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Article: Dynamic management and control of the risk of carbon dioxide content exceeding the standard in green food production base

Xu, Shengli

International journal of environmental technology and management

2020 Volume 23, Issue 5/6, Page(s) 307

Language	English
Document type	Article
ZDB-ID	2080011-3
ISSN	1466-2132
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Natural Killer Cell Engagers (NKCEs): a new frontier in cancer immunotherapy.

Zhang, Minchuan / Lam, Kong-Peng / Xu, Shengli

Frontiers in immunology

2023 Volume 14, Page(s) 1207276

Abstract: Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in immunity by killing virally infected or tumor cells and secreting cytokines and chemokines. NK cell-mediated immunotherapy has emerged as a promising approach for ... ...

Abstract	Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in immunity by killing virally infected or tumor cells and secreting cytokines and chemokines. NK cell-mediated immunotherapy has emerged as a promising approach for cancer treatment due to its safety and effectiveness. NK cell engagers (NKCEs), such as BiKE (bispecific killer cell engager) or TriKE (trispecific killer cell engager), are a novel class of antibody-based therapeutics that exhibit several advantages over other cancer immunotherapies harnessing NK cells. By bridging NK and tumor cells, NKCEs activate NK cells and lead to tumor cell lysis. A growing number of NKCEs are currently undergoing development, with some already in clinical trials. However, there is a need for more comprehensive studies to determine how the molecular design of NKCEs affects their functionality and manufacturability, which are crucial for their development as off-the-shelf drugs for cancer treatment. In this review, we summarize current knowledge on NKCE development and discuss critical factors required for the production of effective NKCEs.
MeSH term(s)	Humans ; Immunity, Innate ; Neoplasms/therapy ; Immunotherapy ; Killer Cells, Natural ; Antibodies
Chemical Substances	Antibodies
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1207276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Multi-criteria decision making for determining best teaching method using fuzzy analytical hierarchy process.

Xu, Sheng-Li / Yeyao, Tang / Shabaz, Mohammad

Soft computing

2022 Volume 27, Issue 6, Page(s) 2795–2807

Abstract: During the outbreak of COVID-19, information technology played a critical role in promoting education all around the world. Online teaching boosts students' learning processes and has a good impact on their learning during the epidemic. Big data ... ...

Abstract	During the outbreak of COVID-19, information technology played a critical role in promoting education all around the world. Online teaching boosts students' learning processes and has a good impact on their learning during the epidemic. Big data technology transforms traditional teaching approaches and learning processes by providing a rich learning resource for diverse teaching elements and improving teachers' teaching techniques. Due to the COVID-19 epidemic, online education spread quickly, and traditional instruction was abruptly switched to online mode, posing a number of issues for students and management. Choosing a decent teaching technique is not an easy option, and it is even more difficult when it comes to selecting the approach. We used the Fuzzy Analytical Hierarchy Process (Fuzzy AHP) method to evaluate four instructional methods based on seven criteria to solve this challenge. Fuzzy AHP is a powerful, simple, and direct way for determining which approach is the most efficient and effective. To simplify the selection process and address the issue of uncertainty, the Fuzzy AHP technique employs the geometric mean method. The Fuzzy AHP approach was found to be efficient and successful in the decision-making process in this study.
Language	English
Publishing date	2022-10-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1476598-6
ISSN	1433-7479 ; 1432-7643
ISSN (online)	1433-7479
ISSN	1432-7643
DOI	10.1007/s00500-022-07554-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Transmembrane Activator and CAML Interactor (TACI): Another Potential Target for Immunotherapy of Multiple Myeloma?

Xu, Shengli / Lam, Kong-Peng

Cancers

2020 Volume 12, Issue 4

Abstract: Multiple myeloma (MM) has emerged as the next most likely oncological or hematological disease indication amenable for cellular immunotherapy. Much of the attention has been focused on B cell maturation antigen (BCMA) as a unique cell surface protein on ... ...

Abstract	Multiple myeloma (MM) has emerged as the next most likely oncological or hematological disease indication amenable for cellular immunotherapy. Much of the attention has been focused on B cell maturation antigen (BCMA) as a unique cell surface protein on myeloma cells that is available for monoclonal antibodies, antibody drug conjugates (ADCs), T-cell redirecting bispecific molecules, and chimeric antigen receptor (CAR) T cell targeting. BCMA is a member of the tumor necrosis factor receptor (TNFR) superfamily that binds two ligands B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) and mediates the growth and survival of plasma and MM cells. Interestingly, transmembrane activator and CAML interactor (TACI), another TNFR superfamily member, also binds the same ligands and plays largely overlapping roles as BCMA in normal plasma and malignant MM cells. In this article, we review the biology of TACI, focusing on its role in normal B and plasma cells and malignant MM cells, and also discuss various ways to incorporate TACI as a potential target for immunotherapies against MM.
Language	English
Publishing date	2020-04-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12041045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harnessing novel strategies and cell types to overcome immune tolerance during adoptive cell therapy in cancer.

