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Article ; Online: Light and Heat-Driven Flexible Solid Supramolecular Polymer Displaying Phosphorescence and Reversible Photochromism.

Xu, Wen-Wen / Chen, Yong / Xu, Xiufang / Liu, Yu

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2311087

Abstract: Herein, a type of light- and heat-driven flexible supramolecular polymer with reversibly long-lived phosphorescence and photochromism is constructed from acrylamide copolymers with 4-phenylpyridinium derivatives containing a cyano group (P-CN, P-oM, P-mM) ...

Abstract	Herein, a type of light- and heat-driven flexible supramolecular polymer with reversibly long-lived phosphorescence and photochromism is constructed from acrylamide copolymers with 4-phenylpyridinium derivatives containing a cyano group (P-CN, P-oM, P-mM), sulfobutylether-β-cyclodextrin (SBCD), and polyvinyl alcohol (PVA). Compared to their parent solid polymers, these flexible supramolecules based on the non-covalent cross-linking of copolymers, SBCD, and PVA efficiently boost the phosphorescence lifetimes (723.0 ms for P-CN, 623.0 ms for P-oM, 945.8 ms for P-mM) through electrostatic interaction and hydrogen bonds. The phosphorescence intensity/lifetime, showing excellent responsiveness to light and heat, sharply decreased after irradiation with a 275 nm flashlight or sunlight and gradually recovered through heating. This is accompanied by the occurrence and fading of visible photochromism, manifesting as dark green for P-CN and pink for P-oM and P-mM. These reversible photochromism and phosphorescence behaviors are mainly attributed to the generation and disappearance of organic radicals in the 4-phenylpyridinium derivatives with a cyano group, which can guide tunable luminescence and photochromism.
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202311087
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular functions and therapeutic applications of exosomal noncoding RNAs in cancer.

Liu, Qin-Wen / He, Yan / Xu, Wen Wen

Experimental & molecular medicine

2022 Volume 54, Issue 3, Page(s) 216–225

Abstract: Cancer is one of the most difficult diseases in human society. Therefore, it is urgent for us to understand its pathogenesis and improve the cure rate. Exosomes are nanoscale membrane vesicles formed by a variety of cells through endocytosis. As a new ... ...

Abstract	Cancer is one of the most difficult diseases in human society. Therefore, it is urgent for us to understand its pathogenesis and improve the cure rate. Exosomes are nanoscale membrane vesicles formed by a variety of cells through endocytosis. As a new means of intercellular information exchange, exosomes have attracted much attention. Noncoding RNAs exist in various cell compartments and participate in a variety of cellular reactions; in particular, they can be detected in exosomes bound to lipoproteins and free circulating molecules. Increasing evidence has suggested the potential roles of exosomal noncoding RNAs in the progression of tumors. Herein, we present a comprehensive update on the biological functions of exosomal noncoding RNAs in the development of cancer. Specifically, we mainly focus on the effects of exosomal noncoding RNAs, including microRNAs, circular RNAs, long noncoding RNAs, small nuclear RNAs, and small nucleolar RNAs, on tumor growth, metastasis, angiogenesis, and chemoresistance. Moreover, we outline the current clinical implications concerning exosomal noncoding RNAs in cancer treatment.
MeSH term(s)	Exosomes/genetics ; Exosomes/metabolism ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; RNA, Circular ; RNA, Long Noncoding/metabolism ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism
Chemical Substances	RNA, Circular ; RNA, Long Noncoding ; RNA, Untranslated
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1328915-9
ISSN	2092-6413 ; 1226-3613 ; 0378-8512
ISSN (online)	2092-6413
ISSN	1226-3613 ; 0378-8512
DOI	10.1038/s12276-022-00744-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4775: Show issues

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Article ; Online: The effect of transcranial magnetic stimulation on the recovery of attention and memory impairment following stroke: a systematic review and meta-analysis.

