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Article: A decentralized and security-enhanced professional title evaluation system in universities under mobile Internet of Things.

Miao, Miao / Jing, Zhengjun / Xu, Xiaolong / Xue, Meiqing

2024 Volume 10, Issue 5, Page(s) e26402

Abstract: Digital online application is a commonly used method for professional title evaluation in colleges and universities. With the rapid development of the mobile Internet of Things, the fastest way for users to access the evaluation system is through mobile ... ...

Abstract	Digital online application is a commonly used method for professional title evaluation in colleges and universities. With the rapid development of the mobile Internet of Things, the fastest way for users to access the evaluation system is through mobile devices. However, this also poses security challenges to the traditional professional title evaluation system. Therefore, this paper proposes a decentralized and security-enhanced digital title evaluation system in mobile IoT. Since the system uses blockchain to implement a decentralized review process, the transparency and fairness of the review process are guaranteed. At the same time, the review data and reviewer information in the system are encrypted and stored in the distributed network to ensure the security and non-tamperability of the data. All review records are recorded on the blockchain, and anyone can view and verify the legitimacy of the review results. Additionally, the system incorporates security enhancement mechanisms such as identity verification, smart contracts, and auditing functions to improve the credibility of the evaluation process and prevent cheating under mobile IoT. Experiments have shown that this system has important application value in the field of professional title review in universities, which can improve review efficiency, reduce human intervention, and provide strong support for the credibility of review results.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26402
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Article ; Online: Therapeutical Utilization and Repurposing of Artemisinin and Its Derivatives: A Narrative Review.

Guan, Lin / Wang, Huiyong / Xu, Xiaolong / Fan, Huahao

Advanced biology

2023 Volume 7, Issue 8, Page(s) e2300086

Abstract: Artemisinin (ART) and its derivatives have great therapeutical utility as antimalarials and can be repurposed for other indications, such as viral infections, autoimmune diseases, and cancer. This review presents a comprehensive overview of the ... ...

Abstract	Artemisinin (ART) and its derivatives have great therapeutical utility as antimalarials and can be repurposed for other indications, such as viral infections, autoimmune diseases, and cancer. This review presents a comprehensive overview of the therapeutic effects of ART-based drugs, beyond their antimalarial effects. This review also summarizes the information on their repurposing in other pathologies, with the hope that it will guide the future optimization of the use of ART-based drugs and of the treatment strategies for the listed diseases. By reviewing related literature, ART extraction and structure as well as the synthesis and structure of its derivatives are presented. Subsequently, the traditional roles of ART and its derivatives against malaria are reviewed, including antimalarial mechanism and occurrence of antimalarial resistance. Finally, the potential of ART and its derivatives to be repurposed for the treatment of other diseases are summarized. The great repurposing potential of ART and its derivatives may be useful for the control of emerging diseases with corresponding pathologies, and future research should be directed toward the synthesis of more effective derivatives or better combinations.
MeSH term(s)	Humans ; Antimalarials/therapeutic use ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Drug Repositioning ; Artemisinins/therapeutic use ; Artemisinins/chemistry ; Artemisinins/pharmacology ; Malaria/drug therapy ; Folic Acid Antagonists/therapeutic use
Chemical Substances	Antimalarials ; artemisinin (9RMU91N5K2) ; Artemisinins ; Folic Acid Antagonists
Language	English
Publishing date	2023-05-13
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2701-0198
ISSN (online)	2701-0198
DOI	10.1002/adbi.202300086
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Article: [Protective effect of dexmedetomidine on testicular torsion-induced ischemia-reperfusion injury: An experimental study].

Xu, Xiao-Long / Yang, Bo

Zhonghua nan ke xue = National journal of andrology

2021 Volume 27, Issue 3, Page(s) 208–212

Abstract: Objective: To investigate the protective effect of dexmedetomidine (Dex) preconditioning against ischemia-reperfusion (IR) injury after testicular torsion in rats.: Methods: Fifty-six adult male rats, were randomly divided into seven groups: sham ... ...

