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  1. Book ; Thesis: Studies of mammalian mitochondrial genomes with special emphasis on the perissodactyla

    Xu, Xiufeng

    1996  

    Author's details Xiufeng Xu
    Language German
    Size Getr. Zählung : graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 1996
    HBZ-ID HT007306350
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    96 E 2014 order for loan Magazin

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  2. Article ; Online: Synthesis of Ni Nanosheets by Template-Free Method and Their Application in Conductive and Magnetic Flexible Electrons.

    Xu, Xiufeng / Dang, Rui / Liu, Jian / Li, Meixin

    ACS applied materials & interfaces

    2023  Volume 15, Issue 30, Page(s) 36698–36705

    Abstract: Two-dimensional Ni nanosheets are synthesized by the template-free method using ... ...

    Abstract Two-dimensional Ni nanosheets are synthesized by the template-free method using Na
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c07059
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  3. Article ; Online: Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder.

    Wu, Yanru / Chu, Zhaosong / Chen, Xianyu / Zhu, Yun / Xu, Xiufeng / Shen, Zonglin

    Neuroreport

    2024  Volume 35, Issue 6, Page(s) 380–386

    Abstract: This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and ... ...

    Abstract This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and were drug-naïve were recruited at baseline as cases. Healthy controls (HCs) matched for sex, age, and education level were also recruited at the same time. At baseline, all participants underwent resting-state functional MRI. FC analyses were performed using the Hb seed region of interest, and three groups including HCs, MDD group and MDD12 group were compared using whole-brain voxel-wise comparisons. Compared to the HCs, the MDD group had decreased FC between the Hb and the right anterior cingulate cortex at baseline. Compared to the HCs, the FC between the Hb and the left medial superior frontal gyrus decreased in the MDD12 group. Additionally, the FC between the left precuneus, bilateral cuneus and Hb increased in the MDD12 group than that in the MDD group. No significant correlation was found between HDRS-17 and the FC between the Hb, bilateral cuneus, and the left precuneus in the MDD12 group. Our study suggests that the FC between the post-default mode network and Hb may be the treatment mechanism of duloxetine and the treatment mechanisms and the pathogenesis of depression may be independent of each other.
    MeSH term(s) Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Duloxetine Hydrochloride/pharmacology ; Duloxetine Hydrochloride/therapeutic use ; Default Mode Network ; Habenula ; Magnetic Resonance Imaging ; Rest/physiology
    Chemical Substances Duloxetine Hydrochloride (9044SC542W)
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000002019
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  4. Book ; Online: Instantaneous and limiting behavior of an n-node blockchain under cyber attacks from a single hacker

    Xu, Xiufeng / Hong, Liang

    2022  

    Abstract: We investigate the instantaneous and limiting behavior of an n-node blockchain which is under continuous monitoring of the IT department of a company but faces non-stop cyber attacks from a single hacker. The blockchain is functional as far as no data ... ...

    Abstract We investigate the instantaneous and limiting behavior of an n-node blockchain which is under continuous monitoring of the IT department of a company but faces non-stop cyber attacks from a single hacker. The blockchain is functional as far as no data stored on it has been changed, deleted, or locked. Once the IT department detects the attack from the hacker, it will immediately re-set the blockchain, rendering all previous efforts of the hacker in vain. The hacker will not stop until the blockchain is dysfunctional. For arbitrary distributions of the hacking times and detecting times, we derive the limiting functional probability, instantaneous functional probability, and mean functional time of the blockchain. We also show that all these quantities are increasing functions of the number of nodes, substantiating the intuition that the more nodes a blockchain has, the harder it is for a hacker to succeed in a cyber attack.
    Keywords Computer Science - Cryptography and Security ; Mathematics - Optimization and Control ; Statistics - Applications ; 90B25 ; 90B36
    Subject code 519
    Publishing date 2022-02-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Silver decorated nickel-cobalt (oxy)hydroxides fabricated

    Liu, Shan-Shan / Xu, Xiu-Feng / Li, Ji-Sen

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 31, Page(s) 11814–11822

    Abstract: Electrochemical water splitting is considered to be a promising renewable hydrogen generation technology but is significantly limited by the kinetically sluggish oxygen evolution reaction (OER) at the anode. Herein, a silver nanoparticle decorated nickel- ...

    Abstract Electrochemical water splitting is considered to be a promising renewable hydrogen generation technology but is significantly limited by the kinetically sluggish oxygen evolution reaction (OER) at the anode. Herein, a silver nanoparticle decorated nickel-cobalt (oxy)hydroxide composite is fabricated on nickel foam (Ag@NiCo(OH)
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt01485h
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  6. Book ; Online: CompSuite

    Xu, Xiufeng / Zhu, Chenguang / Li, Yi

    A Dataset of Java Library Upgrade Incompatibility Issues

    2023  

    Abstract: Modern software systems heavily rely on external libraries developed by third-parties to ensure efficient development. However, frequent library upgrades can lead to compatibility issues between the libraries and their client systems. In this paper, we ... ...

