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  1. Article ; Online: Baseline-Free Structural Damage Identification for Beam-Like Structures Using Curvature Waveforms of Propagating Flexural Waves.

    Xu, Y F / Kim, J S

    Sensors (Basel, Switzerland)

    2021  Volume 21, Issue 7

    Abstract: Curvatures in mode shapes and operating deflection shapes have been extensively studied for vibration-based structural damage identification in recent decades. Curvatures of mode shapes and operating deflection shapes have proved capable of localizing ... ...

    Abstract Curvatures in mode shapes and operating deflection shapes have been extensively studied for vibration-based structural damage identification in recent decades. Curvatures of mode shapes and operating deflection shapes have proved capable of localizing and manifesting local effects of damage on mode shapes and operating deflection shapes in forms of local anomalies. The damage can be inversely identified in the neighborhoods of the anomalies that exist in the curvatures. Meanwhile, propagating flexural waves have also been extensively studied for structural damage identification and proved to be effective, thanks to their high damage-sensitivity and long range of propagation. In this work, a baseline-free structural damage identification method is developed for beam-like structures using curvature waveforms of propagating flexural waves. A multi-resolution local-regression temporal-spatial curvature damage index (TSCDI) is defined in a pointwise manner. A two-dimensional auxiliary TSCDI and a one-dimensional auxiliary damage index are developed to further assist the identification. Two major advantages of the proposed method are: (1) curvature waveforms of propagating flexural waves have relatively high signal-to-noise ratios due to the use of a multi-resolution central finite difference scheme, so that the local effects of the damage can be manifested, and (2) the proposed method does not require quantitative knowledge of a pristine structure associated with a structure to be examined, such as its material properties, waveforms of propagating flexural waves and boundary conditions. Numerical and experimental investigations of the proposed method are conducted on damaged beam-like structures, and the effectiveness of the proposed method is verified by the results of the investigations.
    Language English
    Publishing date 2021-04-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s21072453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Clinical research progress of HBV RNA].

    Xu, Y F / Lei, X Z

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 28, Issue 12, Page(s) 1055–1058

    Abstract: Hepatitis B virus RNA plays an important role in the process of hepatitis B virus replication, especially pregenomic RNA (pgRNA), which serves as a template for the viral capsids, so its particularity is increasing day by day. This article analyzes the ... ...

    Abstract Hepatitis B virus RNA plays an important role in the process of hepatitis B virus replication, especially pregenomic RNA (pgRNA), which serves as a template for the viral capsids, so its particularity is increasing day by day. This article analyzes the recent clinical studies, and further discusses the guiding significance of HBV RNA as a new clinical serological marker for hepatitis B patients.
    MeSH term(s) Hepatitis B ; Hepatitis B virus/genetics ; Humans ; RNA, Viral/genetics ; Virus Replication
    Chemical Substances RNA, Viral
    Language Chinese
    Publishing date 2021-12-05
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20190308-00074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Clinical significance of hepatitis B virus pgRNA for deciding antiviral therapy discontinuation in patients with chronic hepatitis B].

    He, J Z / Xu, Y F / Lei, X Z

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2022  Volume 30, Issue 9, Page(s) 970–975

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Hepatitis B e Antigens ; Hepatitis B, Chronic/drug therapy ; DNA, Viral ; RNA ; Antiviral Agents/therapeutic use ; Recurrence ; Hepatitis B Surface Antigens
    Chemical Substances Hepatitis B e Antigens ; DNA, Viral ; pgRNA ; RNA (63231-63-0) ; Antiviral Agents ; Hepatitis B Surface Antigens
    Language Chinese
    Publishing date 2022-10-27
    Publishing country China
    Document type Observational Study ; English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20210305-00110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A coronary computed tomography angiography study on anatomical characteristics of the diagonal branch of anterior interventricular artery.

    Zhang, D-Q / Xu, Y-F / Dong, Y-P / Yu, S-J

    Folia morphologica

    2022  Volume 82, Issue 4, Page(s) 822–829

    Abstract: Background: This study investigated the anatomical characteristics of the ramus intermedius (RI) and its correlation with the proximal diameter of the branch vessels of the left coronary artery (LCA) using coronary computed tomography angiography (CCTA). ...