Abstract	Objective: To investigate the protective effect of dexmedetomidine (Dex) preconditioning against ischemia-reperfusion (IR) injury after testicular torsion in rats. Methods: Fifty-six adult male rats, were randomly divided into seven groups: sham control, 1h IR, 2h IR, 4h IR, 1h IR + Dex, 2h IR + Dex, and 4h IR + Dex. The torsion model was established in the latter six groups by a counterclockwise 720° left spermatic cord torsion lasting 1, 2 and 4 hours, respectively, and the rats in the last three groups injected intraperitoneally with Dex at 100 μg/kg 30 minutes before testicular reduction. At 4 hours after testicular reduction, the testes were removed for biochemical examination of the tissue homogenate and assessment of the testicular damage based on the results of HE staining and Johnsen testicular biopsy scores. Results: Lower levels of catalase and total superoxide dismutase were associated with longer time of ischemia (P<0.05) and higher in the IR than in the IR + Dex groups with the same duration of ischemia (P<0.05). The levels of malondialdehyde, nitric oxide and myeloperoxidase were all significantly increased in the IR and IR + Dex groups compared with those in the sham control group (P<0.05), higher with longer time of ischemia (P<0.05), but lower in the IR + Dex than in the IR group with the same length of time of ischemia (P<0.05). Histopathological examination revealed edema in the testis tissue, damage to the seminiferous tubules and germ cells and interstitial hemorrhage, more severe in the IR and IR + Dex groups than in the sham control group (P<0.05), which were all remarkably improved in the 1h IR + Dex and 2h IR + Dex groups compared with the 1h IR and 2h IR groups (P<0.05) but showed no statistically significant difference between the 4h IR and 4h IR + Dex groups (P > 0.05). Conclusions: Dexmedetomidine protects the rat testis against testicular torsion-induced early ischemia-reperfusion injury, but it is less effective for longer ischemia than 4 hours.
MeSH term(s)	Animals ; Dexmedetomidine/pharmacology ; Dexmedetomidine/therapeutic use ; Male ; Rats ; Reperfusion Injury/complications ; Reperfusion Injury/prevention & control ; Spermatic Cord Torsion/complications ; Superoxide Dismutase
Chemical Substances	Dexmedetomidine (67VB76HONO) ; Superoxide Dismutase (EC 1.15.1.1)
Language	Chinese
Publishing date	2021-12-22
Publishing country	China
Document type	Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Zs.A 6577: Show issues

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Article ; Online: Inertial migration of polymer micelles in a square microchannel.

Shi, Qingfeng / Wu, Jintang / Chen, Haisong / Xu, Xiaolong / Yang, Yong-Biao / Ding, Mingming

Soft matter

2024 Volume 20, Issue 8, Page(s) 1760–1766

Abstract: Using a hybrid simulation approach that combines a lattice-Boltzmann method for fluid flow and a molecular dynamics model for polymers, we investigate the inertial migration of star-like and crew-cut polymer micelles in a square microchannel. It is found ...

Abstract	Using a hybrid simulation approach that combines a lattice-Boltzmann method for fluid flow and a molecular dynamics model for polymers, we investigate the inertial migration of star-like and crew-cut polymer micelles in a square microchannel. It is found that they exhibit two types of equilibrium positions, which shift further away from the center of the microchannel when the Reynolds number (Re) increases, as can be observed for soft particles. What differs from the behaviors of soft particles is that here, the blockage ratio is no longer the decisive factor. When the sizes are the same, the star-like micelles are always relatively closer to the microchannel wall as they gradually transition from spherical to disc-like with the increase of Re. In comparison, the crew-cut micelles are only transformed into an ellipsoid. Conversely, when the hydrophobic core sizes are the same, the equilibrium position of the star-like micelles becomes closer to that of the crew-cut micelles. Our results demonstrate that for polymer micelles with a core-shell structure, the equilibrium position is no longer solely determined by their overall dimensions but depends on the core and shell's specific dimensions, especially the hydrophobic core size. This finding opens up a new approach for achieving the separation of micelles in inertial migration.
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm01304a
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Article ; Online: Therapeutic effects of finasteride: inhibition of disease progression and serum prostate-specific antigen reduction in patients with prostatic intraepithelial neoplasia.

