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Article ; Online: Phthalates contamination in sediments: A review of sources, influencing factors, benthic toxicity, and removal strategies.

Xu, Yanli / Sun, Yuqiong / Lei, Ming / Hou, Jing

Environmental pollution (Barking, Essex : 1987)

2024 Volume 344, Page(s) 123389

Abstract: Sediments provide habitat and food for benthos, and phthalates (PAEs) have been detected in numerous river and marine sediments as a widely used plastic additive. PAEs in sediments is not only toxic to benthos, but also poses a threat to pelagic fish and ...

Abstract	Sediments provide habitat and food for benthos, and phthalates (PAEs) have been detected in numerous river and marine sediments as a widely used plastic additive. PAEs in sediments is not only toxic to benthos, but also poses a threat to pelagic fish and human health through the food chain, so it is essential to comprehensively assess the contamination of sediments with PAEs. This paper presents a critical evaluation of PAEs in sediments, which is embodied in the analysis of the sources of PAEs in sediments from multiple perspectives. Biological production is indispensable, while artificial synthesis is the most dominant, thus the focus was on analyzing the industrial and commercial sources of synthetic PAEs. In addition, since the content of PAEs in sediments varies, some factors affecting the content of PAEs in sediments are summarized, such as the properties of PAEs, the properties of plastics, and environmental factors (sediments properties and hydrodynamic conditions). As endocrine disruptors, PAEs can produce toxicity to its direct contacts. Therefore, the effects of PAEs on benthos immunity, endocrinology, reproduction, development, and metabolism were comprehensively analyzed. In addition, we found that reciprocal inhibition and activation of the systems lead to genotoxicity and apoptosis. Finally, the paper discusses the feasible measures to control PAEs in wastewater and leachate from the perspective of source control, and summarizes the in-situ treatment measures for PAEs contamination in sediments. This paper provides a comprehensive review of PAEs contamination in sediments, toxic effects and removal strategies, and provides an important reference for reducing the contamination and toxicity of PAEs to benthos.
MeSH term(s)	Animals ; Humans ; Apoptosis ; DNA Damage ; Drug Contamination ; Endocrine Disruptors/toxicity ; Food ; Phthalic Acids/toxicity ; Esters ; China
Chemical Substances	Endocrine Disruptors ; Phthalic Acids ; Esters
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123389
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Zs.A 2599: Show issues

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Article ; Online: Selective Aza-Michael Addition to Dehydrated Amino Acids in Natural Antimicrobial Peptides.

Vargiu, Michela / Xu, Yanli / Kuipers, Oscar P / Roelfes, Gerard

Chembiochem : a European journal of chemical biology

2024 Volume 25, Issue 7, Page(s) e202400043

Abstract: We report the efficient and site selective modification of non-canonical dehydroamino acids in ribosomally synthesized and post-transationally modified peptides (RiPPs) by β-amination. The singly modified thiopeptide Thiostrepton showed an up to 35-fold ... ...

Abstract	We report the efficient and site selective modification of non-canonical dehydroamino acids in ribosomally synthesized and post-transationally modified peptides (RiPPs) by β-amination. The singly modified thiopeptide Thiostrepton showed an up to 35-fold increase in water solubility, and minimum inhibitory concentration (MIC) assays showed that antimicrobial activity remained good, albeit lower than the unmodified peptide. Also the lanthipeptide nisin could be modified using this method.
MeSH term(s)	Amino Acids ; Antimicrobial Peptides ; Protein Processing, Post-Translational
Chemical Substances	Amino Acids ; Antimicrobial Peptides
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202400043
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Article ; Online: A critical review on BDE-209: Source, distribution, influencing factors, toxicity, and degradation.

Sun, Yuqiong / Xu, Yanli / Wu, Haodi / Hou, Jing

Environment international

2023 Volume 183, Page(s) 108410

Abstract: As the most widely used polybrominated diphenyl ether, BDE-209 is commonly used in polymer-based commercial and household products. Due to its unique physicochemical properties, BDE-209 is ubiquitous in a variety of environmental compartments and can be ... ...

Abstract	As the most widely used polybrominated diphenyl ether, BDE-209 is commonly used in polymer-based commercial and household products. Due to its unique physicochemical properties, BDE-209 is ubiquitous in a variety of environmental compartments and can be exposed to organisms in various ways and cause toxic effects. The present review outlines the current state of knowledge on the occurrence of BDE-209 in the environment, influencing factors, toxicity, and degradation. BDE-209 has been detected in various environmental matrices including air, soil, water, and sediment. Additionally, environmental factors such as organic matter, total suspended particulate, hydrodynamic, wind, and temperature affecting BDE-209 are specifically discussed. Toxicity studies suggest BDE-209 may cause systemic toxic effects on living organisms, reproductive toxicity, embryo-fetal toxicity, genetic toxicity, endocrine toxicity, neurotoxicity, immunotoxicity, and developmental toxicity, or even be carcinogenic. BDE-209 has toxic effects on organisms mainly through epigenetic regulation and induction of oxidative stress. Evidence regarding the degradation of BDE-209, including biodegradation, photodegradation, Fenton degradation, zero-valent iron degradation, chemical oxidative degradation, and microwave radiation degradation is summarized. This review may contribute to assessing the environmental risks of BDE-209 to help develop rational management plans.
MeSH term(s)	Halogenated Diphenyl Ethers/toxicity ; Epigenesis, Genetic ; Biodegradation, Environmental ; Carcinogens
Chemical Substances	decabromobiphenyl ether (N80BQ29A0H) ; Halogenated Diphenyl Ethers ; Carcinogens
Language	English
Publishing date	2023-12-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.108410
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Zs.A 3131: Show issues