Xu, Wen-Wen / Liao, Qing-Hong / Zhu, Dan-Wei

Expert review of neurotherapeutics

2022 Volume 22, Issue 11-12, Page(s) 1031–1041

Abstract: Background: Previous studies indicated inconsistent results for the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on attention and memory impairment following stroke.: Methods: Randomized controlled trials (RCTs) on TMS for ... ...

Abstract	Background: Previous studies indicated inconsistent results for the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on attention and memory impairment following stroke. Methods: Randomized controlled trials (RCTs) on TMS for the treatment of stroke were retrieved from Online databases. Data were analyzed by RevMan 5.3 software. Results: Ten RCTs performed in China were included, with a total of 591 younger post-stroke patients ranging in age from their 40s to their 60s. The meta-analysis indicated that TMS could significantly improve the recovery of cognitive impairment following a stroke, according to the Montreal Cognitive Assessment (MoCA) score (8 studies, MD = 2.69, 95% CI: 1.44 to 3.95, P < 0.0001), the Rivermead Behavioral Memory Test (RBMT) score (7 studies, MD = 1.74, 95% CI:1.13 to 2.34, P < 0.00001), and the Modified Barthel Index (MBI) for Activities of Daily Living (3 studies, MD = 8.83, 95% CI:5.34 to 12.32, P < 0.00001). Sub-group analysis of MoCA and RBMT suggested that a low-frequency (1 Hz) stimulation exhibited similar effect with a higher-frequency (10 Hz) treatment. Discussion: TMS might effectively improve the attention and memory impairment of stroke patients without increasing side effects. But this effect needs to be verified by more multi-center, high-quality, large-sample, rigorously designed RCTs.
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation/methods ; Stroke/complications ; Stroke/therapy ; Memory Disorders/etiology ; Cognitive Dysfunction/etiology ; Attention ; Stroke Rehabilitation
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2112534-X
ISSN	1744-8360 ; 1473-7175
ISSN (online)	1744-8360
ISSN	1473-7175
DOI	10.1080/14737175.2022.2155515
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Zs.A 6155: Show issues

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Article: Microbiota in cancer chemoradiotherapy resistance.

He, Yan / Liu, Qin Wen / Liao, Hua Xin / Xu, Wen Wen

Clinical and translational medicine

2022 Volume 11, Issue 1, Page(s) e250

MeSH term(s)	Animals ; Chemoradiotherapy/methods ; Disease Models, Animal ; Mice ; Microbiota/physiology ; Neoplasms/microbiology ; Neoplasms/therapy ; Treatment Outcome
Language	English
Publishing date	2022-05-02
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.250
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Article: Effects of fine substance content in soil substrate on the formation of artificial cyanobacteria crusts.

Zhao, Yan-Qiao / Lian, Yu-Chao / Xu, Wen-Wen / Han, Gao-Ling / Zhao, Yang

Ying yong sheng tai xue bao = The journal of applied ecology

2023 Volume 34, Issue 9, Page(s) 2398–2404

Abstract: The use of artificial cyanobacteria crusts is one of the effective methods to prevention and control of desertification. Soil fine substance is one of the important factors limiting the colonization and growth of artificial cyanobacteria crusts. We ... ...

Title translation	土壤基质中细物质含量对人工蓝藻结皮形成的影响.
Abstract	The use of artificial cyanobacteria crusts is one of the effective methods to prevention and control of desertification. Soil fine substance is one of the important factors limiting the colonization and growth of artificial cyanobacteria crusts. We compared the growth of artificial cyanobacterial crusts with different fine substance contents by setting the volume ratios of fine substance to quicksand as 0:1, 1:1, 2:1, 4:1 and 1:0. The results showed that the cover of artificial cyanobacteria crusts increased gradually with the increases of fine substance contents, while the contents of chlorophyll a and extracellular polysaccharide firstly increased and then decreased slightly. The optimum growth of artificial cyanobacterial crusts was achieved under the treatment of 4:1 ratio. Under such treatment after 60 days of incubation, artificial cyanobacteria crusts cover was 70%, and the contents of chlorophyll a, loosely bound exopolysaccharide (LB-EPS), tightly bound exopolysaccharide (TB-EPS), and glycocalyx exopolysaccharide (G-EPS) were 17.5, 70.0, 175.0, and 200.0 μg·cm
MeSH term(s)	Chlorophyll A/metabolism ; Soil/chemistry ; Soil Microbiology ; Cyanobacteria
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y) ; Soil
Language	English
Publishing date	2023-10-29
Publishing country	China
Document type	Journal Article
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202309.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Novel Molecular Targets and Treatments for Gastroesophageal Cancer.