He, Jia Wei / Huang, Zi-Xuan / Wu, Jian-Liang / Su, Yan-Feng / Xu, Xiao-Long

Annales de biologie clinique

2024 Volume 81, Issue 6, Page(s) 610–620

Abstract: The objective of this study was to evaluate the impact of finasteride on the progression of prostate intraepithelial neoplasia and levels of prostate-specific antigen (PSA) in patients. A total of 120 patients with high-grade prostatic intraepithelial ... ...

Abstract	The objective of this study was to evaluate the impact of finasteride on the progression of prostate intraepithelial neoplasia and levels of prostate-specific antigen (PSA) in patients. A total of 120 patients with high-grade prostatic intraepithelial neoplasia were included in this study from January 2013 to January 2018. All patients underwent prostate biopsies. Among them, 60 patients were assigned to the observation group and received a daily dosage of 5 mg finasteride for 60 months, while the remaining 60 patients were assigned to the control group and did not receive finasteride. PSA levels were measured every six months, and imaging scans were conducted throughout the five-year study period. Additional biopsies were performed if PSA levels exceeded 10 ng/mL or imaging suggested the presence of prostate cancer. Statistical analysis was applied to the collected data. In total, 25 cases of prostate cancer were identified in this study. Of these cases, 7 patients belonged to the observation group, whereas the remaining 18 patients were from the control group. The observation group exhibited significantly lower levels of total serum PSA (p < 0.001) and Gleason scores (p < 0.001) compared to the control group. Our study, which involved 120 participants, demonstrated that finasteride effectively reduces serum PSA levels and mitigates the severity of prostate cancer. These findings suggest that finasteride holds potential as a treatment option for patients with -high-grade prostatic intraepithelial neoplasia.
MeSH term(s)	Male ; Humans ; Prostatic Intraepithelial Neoplasia/diagnosis ; Prostatic Intraepithelial Neoplasia/drug therapy ; Finasteride/pharmacology ; Finasteride/therapeutic use ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/drug therapy ; Disease Progression
Chemical Substances	Finasteride (57GNO57U7G) ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2023.1859
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Ud II Zs.203: Show issues

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Article ; Online: Yinhuang buccal tablet alters airway microbiota composition and metabolite profile in healthy humans.

Li, Zhenxuan / Liu, Tengwen / Wang, Shuo / Chen, Tengfei / Wang, Xuerui / Xu, Xiaolong / Liu, Qingquan

Journal of ethnopharmacology

2024 Volume 328, Page(s) 118043

Abstract: Ethnopharmacological relevance: Perturbations in airway microbiota composition and disruption of microbe-metabolite interactions have been observed in respiratory infectious diseases (RIDs). The Yinhuang (YH) buccal tablet, as an ancient Chinese ... ...

Abstract	Ethnopharmacological relevance: Perturbations in airway microbiota composition and disruption of microbe-metabolite interactions have been observed in respiratory infectious diseases (RIDs). The Yinhuang (YH) buccal tablet, as an ancient Chinese medicinal formula, has been traditionally employed for the management of upper RIDs. However, there is a lack of evidence for the effects of YH buccal tablets on upper respiratory tract microbiota and circulating metabolites. Aim of the study: The aim of this study was to analyze the changes in respiratory microbiota composition and circulating metabolite profile after YH buccal tablets administration. Materials and methods: Throat swab samples and serum samples were collected from 60 healthy subjects for high-throughput 16S ribosomal RNA gene (16S rRNA) sequencing and non-targeted Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. Results: Airway microbial composition changed significantly after YH administration. The abundance of Actinomyces and Prevotella_7 increased, while the abundance of potentially pathogenic Pseudomonas and Corynebacterium decreased. A total of 168 significant HMDB taxonomic metabolites were identified in serum samples, of which lipid metabolites accounted for the largest proportion. Correlation analysis showed that circulatory metabolites were significantly correlated with changes in airway microbiota composition. Conclusions: YH buccal tablets can inhibit opportunistic pathogens, increase beneficial microorganisms in the upper respiratory tract, and regulate the body's metabolic pathways. These findings provide insights into the mechanism of action of YH buccal tablets in the treatment and prevention of respiratory diseases.
MeSH term(s)	Humans ; Chromatography, Liquid ; RNA, Ribosomal, 16S/genetics ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/metabolism ; Tandem Mass Spectrometry/methods ; Respiratory System ; Microbiota ; Tablets
Chemical Substances	RNA, Ribosomal, 16S ; Drugs, Chinese Herbal ; Tablets
Language	English
Publishing date	2024-03-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118043
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Zs.A 1494: Show issues

