosine Monophosphate/pharmacology ; Myocytes, Cardiac ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
Chemical Substances	Coumaric Acids ; Esters ; Angiotensin II (11128-99-7) ; Nitric Oxide (31C4KY9ESH) ; Guanosine Monophosphate (85-32-5) ; ferulic acid (AVM951ZWST) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001277
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Article ; Online: Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice.

Hu, An-Ling / Song, Sheng / Li, Yi / Xu, Shang-Fu / Zhang, Feng / Li, Cen / Liu, Jie

Journal of ethnopharmacology

2020 Volume 254, Page(s) 112674

Abstract: Ethnopharmacological relevance: Mercury sulfides (HgS) are frequently included in Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but the ethnopharmacology remains elusive. The present study examined the protective ... ...

Abstract	Ethnopharmacological relevance: Mercury sulfides (HgS) are frequently included in Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but the ethnopharmacology remains elusive. The present study examined the protective effects of α-HgS-containing Hua-Feng-Dan and β-HgS-containing 70 Wei-Zhen-Zhu-Wan (70W, Rannasangpei) against Parkinson's disease mice induced by lipopolysaccharide (LPS) plus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Method: A single injection of LPS (5 mg/kg ip) was given to adult male C57BL/6 mice, and 150 days later, the low dose of MPTP (15 mg/kg, ip, for 4 days) was given to produce the "two-hit" Parkinson's disease model. Together with MPTP treatment, mice were fed with clinically-relevant doses of Hua-Feng-Dan (0.6 g/kg) and 70W (0.2 g/kg) for 35 days. Rotarod test was performed to examine muscle coordination capability. At the end of the experiment, brain was transcardially perfused with paraformaldehyde, the substantia nigra was sectioned for microglia (Iba1 staining) and dopaminergic neuron (THir staining) determination. Colon bacterial DNA was extracted and subjected to qPCR analysis with 16S rRNA probes. Results: The low-grade, chronic neuroinflammation produced by LPS aggravated MPTP neurotoxicity, as evidenced by decreased motor activity, intensified microglia activation and loss of dopaminergic neurons. Both Hua-Feng-Dan and 70W increased rotarod activity and ameliorated the pathological lesions in the brain. In gut microbiomes examined, LPS plus MPTP increased Verrucomicrobiaceae, Methanobacteriaceae, Pronicromonosporaceae, and Clostridaceae species were attenuated by Hua-Feng-Dan and 70W. Conclusions: α-HgS-containing Hua-Feng-Dan and β-HgS-containing 70W at clinical doses protected against chronic LPS plus MPTP-induced toxicity to the brain and gut, suggesting HgS-containing traditional medicines could target gut microbiota as a mechanism of their therapeutic effects.
MeSH term(s)	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Colon/drug effects ; Colon/microbiology ; Dopaminergic Neurons/pathology ; Lipopolysaccharides ; Male ; Mercury Compounds/pharmacology ; Mice ; Microglia/pathology ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/prevention & control ; Rotarod Performance Test ; Substantia Nigra/pathology
Chemical Substances	Lipopolysaccharides ; Mercury Compounds ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P) ; cinnabar (ZI0T668SF1)
Language	English
Publishing date	2020-02-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112674
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Article ; Online: Ontogeny and aging of Nrf2 pathway genes in livers of rats.

Xu, Shang-Fu / Ji, Li-Li / Wu, Qin / Li, Jin / Liu, Jie

Life sciences

2018 Volume 203, Page(s) 99–104

Abstract: The Nrf2/Keap1 antioxidant system plays important roles in protecting against oxidative stress and toxic stimuli, which may vary in infants, elderly, and females.: Aim: The constitutive expression of the Nrf2 genes during development and aging in both ...

Abstract	The Nrf2/Keap1 antioxidant system plays important roles in protecting against oxidative stress and toxic stimuli, which may vary in infants, elderly, and females. Aim: The constitutive expression of the Nrf2 genes during development and aging in both sexes would help our understanding of the Nrf2/Keap1 pathway in toxicological studies. Main methods: Sprague Dawley rat livers were collected at 11 age points from prenatal (-2 d), neonatal (1, 7, 14 and 21 d), at puberty (28 and 35 d), at adulthood (60 and 180 d), to aging (540 and 800 d) from both sexes. Total RNA and proteins were extracted for real-time RT-PCR and Western-blot analysis. Key findings: The abundant mRNA expression was in the order of Nrf2, Gclm, Nqo1, Gclc, Ho-1, and Keap1. The expression of these genes except Gclc was high in fetal livers, decreased at birth, reached the first peak at 7 days of age, and gradually decreased to adult levels till 180 days of age. All these genes remained high at 540 days of age, but declined at 800 days of age, with more increases with Nqo1 and Ho-1. Females had lower fetal, neonatal, and aged levels than males. Protein expressions of Nrf2, Nqo1, Ho-1, GCLC and GCLM agree with mRNA analysis. Significance: This study characterized the age- and sex-related changes of Nrf2-related gene/proteins in livers of rats, and higher expressions in newborns and aged rats could cope with increased oxidative stress in infants and elderly.
MeSH term(s)	Aging ; Animals ; Female ; Liver/metabolism ; Liver/pathology ; Male ; NF-E2-Related Factor 2/genetics ; Oxidative Stress ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
Chemical Substances	NF-E2-Related Factor 2 ; Nfe2l2 protein, rat ; RNA, Messenger
Language	English
Publishing date	2018-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2018.04.018
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Article ; Online: Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses.