    Abstract Background: This study investigated the anatomical characteristics of the ramus intermedius (RI) and its correlation with the proximal diameter of the branch vessels of the left coronary artery (LCA) using coronary computed tomography angiography (CCTA).
    Materials and methods: We screened patients who underwent CCTA from January to September 2021 and randomly enrolled 267 with RI (RI group) and 134 without RI (control group). We evaluated the anatomical features of RI (distribution, proximal diameter, length). We measured the proximal diameter of the anterior interventricular branch of the left coronary artery (LAD) and the circumflex branch of the left coronary artery (LCX). We compared the differences between groups in the proximal diameter of LAD and LCX and the correlation between gender and each parameter of the LCA (LAD, LCX, RI) within the RI group. In addition, we compared the correlation between the distribution characteristics of RI and the proximal diameter of LAD and LCX within the RI group.
    Results: The LAD and LCX proximal diameters in the RI group were significantly smaller than those in the control group (p < 0.05). Comparisons within the RI group showed the following results: the RI distribution, RI diameter and length, and the LCX proximal diameter were not significantly different between male and female patients (p > 0.05), and the LAD proximal diameter was significantly larger in male than in female patients (p < 0.05). There were statistically significant differences in the LAD and LCX proximal diameters between the different RI distribution groups (p < 0.05). Based on the pairwise comparison, there were significant differences in the LAD (LCX) proximal diameter between the RI-beside- -the-LAD (LCX) group and the RI-middle group, as well as between the RI-beside- -the-LAD (LCX) group and the RI-beside-the-LCX (LAD) group (p < 0.05).
    Conclusions: A CCTA accurately evaluated the anatomical characteristics of an RI, which has an impact on the proximal diameter of the branch vessels of the LCA (i.e. LAD and LCX), the degree of influence of which is correlated with the RI distribution.
    MeSH term(s) Humans ; Male ; Female ; Coronary Vessels/diagnostic imaging ; Computed Tomography Angiography ; Coronary Angiography ; Heart ; Tomography, X-Ray Computed ; Coronary Artery Disease
    Language English
    Publishing date 2022-12-06
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 419361-1
    ISSN 1644-3284 ; 0015-5659
    ISSN (online) 1644-3284
    ISSN 0015-5659
    DOI 10.5603/FM.a2022.0100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [New research advances in hypertrophic scar formation, prevention and treatment].

    Chen, L / Yan, H / Zhou, B / Xu, Y F / Li, J

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2023  Volume 57, Issue 4, Page(s) 597–606

    Abstract: Scarring, naturally induced by fibroblasts(Fb) during wound healing, is an essential process in response to repair damaged tissue. Excessive Fb proliferation which produces the excessive collagen deposition, including increased extracellular matrix ... ...

    Abstract Scarring, naturally induced by fibroblasts(Fb) during wound healing, is an essential process in response to repair damaged tissue. Excessive Fb proliferation which produces the excessive collagen deposition, including increased extracellular matrix synthesis or insufficient decomposition, typically contributes to hypertrophic scar(HS) formation. Although exact mechanisms of HS are not yet fully understood, it is generally believed that dysfunction of Fb and regulation of signal pathways play an important role in HS formation. Biologically, Fb function is affected by various factors such as cytokines, extracellular matrix and itself. In addition, modifications of miRNA, ceRNA, lncRNA, peptides and histones participate in HS formation by affecting the biological function of Fb. Despite the clinical importance, very few therapeutic modalities are available to prevent HS. To achieve this, a deeper characterization of Fb is required to identify mechanisms of HS. To the aspect of HS prevention and treatment, we review recent findings, concentrating on Fb function and collagen secretion. The objective of this article is to frame the current understanding, gain the deeper insights into Fb function, and provide the more comprehensive cognition and perspective for prevention and treatment of HS.
    MeSH term(s) Humans ; Cicatrix, Hypertrophic/prevention & control ; Cicatrix, Hypertrophic/drug therapy ; Cicatrix, Hypertrophic/metabolism ; Collagen/metabolism ; Collagen/therapeutic use ; Fibroblasts ; Signal Transduction ; Extracellular Matrix/metabolism
    Chemical Substances Collagen (9007-34-5)
    Language Chinese
    Publishing date 2023-03-31
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20220506-00451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Prevention and control of birth defects and rare diseases in the era of genomic medicine].