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Article: [Research Progress of Long Non-Coding RNA in Hematological Tumors --Review].

Li, Feng / Yang, Fei-Fei / Xu, Yan-Li

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 1, Page(s) 306–310

Abstract: Long non-coding RNA (lncRNA) is a hot topic in the field of researching tumor pathogenesis, and the importance in hematologic malignancies has been gradually being elucidated. LncRNA not only regulates hematological tumorigenesis and progression through ... ...

Abstract	Long non-coding RNA (lncRNA) is a hot topic in the field of researching tumor pathogenesis, and the importance in hematologic malignancies has been gradually being elucidated. LncRNA not only regulates hematological tumorigenesis and progression through affecting various biological processes such as cell proliferation, differentiation, pluripotency and apoptosis; moreover, abnormal expression and mutation of lncRNA are closely related to drug resistance and prognosis. Thus lncRNA can be used as novel biomarker and potential therapeutic target for hematological tumors. In this review, we will focus on the latest progress of lncRNA in hematological tumors to provide new ideas for the clinical diagnosis, prognostic evaluation together with research and development of target drugs for hematologic malignancies.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Hematologic Neoplasms/genetics ; Neoplasms ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic
Chemical Substances	RNA, Long Noncoding
Language	Chinese
Publishing date	2023-01-29
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.01.049
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Zs.A 6603: Show issues

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Article: [Research Progress of Immune Heterogeneity in Leukemia Microenvironment--Review].

Li, Feng / Yang, Fei-Fei / Xu, Yan-Li

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 5, Page(s) 1569–1573

Abstract: Although the body has a strong immune system which can resists the invasion of leukemia cells, leukemia cells disseminate systemically and form an immunosuppressive microenvironment through a variety of mechanisms, including regulation of antigen ... ...

Abstract	Although the body has a strong immune system which can resists the invasion of leukemia cells, leukemia cells disseminate systemically and form an immunosuppressive microenvironment through a variety of mechanisms, including regulation of antigen presentation, utilization of immunosuppressive enzyme AXL, immune cell inhibitory checkpoint NKG2A and immunoregulatory gene
MeSH term(s)	Humans ; Immunotherapy/methods ; Leukemia/therapy ; Immunity ; Combined Modality Therapy ; Prognosis ; Tumor Microenvironment
Language	Chinese
Publishing date	2023-10-17
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.05.050
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Zs.A 6603: Show issues

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Article ; Online: Stretchable structural colors with polarization dependence using lithium niobate metasurfaces.

Xu, Yanli / Wang, Yulin / Yang, Yinye / Yang, Shengyi / Li, Linfu / Xiang, Rong / Liu, Jiangtao

Optics express

2024 Volume 32, Issue 4, Page(s) 6776–6790

Abstract: Independently tunable biaxial color pixels, composed of isolated nanosquare dimers, are demonstrated in this study. These pixels are capable of displaying a full range of colors under a linear-polarization dependent reflection mode. The metasurface is ... ...

Abstract	Independently tunable biaxial color pixels, composed of isolated nanosquare dimers, are demonstrated in this study. These pixels are capable of displaying a full range of colors under a linear-polarization dependent reflection mode. The metasurface is constructed by arranging LiNbO
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.515566
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Article ; Online: A network meta-analysis on the effects of different exercise types on COPD patients.

Jian, Chengping / Peng, Xiangdong / Yang, Yuting / Xu, Yanli / Wang, Liying / Cai, Defang

Respiratory care

2024

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.11476
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Zs.B 2285: Show issues

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Article: LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis.

Xu, Yanli / Kang, Xiaodi / Liu, Huafang / Jiang, Hongli / Wang, Wenjing

General physiology and biophysics

2023 Volume 42, Issue 5, Page(s) 443–455

Abstract: Many studies have explored the role of lncRNA X inactivation-specific transcript (XIST) in diabetes. This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA ( ...