Liu, Jie / Lu, Yuan-Fu / Wu, Qin / Xu, Shang-Fu / Shi, Fu-Guo / Klaassen, Curtis D

Liver international : official journal of the International Association for the Study of the Liver

2018 Volume 39, Issue 3, Page(s) 427–439

Abstract: Oleanolic acid (OA) is a triterpenoid that exists widely in fruits, vegetables and medicinal herbs. OA is included in some dietary supplements and is used as a complementary and alternative medicine (CAM) in China, India, Asia, the USA and European ... ...

Abstract	Oleanolic acid (OA) is a triterpenoid that exists widely in fruits, vegetables and medicinal herbs. OA is included in some dietary supplements and is used as a complementary and alternative medicine (CAM) in China, India, Asia, the USA and European countries. OA is effective in protecting against various hepatotoxicants, and one of the protective mechanisms is reprogramming the liver to activate the nuclear factor erythroid 2-related factor 2 (Nrf2). OA derivatives, such as CDDO-Im and CDDO-Me, are even more potent Nrf2 activators. OA has recently been shown to also activate the Takeda G-protein-coupled receptor (TGR5). However, whereas a low dose of OA is hepatoprotective, higher doses and long-term use of OA can produce liver injury, characterized by cholestasis. This paradoxical hepatotoxic effect occurs not only for OA, but also for other OA-type triterpenoids. Dose and length of time of OA exposure differentiate the ability of OA to produce hepatoprotection vs hepatotoxicity. Hepatotoxicity produced by herbs is increasingly recognized and is of global concern. Given the appealing nature of OA in dietary supplements and its use as an alternative medicine around the world, as well as the development of OA derivatives (CDDO-Im and CDDO-Me) as therapeutics, it is important to understand not only that they program the liver to protect against hepatotoxic chemicals, but also how they produce hepatotoxicity.
MeSH term(s)	Animals ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Chemical and Drug Induced Liver Injury/prevention & control ; Cytoprotection ; Dose-Response Relationship, Drug ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; NF-E2-Related Factor 2/metabolism ; Oleanolic Acid/adverse effects ; Protective Agents/adverse effects ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism ; Risk Assessment ; Risk Factors ; Signal Transduction ; Time Factors
Chemical Substances	GPBAR1 protein, human ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Protective Agents ; Receptors, G-Protein-Coupled ; Oleanolic Acid (6SMK8R7TGJ)
Language	English
Publishing date	2018-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.13940
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Article: Xiaochaihutang Inhibits the Activation of Hepatic Stellate Cell Line T6 Through the Nrf2 Pathway.

Hu, Rui / Jia, Wei-Yi / Xu, Shang-Fu / Zhu, Zhi-Wei / Xiao, Zhi / Yu, Shou-Yang / Li, Jin

Frontiers in pharmacology

2019 Volume 9, Page(s) 1516

Abstract: Xiaochaihutang (XCHT) is one of classic prescriptions in Treatise on Febrile Diseases in China which was reported to have the effect of anti-hepatic ... ...

Abstract	Xiaochaihutang (XCHT) is one of classic prescriptions in Treatise on Febrile Diseases in China which was reported to have the effect of anti-hepatic fibrosis
Language	English
Publishing date	2019-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01516
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Article ; Online: Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats.

Zhu, Qiong-Ni / Hou, Wei-Yu / Xu, Shang-Fu / Lu, Yuan-Fu / Liu, Jie

Life sciences

2017 Volume 170, Page(s) 108–114

Abstract: Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and ... ...

Abstract	Multidrug resistance proteins (Mrps) are efflux transporters playing important roles in endogenous substances and xenobiotics transport out of the liver. Children, elderly, gender and physio-pathological conditions could influence their expression and result in changes in drug disposition. Aim: This study was aimed to examine the development-, aging-, and sex-dependent changes in Mrp1-4 and ATP-binding cassette sub-family G member 2 (Abcg2) gene expressions in livers of rats. Main methods: The livers from male and female SD rats at development (-2, 1,7,14,21,28,35, and 60d) and aging (28, 60, 180 and 540d) were collected and total RNA was isolated, purified and subjected to real-time RT-PCR analysis. Key findings: Results showed that expression of Mrp1 was low, while Abcg2 and Mrp2 were the high in the liver. Mrp1 expression decreased with maturity but remained constant to 540d, while Mrp3 and 4 increased with liver development, reached the peak with maturity at 35-60days of age, and slightly reduced with aging. Mrp2 and Abcg2 were high at 7days of age and maintained at relative high levels till maturity, while Abcg2 was reduced during aging. Females had higher Mrp3 and Abcg2 mRNA expression than male rats, while male rats had higher Mrp2 and Mrp4 mRNA expression. Significance: The expression of hepatic Mrp1-4 and Abcg2 mRNA during development, aging in male and female rats was characterized, which could be fundamental to our understanding of age- and sex-associated variations in drug disposition in children, elderly, and women.
MeSH term(s)	ATP Binding Cassette Transporter, Sub-Family G, Member 2/metabolism ; ATP-Binding Cassette Transporters/metabolism ; Aging ; Animals ; Female ; Gene Expression Regulation ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Xenobiotics
Chemical Substances	ATP Binding Cassette Transporter, Sub-Family G, Member 2 ; Abcc2 protein, rat ; Abcc4 protein, rat ; Abcg2 protein, rat ; Multidrug Resistance-Associated Proteins ; Xenobiotics ; multidrug resistance-associated protein 3 (1YV0492L5Z) ; multidrug resistance-associated protein 1 (Y49M64GZ4Q)
Language	English
Publishing date	2017-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2016.11.022
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