    Abstract Modern software systems heavily rely on external libraries developed by third-parties to ensure efficient development. However, frequent library upgrades can lead to compatibility issues between the libraries and their client systems. In this paper, we introduce CompSuite, a dataset that includes 123 real-world Java client-library pairs where upgrading the library causes an incompatibility issue in the corresponding client. Each incompatibility issue in CompSuite is associated with a test case authored by the developers, which can be used to reproduce the issue. The dataset also provides a command-line interface that simplifies the execution and validation of each issue. With this infrastructure, users can perform an inspection of any incompatibility issue with the push of a button, or reproduce an issue step-by-step for a more detailed investigation. We make CompSuite publicly available to promote open science. We believe that various software analysis techniques, such as compatibility checking, debugging, and regression test selection, can benefit from CompSuite.
    Keywords Computer Science - Software Engineering
    Publishing date 2023-05-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Reduced gray matter volume of the hippocampal tail in melancholic depression: evidence from an MRI study.

    Chu, Zhaosong / Yuan, Lijin / Lian, Kun / He, Mengxin / Lu, Yi / Cheng, Yuqi / Xu, Xiufeng / Shen, Zonglin

    BMC psychiatry

    2024  Volume 24, Issue 1, Page(s) 183

    Abstract: Background: Melancholic depression (MD) is one of the most prevalent and severe subtypes of major depressive disorder (MDD). Previous studies have revealed inconsistent results regarding alterations in grey matter volume (GMV) of the hippocampus and ... ...

    Abstract Background: Melancholic depression (MD) is one of the most prevalent and severe subtypes of major depressive disorder (MDD). Previous studies have revealed inconsistent results regarding alterations in grey matter volume (GMV) of the hippocampus and amygdala of MD patients, possibly due to overlooking the complexity of their internal structure. The hippocampus and amygdala consist of multiple and functionally distinct subregions, and these subregions may play different roles in MD. This study aims to investigate the volumetric alterations of each subregion of the hippocampus and amygdala in patients with MD and non-melancholic depression (NMD).
    Methods: A total of 146 drug-naïve, first-episode MDD patients (72 with MD and 74 with NMD) and 81 gender-, age-, and education-matched healthy controls (HCs) were included in the study. All participants underwent magnetic resonance imaging (MRI) scans. The subregional segmentation of hippocampus and amygdala was performed using the FreeSurfer 6.0 software. The multivariate analysis of covariance (MANCOVA) was used to detect GMV differences of the hippocampal and amygdala subregions between three groups. Partial correlation analysis was conducted to explore the relationship between hippocampus or amygdala subfields and clinical characteristics in the MD group. Age, gender, years of education and intracranial volume (ICV) were included as covariates in both MANCOVA and partial correlation analyses.
    Results: Patients with MD exhibited a significantly lower GMV of the right hippocampal tail compared to HCs, which was uncorrelated with clinical characteristics of MD. No significant differences were observed among the three groups in overall and subregional GMV of amygdala.
    Conclusions: Our findings suggest that specific hippocampal subregions in MD patients are more susceptible to volumetric alterations than the entire hippocampus. The reduced right hippocampal tail may underlie the unique neuropathology of MD. Future longitudinal studies are required to better investigate the associations between reduced right hippocampal tail and the onset and progression of MD.
    MeSH term(s) Humans ; Gray Matter/diagnostic imaging ; Depressive Disorder, Major/diagnostic imaging ; Depression ; Hippocampus/diagnostic imaging ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-024-05630-5
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  8. Article ; Online: Hub genes, a diagnostic model, and immune infiltration based on ferroptosis-linked genes in schizophrenia.

    Lian, Kun / Li, Yongmei / Yang, Wei / Ye, Jing / Liu, Hongbing / Wang, Tianlan / Yang, Guangya / Cheng, Yuqi / Xu, Xiufeng

    IBRO neuroscience reports

    2024  Volume 16, Page(s) 317–328

    Abstract: Background: Schizophrenia (SCZ) is a prevalent and serious mental disorder, and the exact pathophysiology of this condition is not fully understood. In previous studies, it has been proven that ferroprotein levels are high in SCZ. It has also been shown ...

