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Article ; Online: Enhanced photocurrent response speed in charge-density-wave phase of TiSe

Walmsley, Thayer S / Xu, Ya-Qiong

2021 Volume 13, Issue 27, Page(s) 11836–11843

Abstract: Group IVB transition metal dichalcogenides (TMDCs) have attracted significant attention due to their predicted high charge carrier mobility, large sheet current density, and enhanced thermoelectric power. Here, we investigate the electrical and ... ...

Abstract	Group IVB transition metal dichalcogenides (TMDCs) have attracted significant attention due to their predicted high charge carrier mobility, large sheet current density, and enhanced thermoelectric power. Here, we investigate the electrical and optoelectronic properties of few-layer titanium diselenide (TiSe2)-metal junctions through spatial-, wavelength-, temperature-, power- and temporal-dependent scanning photocurrent measurements. Strong photocurrent responses have been detected at TiSe2-metal junctions, which is likely attributed to both photovoltaic and photothermoelectric effects. A fast response time of 31 μs has been achieved, which is two orders of magnitude better than HfSe2 based devices. More importantly, our experimental results reveal a significant enhancement in the response speed upon cooling to the charge-density-wave (CDW) phase transition temperature (TCDW = 206 K), which may result from dramatic reduction in carrier scattering that occurs as a result of the switching between the normal and CDW phases of TiSe2. Additionally, the photoresponsivity at 145 K is up to an order of magnitude higher than that obtained at room temperature. These fundamental studies not only offer insight for the photocurrent generation mechanisms of group IVB TMDC materials, but also provide a route to engineering future temperature-dependent, two-dimensional, fast electronic and optoelectronic devices.
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr01810h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In situ

Zhang, Xiaosi / Walmsley, Thayer S / Xu, Ya-Qiong

Nanoscale advances

2020 Volume 2, Issue 9, Page(s) 4034–4040

Abstract: Exploring ways to tune and improve the performance of graphene is of paramount importance in creating functional graphene-based electronic and optoelectronic devices. Recent advancements have shown that altering the morphology of graphene can have a ... ...

Abstract	Exploring ways to tune and improve the performance of graphene is of paramount importance in creating functional graphene-based electronic and optoelectronic devices. Recent advancements have shown that altering the morphology of graphene can have a pronounced effect on its properties. Here, we present a practical and facile method to manipulate the morphology of a suspended graphene ribbon using a laser to locally induce heating while monitoring its electrical and optoelectronic properties
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/d0na00413h
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Article ; Online: Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma.

Huang, Shan / Zhang, Jiayi / Li, Yi / Xu, Yaqiong / Jia, Hui / An, Lei / Wang, Xiaotan / Yang, Yuting

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 379

Abstract: Background: Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical role of tight junction proteins in tumorigenesis, the involvement of Claudin5 in ESCC remains poorly ... ...

Abstract	Background: Esophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical role of tight junction proteins in tumorigenesis, the involvement of Claudin5 in ESCC remains poorly understood. Thus, this study aimed to investigate the role of Claudin5 in ESCC malignant progression and radioresistance, as well as the underlying regulatory mechanisms. Methods: The expression of Claudin5 was evaluated in esophageal cancer tissue using both public databases and 123 clinical samples. CCK-8, transwell invasion, wound healing and clonogenic survival assays were used to examine the proliferation, invasion, migration and radiosensitivity of ESCC cells in vitro. Xenograft and animal lung metastasis experiments were conducted to examine the impact of Claudin5 on tumor growth and lung metastasis in vivo. The effect of Claudin5 on autophagy was detected via transmission electron microscopy, western blotting and autophagy flux. Immunohistochemical staining was used to detect Claudin5 expression in ESCC patient samples. The statistical difference was assessed with Student t test or one-way ANOVA. The correlation between Claudin5 expression and radiotherapy response rate was performed by the Chi-square test. The significance of Kaplan-Meier curves was evaluated by the Logrank test. Results: Claudin5 expression was downregulated in ESCC tissues. Downregulation of Claudin5 promoted ESCC cell proliferation, invasion, and migration both in vitro and in vivo. Downregulation of Claudin5 decreased the radiosensitivity of ESCC cells. Moreover, downregulation of Claudin5 promoted autophagy and the expression of Beclin1. Beclin1 knockdown reversed the effect of Claudin5 downregulation on autophagy induction and the promotion of ESCC cell malignant progression and radioresistance. Additionally, low expression of Claudin5 in ESCC cancer tissues was associated with poor radiotherapy response and prognosis. Conclusions: In summary, these findings suggest that downregulation of Claudin5 promotes ESCC malignant progression and radioresistance via Beclin1-autophagy activation and may serve as a promising biomarker for predicting radiotherapy response and patient outcome in ESCC.
MeSH term(s)	Animals ; Humans ; Autophagy/genetics ; Beclin-1/genetics ; Down-Regulation/genetics ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/radiotherapy ; Esophageal Squamous Cell Carcinoma/genetics ; Claudin-5/genetics ; Radiation Tolerance
Chemical Substances	Beclin-1 ; Claudin-5 ; BECN1 protein, human ; CLDN5 protein, human
Language	English
Publishing date	2023-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04248-7
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Article: Human UC-MSC-derived exosomes facilitate ovarian renovation in rats with chemotherapy-induced premature ovarian insufficiency.

