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  1. Article ; Online: Corrigendum: Construction of smart older adults care service model driven by primary health care.

    Zhang, Lechuan / Xu, Xiaoyan

    Frontiers in public health

    2023  Volume 11, Page(s) 1319932

    Abstract: This corrects the article DOI: 10.3389/fpubh.2023.1157758.]. ...

    Abstract [This corrects the article DOI: 10.3389/fpubh.2023.1157758.].
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1319932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Construction of smart older adults care service model driven by primary health care.

    Zhang, Lechuan / Xu, Xiaoyan

    Frontiers in public health

    2023  Volume 11, Page(s) 1157758

    Abstract: In recent years, with the arrival of an overall aging population, how to provide for the elderly has become the focus of government departments and society. The traditional elderly care service model has problems such as backward construction of ... ...

    Abstract In recent years, with the arrival of an overall aging population, how to provide for the elderly has become the focus of government departments and society. The traditional elderly care service model has problems such as backward construction of information platforms, low quality of elderly care services, and "digital divide". For this reason, based on grassroots medical and health care, this paper improves the quality of elderly care services by establishing a smart elderly care service model. Through experiments, it can be found that compared with the traditional elderly care service model, the intelligent elderly care service model has an absolute advantage in the identification of nursing data. The recognition accuracy rate of the smart elderly care service model for all kinds of daily care data is above 94%, while the recognition accuracy rate of the traditional elderly care service model is below 90%. Therefore, it is of great significance to study the smart elderly care service model driven by primary medical care and health.
    MeSH term(s) Humans ; Aged ; Delivery of Health Care ; Aging ; Primary Health Care
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1157758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of tumor suppressor genes of naked mole rats for human cancer treatment.

    Xia, Pu / Xu, Xiao-Yan

    American journal of translational research

    2023  Volume 15, Issue 8, Page(s) 5356–5363

    Abstract: Cancer not only has a significant prevalence in the human population, but is also leading cause of death in animals. Despite a long history, our battle against cancer continues. Cross-species comparative genomics offers insight into shared genes and ... ...

    Abstract Cancer not only has a significant prevalence in the human population, but is also leading cause of death in animals. Despite a long history, our battle against cancer continues. Cross-species comparative genomics offers insight into shared genes and pathways by analyzing genomic data across species, enhancing our understanding of cancer mechanisms, evolutionary processes, and possible therapeutic targets. However, no previous study has demonstrated the inhibitory effects of tumor suppressor genes from one species on tumor cells from another. The naked mole rat is the only mammal yet to be found with cancer that is attributed to its tumor suppressor genes. In this study, we constructed phylogenetic trees and assessed the anti-tumor activity of two suppressor genes, programmed cell death molecule 5 (PDCD5) and dickkopf 3 (DKK3), from rats, mice, and humans. DKK3 robustly inhibited the proliferation of breast cancer cells within and across species due to its highly conserved protein sequence. However, the cross-species inhibitory effect of PDCD5 on breast cancer cells was inconsistent due to significant sequence variations. Intriguingly, PDCD5 from the naked mole rat demonstrated potent anti-tumor activity against breast cancer cells from mice, rats, and humans, surpassing that of PDCD5 from parental species. Our results demonstrate that the suppressor genes from the naked mole rat have a strong inhibitory effect on cancer cells, indicating that the powerful anti-cancer functions of the naked mole rat may be useful for human tumor treatment.
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antizyme inhibitor family: biological and translational research implications.

    Feng, Qiaohui / Wang, Huijie / Shao, Youcheng / Xu, Xiaoyan

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 11

    Abstract: Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine ... ...