Lam, Alfred King-Yin / Li, Bin / Liang, Linhui / Xie, Jianjun / Xu, Wen Wen

Frontiers in oncology

2022 Volume 12, Page(s) 888861

Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.888861
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Article ; Online: A Systematic Review of the Therapeutic Potential of Resveratrol During Colorectal Cancer Chemotherapy.

Wu, Xiao-Yu / Zhai, Jing / Huan, Xiang-Kun / Xu, Wen-Wen / Tian, Jun / Farhood, Bagher

Mini reviews in medicinal chemistry

2022 Volume 23, Issue 10, Page(s) 1137–1152

Abstract: Background: The chemotherapy modality is generally used for treating colorectal cancer. However, the clinical application of chemotherapeutic drugs may be limited due to their adverse effects on normal cells/tissues and the development of cancer ... ...

Abstract	Background: The chemotherapy modality is generally used for treating colorectal cancer. However, the clinical application of chemotherapeutic drugs may be limited due to their adverse effects on normal cells/tissues and the development of cancer resistance. Using the combined treatment of chemotherapy drugs and natural bioactive compounds (such as resveratrol) can alleviate adverse drug reactions and induce synergies between the drugs. Objective: In the current review, the potential therapeutic impacts of resveratrol during colorectal cancer chemotherapy were studied. Methods: Based on the PRISMA guideline, we performed a systematic search in different electronic databases up to May, 2021. Following the search, 321 papers were found and then screened for eligibility. Twenty-seven papers were finally included in the present study Results: Compared to the control group, the growth inhibition of cancerous cells treated with chemotherapeutic drugs was considerably higher, and resveratrol co-administration synergistically increased chemotherapy-induced cytotoxicity. Moreover, a reduction in the tumor weight, volume and growth of mice was observed following chemotherapy administration compared to the untreated groups, and these reductions were predominant in animals treated with resveratrol plus chemotherapy. Other findings showed that chemotherapy alone and in combination with resveratrol modulated the cell cycle profile of cancerous cells. Furthermore, chemotherapy treatment induced a set of biochemical and histopathological alterations in cancer cells/tissues, and these changes were synergized following resveratrol co-treatment (in most of the cases), excluding inflammatory mediators. Conclusion: In most cases, resveratrol co-administration could sensitize cancerous cells to chemotherapy drugs through its oxidant, apoptosis, anti-inflammatory activities,
MeSH term(s)	Humans ; Animals ; Colorectal Neoplasms/drug therapy ; Resveratrol/therapeutic use ; Antineoplastic Agents/therapeutic use
Chemical Substances	Resveratrol (Q369O8926L) ; Antineoplastic Agents
Language	English
Publishing date	2022-10-06
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article
ZDB-ID	2104081-3
ISSN	1875-5607 ; 1389-5575
ISSN (online)	1875-5607
ISSN	1389-5575
DOI	10.2174/1389557522666220907145153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5891: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: MALAT1-related signaling pathways in colorectal cancer.

Xu, Wen-Wen / Jin, Jin / Wu, Xiao-Yu / Ren, Qing-Ling / Farzaneh, Maryam

Cancer cell international

2022 Volume 22, Issue 1, Page(s) 126

Abstract: Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcribed RNA molecules play an important role in ... ...