Pu, Xiaodi / Zhang, Leisheng / Zhang, Peiyu / Xu, Yaqiong / Wang, Jun / Zhao, Xiaomei / Dai, Zhihua / Zhou, Hua / Zhao, Shuyun / Fan, Anran

Frontiers in endocrinology

2023 Volume 14, Page(s) 1205901

Abstract: Premature ovarian insufficiency (POI) induced by chemotherapy is an intractable disorder with a considerable incidence that commonly results in insufficient fertility and concomitant complications in female patients. Due to limitations in the current ... ...

Abstract	Premature ovarian insufficiency (POI) induced by chemotherapy is an intractable disorder with a considerable incidence that commonly results in insufficient fertility and concomitant complications in female patients. Due to limitations in the current progress in POI diagnosis and treatment, there is an urgent need to develop novel remedies to improve ovarian function and protect fertility. The ameliorative effect of human umbilical cord mesenchymal stem cells (hUCMSCs) and exosomes derived from them in POI treatment could be a new hope for patients. Herein, we identified exosomes from hUCMSCs (hUCMSC-Exos). Then, systematic infusion of hUCMSC-Exos was accomplished via tail intravenous injection to investigate the feasibility of the treatment of rats with chemotherapy-induced POI by intraperitoneal injection of cyclophosphamide (CTX) and busulfan (BUS). Ovarian functions in the indicated group were evaluated, including oestrous cycle, serum sex hormone levels, follicle counts, ovarian pathological changes, proliferation and apoptosis of granulosa cells (GCs), and reproductive ability testing. Furthermore, the potential influence of hUCMSC-Exos on ovarian tissues was illuminated by conducting RNA-seq and multifaceted bioinformatics analyses. POI rats with hUCMSC-Exos transplantation exhibited a decrease in follicle-stimulating hormone (FSH) and apoptosis of GCs but an increase in oestradiol (E2), anti-Müllerian hormone (AMH), and the number of ovarian follicles and foetuses in the uterus. And the immunomodulation- and cellular vitality-associated gene sets in rats had also undergone moderate changes. Our data indicated the feasibility of hUCMSC-Exos in improving ovarian function and protecting fertility in chemotherapy-induced POI rats. HUCMSC-Exos can improve the local microenvironment of ovarian tissue in POI rats by participating in immune regulation, cellular viability, inflammation regulation, fibrosis and metabolism, and other related signal pathways.
MeSH term(s)	Rats ; Humans ; Female ; Animals ; Exosomes/metabolism ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/therapy ; Primary Ovarian Insufficiency/pathology ; Menopause, Premature ; Antineoplastic Agents/adverse effects
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1205901
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Article ; Online: Graphene-based microfluidic perforated microelectrode arrays for retinal electrophysiological studies.

Esteban-Linares, Alberto / Zhang, Xiaosi / Lee, Hannah H / Risner, Michael L / Weiss, Sharon M / Xu, Ya-Qiong / Levine, Edward / Li, Deyu

Lab on a chip

2023 Volume 23, Issue 9, Page(s) 2193–2205

Abstract: Perforated microelectrode arrays (pMEAs) have become essential tools ... ...