Neo, Shi Yong / Xu, Shengli / Chong, Joni / Lam, Kong-Peng / Wu, Jing

Journal for immunotherapy of cancer

2023 Volume 11, Issue 4

Abstract: Cell therapy encompasses an expanding spectrum of cell-based regimes for the treatment of human ailments, such as the use of immune cells, in particular T cells, for combating tumors and the modulation of inflammatory immune responses. In this review, we ...

Abstract	Cell therapy encompasses an expanding spectrum of cell-based regimes for the treatment of human ailments, such as the use of immune cells, in particular T cells, for combating tumors and the modulation of inflammatory immune responses. In this review, we focus on cell therapy in the immuno-oncology space, which is largely driven by interests and demands from the clinics for better solutions to target various hard-to-treat cancers. We discuss recent advances in various types of cell therapies, including T cell receptor-T cells, chimeric antigen receptor (CAR)-T cells, tumor-infiltrating lymphocytes and natural killer cells. Particularly, the present review focuses on the strategies to improve therapeutic responses by either enhancing tumor recognition or the resilience of infused immune cells within tumor microenvironment. Finally, we discuss the potential of other innate or innate-like immune cell types currently being explored as promising CAR-cell alternatives that seek to address the limitations of conventional adoptive cell therapies.
MeSH term(s)	Humans ; Immunotherapy, Adoptive ; Neoplasms ; T-Lymphocytes ; Immune Tolerance ; Cell- and Tissue-Based Therapy ; Tumor Microenvironment
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-006434
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response.

Tan, Ivan / Xu, Shengli / Huo, Jianxin / Huang, Yuhan / Lim, Hong-Hwa / Lam, Kong-Peng

The Journal of biological chemistry

2023 Volume 299, Issue 7, Page(s) 104906

Abstract: The tumor suppressor Liver Kinase B1 (LKB1) is a multifunctional serine/threonine protein kinase that regulates cell metabolism, polarity, and growth and is associated with Peutz-Jeghers Syndrome and cancer predisposition. The LKB1 gene comprises 10 ... ...

Abstract	The tumor suppressor Liver Kinase B1 (LKB1) is a multifunctional serine/threonine protein kinase that regulates cell metabolism, polarity, and growth and is associated with Peutz-Jeghers Syndrome and cancer predisposition. The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence (NLS) and are able to shuttle into the nucleus. Here, we report the identification of a fourth and novel LKB1 isoform that is, interestingly, targeted to the mitochondria. We show that this mitochondria-localized LKB1 (mLKB1) is generated from alternative splicing in the 5' region of the transcript and translated from an alternative initiation codon encoded by a previously unknown exon 1b (131 bp) hidden within the long intron 1 of LKB1 gene. We found by replacing the N-terminal NLS of the canonical LKB1 isoform, the N-terminus of the alternatively spliced mLKB1 variant encodes a mitochondrial transit peptide that allows it to localize to the mitochondria. We further demonstrate that mLKB1 colocalizes histologically with mitochondria-resident ATP Synthase and NAD-dependent deacetylase sirtuin-3, mitochondrial (SIRT3) and that its expression is rapidly and transiently upregulated by oxidative stress. We conclude that this novel LKB1 isoform, mLKB1, plays a critical role in regulating mitochondrial metabolic activity and oxidative stress response.
MeSH term(s)	AMP-Activated Protein Kinase Kinases/genetics ; AMP-Activated Protein Kinase Kinases/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Oxidative Stress/genetics ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Sirtuin 3/metabolism ; Mutation ; Protein Sorting Signals ; Protein Transport ; Mitochondrial Proton-Translocating ATPases/metabolism ; Alternative Splicing ; Codon, Initiator
Chemical Substances	AMP-Activated Protein Kinase Kinases (EC 2.7.11.3) ; Protein Isoforms ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Sirtuin 3 (EC 3.5.1.-) ; Protein Sorting Signals ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-) ; Codon, Initiator
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.104906
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis.

Huo, Jianxin / Xu, Shengli / Lam, Kong-Peng

Cells

2020 Volume 9, Issue 3

Abstract: ...

Abstract	:
MeSH term(s)	Animals ; Apoptosis/physiology ; Female ; MAP Kinase Kinase Kinase 5/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Inbred C57BL ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Thymocytes/cytology ; Thymocytes/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Nr4a1 protein, mouse ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Receptors, Antigen, T-Cell ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; Map3k5 protein, mouse (EC 2.7.11.25)
Language	English
Publishing date	2020-03-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9030585
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies.