Abstract	Colorectal cancer (CRC) is one of the most lethal and prevalent solid malignancies worldwide. There is a great need of accelerating the development and diagnosis of CRC. Long noncoding RNAs (lncRNA) as transcribed RNA molecules play an important role in every level of gene expression. Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) is a highly conserved nucleus-restricted lncRNA that regulates genes at the transcriptional and post-transcriptional levels. High expression of MALAT1 is closely related to numerous human cancers. It is generally believed that MALAT1 expression is associated with CRC cell proliferation, tumorigenicity, and metastasis. MALAT1 by targeting multiple signaling pathways and microRNAs (miRNAs) plays a pivotal role in CRC pathogenesis. Therefore, MALAT1 can be a potent gene for cancer prediction and diagnosis. In this review, we will demonstrate signaling pathways associated with MALAT1 in CRC.
Language	English
Publishing date	2022-03-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02540-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Morpholine-modified permethyl β-cyclodextrin supramolecular nanoparticles for precise dual-targeted imaging.

Niu, Jie / Liu, Yao-Hua / Xu, Wenshi / Xu, Wen-Wen / Song, Ya-Hui / Yu, Jie / Zhang, Ying-Ming / Liu, Yu

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 31, Page(s) 4680–4683

Abstract: Possessing dual-targeted agents toward the lysosome and cancer cells, a ternary supramolecular assembly was constructed by a morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified ... ...

Abstract	Possessing dual-targeted agents toward the lysosome and cancer cells, a ternary supramolecular assembly was constructed by a morpholine-modified permethyl β-cyclodextrin, sulfonated porphyrin, and folic acid-modified chitosan
MeSH term(s)	Antineoplastic Agents/pharmacology ; beta-Cyclodextrins ; Nanoparticles ; Porphyrins/pharmacology ; Morpholines/pharmacology
Chemical Substances	Antineoplastic Agents ; beta-Cyclodextrins ; Porphyrins ; Morpholines
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc00735a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Erythropoietin, as a biological macromolecule in modification of tissue engineered constructs: A review

Wu, Xiao-yu / Zhu, Yi-miao / Qi, Yang / Xu, Wen-Wen / Jing-Zhai

International journal of biological macromolecules. 2021 Dec. 15, v. 193

2021

Abstract: In recent years, tissue engineering has emerged as a promising approach to address limitations of organ transplantation. The ultimate goal of tissue engineering is to provide scaffolds that closely mimic the physicochemical and biological cues of native ... ...

Abstract	In recent years, tissue engineering has emerged as a promising approach to address limitations of organ transplantation. The ultimate goal of tissue engineering is to provide scaffolds that closely mimic the physicochemical and biological cues of native tissues' extracellular matrix. In this endeavor, new generation of scaffolds have been designed that utilize the incorporation of signaling molecules in order to improve cell recruitment, enhance angiogenesis, exert healing activities, and increase the engraftment of the scaffolds. Among different signaling molecules, the role of erythropoietin (EPO) in regenerative medicine is increasingly being appreciated. It is a biological macromolecule which can prevent programed cell death, modulate inflammation, induce cell proliferation, and provide tissue protection in different disease models. In this review, we have outlined and critically analyzed different techniques of scaffolds' modification with EPO or EPO-loaded nanoparticles. We have also explored different strategies for the incorporation of EPO into scaffolds. Non-hematopoietic functions of EPO have also been discussed. Finalizing with detailed discussion surrounding the applications, challenges, and future perspectives of EPO-modified scaffolds in regenerative medicine.
Keywords	angiogenesis ; cell proliferation ; erythropoietin ; extracellular matrix ; inflammation ; medicine ; organ transplantation ; programmed cell death
Language	English
Dates of publication	2021-1215
Size	p. 2332-2342.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.11.065
Database	NAL-Catalogue (AGRICOLA)

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