    Abstract Metabolism of polyamines is of critical importance to physiological processes. Ornithine decarboxylase (ODC) antizyme inhibitors (AZINs) are capable of interacting with antizymes (AZs), thereby releasing ODC from ODC-AZs complex, and promote polyamine biosynthesis. AZINs regulate reproduction, embryonic development, fibrogenesis and tumorigenesis through polyamine and other signaling pathways. Dysregulation of AZINs has involved in multiple human diseases, especially malignant tumors. Adenosine-to-inosine (A-to-I) RNA editing is the most common type of post-transcriptional nucleotide modification in humans. Additionally, the high frequencies of RNA-edited AZIN1 in human cancers correlates with increase of cancer cell proliferation, enhancement of cancer cell stemness, and promotion of tumor angiogenesis. In this review, we summarize the current knowledge on the various contribution of AZINs related with potential cancer promotion, cancer stemness, microenvironment and RNA modification, especially underlying molecular mechanisms, and furthermore explored its promising implication for cancer diagnosis and treatment.
    MeSH term(s) Humans ; Ornithine Decarboxylase/genetics ; Ornithine Decarboxylase/metabolism ; Translational Research, Biomedical ; Polyamines/metabolism ; Cell Transformation, Neoplastic ; RNA ; Tumor Microenvironment
    Chemical Substances Ornithine Decarboxylase (EC 4.1.1.17) ; Polyamines ; RNA (63231-63-0)
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01445-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Research on the Design of Map Cultural Products -– Taking Anhui Province as An Example

    Xu Xiaoyan / Liu Xu / Yuan Yong

    SHS Web of Conferences, Vol 162, p

    2023  Volume 01008

    Abstract: This paper systematically sorts out the development of maps and map culture, and takes it as a guide to focus on the design background, design ideas, production plans, and design results of Anhui map cultural products, providing a reference for the ... ...

    Abstract This paper systematically sorts out the development of maps and map culture, and takes it as a guide to focus on the design background, design ideas, production plans, and design results of Anhui map cultural products, providing a reference for the design and development of map cultural products in the future.
    Keywords map culture ; design ; theme selection ; content design ; Social Sciences ; H
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Fixed-time event-triggered control for multi-agent systems with input delay.

    Wang, Linling / Xu, Xiaoyan / Han, Bing

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0293424

    Abstract: An in-depth study on the fixed-time event-triggered obstacle avoidance consensus control in heterogeneous USV-AUV systems with input delay and uncertain disturbances are conducted in this paper. When initial state of the system fails to achieve consensus, ...

    Abstract An in-depth study on the fixed-time event-triggered obstacle avoidance consensus control in heterogeneous USV-AUV systems with input delay and uncertain disturbances are conducted in this paper. When initial state of the system fails to achieve consensus, the desired heterogeneous USV-AUV formation can be achieved by fixed-time consensus control, within a fixed predetermined time, regardless of the initial states. Besides, an event-triggered communication strategy among the agents is introduced in the system, significantly reducing communication energy consumption. By employing the proposed control strategy, the Zeno behavior also can be avoided. Additionally, an obstacle avoidance control algorithm for the heterogeneous USV-AUV system based on improved artificial potential fields (IAPF) is designed, which helps in avoiding both static and dynamic obstacles. Compared to existing research, this algorithm reduces control input jitter, resulting in smoother obstacle avoidance paths. Through extensive simulation experiments and comparisons with other methods, effectiveness and superiority of the proposed algorithm is validated.
    MeSH term(s) Precipitating Factors ; Algorithms ; Communication ; Computer Simulation ; Consensus
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A multi-block data approach to assessing beef quality: ComDim analysis of hyperspectral imaging,

    You, Qian / Wang, Ziyuan / Tian, Xingguo / Xu, Xiaoyan

    Food chemistry

    2023  Volume 425, Page(s) 136469

    Abstract: Several factors affect the quality of beef. In the field of chemometrics, multi-block data analysis methods are useful for examining multiple sources of information from a sample. This study focuses on the application of ComDim, a multi-block data ... ...

    Abstract Several factors affect the quality of beef. In the field of chemometrics, multi-block data analysis methods are useful for examining multiple sources of information from a sample. This study focuses on the application of ComDim, a multi-block data analysis method, to evaluate beef from different parts of hyperspectral spectrum and image texture information,
    MeSH term(s) Animals ; Cattle ; Hyperspectral Imaging ; Electronic Nose ; Proton Magnetic Resonance Spectroscopy ; Principal Component Analysis
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2023.136469
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  8. Article ; Online: Characterization, mechanism and

    Li, Junyi / Peng, Fei / Huang, Hui / Xu, Xiaoyan / Guan, Qianqian / Xie, Mingyong / Xiong, Tao

    Food & function

    2024  Volume 15, Issue 3, Page(s) 1170–1190

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    MeSH term(s) Infant ; Animals ; Humans ; Helicobacter pylori/physiology ; Gastric Mucosa/metabolism ; Lactobacillales ; Feces/microbiology ; Probiotics/pharmacology ; Mouth/pathology ; Helicobacter Infections/microbiology
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04592g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  9. Article: Efficacy of the spirit-regulation method of Jin's three-needle therapy for post-stroke anxiety and its effect on the hypothalamus-pituitary-adrenal axis.