Loh, Han Ping / Mahfut, Farouq Bin / Chen, Serene W / Huang, Yuhan / Huo, Jianxin / Zhang, Wei / Lam, Kong Peng / Xu, Shengli / Yang, Yuansheng

mAbs

2023 Volume 15, Issue 1, Page(s) 2231129

Abstract: T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages and ... ...

Abstract	T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells. Numerous T-bsAb formats have been developed, each with advantages and disadvantages in terms of developability, immunogenicity, effector functions, and pharmacokinetics. Here, we systematically compared T-bsAbs produced using eight different formats, evaluating the effect of molecular design of T-bsAbs on their manufacturability and functionality. These eight T-bsAb formats were constructed using antigen-binding fragments (Fabs) and single-chain variable fragments (scFvs) of antibodies linked to the crystallizable fragment (Fc) domain of immunoglobulin G. To ensure a fair comparison of growth and production data, we used recombinase-mediated cassette exchange technology to generate the T-bsAb-producing CHO cell lines. The produced T-bsAbs were assessed for their purification profile and recovery, binding capability, and biological activities. Our findings indicated that the manufacturability of bsAbs was adversely affected with increased number of scFv building blocks, while the functionality was affected by the combination of multiple factors, including the binding affinity and avidity of targeting moieties and the flexibility and geometry of formats. These results provide valuable insights into the impact of the format design on the optimal production and function of T-bsAbs.
MeSH term(s)	Antibodies, Bispecific ; T-Lymphocytes ; Immunoglobulin Fab Fragments ; Immunoglobulin G ; Single-Chain Antibodies
Chemical Substances	Antibodies, Bispecific ; Immunoglobulin Fab Fragments ; Immunoglobulin G ; Single-Chain Antibodies
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2537838-7
ISSN	1942-0870 ; 1942-0870
ISSN (online)	1942-0870
ISSN	1942-0870
DOI	10.1080/19420862.2023.2231129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: FAIM: An Antagonist of Fas-Killing and Beyond.

Huo, Jianxin / Xu, Shengli / Lam, Kong-Peng

Cells

2019 Volume 8, Issue 6

Abstract: Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein that is up-regulated in B cell receptor (BCR)-activated B cells and confers upon them resistance to Fas-mediated cell death. ...

Abstract	Fas Apoptosis Inhibitory Molecule (FAIM) is an anti-apoptotic protein that is up-regulated in B cell receptor (BCR)-activated B cells and confers upon them resistance to Fas-mediated cell death.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Apoptosis ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; Apoptosis Regulatory Proteins/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Energy Metabolism ; Humans ; Intellectual Disability/metabolism ; Intellectual Disability/pathology ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Antigen, T-Cell/metabolism
Chemical Substances	Apoptosis Regulatory Proteins ; FAIM protein, human ; Receptors, Antigen, T-Cell ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-06-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8060541
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spliceosome component PHD finger 5A is essential for early B lymphopoiesis.

Zhang, Rui / Wang, Daoqin / Ruan, Gui-Xin / Wang, Ruisi / Li, Yuxing / Chen, Wenjing / Huang, Hengjun / Wang, Jing / Meng, Limin / Zhu, Zhijian / Lei, Dengfeng / Xu, Shengli / Ou, Xijun

Development (Cambridge, England)

2024 Volume 151, Issue 2

Abstract: The spliceosome, a multi-megadalton ribonucleoprotein complex, is essential for pre-mRNA splicing in the nucleus and ensuring genomic stability. Its precise and dynamic assembly is pivotal for its function. Spliceosome malfunctions can lead to ... ...

Abstract	The spliceosome, a multi-megadalton ribonucleoprotein complex, is essential for pre-mRNA splicing in the nucleus and ensuring genomic stability. Its precise and dynamic assembly is pivotal for its function. Spliceosome malfunctions can lead to developmental abnormalities and potentially contribute to tumorigenesis. The specific role of the spliceosome in B cell development is poorly understood. Here, we reveal that the spliceosomal U2 snRNP component PHD finger protein 5A (Phf5a) is vital for early B cell development. Loss of Phf5a results in pronounced defects in B cell development, causing an arrest at the transition from pre-pro-B to early pro-B cell stage in the bone marrow of mutant mice. Phf5a-deficient B cells exhibit impaired immunoglobulin heavy (IgH) chain expression due to defective V-to-DJ gene rearrangement. Mechanistically, our findings suggest that Phf5a facilitates IgH gene rearrangement by regulating the activity of recombination-activating gene endonuclease and influencing chromatin interactions at the Igh locus.
MeSH term(s)	Animals ; Mice ; Spliceosomes/metabolism ; Trans-Activators/genetics ; RNA-Binding Proteins/metabolism ; PHD Zinc Fingers ; Lymphopoiesis/genetics
Chemical Substances	Trans-Activators ; RNA-Binding Proteins
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.202247
Database	MEDical Literature Analysis and Retrieval System OnLINE

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