    Abstract Background: Schizophrenia (SCZ) is a prevalent and serious mental disorder, and the exact pathophysiology of this condition is not fully understood. In previous studies, it has been proven that ferroprotein levels are high in SCZ. It has also been shown that this inflammatory response may modify fibromodulin. Accumulating evidence indicates a strong link between metabolism and ferroptosis. Therefore, the present study aims to identify ferroptosis-linked hub genes to further investigate the role that ferroptosis plays in the development of SCZ.
    Material and methods: From the GEO database, four microarray data sets on SCZ (GSE53987, GSE38481, GSE18312, and GSE38484) and ferroptosis-linked genes were extracted. Using the prefrontal cortex expression matrix of SCZ patients and healthy individuals as the control group from GSE53987, weighted gene co-expression network analysis (WGCNA) was performed to discover SCZ-linked module genes. From the feed, genes associated with ferroptosis were retrieved. The intersection of the module and ferroptosis-linked genes was done to obtain the hub genes. Then, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, and Gene Set Enrichment Analysis (GSEA) were conducted. The SCZ diagnostic model was established using logistic regression, and the GSE38481, GSE18312, and GSE38484 data sets were used to validate the model. Finally, hub genes linked to immune infiltration were examined.
    Results: A total of 13 SCZ module genes and 7 hub genes linked to ferroptosis were obtained:
    Conclusion: In this study, seven critical genes that are strongly associated with ferroptosis in patients with SCZ were discovered, a valid clinical diagnostic model was built, and a novel therapeutic target for the treatment of SCZ was identified by the investigation of immune infiltration.
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2667-2421
    ISSN (online) 2667-2421
    DOI 10.1016/j.ibneur.2024.01.007
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  9. Article ; Online: Subcortical neural mechanisms of childhood trauma impacts on personality traits.

    Chu, Zhaosong / Wang, Xin / Cheng, Yuqi / Yuan, Lijin / Jin, Mengyun / Lu, Yi / Shen, Zonglin / Xu, Xiufeng

    Asian journal of psychiatry

    2024  Volume 94, Page(s) 103966

    Abstract: This study aims to explore the relationships between childhood trauma (CT), personality traits, and subcortical structures. 171 healthy individuals completed the Childhood Trauma Questionnaire (CTQ), the Neuroticism-Extraversion-Openness Five-Factor ... ...

    Abstract This study aims to explore the relationships between childhood trauma (CT), personality traits, and subcortical structures. 171 healthy individuals completed the Childhood Trauma Questionnaire (CTQ), the Neuroticism-Extraversion-Openness Five-Factor Inventory (NEO-FFI), and underwent 3D T1-weighted MRI scans. Linear regression analyses indicated the complex relationship between CT, personality traits, and subcortical gray matter volume (GMV). Mediation analyses revealed that the right hippocampal GMV partially mediated the effects of CT on neuroticism. These findings suggest that CT affects the development of the Big Five personality traits, and alterations in subcortical structures are closely related to this process. Altered GMV in the right hippocampus may be a key neural mechanism for CT-induced neuroticism.
    MeSH term(s) Humans ; Personality ; Adverse Childhood Experiences ; Neuroticism ; Gray Matter/diagnostic imaging ; Personality Inventory ; Psychological Tests ; Self Report
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2024.103966
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  10. Article ; Online: Family-based genetic analysis in schizophrenia by whole-exome sequence to identify rare pathogenic variants.

    Shang, Binli / Yang, Runxu / Lian, Kun / Dong, Lei / Liu, Hongbing / Wang, Tianlan / Yang, Guangya / Xi, Kang / Xu, Xiufeng / Cheng, Yuqi

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2024  , Page(s) e32968

    Abstract: Schizophrenia (SCZ) is influenced by a combination of genetic and environmental factors. Although several studies have been conducted to identify the causative loci and genes, few of these loci or genes can be repeated due to the high phenotypic and ... ...

    Abstract Schizophrenia (SCZ) is influenced by a combination of genetic and environmental factors. Although several studies have been conducted to identify the causative loci and genes, few of these loci or genes can be repeated due to the high phenotypic and genetic heterogeneity of disease, and their mechanisms are not fully understood. There may be some "missing heritability" that has not yet been found. In order to investigate the deleterious heritable mutations, whole-exome sequencing (WES) in pedigrees with SCZ was used in the current work. Two unrelated pedigrees with SCZ were recruited to perform WES. Genetic analysis was next performed to find potential variants in accordance with the prioritized strategy. Followed by genetic analysis to detect candidate variants according to the prioritized strategy. Next, a series of algorithms was used to predict the pathogenicity of variants. Sanger sequencing was finally conducted to verify the co-segregation. Recessive mutations in six genes (TFEB, SNAI2, TFAP2B, PRKDC, ST18 in Pedigree 1 and PKHD1L1 in Pedigree 2) that co-segregated with SCZ in two families were discovered through genetic analysis by WES. Sanger sequencing verified that all of the mutations in the affected siblings were homozygous. These results corroborated the hypothesis that SCZ exhibits strong heterogeneity and complex inheritance patterns. The newly discovered homozygous variations deepen our understanding of the mutation spectrum and offer more proof for the involvement of TFEB, SNAI2, TFAP2B, PRKDC, ST18, and PKHD1L1 in the development of SCZ.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108616-3
    ISSN 1552-485X ; 1552-4841 ; 0148-7299
    ISSN (online) 1552-485X
    ISSN 1552-4841 ; 0148-7299
    DOI 10.1002/ajmg.b.32968
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