    Li, Mei-Chen / Wang, Yu-Ting / Li, Ke-Yi / Xu, Xiao-Yan / Zhuang, Li-Xing

    Zhen ci yan jiu = Acupuncture research

    2024  Volume 49, Issue 1, Page(s) 57–63

    Abstract: Objectives: To observe the clinical efficacy of the spirit-regulation method of Jin's three-needle therapy on post-stroke anxiety and its effects on the hypothalamus-pituitary-adrenal (HPA) axis.: Methods: Fifty-four patients with post-stroke anxiety ...

    Title translation 靳三针调神针法治疗卒中后焦虑的疗效观察及对下丘脑-垂体-肾上腺轴的影响.
    Abstract Objectives: To observe the clinical efficacy of the spirit-regulation method of Jin's three-needle therapy on post-stroke anxiety and its effects on the hypothalamus-pituitary-adrenal (HPA) axis.
    Methods: Fifty-four patients with post-stroke anxiety were divided into spirit regulation (Jin's three needle therapy) group and sham-acupuncture group according to the random number table method, 28 cases in the spirit regulation and 26 cases in the sham-acupuncture group. The patients of the two groups received the same regimen of basic medication and rehabilitation, and the same acupoint prescription was adopted, including Sishenzhen (extra points, 1.5
    Results: In the within-group comparison before and after treatment, HAMA score and NIHSS score dropped on day 10 and day 21 after treatment in the spirit regulation group (
    Conclusions: Using sham acupuncture as a control, it is preliminarily confirmed that the spirit regulation method of Jin's three-needle therapy is effective on post-stroke anxiety. In association of the downtrend of serological indicators, it is speculated that the underlying mechanism of this therapy is related to HPA axis.
    MeSH term(s) Humans ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Stroke/complications ; Stroke/therapy ; Acupuncture Therapy/methods ; Anxiety/therapy ; Treatment Outcome ; Acupuncture Points ; Adrenocorticotropic Hormone
    Chemical Substances Adrenocorticotropic Hormone (9002-60-2)
    Language Chinese
    Publishing date 2024-01-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    DOI 10.13702/j.1000-0607.20220949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus).

    Yu, Hongyan / Chen, Zheyan / Yu, Qiaozhen / Shen, Yubang / Gui, Lang / Xu, Xiaoyan / Li, Jiale

    Fish & shellfish immunology

    2024  Volume 147, Page(s) 109453

    Abstract: miRNAs are increasingly recognized for their crucial role in autophagy processes. Recent research has highlighted the significant function of autophagy in modulating immune responses. Within this context, specific miRNAs have been identified as indirect ... ...

    Abstract miRNAs are increasingly recognized for their crucial role in autophagy processes. Recent research has highlighted the significant function of autophagy in modulating immune responses. Within this context, specific miRNAs have been identified as indirect mediators of immune functions through their modulation of autophagy. In this study, we verified that miR-193b-5p simultaneously targeted the grass carp autophagy-related gene deptor, thereby reducing autophagy levels in CIK cells. Moreover, we found the expression levels of miR-193b-5p and deptor responding to pathogen infections in the GCRV-infected CIK cells. Notably, the overexpression of miR-193b-5p was found to induce the GCRV replication and reduce the irf3, irf7 and IFN1 expression. These findings also demonstrated that grass carp miR-193b-5p impacted the proliferation, migration, and antiapoptotic abilities of CIK cells. All the above results indicated that miR-193b-5p was linked to grass carp autophagy and played a vital role in antiviral immunity by targeting deptor. Our study may provide important insights into autophagy-related miRNAs and their roles in defense and immune mechanisms against pathogens in teleost.
    MeSH term(s) Animals ; Reoviridae/physiology ; Reoviridae Infections ; Carps/metabolism ; Autophagy ; MicroRNAs/metabolism ; Fish Diseases ; Fish Proteins/genetics
    Chemical Substances MicroRNAs ; Fish Proteins
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2024.109453
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    In stock of ZB MED Bonn / Germany

    Z 5917: Show issues

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