Abstract	Perforated microelectrode arrays (pMEAs) have become essential tools for
MeSH term(s)	Microelectrodes ; Graphite ; Microfluidics ; Retina/physiology ; Neurons/physiology ; Electric Stimulation
Chemical Substances	Graphite (7782-42-5)
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d3lc00064h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Proband-independent haplotyping based on NGS-based long-read sequencing for detecting pathogenic variant carrier status in preimplantation genetic testing for monogenic diseases.

Zhang, Peiyu / Zhao, Xiaomei / Li, Qinshan / Xu, Yaqiong / Cheng, Zengmei / Yang, Lu / Wang, Houmei / Tao, Yang / Huang, Guanyou / Wu, Rui / Zhou, Hua / Zhao, Shuyun

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1329580

Abstract: Preimplantation genetic testing for monogenic diseases (PGT-M) can be used to select embryos that do not develop disease phenotypes or carry disease-causing genes for implantation into the mother's uterus, to block disease transmission to the offspring, ... ...

Abstract	Preimplantation genetic testing for monogenic diseases (PGT-M) can be used to select embryos that do not develop disease phenotypes or carry disease-causing genes for implantation into the mother's uterus, to block disease transmission to the offspring, and to increase the birth rate of healthy newborns. However, the traditional PGT-M technique has some limitations, such as its time consumption, experimental procedural complexity, and the need for a complete family or reference embryo to construct the haplotype. In this study, proband-independent haplotyping based on NGS-based long-read sequencing (Phbol-seq) was used to effectively construct haplotypes. By targeting the mutation sites of single gene disease point mutations and small fragment deletion carriers, embryos carrying parental disease-causing mutations were successfully identified by linkage analysis. The efficiency of embryo resolution was then verified by classical Sanger sequencing, and it was confirmed that the construction of haplotype and SNP linkage analysis by Phbol-seq could accurately and effectively detect whether embryos carried parental pathogenic mutations. After the embryos confirmed to be nonpathogenic by Phbol-seq-based PGT-M and confirmed to have normal copy number variation by Phbol-seq-based PGT-A were transplanted into the uterus, gene detection in amniotic fluid of the implanted embryos was performed, and the results confirmed that Phbol-seq technology could accurately distinguish normal genotype embryos from genetically modified carrier embryos. Our results suggest that Phbol-seq is an effective strategy for accurately locating mutation sites and accurately distinguishing between embryos that inherit disease-causing genes and normal embryos that do not. This is critical for Phbol-seq-based PGT-M and could help more single-gene disease carriers with incomplete families,
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1329580
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Article ; Online: Direct Measurement of π Coupling at the Single-Molecule Level using a Carbon Nanotube Force Sensor.

Hong, Tu / Wang, Tianjiao / Xu, Ya-Qiong

Nano letters

2018 Volume 18, Issue 12, Page(s) 7883–7888

Abstract: We report a carbon nanotube (CNT) force sensor that combines a suspended CNT transistor with dual-trap optical tweezers to explore the interactions between two individual molecules in the near-equilibrium regime with sub-piconewton resolution. The ... ...

Abstract	We report a carbon nanotube (CNT) force sensor that combines a suspended CNT transistor with dual-trap optical tweezers to explore the interactions between two individual molecules in the near-equilibrium regime with sub-piconewton resolution. The directly measured equilibrium force (1.2 ± 0.5 pN) is likely related to the binding force between a CNT and a single DNA base, where two aromatic rings spontaneously attract to each other due to the noncovalent forces between them. On the basis of our force measurements, the binding free energy per base is calculated (∼0.34 eV), which is in good agreement with theoretical simulations. Moreover, three-dimensional scanning photocurrent microscopy enables us to simultaneously monitor the morphology changes of the CNT, leading to a comprehensive reconstruction of the CNT-DNA binding dynamics. These experimental results shed light on the fundamental understanding of the mechanical coupling between CNTs and DNA molecules and, more importantly, provide a new platform for direct observation of intermolecular interfaces at the single-molecule level.
Language	English
Publishing date	2018-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.8b03690
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Article ; Online: Probing Light-Stimulated Activities in the Retina via Transparent Graphene Electrodes.

Zhang, Xiaosi / Lee, Hannah / Zhang, Yuchen / Walmsley, Thayer S / Li, Deyu / Levine, Edward / Xu, Ya-Qiong

ACS applied bio materials

2022 Volume 5, Issue 1, Page(s) 305–312

Abstract: Graphene has triggered tremendous research due to its superior properties. In particular, the intrinsic high light transmission illustrates the unique advantage in neural biosensing. Here, we combine perforated flexible graphene electrodes with ... ...