    Wang, J / Xu, Y F / Fu, Q H

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2021  Volume 55, Issue 9, Page(s) 1023–1027

    Abstract: Birth defects and rare diseases have become major public health problems, and early prevention and control are the most effective interventions. In recent years, with the rapid development of genomic techniques such as high-throughput sequencing, the ... ...

    Abstract Birth defects and rare diseases have become major public health problems, and early prevention and control are the most effective interventions. In recent years, with the rapid development of genomic techniques such as high-throughput sequencing, the level of screening and diagnosis of genetic birth defects and rare diseases has been greatly improved. This article reviews the application of genomic technologies in the pre-pregnancy, preimplantation, prenatal and neonatal stages, as well as the trend of clinical transformation, highlighting the broad prospects of constructing an early and precise prevention and control system in the era of genomic medicine.
    MeSH term(s) Female ; Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Pregnancy ; Rare Diseases/genetics ; Rare Diseases/prevention & control
    Language Chinese
    Publishing date 2021-09-30
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20210427-00420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Value of artificial intelligence in the improvement of diagnostic consistency of radiology residents].

    Liu, X / Xie, H H / Xu, Y F / Zhang, X D / Tao, X F / Liu, L / Wang, X Y

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2023  Volume 55, Issue 4, Page(s) 670–675

    Abstract: Objective: To explore the value of artificial intelligence (AI) in improving the detection rate of traumatic rib fractures by radiologist residents and the consistency among different readers.: Methods: Chest CT images of 393 patients with acute ... ...

    Abstract Objective: To explore the value of artificial intelligence (AI) in improving the detection rate of traumatic rib fractures by radiologist residents and the consistency among different readers.
    Methods: Chest CT images of 393 patients with acute trauma from China-Japan Union Hospital of Jilin University (hospital 02) and Shanghai Ninth People' s Hospital (hospital 03) were collected in this research. The consensus achieved by three radiology experts was regarded as the reference standard. All the images assigned to three hospitals: Peking University First Hospital (hospital 01), hospital 02 and hospital 03, and were then randomly divided into two groups (group A and group B: group A included 197 patients, and group B included 196 patients). Each group was read by one radiologist resident from each hospital for rib fracture detection. Each case was read twice by the same radiologist, with and without the assistance of the AI ["radiologist-only" reading and "radiologist + AI" reading]. The detection rates of different types of rib fractures (displaced fractures and occult fractures) were compared between "radiologist-only" reading and "radiologist + AI" reading. The consistencies of different radiologists with different reading methods were evaluated.
    Results: The detection rates of displaced rib fractures and occult rib fractures by "radiologist + AI" reading were significantly higher than those read by "radiologist-only" reading (94.56%
    Conclusion: AI software can be used to automatically detect suspected rib fracture lesions, which helps to improve the detection rate of fracture lesions and the consistency among different readers.
    MeSH term(s) Humans ; Rib Fractures/diagnostic imaging ; Artificial Intelligence ; China ; Radiography ; Retrospective Studies ; Radiology
    Language Chinese
    Publishing date 2023-08-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2452593-5
    ISSN 1671-167X
    ISSN 1671-167X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MiR-186 promotes the apoptosis of glioma U87 cells by down-regulating the expression of Smad6.

    Xu, Y-F / Liu, J / Wang, J / Guo, Y-C / Shen, Y-Z

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 14, Page(s) 7681–7689

    Abstract: Objective: MiRNA family gene is an evolutionarily conserved non-coding small RNA that directly participates in a variety of physiological processes and cancer development via regulating gene expression in the biological level of transcription. To ... ...