Abstract	Many studies have explored the role of lncRNA X inactivation-specific transcript (XIST) in diabetes. This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels in GDM mice were detected. The GDM mice were subjected to gain- and loss-of-function assays to examine the change of glucose metabolism indices (fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)), serum inflammatory factors (interleukin-1 β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α)), pathological changes of pancreatic tissues, and apoptotic cells in pancreatic islets in GDM mice. XIST and NDRG2 expression were elevated while miR-181b-5p expression was depleted in GDM mice. Down-regulated XIST or NDRG2 or up-regulated miR-181b-5p reduced the FBG level, HOMA-IR, and serum IL-1β, IL-6, and TNF-α, and MDA contents, elevated the FINS, GSH, and SOD level, mitigated pathological changes in pancreatic tissues, and decelerated apoptotic cells in pancreatic islets in GDM mice. Silenced XIST dampens insulin resistance in GDM mice via the modulation of the miR-181b-5p/NDRG2 axis.
MeSH term(s)	Animals ; Mice ; Female ; Humans ; Pregnancy ; Diabetes, Gestational/genetics ; Insulin Resistance ; RNA, Long Noncoding/genetics ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Glutathione ; MicroRNAs/genetics ; Tumor Suppressor Proteins
Chemical Substances	RNA, Long Noncoding ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Glutathione (GAN16C9B8O) ; MicroRNAs ; NDRG2 protein, human ; Tumor Suppressor Proteins
Language	English
Publishing date	2023-09-13
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2023019
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Zs.A 1874: Show issues

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Article ; Online: Tissue-specific toxic effects of nano-copper on zebrafish.

Liu, Haiqiang / Xu, Yanli / Sun, Yuqiong / Wu, Haodi / Hou, Jing

Environmental research

2023 Volume 242, Page(s) 117717

Abstract: Understanding the behavior and potential toxicity of copper nanoparticles (nano-Cu) in the aquatic environment is a primary way to assess their environmental risks. In this study, RNA-seq was performed on three different tissues (gills, intestines, and ... ...

Abstract	Understanding the behavior and potential toxicity of copper nanoparticles (nano-Cu) in the aquatic environment is a primary way to assess their environmental risks. In this study, RNA-seq was performed on three different tissues (gills, intestines, and muscles) of zebrafish exposed to nano-Cu, to explore the potential toxic mechanism of nano-Cu on zebrafish. The results indicated that the toxic mechanism of nano-Cu on zebrafish was tissue-specific. Nano-Cu enables the CB1 receptor of the presynaptic membrane of gill cells to affect short-term synaptic plasticity or long-term synaptic changes (ECB-LTD) through DSI and DSE, causing dysfunction of intercellular signal transmission. Imbalance of de novo synthesis of UMP in intestinal cells and its transformation to UDP, UTP, uridine, and uracil, resulted in many functions involved in the pyrimidine metabolic pathway being blocked. Meanwhile, the toxicity of nano-Cu caused abnormal expression of RAD51 gene in muscle cells, which affects the repair of damaged DNA through Fanconi anemia and homologous recombination pathway, thus causing cell cycle disorder. These results provide insights for us to better understand the differences in toxicity of nano-Cu on zebrafish tissues and are helpful for a comprehensive assessment of nano-Cu's effects on aquatic organisms.
MeSH term(s)	Animals ; Copper/toxicity ; Zebrafish/metabolism ; Nanoparticles/toxicity ; Cell Cycle ; Water Pollutants, Chemical/toxicity
Chemical Substances	Copper (789U1901C5) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-11-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.117717
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Zs.A 726: Show issues

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Article ; Online: Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides.

Fu, Yuxin / Xu, Yanli / Ruijne, Fleur / Kuipers, Oscar P

FEMS microbiology reviews

2023 Volume 47, Issue 3

Abstract: Natural bioactive peptide discovery is a challenging and time-consuming process. However, advances in synthetic biology are providing promising new avenues in peptide engineering that allow for the design and production of a large variety of new-to- ... ...

Abstract	Natural bioactive peptide discovery is a challenging and time-consuming process. However, advances in synthetic biology are providing promising new avenues in peptide engineering that allow for the design and production of a large variety of new-to-nature peptides with enhanced or new bioactivities, using known peptides as templates. Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs). The modularity of post-translational modification (PTM) enzymes and ribosomal biosynthesis inherent to lanthipeptides enables their engineering and screening in a high-throughput manner. The field of RiPPs research is rapidly evolving, with many novel PTMs and their associated modification enzymes being identified and characterized. The modularity presented by these diverse and promiscuous modification enzymes has made them promising tools for further in vivo engineering of lanthipeptides, allowing for the diversification of their structures and activities. In this review, we explore the diverse modifications occurring in RiPPs and discuss the potential applications and feasibility of combining various modification enzymes for lanthipeptide engineering. We highlight the prospect of lanthipeptide- and RiPP-engineering to produce and screen novel peptides, including mimics of potent non-ribosomally produced antimicrobial peptides (NRPs) such as daptomycin, vancomycin, and teixobactin, which offer high therapeutic potential.
MeSH term(s)	Peptides/metabolism ; Protein Processing, Post-Translational
Chemical Substances	Peptides
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	283740-7
ISSN	1574-6976 ; 0168-6445
ISSN (online)	1574-6976
ISSN	0168-6445
DOI	10.1093/femsre/fuad017
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