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Article ; Online: PANoptosis-related signature in melanoma: Transcriptomic mapping and clinical prognostication.

Xie, Jiaheng / Zhang, Pengpeng / Xu, Xiaolong / Zhou, Xinxin / Zhao, Songyun / Zhang, Min / Qi, Min

Environmental toxicology

2024 Volume 39, Issue 5, Page(s) 2545–2559

Abstract: Programmed cell death plays a pivotal role in maintaining tissue homeostasis, and recent advancements in cell biology have uncovered PANoptosis-a novel paradigm integrating pyroptosis, apoptosis, and necroptosis. This study investigates the implications ... ...

Abstract	Programmed cell death plays a pivotal role in maintaining tissue homeostasis, and recent advancements in cell biology have uncovered PANoptosis-a novel paradigm integrating pyroptosis, apoptosis, and necroptosis. This study investigates the implications of PANoptosis in melanoma, a formidable skin cancer known for its metastatic potential and resistance to conventional therapies. Leveraging bulk and single-cell transcriptome analyses, machine learning modeling, and immune correlation assessments, we unveil the molecular intricacies of PANoptosis in melanoma. Single-cell sequencing identifies diverse cell types involved in PANoptosis, while bulk transcriptome analysis reveals key gene sets correlated with PANoptosis. Machine learning algorithms construct a robust prognostic model, demonstrating consistent predictive power across diverse cohorts. Patients with different cohorts can be divided into high-risk and low-risk groups according to this PANoptosis score, with the high-risk group having a significantly worse prognosis. Immune correlation analyses unveil a link between PANoptosis and immunotherapy response, with potential therapeutic implications. Mutation analysis and enrichment studies provide insights into the mutational landscape associated with PANoptosis. Finally, we used cell experiments to verify the expression and function of key gene PARVA, showing that PARVA was highly expressed in melanoma cell lines, and after PARVA is knocked down, cell invasion, migration, and colony formation ability were significantly decreased. This study advances our understanding of PANoptosis in melanoma, offering a comprehensive framework for targeted therapeutic interventions and personalized medicine strategies in combating this aggressive malignancy.
MeSH term(s)	Humans ; Melanoma/genetics ; Gene Expression Profiling ; Transcriptome ; Skin Neoplasms/genetics ; Apoptosis
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24126
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Zs.A 2676: Show issues

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Article ; Online: Structural insights into the Clp protein degradation machinery.

Xu, Xiaolong / Wang, Yanhui / Huang, Wei / Li, Danyang / Deng, Zixin / Long, Feng

mBio

2024 Volume 15, Issue 4, Page(s) e0003124

Abstract: The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1. The hexameric ATPase ClpC1 utilizes the energy of ATP binding and hydrolysis to engage, unfold, and ... ...