    Abstract Objective: MiRNA family gene is an evolutionarily conserved non-coding small RNA that directly participates in a variety of physiological processes and cancer development via regulating gene expression in the biological level of transcription. To research the specific mechanism by which miR-186 regulates apoptosis within gliomas.
    Patients and methods: RT-qPCR was performed to verify the transcriptional level of miR-186 within glioma tissues and glioma cells. miRanda and Dual-Luciferase assay were performed to predict and confirm that Smad6 gene is an effective target of miR-186 within glioma. The expression of Smad6 protein was tested by Western blot following cell effective transfection. Apoptosis of gliomas was analyzed by inverted fluorescence microscopy and flow cytometry.
    Results: The mRNA level of miR-186 was suppressed within glioma tissues and glioma U87 cells. MiR-186 is associated with apoptosis in glioma. Overexpression of miR-186 promoted U87 cell apoptosis, whereas suppression of miR-186 had the opposite effect. Besides, miR-186 directly targeted Smad6 and suppress its expression in glioma. The expression of Smad6 affected the regulation of miR-186 on glioma cell apoptosis, restoration of Smad6 rescued apoptosis of glioma U87 cells induced by miR-186 mimics, whereas inhibition of Smad6 promoted apoptosis.
    Conclusions: As noted above, miR-186 exerts a tumor-suppressing effect by targeting Smad6. We propose that miR-186 can be used as a novel biomarker for glioma diagnosis in the future, or as a new pharmacy target in the cure of gliomas.
    MeSH term(s) Apoptosis ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Signal Transduction ; Smad6 Protein/genetics ; Smad6 Protein/metabolism
    Chemical Substances MIRN186 microRNA, human ; MicroRNAs ; SMAD6 protein, human ; Smad6 Protein
    Language English
    Publishing date 2020-08-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202007_22269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Impacts of high-voltage electrical burn on serum platelet-related factors and platelet aggregation number in rats and the interventive effect of Xuebijing].

    Zhang, Q F / Gao, Z J / Zhang, Z W / Zhao, X G / Feng, J K / Xu, Y F / Tu, L L / Zhang, J

    Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns

    2020  Volume 36, Issue 6, Page(s) 426–432

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Animals ; Burns, Electric ; Drugs, Chinese Herbal ; Female ; Male ; Platelet Aggregation ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal ; Xuebijing
    Language Chinese
    Publishing date 2020-06-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 2229222-6
    ISSN 1009-2587
    ISSN 1009-2587
    DOI 10.3760/cma.j.cn501120-20200407-00212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The gene regulatory network in different brain regions of neuropathic pain mouse models.

    Li, X / Xu, L-S / Xu, Y-F / Yang, Q / Fang, Z-X / Yao, M / Chen, W-Y

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 9, Page(s) 5053–5061

    Abstract: Objective: Neuropathic pain is directly developed from lesions or somatosensory nervous system diseases that are associated with emotion regulation. In general population, the incidence of neuropathic pain ranges from 7% to 10%, but the underlying ... ...

    Abstract Objective: Neuropathic pain is directly developed from lesions or somatosensory nervous system diseases that are associated with emotion regulation. In general population, the incidence of neuropathic pain ranges from 7% to 10%, but the underlying mechanism remains largely unknown. Neuropathic pain is often associated with structural and functional abnormalities in multiple brain regions, and its regulation has been shown to correspond with the forebrain, including nucleus accumbens (NAc), medial prefrontal cortex (mPFC) and periaqueductal gray (PAG).
    Materials and methods: To investigate the molecular mechanism of neuropathic pain across different brain regions, we identified the differentially expressed genes (DEGs) between the spared nerve injury model (SNI) mice suffering neuropathic pain and the control Sham mice in NAc, mPFC and PAG three brain regions, and mapped these genes onto a comprehensively functional association network. Thereafter, novel neuropathic pain genes in these three regions were identified using With Random Walk with Restart (RWR) analysis, such as Asic3, Cd200r1 and MT2, besides well-known Capn11 and CYP2E1.
    Results: Interactions or cross talks among DEGs in NAc, mPFC and PAG three brain regions were discovered.
    Conclusions: Our results provide novel insights into neuropathic pain and help to explore therapeutic targets in the treatment.
    MeSH term(s) Animals ; Disease Models, Animal ; Gene Regulatory Networks/genetics ; Mice ; Neuralgia/genetics ; Neuralgia/metabolism ; Neuralgia/pathology ; Nucleus Accumbens/metabolism ; Nucleus Accumbens/pathology ; Periaqueductal Gray/metabolism ; Periaqueductal Gray/pathology ; Prefrontal Cortex/metabolism ; Prefrontal Cortex/pathology
    Language English
    Publishing date 2020-06-01
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202005_21198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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