Abstract	Graphene has triggered tremendous research due to its superior properties. In particular, the intrinsic high light transmission illustrates the unique advantage in neural biosensing. Here, we combine perforated flexible graphene electrodes with microfluidic platforms to explore real-time extracellular electrical activities of retinal ganglion cells (RGCs). Under light stimulation, the transparent graphene electrodes have demonstrated the capability of recording the electrical activities of stimulated RGCs in direct contact. Different types of RGCs have shown three distinct light induced patterns, ON, OFF, and ON-OFF, which are primarily operated by cone photoreceptors. Moreover, the observed spiking waveforms can be divided into two groups: the biphasic waveform usually occurs at contacts with soma, while the triphasic waveform is likely related to the axon. Under high K
MeSH term(s)	Electric Stimulation/methods ; Electrodes ; Graphite ; Retina ; Retinal Ganglion Cells/physiology
Chemical Substances	Graphite (7782-42-5)
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.1c01091
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Article ; Online: Dynamic Observation of Retinal Response to Pressure Elevation in a Microfluidic Chamber.

Esteban-Linares, Alberto / Wareham, Lauren K / Walmsley, Thayer S / Holden, Joseph M / Fitzgerald, Matthew L / Pan, Zhiliang / Xu, Ya-Qiong / Li, Deyu

Analytical chemistry

2022 Volume 94, Issue 36, Page(s) 12297–12304

Abstract: Dynamic observation of cell and tissue responses to elevated pressure could help our understanding of important physiological and pathological processes related to pressure-induced injury. Here, we report on a microfluidic platform capable of maintaining ...

Abstract	Dynamic observation of cell and tissue responses to elevated pressure could help our understanding of important physiological and pathological processes related to pressure-induced injury. Here, we report on a microfluidic platform capable of maintaining a wide range of stable operating pressures (30 to 200 mmHg) while using a low flowrate (2-14 μL/h) to limit shear stress. This is achieved by forcing flow through a porous resistance matrix composed of agarose gel downstream of a microfluidic chamber. The flow characteristics were investigated and the permeabilities of the agarose with four different concentrations were extracted, agreeing well with results found in the literature. To demonstrate the capability of the device, we measured the change in intracellular Ca
MeSH term(s)	Animals ; Mice ; Microfluidics ; Retina ; Retinal Ganglion Cells/pathology ; Retinal Ganglion Cells/physiology ; Sepharose ; Stress, Mechanical
Chemical Substances	Sepharose (9012-36-6)
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c05652
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Article: Dynamic Observation of Retinal Response to Pressure Elevation in a Microfluidic Chamber

Esteban-Linares, Alberto / Wareham, Lauren K. / Walmsley, Thayer S. / Holden, Joseph M. / Fitzgerald, Matthew L. / Pan, Zhiliang / Xu, Ya-Qiong / Li, Deyu

Analytical chemistry. 2022 Aug. 26, v. 94, no. 36

2022

Abstract	Dynamic observation of cell and tissue responses to elevated pressure could help our understanding of important physiological and pathological processes related to pressure-induced injury. Here, we report on a microfluidic platform capable of maintaining a wide range of stable operating pressures (30 to 200 mmHg) while using a low flowrate (2–14 μL/h) to limit shear stress. This is achieved by forcing flow through a porous resistance matrix composed of agarose gel downstream of a microfluidic chamber. The flow characteristics were investigated and the permeabilities of the agarose with four different concentrations were extracted, agreeing well with results found in the literature. To demonstrate the capability of the device, we measured the change in intracellular Ca²⁺ levels of retinal ganglion cells in whole mouse retina in response to pressure. The onset of enhanced pressure results in, on average, an immediate 119.16% increase in the intracellular Ca²⁺ levels of retinal ganglion cells. The demonstrated microfluidic platform could be widely used to probe cell and tissue responses to elevated pressure.
Keywords	agarose ; analytical chemistry ; calcium ; ganglia ; gels ; mice ; retina ; shear stress
Language	English
Dates of publication	2022-0826
Size	p. 12297-12304.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c05652
Database	NAL-Catalogue (AGRICOLA)

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