Abstract	The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1. The hexameric ATPase ClpC1 utilizes the energy of ATP binding and hydrolysis to engage, unfold, and translocate substrates into the proteolytic chamber of homo- or hetero-tetradecameric ClpP for degradation. The assembly between the hetero-tetradecameric ClpP1P2 chamber and the Clp-ATPases containing tandem ATPase domains from the same species has not been studied in depth. Here, we present cryo-EM structures of the substrate-bound ClpC1:shClpP1P2 from
MeSH term(s)	Endopeptidase Clp/genetics ; Endopeptidase Clp/metabolism ; Proteolysis ; Adenosine Triphosphatases/metabolism ; ATPases Associated with Diverse Cellular Activities/metabolism ; Peptide Hydrolases/metabolism ; Adenosine Triphosphate/metabolism ; Streptomyces
Chemical Substances	Endopeptidase Clp (EC 3.4.21.92) ; Adenosine Triphosphatases (EC 3.6.1.-) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Peptide Hydrolases (EC 3.4.-) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00031-24
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Article ; Online: Hygeia: A Multilabel Deep Learning-Based Classification Method for Imbalanced Electrocardiogram Data.

Xu, Xiaolong / Xu, Haoyan / Wang, Liying / Zhang, Yuanyuan / Xaio, Fu

IEEE/ACM transactions on computational biology and bioinformatics

2023 Volume 20, Issue 4, Page(s) 2480–2493

Abstract: Electrocardiogram (ECG) is a common diagnostic indicator of heart disease in hospitals. Because of the low price and noninvasiveness of ECG diagnosis, it is widely used for prescreening and physical examination of heart diseases. In several studies on ... ...

Abstract	Electrocardiogram (ECG) is a common diagnostic indicator of heart disease in hospitals. Because of the low price and noninvasiveness of ECG diagnosis, it is widely used for prescreening and physical examination of heart diseases. In several studies on ECG analysis, only rough diagnoses are made to determine whether ECGs are abnormal or on a few kinds of ECG. In actual scenarios, doctors must analyze ECG samples in detail, which is a multilabel classification problem. Herein, we propose Hygeia, a multilabel deep learning-based ECG classification method that can analyze and classify 55 types of ECG. First, a guidance model is constructed to transform the multilabel classification problem into multiple interrelated two-classification models. This method ensures the good performance of each ECG analysis model, and the relationship between various types of ECG can be used in the analysis. The imbalance of samples in ECG datasets makes it difficult to analyze abnormal ECGs with high sensitivity and accuracy. We used data generation and mixed sampling methods for 11 ECG types with imbalanced problems to improve the average accuracy, sensitivity, F1 value, and accuracy from 87.74%, 43.11%, 0.3929, and 0.3929, to 92.68%, 96.92, 0.9287, and 99.47%, respectively. The average accuracy, sensitivity, F1 value, and accuracy of 44 of the 55 tags of the abnormal ECG analysis model are 99.69%, 95.81%, 0.9758, and 99.72%, respectively.
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2022.3176905
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Article: Mechanism of Qiguiyin Decoction Treats Pulmonary Infection Caused by

Cui, Xuran / Xu, Xiaolong / Hu, Yahui / Li, Rui / Liu, Qingquan

Infection and drug resistance

2023 Volume 16, Page(s) 3073–3084

Abstract: Background: Qiguiyin decoction (QGYD) was a traditional Chinese medicine (TCM) used to treat : Materials and methods: Pulmonary infections were induced in mice by CRPA. The therapeutic effect of QGYD was evaluated by lung index and pulmonary ... ...

Abstract	Background: Qiguiyin decoction (QGYD) was a traditional Chinese medicine (TCM) used to treat Materials and methods: Pulmonary infections were induced in mice by CRPA. The therapeutic effect of QGYD was evaluated by lung index and pulmonary pathology. The potential effects of QGYD on intestinal flora were detected by gut microbiome. The overall metabolism regulation of QGYD in blood was investigated by metabonomics. Next, the correlation between intestinal flora and metabolites was analyzed to illustrate the relationship between the regulatory effects of QGYD on metabolites and the beneficial effects of intestinal flora. Results: QGYD has significant therapeutic effect on CRPA infection. QGYD profoundly inhibited the excessive accumulation of Conclusion: QGYD can improve CRPA infection and has the effect of regulating intestinal flora and metabolism. It was a promising drug against infection.
Language	English
Publishing date	2023-05-18
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S405033
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